POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		1osg TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
13B
(Homo
sapiens)		5 / 12ILE A 212
VAL A 199
ALA A 151
VAL A 166
PHE A 172
None
1.02A23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		1zly PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE
(Homo
sapiens)		5 / 12ILE A 107
ALA A  28
VAL A   3
GLY A 187
THR A 188
GRF  A1300 (-4.5A)
None
None
None
None
1.20A23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		2bq8 TARTRATE-RESISTANT
ACID PHOSPHATASE
TYPE 5
(Homo
sapiens)		5 / 12ILE X 131
VAL X 274
ALA X 272
VAL X 235
GLY X 240
None
1.18A22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		2d9y PLECKSTRIN HOMOLOGY
DOMAIN-CONTAINING
PROTEIN FAMILY A
MEMBER 6
(Homo
sapiens)		5 / 12ILE A  51
VAL A  11
GLY A 105
PHE A  60
TYR A  87
None
1.26A15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		3e7o MITOGEN-ACTIVATED
PROTEIN KINASE 9
(Homo
sapiens)		5 / 12ILE A 214
VAL A 118
ALA A 113
VAL A 159
GLY A  33
None
None
35F  A   1 (-4.9A)
None
35F  A   1 ( 4.8A)
1.10A20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		3zwf ZINC
PHOSPHODIESTERASE
ELAC PROTEIN 1
(Homo
sapiens)		5 / 12ILE A 359
VAL A 310
GLY A 252
THR A  61
PHE A  59
None
1.11A23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		4es7 PROTEIN AMBP
(Homo
sapiens)		5 / 12MET A 156
ILE A  23
VAL A  39
GLY A  16
TYR A  72
None
1.13A20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens)		5 / 12VAL A  29
ALA A  42
VAL A  46
THR A 184
PHE A 178
None
1.22A17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		4zch TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
13,TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
13B,TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
13B
(Homo
sapiens)		5 / 12ILE A 371
VAL A 358
ALA A 310
VAL A 325
PHE A 331
None
1.05A22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		1h4l CELL DIVISION
PROTEIN KINASE 5
(Homo
sapiens)		4 / 6PRO A 169
HIS A 124
GLU A  51
ALA A 150
None
1.06A20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		1mco IGG1 MCG INTACT
ANTIBODY (HEAVY
CHAIN)
(Homo
sapiens)		4 / 6PRO H 229
HIS H 420
LEU H 391
TYR H 358
GAL  H 435 (-4.8A)
None
None
None
1.07A21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1
(Homo
sapiens)		4 / 6PRO A 340
GLU A 161
ALA A 169
LEU A 329
None
1.04A17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		3mi9 CELL DIVISION
PROTEIN KINASE 9
(Homo
sapiens)		4 / 6PRO A 196
HIS A 147
GLU A  66
ALA A 173
None
0.93A21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		3thz DNA MISMATCH REPAIR
PROTEIN MSH2
(Homo
sapiens)		4 / 6GLU A 749
ALA A 309
LEU A 310
TYR A 678
None
0.98A15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens)		4 / 6PRO A 633
GLU A 453
ALA A 461
LEU A 622
None
0.99A19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		4asi ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens)		4 / 6HIS A1944
GLU A1746
ALA A1847
LEU A1846
None
1.10A17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		4mrm GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1
(Homo
sapiens)		4 / 6PRO A 120
GLU A  80
ALA A 361
LEU A 360
None
1.06A21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		4px9 ATP-DEPENDENT RNA
HELICASE DDX3X
(Homo
sapiens)		4 / 6GLU A 284
ALA A 232
LEU A 236
TYR A 291
None
1.07A21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		4xq7 2'-5'-OLIGOADENYLATE
SYNTHASE-LIKE
PROTEIN
(Homo
sapiens)		4 / 6PRO A 306
GLU A 299
LEU A 267
TYR A 317
None
0.97A19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		5bug PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
3-PHOSPHATASE AND
DUAL-SPECIFICITY
PROTEIN PHOSPHATASE
PTEN
(Homo
sapiens)		4 / 6PRO A 283
ALA A 151
LEU A 152
TYR A 174
None
1.00A19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		5e7j ATP-DEPENDENT RNA
HELICASE DDX3X
(Homo
sapiens)		4 / 6GLU A 284
ALA A 232
LEU A 236
TYR A 291
None
AMP  A 801 ( 4.3A)
None
None
1.03A20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		6ez8 HUNTINGTIN
(Homo
sapiens)		4 / 6HIS A2308
GLU A2357
ALA A2396
LEU A2452
None
1.05A10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		1wuu GALACTOKINASE
(Homo
sapiens)		5 / 12GLY A 350
HIS A 311
GLU A 330
ILE A 368
TYR A 372
None
1.21A22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		1ybw HEPATOCYTE GROWTH
FACTOR ACTIVATOR
PRECURSOR
(Homo
sapiens)		5 / 12ILE A 616
GLY A 619
TYR A 631
ALA A 584
SER A 412
None
0.93A19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		2jjd RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE EPSILON
(Homo
sapiens)		5 / 12ILE A 230
GLU A 264
ARG A 291
ALA A 328
ILE A 259
None
1.15A19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		2okj GLUTAMATE
DECARBOXYLASE 1
(Homo
sapiens)		5 / 12GLY A 246
ASP A 373
HIS A 371
ALA A 263
ILE A 254
None
LLP  A 405 ( 2.7A)
None
None
None
1.23A21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		2vr2 DIHYDROPYRIMIDINASE
(Homo
sapiens)		5 / 12GLY A  94
TYR A 448
ALA A 450
SER A 415
ILE A 414
None
1.07A18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		3gbj KIF13B PROTEIN
(Homo
sapiens)		5 / 12GLY A 103
TYR A 346
ALA A 350
SER A 250
MET A 113
None
1.22A20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		3thw DNA MISMATCH REPAIR
PROTEIN MSH3
(Homo
sapiens)		5 / 12ILE B 666
HIS B 818
ALA B 820
SER B 656
ILE B 654
None
1.10A16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		4f4p TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens)		5 / 12TYR A 539
GLU A 420
SER A 511
ILE A 510
MET A 482
None
None
0SB  A 701 (-3.2A)
None
None
1.26A22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		4klz GTP-BINDING PROTEIN
RIT1
(Homo
sapiens)		5 / 12ILE A  42
ASP A 172
ALA A  69
ILE A  97
MET A  26
None
1.16A21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		5c1b TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE
(Homo
sapiens)		5 / 12ILE A 371
GLY A 370
HIS A 404
SER A 541
ILE A 540
None
1.22A18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		5clw 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME
(Homo
sapiens)		5 / 12GLY A 358
TYR A 251
HIS A 480
ALA A 239
ILE A 410
None
1.13A19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		6b67 PROTEIN PHOSPHATASE
1A
(Homo
sapiens)		5 / 12GLY A 149
HIS A 222
GLU A 225
SER A 135
ILE A 134
None
1.26A12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		2ayn UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 14
(Homo
sapiens)		4 / 4ASN A 339
ILE A 473
TYR A 475
PHE A 277
None
1.19A20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		2nsm CARBOXYPEPTIDASE N
CATALYTIC CHAIN
(Homo
sapiens)		4 / 4ASN A 188
ILE A 285
TYR A 277
PHE A 143
None
1.46A19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		4uom FAB FRAGMENT HEAVY
CHAIN
FAB FRAGMENT LIGHT
CHAIN
(Homo
sapiens)		4 / 4ASN L  97
ILE H  34
TYR H  33
PHE H 102
None
1.49A20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		5j1t TORSIN-1A
(Homo
sapiens)		4 / 4ASN A  89
ILE A  79
TYR A 265
PHE A 203
None
1.35A19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		1e5w MOESIN
(Homo
sapiens)		4 / 7ARG A  81
PHE A  78
LEU A  29
SER A   6
None
1.15A22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		1r4n AMYLOID BETA
PRECURSOR
PROTEIN-BINDING
PROTEIN 1
UBIQUITIN-ACTIVATING
ENZYME E1C
(Homo
sapiens)		4 / 7THR B  31
ARG A 484
LEU B  24
SER B  70
None
1.11A22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		2dl3 SORBIN AND SH3
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens)		4 / 7THR A  57
ARG A  56
PHE A  54
LEU A  26
None
1.19A13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		2jak SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
56 KDA REGULATORY
SUBUNIT GAMMA
ISOFORM
(Homo
sapiens)		4 / 7THR A 282
PHE A 274
ASP A 278
LEU A 239
None
1.17A20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		2rhp THROMBOSPONDIN-2
(Homo
sapiens)		4 / 7ARG A 960
PHE A 959
LEU A1152
SER A1011
None
1.25A15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		2xwb COMPLEMENT C3B
ALPHA' CHAIN
(Homo
sapiens)		4 / 7ARG B1405
PHE B1439
LEU B1364
SER B1384
None
1.24A15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		3eh2 PROTEIN TRANSPORT
PROTEIN SEC24C
(Homo
sapiens)		4 / 7ARG A 435
PHE A 466
LEU A 480
SER A  51
None
1.30A16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		3q4t ACTIVIN RECEPTOR
TYPE-2A
(Homo
sapiens)		4 / 7ARG A 363
ARG A 202
ASP A 322
SER A 276
SO4  A   4 (-4.1A)
SO4  A   4 (-3.8A)
None
None
1.29A22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		3syx SPROUTY-RELATED,
EVH1
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens)		4 / 7ARG A 114
PHE A 112
LEU A 101
SER A  41
None
1.29A17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		4akv SORTING NEXIN-33
(Homo
sapiens)		4 / 7THR A 380
ARG A 377
LEU A 527
SER A 285
None
1.07A19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		4twe N-ACETYLATED-ALPHA-L
INKED ACIDIC
DIPEPTIDASE-LIKE
PROTEIN
(Homo
sapiens)		4 / 7ARG A 664
PHE A 666
LEU A 682
SER A 593
None
1.26A18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		4zdl O-PHOSPHOSERYL-TRNA(
SEC) SELENIUM
TRANSFERASE
(Homo
sapiens)		4 / 7THR A 154
PHE A 152
LEU A 148
SER A 222
None
1.10A19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens)		4 / 7ARG A 588
ASP A 589
LEU A  76
SER A 103
None
1.00A12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		5fxv HISTONE DEMETHYLASE
UTY
(Homo
sapiens)		4 / 7ARG A 896
ASP A 897
LEU A 892
SER A 889
None
1.30A18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		5ggk PROTEIN
O-LINKED-MANNOSE
BETA-1,2-N-ACETYLGLU
COSAMINYLTRANSFERASE
1
(Homo
sapiens)		4 / 7THR A 176
PHE A 212
LEU A 173
SER A 195
None
1.27A20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		5jja SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
56 KDA REGULATORY
SUBUNIT GAMMA
ISOFORM
(Homo
sapiens)		4 / 7THR A 282
PHE A 274
ASP A 278
LEU A 239
THR  A 282 ( 0.8A)
PHE  A 274 ( 1.3A)
ASP  A 278 ( 0.6A)
LEU  A 239 ( 0.6A)
1.25A20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens)		4 / 7ARG A 588
ASP A 589
LEU A  76
SER A 103
None
1.09A9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA307_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		2qdj RETINOBLASTOMA-ASSOC
IATED PROTEIN
(Homo
sapiens)		4 / 5ASP A 111
PRO A  67
GLU A  72
ARG A  73
None
1.49A21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA307_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV
(Homo
sapiens)		4 / 5ASP A  40
PRO A 111
GLU A 113
THR A 110
None
1.48A21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA307_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6
(Homo
sapiens)		4 / 5ASP A 185
GLU A 138
ARG A 180
THR A 182
None
1.15A23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA307_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		3zg6 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-6
(Homo
sapiens)		4 / 5ASP A 185
GLU A 138
ARG A 180
THR A 182
None
1.05A24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA307_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		4nef AQUAPORIN-2
(Homo
sapiens)		4 / 5PRO A  69
GLU A  16
ARG A  85
THR A  72
None
1.35A26.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA307_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		4z2a FURIN
(Homo
sapiens)		4 / 5ASP A 526
PRO A 256
GLU A 257
THR A 262
None
1.45A21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA307_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		5c5x AQUAPORIN-5
(Homo
sapiens)		4 / 5PRO A  70
GLU A  17
ARG A  86
THR A  73
None
1.36A24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA307_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		5oy9 GLYCOPROTEIN G
LOW-DENSITY
LIPOPROTEIN RECEPTOR
(Homo
sapiens;
Indiana
vesiculovirus)		4 / 5ASP A 334
GLU D 119
ARG A 354
THR A 352
None
CA  D1001 (-2.9A)
None
None
0.87A10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA307_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		6cet GATOR COMPLEX
PROTEIN DEPDC5
(Homo
sapiens)		4 / 5ASP D 297
GLU D 344
ARG D 223
THR D 300
None
1.41A12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		2bov MONO-ADP-RIBOSYLTRAN
SFERASE C3
RAS-RELATED PROTEIN
RAL-A
(Clostridium
botulinum;
Homo
sapiens)		4 / 7GLU A 147
ALA B1057
GLY B1059
TYR B1063
None
1.04A20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1
(Homo
sapiens)		4 / 7TYR A 296
PHE A 297
ALA A 379
GLY A 377
None
None
ZN  A1946 ( 4.2A)
None
1.07A15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		3jbz SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens)		4 / 7GLU A1401
ALA A1429
GLY A1431
TYR A1435
None
1.00A14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		3kb5 TRIPARTITE
MOTIF-CONTAINING
PROTEIN 72
(Homo
sapiens)		4 / 7ALA A 429
GLY A 414
TYR A 427
TYR A 416
None
1.04A20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		3uyq CARBONIC ANHYDRASE 3
(Homo
sapiens)		4 / 7GLU A   4
ALA A   8
GLY A  12
TYR A   7
None
1.07A22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		5czv NEUROGENIC LOCUS
NOTCH HOMOLOG
PROTEIN 3
(Homo
sapiens)		4 / 7TYR A1624
PHE A1622
ALA A1537
GLY A1494
None
0.91A22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens)		4 / 7TYR A 313
PHE A 314
ALA A 396
GLY A 394
None
None
ZN  A1001 ( 4.5A)
None
1.07A15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		5tws HUMAN DNA POLYMERASE
MU
(Homo
sapiens)		4 / 7GLU A 165
TYR A 234
ALA A 251
GLY A 247
None
None
None
NA  A 508 ( 4.7A)
1.06A24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		1mx3 C-TERMINAL BINDING
PROTEIN 1
(Homo
sapiens)		5 / 12ILE A 284
ASP A 271
LEU A 139
PHE A 299
GLY A 302
None
1.06A24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		2dzr GENERAL
TRANSCRIPTION FACTOR
II-I REPEAT
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens)		5 / 12ILE A  69
LEU A  15
ASP A  14
ALA A  23
GLY A  21
None
1.13A16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		2ome C-TERMINAL-BINDING
PROTEIN 2
(Homo
sapiens)		5 / 12ILE A 290
ASP A 277
LEU A 145
PHE A 305
GLY A 308
None
1.01A26.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		3eh2 PROTEIN TRANSPORT
PROTEIN SEC24C
(Homo
sapiens)		5 / 12ILE A 181
LEU A 314
LEU A 275
ALA A 176
GLY A 310
None
1.02A16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		3h2x TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 22
(Homo
sapiens)		5 / 12ILE A 252
VAL A 286
ALA A  98
GLY A  95
TYR A  94
None
0.92A21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		4b6l SERINE/THREONINE-PRO
TEIN KINASE PLK3
(Homo
sapiens)		5 / 12ILE A 150
LEU A 188
LEU A 323
PHE A 313
GLY A 247
None
0.99A23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		4dhz UBIQUITIN
THIOESTERASE
OTUBAIN-LIKE
(Caenorhabditis
elegans;
Homo
sapiens)		5 / 12ASP A 104
LEU A 160
VAL A  44
PHE A 139
ALA A 225
None
1.13A21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		4i6f SERINE/THREONINE-PRO
TEIN KINASE PLK2
(Homo
sapiens)		5 / 12ILE A 170
LEU A 208
LEU A 343
PHE A 333
GLY A 267
None
0.95A19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		4jmj RNA/RNP
COMPLEX-1-INTERACTIN
G PHOSPHATASE
(Homo
sapiens)		5 / 12LEU A  66
LEU A  78
VAL A  82
TYR A  73
PHE A  44
None
0.94A19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		4ra4 PROTEIN KINASE C
(Homo
sapiens)		5 / 12ILE A 447
LEU A 425
LEU A 572
GLU A 530
GLY A 433
None
1.01A20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1
(Homo
sapiens;
synthetic
construct)		5 / 12ILE A2611
LEU A2667
LEU A2602
ALA A2587
GLY A2673
None
1.05A6.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		5j39 TUDOR AND KH
DOMAIN-CONTAINING
PROTEIN
(Homo
sapiens)		5 / 12LEU A 451
VAL A 312
GLU A 485
ALA A 492
GLY A 490
UNX  A 503 ( 4.3A)
UNX  A 503 ( 4.0A)
None
None
None
1.07A22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		5l01 TRYPTOPHAN
5-HYDROXYLASE 1
(Homo
sapiens)		5 / 12ILE A 366
GLU A 340
TYR A 264
ALA A 332
GLY A 331
6Z4  A 502 (-3.8A)
None
6Z4  A 502 (-4.3A)
FE  A 501 ( 4.6A)
None
1.08A21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		5t0h PROTEASOME SUBUNIT
BETA TYPE-7
(Homo
sapiens)		5 / 12ILE O  34
VAL O 177
PHE O 138
ALA O 134
GLY O 130
None
1.10A21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6b57 TUDOR AND KH
DOMAIN-CONTAINING
PROTEIN
(Homo
sapiens)		5 / 12LEU A 451
VAL A 312
GLU A 485
ALA A 492
GLY A 490
None
1.02A22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		6c0b FRIZZLED-2
TOXIN B
(Clostridioides
difficile;
Homo
sapiens)		5 / 12LEU A1488
ASP A1490
LEU A1527
VAL A1518
PHE B 128
None
None
None
None
PAM  B 202 (-3.9A)
1.04A12.87