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| PDB ID: 6y7m Macromolecule: Replicase polyprotein 1a Source Organism: SARSr-CoV Gene names: - UniProt ID: - |
SIMILAR PATTERN OF AMINO ACIDS MAPPED TO PDBID '6y7m'
1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.| DrReposER ID / Desc. | Drug | Res. Matches |
View | Interface | RMSD | Seq. Identity (%) |
HETATM | Dock | |
|---|---|---|---|---|---|---|---|---|---|
 Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6FBV_D_FI8D1904_0 (DNA-DIRECTED RNAPOLYMERASE SUBUNITBETADNA-DIRECTED RNAPOLYMERASE SUBUNITBETA') | Fidaxomicin | 4 / 8 | ILE A 281THR A 304VAL A 303SER A 1 | 1.38A | 13.38 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4YPU_B_SAMB2304_0 (HISTONE-LYSINEN-METHYLTRANSFERASEASH1L) | S-Adenosylmethionine | 5 / 11 | LYS A 180ASP A 187HIS A 41TYR A 54ASN A 84 | 1.63A | 22.36 | NoneNoneOEW A 401 ( 3.8A)NoneNone | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6MN5_B_LLLB301_0 (AMINOGLYCOSIDEN(3)-ACETYLTRANSFERASE, AAC(3)-IVA) | GENTAMICIN C1A | 4 / 7 | ASP A 295GLU A 288ASP A 289GLU A 240 | 1.31A | 24.05 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2W3B_A_FOLA401_1 (DIHYDROFOLATEREDUCTASE) | Folic Acid | 4 / 4 | GLU A 290GLN A 127ASN A 151ARG A 298 | 1.75A | 18.53 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1IWH_A_PEMA501_1 (HEMOGLOBIN ALPHACHAIN) | Bezafibrate | 4 / 6 | ALA A 234LYS A 269ALA A 267LEU A 208 | 1.45A | 17.59 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3OXV_C_478C200_1 (HIV-1 PROTEASE) | Amprenavir | 5 / 9 | ASP A 176VAL A 104GLY A 149VAL A 114ILE A 106 | 1.43A | 17.13 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5W97_B_CHDB301_0 (CYTOCHROME C OXIDASESUBUNIT 1CYTOCHROME C OXIDASESUBUNIT 2CYTOCHROME C OXIDASESUBUNIT 6A2,MITOCHONDRIAL) | Cholic Acid | 5 / 11 | GLY A 143MET A 17GLY A 29GLN A 19THR A 21 | 1.44A | 14.3320.2322.78 | OEW A 401 ( 3.1A)NoneNoneNoneNone |