 |
| PDB ID: 5n5o Macromolecule: REPLICASE POLYPROTEIN 1AB Source Organism: SARSr-CoV Gene names: 1a-1brep UniProt ID: P0C6X7 |
SIMILAR PATTERN OF AMINO ACIDS MAPPED TO PDBID '5n5o'
1) User may click on the DrReposER ID (the first column) to get information on the binding sites and drug molecule.2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.| DrReposER ID / Desc. | Drug | Res. Matches |
View | Interface | RMSD | Seq. Identity (%) |
HETATM | Dock | |
|---|---|---|---|---|---|---|---|---|---|
 Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5B3S_B_CHDB304_0 (CYTOCHROME C OXIDASESUBUNIT 1CYTOCHROME C OXIDASESUBUNIT 2CYTOCHROME C OXIDASESUBUNIT 6A2,MITOCHONDRIAL) | Cholic Acid | 5 / 11 | MET A 17GLY A 29GLN A 19THR A 21GLY A 143 | 1.77A | 20.2322.7814.33 | NoneNoneNoneNone8O5 A 401 (-3.4A) | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ZCQ_B_CHDB301_0 (CYTOCHROME C OXIDASESUBUNIT 1CYTOCHROME C OXIDASESUBUNIT 2CYTOCHROME C OXIDASESUBUNIT 6A2,MITOCHONDRIAL) | Cholic Acid | 5 / 11 | MET A 17GLY A 29GLN A 19THR A 21GLY A 143 | 1.75A | 20.2322.7814.33 | NoneNoneNoneNone8O5 A 401 (-3.4A) | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3AG4_B_CHDB1085_0 (CYTOCHROME C OXIDASESUBUNIT 1CYTOCHROME C OXIDASESUBUNIT 2CYTOCHROME C OXIDASESUBUNIT 6A2) | Cholic Acid | 5 / 12 | MET A 17GLY A 29GLN A 19THR A 21GLY A 143 | 1.66A | 20.2322.7814.33 | NoneNoneNoneNone8O5 A 401 (-3.4A) | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4A7A_B_RGZB601_1 (AMINE OXIDASE[FLAVIN-CONTAINING]B) | Rosiglitazone | 5 / 12 | PRO A 39LEU A 86LEU A 177TYR A 161PHE A 112 | 1.49A | 21.88 | None | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5B1A_B_CHDB303_0 (CYTOCHROME C OXIDASESUBUNIT 1CYTOCHROME C OXIDASESUBUNIT 2CYTOCHROME C OXIDASESUBUNIT 6A2,MITOCHONDRIAL) | Cholic Acid | 5 / 11 | MET A 17GLY A 29GLN A 19THR A 21GLY A 143 | 1.79A | 20.2322.7814.33 | NoneNoneNoneNone8O5 A 401 (-3.4A) | ||
| Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3PYY_B_STIB4_1 (V-ABL ABELSON MURINELEUKEMIA VIRALONCOGENE HOMOLOG 1ISOFORM B VARIANT) | Imatinib | 5 / 12 | LEU A 253VAL A 296ALA A 210ILE A 286ASP A 289 | 1.28A | 21.01 | None |