PDB ID: 6z4u


Macromolecule:
PROTEIN 9B

Source Organism:
SARS-CoV-2

Gene names:
-

UniProt ID:
P0DTD2

SIMILAR PATTERN OF AMINO ACIDS MAPPED TO PDBID '6z4u'

1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Drug Res.
Matches		 View Interface RMSD Seq.
Identity (%)		 HETATM Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_G_TOPG200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		Trimethoprim5 / 12
LEU A  21
LEU B  54
VAL B  76
ILE B  44
LEU B  46
1.26A22.50
None
15P  B 100 ( 4.0A)
15P  B 100 ( 4.6A)
15P  B 100 ( 4.5A)
15P  B 100 ( 4.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		Rosiglitazone4 / 4
ILE A  19
LEU B  52
VAL B  94
ILE B  44
1.39A18.18
None
15P  B 100 (-4.0A)
None
15P  B 100 ( 4.5A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_B_TOPB200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		Trimethoprim5 / 12
LEU A  21
LEU B  54
VAL B  76
ILE B  44
LEU B  46
1.30A22.50
None
15P  B 100 ( 4.0A)
15P  B 100 ( 4.6A)
15P  B 100 ( 4.5A)
15P  B 100 ( 4.9A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_2
(CDL2.2)		Calcidiol5 / 12
ILE B  44
LEU B  46
VAL A  96
ILE A  44
LEU A  46
1.09A19.40
15P  B 100 ( 4.5A)
15P  B 100 ( 4.9A)
None
15P  B 100 ( 4.8A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9K_A_TYLA2200_1
(CREB-BINDING PROTEIN)		Acetaminophen4 / 6
VAL B  94
LEU B  46
ILE B  44
VAL A  94
1.17A20.83
None
15P  B 100 ( 4.9A)
15P  B 100 ( 4.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		Methotrexate3 / 3
ILE B  19
ILE B  44
THR A  24
1.23A20.81
None
15P  B 100 ( 4.5A)
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		L-Tryptophan4 / 8
VAL A  96
ILE A  44
VAL A  15
VAL A  76
0.89A17.35
None
15P  B 100 ( 4.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_A_ANWA601_0
(RHODOPSIN KINASE)		Amlexanox4 / 7
LEU A  87
ILE A   5
VAL A  93
ALA B  57
1.37A11.69
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_2
(PHOSPHOLIPASE A2)		Suramin4 / 7
VAL B  23
ILE A  44
ARG A  13
LEU A  81
1.27A20.97
None
15P  B 100 ( 4.8A)
None
None
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P)		Etacrynic acid4 / 8
VAL B  94
VAL A  96
ILE B  19
VAL B  76
1.33A18.57
None
None
None
15P  B 100 ( 4.6A)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		Methotrexate3 / 3
ILE A  19
ILE A  44
THR B  24
1.11A20.81
None
15P  B 100 ( 4.8A)
None