SIMILAR PATTERN OF AMINO ACIDS MAPPED TO UNIPROT ID 'A0A0U2GPI9'

DrReposER ID / Desc. Drug Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXE_A_DR7A102_1
(POL PROTEIN)		Atazanavir5yvd NSP15
(MERS-CoV)		5 / 12
GLY A 158
ALA A 159
PRO A 170
VAL A 171
ILE A 161
1.45A14.37
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		Sorafenib5yvd NSP15
(MERS-CoV)		5 / 12
ALA A  59
ILE A  40
VAL A   9
PHE A  15
GLY A   1
1.26A22.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		Trifluoperazine5yvd NSP15
(MERS-CoV)		4 / 7
PHE B 229
PHE B 218
MET B 206
SER B 204
0.97A15.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2C_F_MFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		Moxifloxacin5yvd NSP15
(MERS-CoV)		2 / 4
GLY B   1
GLU B  21
0.15A20.08
20.98
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NV6_A_CAMA422_0
(CYTOCHROME P450)		Camphor5yvd NSP15
(MERS-CoV)		3 / 3
GLY B 250
ILE B 292
VAL B 291
0.87A20.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVO_B_MK1B902_2
(POL POLYPROTEIN)		Indinavir5yvd NSP15
(MERS-CoV)		5 / 12
GLY A 158
ALA A 159
PRO A 170
VAL A 171
ILE A 161
1.30A14.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R5L_A_VIVA301_0
(PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN))		Vitamin E5yvd NSP15
(MERS-CoV)		5 / 12
PHE A 338
ILE A 272
ILE A 324
ILE A 302
ILE A 319
1.35A20.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_E_GBME2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		Glyburide5yvd NSP15
(MERS-CoV)		3 / 3
LEU B 245
THR B 282
ASN B 281
1.01A12.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_2
(PROTEASE)		Darunavir5yvd NSP15
(MERS-CoV)		5 / 12
ARG A  64
LEU A  85
ALA A  77
ASP A  78
ILE A  79
1.19A15.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_A_SAMA301_0
(HYPOTHETICAL PROTEIN
TTHA0223)		S-Adenosylmethionine5yvd NSP15
(MERS-CoV)		5 / 12
LEU A 248
VAL A 232
HIS A 231
LEU A 245
LEU A 242
1.42A21.21
None
None
GOL  A 401 (-4.7A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBK_A_RAPA225_1
(FKBP25)		Sirolimus5yvd NSP15
(MERS-CoV)		5 / 12
ASP B 293
LEU B 296
VAL B 300
ILE B 302
ILE B 319
1.44A16.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		Dabrafenib5yvd NSP15
(MERS-CoV)		3 / 3
PHE B 210
ILE B 249
ASP B 298
1.38A24.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVO_B_MK1B902_2
(POL POLYPROTEIN)		Indinavir5yvd NSP15
(MERS-CoV)		5 / 12
GLY B 158
ALA B 159
PRO B 170
VAL B 171
ILE B 161
1.35A14.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDU_B_MK1B902_2
(PROTEASE RETROPEPSIN)		Indinavir5yvd NSP15
(MERS-CoV)		5 / 12
GLY B 158
ALA B 159
PRO B 170
VAL B 171
ILE B 161
1.46A14.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4S_A_AB1A400_2
(PROTEASE)		Lopinavir5yvd NSP15
(MERS-CoV)		5 / 12
GLY A 158
ALA A 159
PRO A 170
VAL A 171
ILE A 161
1.39A14.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		Metyrapone5yvd NSP15
(MERS-CoV)		4 / 6
ILE B 135
ALA B 134
THR B 131
ALA B 112
1.47A20.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OHR_A_1UNA201_1
(ASPARTYLPROTEASE)		Nelfinavir5yvd NSP15
(MERS-CoV)		5 / 11
GLY A 158
ALA A 159
PRO A 170
VAL A 171
ILE A 161
1.27A14.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1Y_A_017A106_2
(ASPARTYL PROTEASE)		Darunavir5yvd NSP15
(MERS-CoV)		5 / 12
ARG A  64
LEU A  85
ALA A  77
ASP A  78
ILE A  79
1.26A14.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AQU_B_DR7B300_1
(HIV-1 PROTEASE)		Atazanavir5yvd NSP15
(MERS-CoV)		5 / 10
GLY A 158
ALA A 159
PRO A 170
VAL A 171
ILE A 161
1.26A14.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		Vitamin E5yvd NSP15
(MERS-CoV)		5 / 12
ILE A 272
ILE A 319
ILE A 302
LEU A 303
VAL A 335
1.17A20.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_E_GBME2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		Glyburide5yvd NSP15
(MERS-CoV)		3 / 3
LEU B 245
THR B 280
ASN B 281
0.97A12.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		Levofloxacin5yvd NSP15
(MERS-CoV)		3 / 4
SER A 204
GLY A 250
GLU A 230
1.25A22.74
20.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_2
(PROTEASE)		Saquinavir5yvd NSP15
(MERS-CoV)		3 / 3
ARG B 341
VAL B 232
THR B 337
1.10A14.79
None
None
GOL  B 401 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NV6_A_CAMA422_0
(CYTOCHROME P450)		Camphor5yvd NSP15
(MERS-CoV)		3 / 3
GLY A 250
ILE A 292
VAL A 291
0.87A20.44
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0R_A_PX9A201_0
(BETA-LACTOGLOBULIN)		Pramocaine5yvd NSP15
(MERS-CoV)		5 / 12
LEU A 303
LEU A 247
ILE A 190
VAL A 317
PHE A 326
1.27A19.76
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		Dabrafenib5yvd NSP15
(MERS-CoV)		3 / 3
PHE A 210
ILE A 249
ASP A 298
1.40A24.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_E_GBME2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		Glyburide5yvd NSP15
(MERS-CoV)		3 / 3
LEU A 251
THR A 280
ASN A 281
1.31A12.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSG_B_MK1B902_2
(HIV-1 PROTEASE)		Indinavir5yvd NSP15
(MERS-CoV)		5 / 12
GLY B 158
ALA B 159
PRO B 170
VAL B 171
ILE B 161
1.42A14.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZBF_A_VGHA3000_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS)		Crizotinib5yvd NSP15
(MERS-CoV)		5 / 12
LEU A 242
GLY A 250
LEU A 245
GLY A 243
ASP A 236
1.04A20.78
None
None
None
GOL  A 401 ( 3.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NDV_1_PAR13413_1
(25S RIBOSOMAL RNA
5S RIBOSOMAL RNA)		Paromomycin5yvd NSP15
(MERS-CoV)		3 / 3
LYS A  30
GLU A  44
LYS A  46
1.27A10.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_A_BRLA1_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		Rosiglitazone5yvd NSP15
(MERS-CoV)		3 / 3
ILE B 319
ILE B 272
LEU B 175
0.83A21.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_A_BRLA1_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		Rosiglitazone5yvd NSP15
(MERS-CoV)		3 / 3
ILE A 319
ILE A 272
LEU A 203
1.30A21.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT3_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		Calcitriol5yvd NSP15
(MERS-CoV)		3 / 3
LEU B  85
ILE B 160
TYR B  88
1.27A19.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		S-Adenosylmethionine5yvd NSP15
(MERS-CoV)		3 / 3
ARG B 195
ASP B  68
ASP B 293
1.37A14.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		Trifluoperazine5yvd NSP15
(MERS-CoV)		4 / 7
PHE A 229
PHE A 218
MET A 206
SER A 204
0.97A15.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSG_B_MK1B902_2
(HIV-1 PROTEASE)		Indinavir5yvd NSP15
(MERS-CoV)		5 / 12
GLY A 158
ALA A 159
PRO A 170
VAL A 171
ILE A 161
1.37A14.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZBF_A_VGHA3000_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS)		Crizotinib5yvd NSP15
(MERS-CoV)		5 / 12
LEU B 242
GLY B 250
LEU B 245
GLY B 243
ASP B 236
1.04A20.78
None
None
None
GOL  B 401 (-3.6A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_3
(PROTEASE)		Saquinavir5yvd NSP15
(MERS-CoV)		5 / 12
GLY A 158
ALA A 159
PRO A 170
VAL A 171
ILE A 161
1.39A15.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		Folic Acid5yvd NSP15
(MERS-CoV)		5 / 12
ILE B 219
ALA B 228
LEU B 303
PHE B 229
LEU B 296
1.42A20.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		Trifluoperazine5yvd NSP15
(MERS-CoV)		4 / 6
PHE B 229
VAL B 233
MET B 206
SER B 204
0.83A15.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		Levomefolic acid5yvd NSP15
(MERS-CoV)		5 / 12
ASN A   8
GLY A  17
VAL A  24
GLY A   1
ILE A   5
1.24A21.73
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_2
(PROTEASE)		Indinavir5yvd NSP15
(MERS-CoV)		4 / 7
LEU A 113
ALA A  97
VAL A 101
ILE A  79
0.88A15.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_2
(HIV-1 PROTEASE)		Saquinavir5yvd NSP15
(MERS-CoV)		3 / 3
ARG B 341
VAL B 232
THR B 337
1.06A14.79
None
None
GOL  B 401 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_2
(PROTEASE)		Indinavir5yvd NSP15
(MERS-CoV)		4 / 7
LEU B 113
ALA B  97
VAL B 101
ILE B  79
0.87A15.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_2
(PROTEASE)		Saquinavir5yvd NSP15
(MERS-CoV)		3 / 3
ARG A 341
VAL A 232
THR A 337
1.15A14.50
None
None
GOL  A 401 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q70_A_RITA2001_2
(CANDIDAPEPSIN-2)		Ritonavir5yvd NSP15
(MERS-CoV)		4 / 6
THR B  47
ILE B  79
ASP B  87
THR B  48
1.47A21.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ1_B_AB1B201_0
(HIV-1 PROTEASE)		Lopinavir5yvd NSP15
(MERS-CoV)		5 / 12
GLY A 158
ALA A 159
PRO A 170
VAL A 171
ILE A 161
1.37A14.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z54_A_AB1A200_2
(HIV-1 PROTEASE)		Lopinavir5yvd NSP15
(MERS-CoV)		5 / 12
GLY A 158
ALA A 159
PRO A 170
VAL A 171
ILE A 161
1.41A14.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		Metyrapone5yvd NSP15
(MERS-CoV)		4 / 6
ILE A 135
ALA A 134
THR A 131
ALA A 112
1.37A20.90
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1Y_A_017A106_2
(ASPARTYL PROTEASE)		Darunavir5yvd NSP15
(MERS-CoV)		5 / 12
LEU B  85
ALA B  77
ASP B  78
ILE B  79
ILE B 115
1.41A14.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DZ2_A_FK5A200_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		Tacrolimus5yvd NSP15
(MERS-CoV)		5 / 11
ASP B 293
ARG B 195
VAL B 300
ILE B 302
ILE B 319
1.01A14.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_B_FK5B201_1
(FK506-BINDING
PROTEIN 1)		Tacrolimus5yvd NSP15
(MERS-CoV)		5 / 11
ASP B 293
ARG B 195
VAL B 300
ILE B 190
ILE B 319
1.02A16.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		Trifluoperazine5yvd NSP15
(MERS-CoV)		5 / 6
PHE A 229
VAL A 233
PHE A 218
MET A 206
SER A 204
1.07A15.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		Agmatine5yvd NSP15
(MERS-CoV)		4 / 7
ASP A 293
LEU A 294
ILE A 249
ARG A 195
1.29A9.39
15.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JUO_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA)		Levofloxacin5yvd NSP15
(MERS-CoV)		3 / 4
SER A 204
GLY A 250
GLU A 230
1.27A22.74
18.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_A_PXLA1003_1
(PYRIDOXINE KINASE)		Pyridoxal5yvd NSP15
(MERS-CoV)		4 / 8
LEU B 175
PRO B  67
HIS B  66
ASP B 121
1.26A21.64
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGP_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		Colfosceril palmitate5yvd NSP15
(MERS-CoV)		5 / 12
ILE B 190
ILE B 319
VAL B 315
PRO B 340
PHE B 338
1.37A16.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT3_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		Calcitriol5yvd NSP15
(MERS-CoV)		3 / 3
LEU B  75
ILE B 324
TYR B 191
1.16A19.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT3_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		Calcitriol5yvd NSP15
(MERS-CoV)		3 / 3
LEU A  85
ILE A 160
TYR A  88
1.24A19.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JUO_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA)		Levofloxacin5yvd NSP15
(MERS-CoV)		3 / 4
SER A 111
GLY A 100
GLU A  56
1.06A22.74
18.30
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		Folic Acid5yvd NSP15
(MERS-CoV)		5 / 12
ILE A 219
ALA A 228
LEU A 303
PHE A 229
LEU A 296
1.45A20.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB1_0
(HEME-BINDING PROTEIN
HUTZ)		Benzoic Acid5yvd NSP15
(MERS-CoV)		4 / 6
GLN A 256
TYR A 252
PHE A 200
LEU A 201
1.45A16.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		Citalopram5yvd NSP15
(MERS-CoV)		5 / 12
ASP A 121
ILE A 115
ALA A 134
GLY A 100
SER A 124
1.21A20.97
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		Bepridil5yvd NSP15
(MERS-CoV)		5 / 12
ILE A 137
LEU A  72
ILE A 135
MET A 148
CYH A 189
1.39A15.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q70_A_RITA2001_2
(CANDIDAPEPSIN-2)		Ritonavir5yvd NSP15
(MERS-CoV)		4 / 6
THR A  47
ILE A  79
ASP A  87
THR A  48
1.44A21.34
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL1_A_DR7A100_2
(PROTEASE)		Atazanavir5yvd NSP15
(MERS-CoV)		5 / 12
GLY A 158
ALA A 159
PRO A 170
VAL A 171
ILE A 161
1.24A14.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_1
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		Sorafenib5yvd NSP15
(MERS-CoV)		5 / 12
ALA B  59
ILE B  40
VAL B   9
PHE B  15
GLY B   1
1.29A22.40
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_A_BRLA1_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		Rosiglitazone5yvd NSP15
(MERS-CoV)		3 / 3
ILE B 190
ILE B 292
LEU B 175
1.02A21.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_E_GBME2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		Glyburide5yvd NSP15
(MERS-CoV)		3 / 3
LEU B 251
THR B 280
ASN B 281
1.33A12.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB1_0
(HEME-BINDING PROTEIN
HUTZ)		Benzoic Acid5yvd NSP15
(MERS-CoV)		4 / 6
GLN B 256
TYR B 252
PHE B 200
LEU B 201
1.44A16.52
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HMY_A_SAMA328_0
(HAEIII
METHYLTRANSFERASE)		S-Adenosylmethionine5yvd NSP15
(MERS-CoV)		5 / 8
PHE B 326
ASP B 320
ILE B 319
THR B 192
PRO B 340
1.30A20.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT3_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		Calcitriol5yvd NSP15
(MERS-CoV)		3 / 3
LEU A  75
ILE A 324
TYR A 191
1.11A19.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1Y_A_017A106_2
(ASPARTYL PROTEASE)		Darunavir5yvd NSP15
(MERS-CoV)		5 / 12
LEU A  85
ALA A  77
ASP A  78
ILE A  79
ILE A 115
1.44A14.50
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LXF_C_BEPC92_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		Bepridil5yvd NSP15
(MERS-CoV)		5 / 12
ILE B 137
LEU B  72
ILE B 135
MET B 148
CYH B 189
1.44A15.27
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVB_B_017B401_1
(PROTEASE
(RETROPEPSIN))		Darunavir5yvd NSP15
(MERS-CoV)		5 / 12
GLY A 158
ALA A 159
PRO A 170
VAL A 171
ILE A 161
1.39A15.09
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_D_VDYD6178_1
(VITAMIN D
HYDROXYLASE)		Calcidiol5yvd NSP15
(MERS-CoV)		5 / 12
ILE B 292
ASN A 180
LEU B 294
ILE B 302
PRO B 340
1.24A21.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		Agmatine5yvd NSP15
(MERS-CoV)		4 / 7
ASP B 293
LEU B 294
ILE B 249
ARG B 195
1.37A9.39
15.41
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_B_1UNB900_2
(PROTEASE)		Nelfinavir5yvd NSP15
(MERS-CoV)		5 / 11
GLY A 158
ALA A 159
PRO A 170
VAL A 171
ILE A 161
1.38A13.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_C_HFGC1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		Halofuginone5yvd NSP15
(MERS-CoV)		5 / 12
VAL A 311
THR A 337
HIS A 246
THR A 241
GLY A 243
1.46A20.20
None
GOL  A 401 (-3.6A)
GOL  A 401 (-4.5A)
None
GOL  A 401 ( 3.8A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUI_B_AB1B100_2
(PROTEASE)		Lopinavir5yvd NSP15
(MERS-CoV)		5 / 12
GLY A 158
ALA A 159
PRO A 170
VAL A 171
ILE A 161
1.37A14.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R5L_A_VIVA301_0
(PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN))		Vitamin E5yvd NSP15
(MERS-CoV)		5 / 12
PHE B 210
ILE B 292
PHE B 200
VAL B 233
VAL B 291
1.26A20.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_1
(BETA-LACTOGLOBULIN)		Pramocaine5yvd NSP15
(MERS-CoV)		3 / 3
LYS A 286
ILE A 277
ILE A 260
1.24A19.76
GOL  A 401 (-3.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_2
(PROTEASE)		Saquinavir5yvd NSP15
(MERS-CoV)		3 / 3
ARG A 341
VAL A 232
THR A 337
1.06A15.68
None
None
GOL  A 401 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT3_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		Calcitriol5yvd NSP15
(MERS-CoV)		3 / 3
LEU B  85
ILE B 161
TYR B  88
1.26A19.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_A_BRLA1_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		Rosiglitazone5yvd NSP15
(MERS-CoV)		3 / 3
ILE B 319
ILE B 272
LEU B 203
1.32A21.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_B_FK5B201_1
(FK506-BINDING
PROTEIN 1)		Tacrolimus5yvd NSP15
(MERS-CoV)		5 / 11
ASP A 293
ARG A 195
VAL A 300
ILE A 190
ILE A 319
1.06A16.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FB7_A_ROCA100_1
(HIV-1 PROTEASE)		Saquinavir5yvd NSP15
(MERS-CoV)		5 / 12
GLY A 158
ALA A 159
PRO A 170
VAL A 171
ILE A 161
1.36A13.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_1
(PROTEASE)		Saquinavir5yvd NSP15
(MERS-CoV)		5 / 12
GLY B 158
ALA B 159
PRO B 170
VAL B 171
ILE B 161
1.49A14.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPC_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		S-Adenosylmethionine5yvd NSP15
(MERS-CoV)		5 / 11
ILE B 302
ASP B 298
VAL B 317
ILE B 324
ILE B 292
1.43A16.13
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		Trifluoperazine5yvd NSP15
(MERS-CoV)		4 / 6
PHE B 229
PHE B 218
MET B 206
SER B 204
0.93A15.02
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		Nelfinavir5yvd NSP15
(MERS-CoV)		5 / 12
GLY A 158
ALA A 159
PRO A 170
VAL A 171
ILE A 161
1.44A14.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		Apramycin5yvd NSP15
(MERS-CoV)		4 / 8
ASP B 199
HIS B 273
ARG B 195
ASP B 293
1.38A21.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT3_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		Calcitriol5yvd NSP15
(MERS-CoV)		3 / 3
LEU A  85
ILE A 161
TYR A  88
1.23A19.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_E_GBME2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		Glyburide5yvd NSP15
(MERS-CoV)		3 / 3
LEU A 245
THR A 282
ASN A 281
1.01A12.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9H_A_RAPA108_1
(FKBP12.6)		Sirolimus5yvd NSP15
(MERS-CoV)		5 / 12
ASP B 236
ILE B 277
HIS B 246
VAL B 232
PHE B 237
1.41A13.99
None
None
GOL  B 401 (-4.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VHW_A_ADNA252_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		Adenosine5yvd NSP15
(MERS-CoV)		5 / 11
GLY B  17
VAL B  18
GLU B  19
GLU B  21
ILE B  16
1.45A21.45
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HMY_A_SAMA328_0
(HAEIII
METHYLTRANSFERASE)		S-Adenosylmethionine5yvd NSP15
(MERS-CoV)		5 / 8
PHE A 326
ASP A 320
ILE A 319
THR A 192
PRO A 340
1.34A20.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_E_P77E203_1
(PROTEIN S100-A4)		Prochlorperazine5yvd NSP15
(MERS-CoV)		4 / 8
PHE B 173
SER B  65
PHE B 136
ASP B 121
1.46A12.43
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERS_A_ACTA803_0
(GEPHYRIN)		Acetic acid5yvd NSP15
(MERS-CoV)		3 / 3
THR B  47
ALA B  54
ASN B  45
0.79A22.68
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVS_B_MK1B902_3
(POL POLYPROTEIN)		Indinavir5yvd NSP15
(MERS-CoV)		5 / 12
GLY A 158
ALA A 159
VAL A  63
PRO A 170
ILE A 161
1.43A14.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_E_GBME2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		Glyburide5yvd NSP15
(MERS-CoV)		3 / 3
LEU A 245
THR A 280
ASN A 281
0.97A12.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBM_A_CAMA517_0
(CYTOCHROME P450-CAM)		Camphor5yvd NSP15
(MERS-CoV)		4 / 8
VAL A  24
THR A  33
VAL A   9
ILE A   5
1.46A22.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_1
(16S RRNA METHYLASE)		S-Adenosylmethionine5yvd NSP15
(MERS-CoV)		3 / 3
ASP A 121
GLU A 126
SER A  65
1.38A22.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_A_SAMA505_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		S-Adenosylmethionine5yvd NSP15
(MERS-CoV)		3 / 3
ILE B 272
ASN B  74
CYH B 189
1.36A20.91
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_1
(PROTEASE)		Saquinavir5yvd NSP15
(MERS-CoV)		5 / 12
GLY A 158
ALA A 159
PRO A 170
VAL A 171
ILE A 161
1.43A14.79
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUM_A_Z80A201_1
(BETA-LACTOGLOBULIN)		Chlorpromazine5yvd NSP15
(MERS-CoV)		4 / 8
VAL B 291
ILE B 277
ILE B 260
SER B 198
1.05A18.18
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NV6_A_CAMA422_0
(CYTOCHROME P450)		Camphor5yvd NSP15
(MERS-CoV)		3 / 3
GLY B 244
ILE B 292
VAL B 291
0.88A20.44
GOL  B 401 (-4.2A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_2
(PROTEASE)		Saquinavir5yvd NSP15
(MERS-CoV)		3 / 3
ARG B 341
VAL B 232
THR B 337
1.18A14.50
None
None
GOL  B 401 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDU_B_MK1B902_2
(PROTEASE RETROPEPSIN)		Indinavir5yvd NSP15
(MERS-CoV)		5 / 12
GLY A 158
ALA A 159
PRO A 170
VAL A 171
ILE A 161
1.41A14.20
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQX_A_ROCA101_1
(PROTEASE E35D-SQV)		Saquinavir5yvd NSP15
(MERS-CoV)		5 / 12
GLY A 158
ALA A 159
PRO A 170
VAL A 171
ILE A 161
1.42A15.38
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_1
(BETA-LACTOGLOBULIN)		Pramocaine5yvd NSP15
(MERS-CoV)		3 / 3
LYS B 286
ILE B 277
ILE B 260
1.18A19.76
GOL  B 401 (-3.3A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FBX_A_ACTA608_0
(PUTATIVE
PHOSPHOLIPASE B-LIKE
2)		Acetic acid5yvd NSP15
(MERS-CoV)		3 / 3
GLU A  56
VAL A 101
CYH A 102
1.32A20.67
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_E_GBME2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		Glyburide5yvd NSP15
(MERS-CoV)		3 / 3
LEU B  75
THR B 187
ASN A 181
1.20A12.12
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9H_A_RAPA108_1
(FKBP12.6)		Sirolimus5yvd NSP15
(MERS-CoV)		5 / 12
ASP A 236
ILE A 277
HIS A 246
VAL A 232
PHE A 237
1.43A13.99
None
None
GOL  A 401 (-4.5A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		Levofloxacin5yvd NSP15
(MERS-CoV)		3 / 4
SER A 111
GLY A 100
GLU A  56
1.09A22.74
20.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_2
(PROTEASE)		Saquinavir5yvd NSP15
(MERS-CoV)		3 / 3
ARG B 341
VAL B 232
THR B 337
1.05A15.68
None
None
GOL  B 401 (-3.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT3_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		Calcitriol5yvd NSP15
(MERS-CoV)		3 / 3
LEU A 203
ILE A 319
TYR A 153
1.16A19.94
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_2
(HIV-1 PROTEASE)		Saquinavir5yvd NSP15
(MERS-CoV)		3 / 3
ARG A 341
VAL A 232
THR A 337
1.06A14.79
None
None
GOL  A 401 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_A_BRLA1_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		Rosiglitazone5yvd NSP15
(MERS-CoV)		3 / 3
ILE B 119
ILE B 142
LEU B  85
1.15A21.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		Ribavirin5yvd NSP15
(MERS-CoV)		3 / 3
THR B 280
HIS B 273
LEU B 251
0.82A22.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DZ2_A_FK5A200_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		Tacrolimus5yvd NSP15
(MERS-CoV)		5 / 11
ASP A 293
ARG A 195
VAL A 300
ILE A 302
ILE A 319
1.10A14.33
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R5L_A_VIVA301_0
(PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN))		Vitamin E5yvd NSP15
(MERS-CoV)		5 / 12
PHE A 210
ILE A 292
PHE A 200
VAL A 233
VAL A 291
1.23A20.62
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_2
(PROTEASE)		Saquinavir5yvd NSP15
(MERS-CoV)		3 / 3
ARG A 341
VAL A 232
THR A 337
1.09A14.79
None
None
GOL  A 401 (-3.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		Ribavirin5yvd NSP15
(MERS-CoV)		3 / 3
THR A 280
HIS A 273
LEU A 251
0.83A22.81
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		Apramycin5yvd NSP15
(MERS-CoV)		4 / 8
ASP A 199
HIS A 273
ARG A 195
ASP A 293
1.40A21.49
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBM_A_CAMA517_0
(CYTOCHROME P450-CAM)		Camphor5yvd NSP15
(MERS-CoV)		4 / 8
VAL B  24
THR B  33
VAL B   9
ILE B   5
1.42A22.06
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		Folic Acid5yvd NSP15
(MERS-CoV)		5 / 12
ILE B 190
LEU B 247
THR B 271
ILE B 272
ILE B 319
1.40A20.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		Nelfinavir5yvd NSP15
(MERS-CoV)		5 / 12
GLY A 158
ALA A 159
PRO A 170
VAL A 171
ILE A 161
1.41A13.61
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_0
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		S-Adenosylmethionine5yvd NSP15
(MERS-CoV)		5 / 12
ILE A 249
ILE A 292
ILE A 260
ARG A 254
ASP A 293
1.32A22.11
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_A_BRLA1_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		Rosiglitazone5yvd NSP15
(MERS-CoV)		3 / 3
ILE A 319
ILE A 272
LEU A 175
0.79A21.08
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERS_A_ACTA803_0
(GEPHYRIN)		Acetic acid5yvd NSP15
(MERS-CoV)		3 / 3
THR A  47
ALA A  54
ASN A  45
0.77A22.68
None