POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		1py5 TGF-BETA RECEPTOR
TYPE I
(Homo
sapiens)		7 / 12GLY A 212
VAL A 219
LYS A 232
GLU A 245
TYR A 282
LEU A 340
ASP A 351
None
PY1  A 700 ( 4.7A)
PY1  A 700 (-3.9A)
PY1  A 700 ( 4.9A)
PY1  A 700 (-4.6A)
PY1  A 700 (-4.4A)
PY1  A 700 (-2.7A)
0.58A26.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG
(Homo
sapiens)		8 / 12LEU A 595
GLY A 596
VAL A 603
LYS A 623
GLU A 640
LEU A 644
TYR A 672
LEU A 799
STI  A   3 ( 3.8A)
None
STI  A   3 ( 4.6A)
STI  A   3 (-3.7A)
STI  A   3 (-3.6A)
STI  A   3 (-4.4A)
STI  A   3 ( 4.0A)
STI  A   3 (-4.4A)
0.60A45.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1
(Homo
sapiens)		7 / 12LEU A  15
GLY A  16
VAL A  23
LYS A  38
LEU A  82
TYR A  86
LEU A 137
HYM  A 400 (-4.2A)
HYM  A 400 ( 3.8A)
HYM  A 400 (-4.3A)
HYM  A 400 (-3.2A)
None
HYM  A 400 (-4.7A)
HYM  A 400 (-4.5A)
0.64A25.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		1zws DAP-KINASE RELATED
PROTEIN 1
(Homo
sapiens)		6 / 12LEU A  19
GLY A  20
VAL A  27
LYS A  42
LEU A  68
LEU A  91
None
0.53A27.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens)		7 / 12GLY A  20
VAL A  27
LYS A  42
GLU A  64
LEU A  68
LEU A  91
ASP A 161
None
0.90A27.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2
(Homo
sapiens)		7 / 12LEU A  19
GLY A  20
VAL A  27
LYS A  42
GLU A  64
LEU A  68
LEU A  91
None
0.68A27.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN
(Homo
sapiens)		7 / 12LEU X  17
GLY X  18
VAL X  25
LYS X  39
GLU X  54
TYR X  84
LEU X 137
STU  X 902 (-3.8A)
STU  X 902 ( 3.7A)
STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
STU  X 902 ( 4.4A)
STU  X 902 (-4.6A)
STU  X 902 (-4.4A)
0.61A34.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens)		6 / 12LEU A 273
GLY A 274
VAL A 281
LYS A 295
TYR A 340
LEU A 393
H8H  A 534 (-3.8A)
H8H  A 534 ( 3.8A)
H8H  A 534 (-4.4A)
H8H  A 534 (-3.7A)
H8H  A 534 (-4.3A)
H8H  A 534 (-4.5A)
0.52A24.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		2hw6 MAP
KINASE-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1
(Homo
sapiens)		6 / 12LEU A  55
GLY A  56
VAL A  63
LYS A  78
LEU A  98
LEU A 122
None
0.54A27.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		2iwi SERINE/THREONINE-PRO
TEIN KINASE PIM-2
(Homo
sapiens)		6 / 12LEU A  38
GLY A  39
VAL A  46
GLU A  83
LEU A  87
LEU A 114
HB1  A1289 ( 4.1A)
HB1  A1289 (-3.1A)
HB1  A1289 (-3.6A)
None
None
None
0.50A26.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens)		7 / 12LEU A 487
GLY A 488
GLU A 534
VAL A 564
TYR A 566
LEU A 633
ASP A 644
None
0.84A44.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens)		8 / 12LEU A 487
VAL A 495
GLU A 534
VAL A 564
TYR A 566
ALA A 567
LEU A 633
ASP A 644
None
0.64A44.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1
(Homo
sapiens)		7 / 12LEU A  19
GLY A  20
VAL A  27
LYS A  42
GLU A  64
LEU A  68
LEU A  91
ADP  A1303 ( 3.9A)
ADP  A1303 (-3.4A)
ADP  A1303 (-4.0A)
ADP  A1303 (-2.7A)
ADP  A1303 ( 4.8A)
None
None
0.66A27.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM
(Homo
sapiens)		7 / 12GLY A  31
VAL A  38
LYS A  53
LEU A  81
LEU A 105
LEU A 160
ASP A 171
B49  A1294 (-4.0A)
None
None
None
None
B49  A1294 (-4.4A)
B49  A1294 (-4.2A)
0.60A24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1
(Homo
sapiens)		7 / 12LEU A  97
GLY A  98
VAL A 105
GLU A 143
LEU A 147
LEU A 170
TYR A 174
STU  A 400 (-3.8A)
STU  A 400 (-3.6A)
STU  A 400 (-4.9A)
STU  A 400 ( 4.3A)
None
None
STU  A 400 (-4.7A)
0.66A27.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1
(Homo
sapiens)		7 / 12LEU A  97
GLY A  98
VAL A 105
LYS A 123
GLU A 143
LEU A 147
LEU A 170
STU  A 400 (-3.8A)
STU  A 400 (-3.6A)
STU  A 400 (-4.9A)
STU  A 400 ( 4.3A)
STU  A 400 ( 4.3A)
None
None
0.72A27.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens)		7 / 12GLY A 488
LYS A 517
GLU A 534
VAL A 564
TYR A 566
ALA A 567
LEU A 633
M33  A1996 ( 3.8A)
M33  A1996 ( 4.5A)
None
None
M33  A1996 ( 4.7A)
M33  A1996 (-3.8A)
M33  A1996 (-4.5A)
0.72A50.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens)		8 / 12LEU A 487
GLY A 488
VAL A 495
GLU A 534
VAL A 564
TYR A 566
ALA A 567
LEU A 633
M33  A1996 (-4.0A)
M33  A1996 ( 3.8A)
M33  A1996 ( 4.7A)
None
None
M33  A1996 ( 4.7A)
M33  A1996 (-3.8A)
M33  A1996 (-4.5A)
0.55A50.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2
(Homo
sapiens)		8 / 12LEU A 487
VAL A 495
GLU A 534
VAL A 564
TYR A 566
ALA A 567
LEU A 633
ASP A 644
M33  A1996 (-4.0A)
M33  A1996 ( 4.7A)
None
None
M33  A1996 ( 4.7A)
M33  A1996 (-3.8A)
M33  A1996 (-4.5A)
M33  A1996 (-4.0A)
0.45A50.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens)		7 / 12LEU A 484
VAL A 492
VAL A 561
TYR A 563
ALA A 564
LEU A 630
ASP A 641
C4F  A   1 ( 3.9A)
None
C4F  A   1 ( 4.8A)
None
C4F  A   1 (-3.5A)
C4F  A   1 (-4.6A)
C4F  A   1 (-4.5A)
0.80A51.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens)		8 / 12LEU A  44
GLY A  45
VAL A  52
LYS A  67
GLU A  89
LEU A  93
LEU A 118
ASP A 186
985  A   1 (-4.1A)
985  A   1 ( 3.9A)
985  A   1 (-4.5A)
985  A   1 ( 2.8A)
MG  A 314 (-3.6A)
MG  A 314 ( 4.8A)
None
985  A   1 ( 4.0A)
0.78A23.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens)		8 / 12LEU A 833
GLY A 834
VAL A 841
LYS A 861
GLU A 878
LEU A 882
VAL A 909
TYR A 911
8ST  A2001 ( 4.7A)
None
8ST  A2001 ( 4.6A)
8ST  A2001 (-4.0A)
8ST  A2001 (-3.7A)
None
8ST  A2001 (-4.1A)
8ST  A2001 (-4.9A)
0.36A42.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens)		8 / 12LEU A  39
GLY A  40
VAL A  47
LEU A  84
LEU A 108
TYR A 112
ALA A 113
ASP A 179
QUE  A   1 ( 3.8A)
None
QUE  A   1 ( 4.6A)
QUE  A   1 ( 4.6A)
None
QUE  A   1 (-4.9A)
QUE  A   1 (-3.9A)
QUE  A   1 (-2.9A)
0.56A25.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B
(Homo
sapiens)		8 / 12LEU A  39
GLY A  40
VAL A  47
LEU A 108
TYR A 112
ALA A 113
LEU A 165
ASP A 179
QUE  A   1 ( 3.8A)
None
QUE  A   1 ( 4.6A)
None
QUE  A   1 (-4.9A)
QUE  A   1 (-3.9A)
None
QUE  A   1 (-2.9A)
0.67A25.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens)		7 / 12LEU A  49
GLY A  50
VAL A  57
LYS A  72
GLU A  91
LEU A  95
ASP A 184
XFE  A 351 (-4.2A)
XFE  A 351 ( 4.0A)
XFE  A 351 ( 4.5A)
None
None
None
None
0.78A24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
(Homo
sapiens)		7 / 12LEU A  49
GLY A  50
VAL A  57
LYS A  72
GLU A  91
LEU A  95
TYR A 122
XFE  A 351 (-4.2A)
XFE  A 351 ( 4.0A)
XFE  A 351 ( 4.5A)
None
None
None
None
0.62A24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		3nuu PKB-LIKE
(Homo
sapiens)		7 / 12LEU A  88
GLY A  89
VAL A  96
LYS A 111
TYR A 161
ALA A 162
LEU A 212
JOZ  A 361 (-4.1A)
JOZ  A 361 ( 4.3A)
JOZ  A 361 ( 4.7A)
SO4  A   5 (-2.8A)
None
JOZ  A 361 (-3.8A)
None
0.69A27.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens)		7 / 12LEU A 192
GLY A 193
LYS A 215
GLU A 234
LEU A 238
LEU A 261
LEU A 318
AMP  A 577 ( 4.3A)
AMP  A 577 ( 3.7A)
AMP  A 577 (-2.8A)
None
None
None
AMP  A 577 (-4.8A)
0.49A21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens)		7 / 12LEU A 192
GLY A 193
VAL A 200
LYS A 215
LEU A 238
LEU A 261
LEU A 318
AMP  A 577 ( 4.3A)
AMP  A 577 ( 3.7A)
AMP  A 577 (-4.3A)
AMP  A 577 (-2.8A)
None
None
AMP  A 577 (-4.8A)
0.45A21.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2
(Homo
sapiens)		6 / 12LEU A 726
GLY A 727
VAL A 734
LYS A 753
LEU A 796
LEU A 852
03Q  A   1 (-3.8A)
None
03Q  A   1 (-4.5A)
03Q  A   1 (-4.7A)
03Q  A   1 (-4.3A)
03Q  A   1 (-4.4A)
0.50A32.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		3qfv CDC42BPB PROTEIN
(Homo
sapiens)		7 / 12GLY A  83
VAL A  90
LYS A 105
GLU A 124
LEU A 128
TYR A 155
ASP A 218
NM7  A 416 (-3.0A)
NM7  A 416 (-3.7A)
EDO  A 417 (-3.5A)
EDO  A 417 (-4.0A)
None
NM7  A 416 (-4.4A)
EDO  A 417 (-3.7A)
0.76A22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		3qfv CDC42BPB PROTEIN
(Homo
sapiens)		7 / 12GLY A  83
VAL A  90
LYS A 105
GLU A 124
LEU A 151
TYR A 155
ASP A 218
NM7  A 416 (-3.0A)
NM7  A 416 (-3.7A)
EDO  A 417 (-3.5A)
EDO  A 417 (-4.0A)
None
NM7  A 416 (-4.4A)
EDO  A 417 (-3.7A)
0.78A22.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens)		7 / 12LEU A 484
GLY A 485
VAL A 492
GLU A 531
VAL A 561
TYR A 563
ASP A 641
07J  A   1 ( 4.3A)
07J  A   1 ( 4.9A)
07J  A   1 (-4.0A)
07J  A   1 (-3.8A)
07J  A   1 (-4.7A)
07J  A   1 (-4.7A)
07J  A   1 (-4.7A)
0.60A48.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens)		7 / 12LEU A 484
GLY A 485
VAL A 492
LYS A 514
GLU A 531
VAL A 561
TYR A 563
07J  A   1 ( 4.3A)
07J  A   1 ( 4.9A)
07J  A   1 (-4.0A)
07J  A   1 (-4.5A)
07J  A   1 (-3.8A)
07J  A   1 (-4.7A)
07J  A   1 (-4.7A)
0.52A48.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens)		7 / 12LEU A 484
GLY A 485
VAL A 492
LYS A 514
VAL A 561
TYR A 563
ALA A 564
07J  A   1 ( 4.3A)
07J  A   1 ( 4.9A)
07J  A   1 (-4.0A)
07J  A   1 (-4.5A)
07J  A   1 (-4.7A)
07J  A   1 (-4.7A)
07J  A   1 (-3.8A)
0.62A48.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens)		7 / 12LEU A 484
GLY A 485
VAL A 492
TYR A 563
ALA A 564
LEU A 630
ASP A 641
07J  A   1 ( 4.3A)
07J  A   1 ( 4.9A)
07J  A   1 (-4.0A)
07J  A   1 (-4.7A)
07J  A   1 (-3.8A)
07J  A   1 ( 4.4A)
07J  A   1 (-4.7A)
0.59A48.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens)		7 / 12LEU A 484
GLY A 485
VAL A 492
VAL A 561
TYR A 563
ALA A 564
ASP A 641
07J  A   1 ( 4.3A)
07J  A   1 ( 4.9A)
07J  A   1 (-4.0A)
07J  A   1 (-4.7A)
07J  A   1 (-4.7A)
07J  A   1 (-3.8A)
07J  A   1 (-4.7A)
0.60A48.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens)		7 / 12LEU A 840
GLY A 841
VAL A 848
LYS A 868
GLU A 885
LEU A 889
VAL A 916
4TT  A2001 ( 4.0A)
4TT  A2001 ( 4.8A)
4TT  A2001 ( 4.5A)
None
None
None
None
0.42A43.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		3w18 AURORA KINASE A
(Homo
sapiens)		7 / 12LEU A 139
GLY A 140
VAL A 147
LEU A 208
TYR A 212
ALA A 213
LEU A 263
N13  A 501 (-3.7A)
None
N13  A 501 ( 4.7A)
N13  A 501 (-4.9A)
N13  A 501 (-4.4A)
N13  A 501 (-3.7A)
N13  A 501 (-4.5A)
0.60A26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		3w18 AURORA KINASE A
(Homo
sapiens)		7 / 12LEU A 139
VAL A 147
LYS A 162
LEU A 208
TYR A 212
ALA A 213
LEU A 263
N13  A 501 (-3.7A)
N13  A 501 ( 4.7A)
N13  A 501 (-2.9A)
N13  A 501 (-4.9A)
N13  A 501 (-4.4A)
N13  A 501 (-3.7A)
N13  A 501 (-4.5A)
0.65A26.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens)		6 / 12LEU A 840
VAL A 848
LYS A 868
GLU A 885
LEU A 889
VAL A 916
LEV  A1201 ( 3.8A)
LEV  A1201 ( 4.9A)
None
LEV  A1201 (-3.7A)
LEV  A1201 ( 4.4A)
LEV  A1201 ( 4.6A)
0.50A44.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3
(Homo
sapiens)		7 / 12GLY A  11
VAL A  18
LYS A  33
GLU A  50
LEU A  54
LEU A  77
LEU A 132
38R  A 350 ( 3.9A)
38R  A 350 ( 4.8A)
38R  A 350 (-2.9A)
38R  A 350 ( 4.8A)
None
None
38R  A 350 (-4.3A)
0.62A24.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		4af3 AURORA KINASE B
(Homo
sapiens)		7 / 12LEU A  83
GLY A  84
VAL A  91
LEU A 152
TYR A 156
ALA A 157
LEU A 207
VX6  A 500 (-3.8A)
VX6  A 500 ( 4.1A)
VX6  A 500 ( 4.8A)
None
VX6  A 500 (-4.2A)
VX6  A 500 (-3.7A)
VX6  A 500 (-4.6A)
0.64A24.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens)		6 / 12LEU A 840
GLY A 841
VAL A 848
GLU A 885
LEU A 889
VAL A 916
B49  A2000 (-3.7A)
B49  A2000 ( 4.6A)
None
None
None
B49  A2000 (-4.8A)
0.39A43.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		4agu CYCLIN-DEPENDENT
KINASE-LIKE 1
(Homo
sapiens)		8 / 12GLY A  11
VAL A  18
LYS A  33
GLU A  51
LEU A  55
LEU A  78
TYR A  82
LEU A 133
D15  A 500 (-3.8A)
D15  A 500 (-4.6A)
D15  A 500 ( 4.1A)
None
None
None
D15  A 500 (-4.8A)
D15  A 500 (-4.5A)
0.63A26.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens)		7 / 12LEU A  15
GLY A  16
VAL A  23
LYS A  38
GLU A  55
LEU A  59
LEU A  84
BX7  A 401 (-3.9A)
BX7  A 401 ( 3.8A)
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.5A)
None
None
None
0.66A24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens)		7 / 12LEU A 377
GLY A 378
VAL A 385
LYS A 402
ALA A 451
LEU A 501
ASP A 512
ANP  A 701 ( 4.6A)
ANP  A 701 ( 4.0A)
ANP  A 701 (-4.1A)
ANP  A 701 (-2.7A)
ANP  A 701 (-4.1A)
ANP  A 701 (-4.5A)
MG  A 702 ( 3.1A)
0.78A21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		4fl3 TYROSINE-PROTEIN
KINASE SYK
(Homo
sapiens)		7 / 12LEU A 377
GLY A 378
VAL A 385
LYS A 402
LEU A 446
ALA A 451
LEU A 501
ANP  A 701 ( 4.6A)
ANP  A 701 ( 4.0A)
ANP  A 701 (-4.1A)
ANP  A 701 (-2.7A)
None
ANP  A 701 (-4.1A)
ANP  A 701 (-4.5A)
0.36A21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		4gv1 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE
(Homo
sapiens)		9 / 12LEU A 156
GLY A 157
VAL A 164
LYS A 179
GLU A 198
LEU A 202
TYR A 229
ALA A 230
ASP A 292
0XZ  A 501 ( 4.1A)
GOL  A 505 ( 3.4A)
0XZ  A 501 (-4.5A)
GOL  A 503 ( 2.8A)
GOL  A 503 (-3.6A)
None
0XZ  A 501 ( 4.9A)
0XZ  A 501 (-3.7A)
0XZ  A 501 ( 3.4A)
0.54A27.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		4id7 ACTIVATED CDC42
KINASE 1
(Homo
sapiens)		6 / 12LEU A 132
GLY A 133
VAL A 140
LYS A 158
ALA A 208
LEU A 259
1G0  A 401 ( 4.5A)
1G0  A 401 ( 4.2A)
1G0  A 401 (-4.4A)
1G0  A 401 (-3.7A)
1G0  A 401 (-3.8A)
1G0  A 401 (-4.6A)
0.45A33.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC
(Homo
sapiens)		7 / 12LEU A 273
GLY A 274
VAL A 281
LYS A 295
TYR A 340
LEU A 393
ASP A 404
0J9  A 601 (-4.0A)
0J9  A 601 ( 4.0A)
0J9  A 601 (-4.4A)
0J9  A 601 ( 4.7A)
0J9  A 601 ( 4.7A)
0J9  A 601 (-4.5A)
0J9  A 601 (-3.1A)
0.76A26.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3
(Homo
sapiens)		8 / 12LEU A 478
GLY A 479
VAL A 486
LYS A 508
GLU A 525
VAL A 555
TYR A 557
LEU A 624
ACP  A 801 (-3.8A)
ACP  A 801 (-3.4A)
ACP  A 801 (-4.2A)
ACP  A 801 (-2.7A)
ACP  A 801 ( 4.8A)
ACP  A 801 (-4.7A)
None
ACP  A 801 (-4.4A)
0.56A51.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3
(Homo
sapiens)		8 / 12LEU A 478
VAL A 486
LYS A 508
GLU A 525
VAL A 555
TYR A 557
ALA A 558
LEU A 624
ACP  A 801 (-3.8A)
ACP  A 801 (-4.2A)
ACP  A 801 (-2.7A)
ACP  A 801 ( 4.8A)
ACP  A 801 (-4.7A)
None
ACP  A 801 (-3.7A)
ACP  A 801 (-4.4A)
0.54A51.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		4q9z HUMAN PROTEIN KINASE
C THETA
(Homo
sapiens)		7 / 12LEU A 386
GLY A 387
LYS A 409
GLU A 428
LEU A 432
TYR A 460
ASP A 522
PZW  A 801 (-3.9A)
PZW  A 801 ( 3.8A)
None
None
None
None
PZW  A 801 (-3.2A)
0.70A27.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		4q9z HUMAN PROTEIN KINASE
C THETA
(Homo
sapiens)		8 / 12LEU A 386
GLY A 387
VAL A 394
LYS A 409
LEU A 432
TYR A 460
LEU A 511
ASP A 522
PZW  A 801 (-3.9A)
PZW  A 801 ( 3.8A)
PZW  A 801 (-4.6A)
None
None
None
PZW  A 801 (-4.8A)
PZW  A 801 (-3.2A)
0.61A27.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		4qpm MITOTIC CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1
(Homo
sapiens)		6 / 12LEU A 793
GLY A 794
VAL A 801
LYS A 821
GLU A 830
LEU A 864
ADP  A1501 ( 3.7A)
ADP  A1501 (-3.3A)
ADP  A1501 (-3.8A)
ADP  A1501 (-2.7A)
ADP  A1501 ( 4.8A)
None
0.31A24.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens)		7 / 12LEU A 616
GLY A 617
VAL A 624
LYS A 644
GLU A 661
LEU A 689
TYR A 693
P30  A1001 (-3.8A)
None
None
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
None
P30  A1001 (-4.1A)
0.46A39.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens)		7 / 12LEU A 616
GLY A 617
VAL A 624
LYS A 644
LEU A 689
TYR A 693
LEU A 818
P30  A1001 (-3.8A)
None
None
P30  A1001 (-3.4A)
None
P30  A1001 (-4.1A)
P30  A1001 (-4.6A)
0.45A39.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		4uy9 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9
(Homo
sapiens)		7 / 12GLY A 151
VAL A 158
LYS A 171
LEU A 218
ALA A 223
LEU A 275
ASP A 294
None
0.87A30.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4
(Homo
sapiens)		6 / 12LEU A 473
GLY A 474
VAL A 481
LYS A 503
GLU A 520
VAL A 550
40M  A1002 ( 4.6A)
None
40M  A1002 ( 4.5A)
40M  A1002 (-4.0A)
40M  A1002 (-3.7A)
40M  A1002 (-4.7A)
0.52A52.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens)		6 / 12LEU A 616
GLY A 617
VAL A 624
LEU A 689
TYR A 693
LEU A 818
P30  A1001 (-4.0A)
None
P30  A1001 ( 4.8A)
None
P30  A1001 ( 4.4A)
P30  A1001 (-4.3A)
0.36A46.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3
(Homo
sapiens)		7 / 12LEU A 616
GLY A 617
VAL A 624
LYS A 644
GLU A 661
LEU A 689
TYR A 693
P30  A1001 (-4.0A)
None
P30  A1001 ( 4.8A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
None
P30  A1001 ( 4.4A)
0.66A46.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4
(Homo
sapiens)		7 / 12LEU A 193
GLY A 194
VAL A 201
LYS A 216
LEU A 239
LEU A 262
LEU A 319
AN2  A 601 ( 4.2A)
AN2  A 601 (-3.4A)
AN2  A 601 (-4.0A)
AN2  A 601 ( 3.9A)
None
None
None
0.62A20.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens)		8 / 12LEU A 484
GLY A 485
VAL A 492
GLU A 531
VAL A 561
TYR A 563
LEU A 630
ASP A 641
38O  A1769 (-3.2A)
38O  A1769 ( 4.7A)
38O  A1769 (-4.5A)
EDO  A1766 (-4.1A)
38O  A1769 (-4.3A)
38O  A1769 (-4.2A)
38O  A1769 (-4.6A)
38O  A1769 (-4.0A)
0.62A44.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens)		9 / 12LEU A 484
GLY A 485
VAL A 492
LYS A 514
GLU A 531
TYR A 563
ALA A 564
LEU A 630
ASP A 641
38O  A1769 (-3.2A)
38O  A1769 ( 4.7A)
38O  A1769 (-4.5A)
38O  A1769 ( 3.1A)
EDO  A1766 (-4.1A)
38O  A1769 (-4.2A)
38O  A1769 (-3.9A)
38O  A1769 (-4.6A)
38O  A1769 (-4.0A)
0.59A44.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1
(Homo
sapiens)		9 / 12GLY A  23
VAL A  30
LYS A  46
GLU A  63
LEU A  67
LEU A  90
TYR A  94
LEU A 145
ASP A 165
51W  A 401 (-3.3A)
51W  A 401 ( 4.3A)
GOL  A 404 ( 3.1A)
None
None
None
51W  A 401 ( 3.4A)
51W  A 401 (-4.5A)
GOL  A 404 (-3.2A)
0.66A26.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4
(Homo
sapiens)		6 / 12GLY A  63
VAL A  70
LYS A  85
LEU A 130
TYR A 134
ALA A 135
5RC  A4000 ( 4.3A)
5RC  A4000 (-4.6A)
5RC  A4000 (-2.8A)
None
5RC  A4000 (-4.5A)
5RC  A4000 (-3.7A)
0.46A27.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens)		8 / 12LEU A 903
GLY A 904
VAL A 911
LYS A 930
GLU A 947
LEU A 951
TYR A 980
LEU A1030
5U3  A1200 (-3.8A)
5U3  A1200 ( 3.7A)
5U3  A1200 ( 4.4A)
None
None
None
5U3  A1200 (-4.5A)
5U3  A1200 (-4.4A)
0.62A34.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens)		11 / 12LEU A 730
GLY A 731
VAL A 738
LYS A 758
GLU A 775
LEU A 779
LEU A 802
VAL A 804
TYR A 806
ALA A 807
LEU A 881
PP1  A2012 (-4.6A)
PP1  A2012 ( 3.9A)
PP1  A2012 (-4.4A)
PP1  A2012 (-4.1A)
PP1  A2012 (-3.5A)
None
None
PP1  A2012 (-4.5A)
None
PP1  A2012 ( 3.5A)
PP1  A2012 (-4.6A)
0.51A87.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens)		6 / 12LEU A 599
GLY A 600
VAL A 607
LYS A 627
GLU A 644
TYR A 676
748  A1001 (-3.8A)
None
748  A1001 ( 4.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-4.0A)
0.55A43.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA
(Homo
sapiens)		6 / 12LEU A 599
GLY A 600
VAL A 607
LYS A 627
TYR A 676
LEU A 825
748  A1001 (-3.8A)
None
748  A1001 ( 4.7A)
748  A1001 (-4.0A)
748  A1001 (-4.0A)
748  A1001 (-4.3A)
0.47A43.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		5idn CYCLIN-DEPENDENT
KINASE 8
(Homo
sapiens)		7 / 12GLY A  28
VAL A  35
GLU A  66
LEU A  95
TYR A  99
ALA A 100
LEU A 158
6A7  A 401 (-3.6A)
6A7  A 401 ( 4.5A)
FMT  A 404 ( 4.2A)
None
6A7  A 401 (-4.9A)
6A7  A 401 (-3.7A)
6A7  A 401 (-4.8A)
0.70A26.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		5idn CYCLIN-DEPENDENT
KINASE 8
(Homo
sapiens)		7 / 12VAL A  35
GLU A  66
LEU A  70
LEU A  95
TYR A  99
ALA A 100
LEU A 158
6A7  A 401 ( 4.5A)
FMT  A 404 ( 4.2A)
None
None
6A7  A 401 (-4.9A)
6A7  A 401 (-3.7A)
6A7  A 401 (-4.8A)
0.74A26.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		5mov CASEIN KINASE II
SUBUNIT ALPHA
(Homo
sapiens)		7 / 12LEU A  45
GLY A  46
VAL A  53
LYS A  68
LEU A  85
LEU A 111
ASP A 175
HC4  A 401 ( 4.8A)
None
None
HC4  A 401 (-2.7A)
None
None
HC4  A 401 (-4.0A)
0.80A23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		5mov CASEIN KINASE II
SUBUNIT ALPHA
(Homo
sapiens)		7 / 12LEU A  45
VAL A  53
LYS A  68
GLU A  81
LEU A  85
LEU A 111
ASP A 175
HC4  A 401 ( 4.8A)
None
HC4  A 401 (-2.7A)
None
None
None
HC4  A 401 (-4.0A)
0.92A23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		5tur SERINE/THREONINE-PRO
TEIN KINASE PIM-1
(Homo
sapiens)		7 / 12LEU A  44
GLY A  45
VAL A  52
LYS A  67
GLU A  89
LEU A  93
LEU A 118
None
None
7LK  A 401 (-4.9A)
None
None
None
None
0.57A24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		6b3e CYCLIN-DEPENDENT
KINASE 12
(Homo
sapiens)		8 / 12GLY A 734
VAL A 741
LYS A 756
GLU A 774
LEU A 778
LEU A 811
TYR A 815
ASP A 877
CJM  A1102 (-3.4A)
None
None
None
None
None
CJM  A1102 (-4.1A)
MG  A1101 (-2.5A)
0.87Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		6c7y TYROSINE-PROTEIN
KINASE JAK1
(Homo
sapiens)		6 / 12LEU A 881
GLY A 882
VAL A 889
LYS A 908
GLU A 925
LEU A1010
ADP  A1201 ( 4.5A)
ADP  A1201 (-3.5A)
ADP  A1201 (-4.3A)
ADP  A1201 (-2.8A)
None
ADP  A1201 (-4.5A)
0.55Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
(Homo
sapiens)		10 / 12LEU A 730
GLY A 731
VAL A 738
GLU A 775
LEU A 779
LEU A 802
VAL A 804
TYR A 806
ALA A 807
LEU A 881
ADN  A1104 ( 4.0A)
ADN  A1104 ( 3.9A)
ADN  A1104 (-4.4A)
None
None
None
ADN  A1104 ( 4.6A)
ADN  A1104 ( 4.1A)
ADN  A1104 (-3.6A)
ADN  A1104 (-4.3A)
0.32Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		1lpb LIPASE
(Homo
sapiens)		3 / 3ALA B 155
GLY B 216
SER B 266
None
0.44A22.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IVU_A_ZD6A3015_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		1snx TYROSINE-PROTEIN
KINASE ITK/TSK
(Homo
sapiens)		3 / 3ALA A 389
GLY A 441
SER A 499
None
0.46A33.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		1uzj FIBRILLIN-1
(Homo
sapiens)		3 / 3ALA A1560
GLY A1591
SER A1499
None
0.53A20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		2jis CYSTEINE SULFINIC
ACID DECARBOXYLASE
(Homo
sapiens)		3 / 3ALA A 300
GLY A 151
SER A 193
None
PLP  A1494 (-3.5A)
PLP  A1494 ( 4.1A)
0.59A21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		2ppl PANCREATIC
LIPASE-RELATED
PROTEIN 1
(Homo
sapiens)		3 / 3ALA A 174
GLY A 234
SER A 284
None
NA  A 480 (-4.3A)
None
0.55A19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		2pvs PANCREATIC
LIPASE-RELATED
PROTEIN 2
(Homo
sapiens)		3 / 3ALA A 155
GLY A 216
SER A 266
None
0.53A22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		2qob EPHRIN RECEPTOR
(Homo
sapiens)		3 / 3ALA A 651
GLY A 705
SER A 763
PTR  A 701 ( 4.7A)
None
None
0.28A29.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IVU_A_ZD6A3015_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens)		3 / 3ALA A 705
GLY A 759
SER A 817
None
0.27A32.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IVU_A_ZD6A3015_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		3kul EPHRIN TYPE-A
RECEPTOR 8
(Homo
sapiens)		3 / 3ALA A 665
GLY A 719
SER A 777
None
GOL  A 403 (-3.4A)
None
0.53A31.36