POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZGF_A_TRUA300_1
(CARBONIC ANHYDRASE
II)		1jd0 CARBONIC ANHYDRASE
XII
(Homo
sapiens)		6 / 12ASN A  62
HIS A  96
VAL A 121
LEU A 198
THR A 199
THR A 200
None
ZN  A 901 ( 3.2A)
AZM  A1400 (-4.6A)
AZM  A1400 (-3.9A)
AZM  A1400 (-3.6A)
AZM  A1400 (-3.3A)
0.93A36.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZGF_A_TRUA300_1
(CARBONIC ANHYDRASE
II)		1jd0 CARBONIC ANHYDRASE
XII
(Homo
sapiens)		10 / 12GLN A  92
HIS A  94
HIS A  96
HIS A 119
VAL A 121
VAL A 143
LEU A 198
THR A 199
THR A 200
TRP A 209
AZM  A1400 (-3.2A)
ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.1A)
AZM  A1400 (-4.6A)
AZM  A1400 ( 4.9A)
AZM  A1400 (-3.9A)
AZM  A1400 (-3.6A)
AZM  A1400 (-3.3A)
None
0.34A36.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZGF_A_TRUA300_1
(CARBONIC ANHYDRASE
II)		1jd0 CARBONIC ANHYDRASE
XII
(Homo
sapiens)		6 / 12HIS A  96
HIS A 119
LEU A 198
THR A 199
THR A 200
TRP A 209
 ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.1A)
AZM  A1400 (-3.9A)
AZM  A1400 (-3.6A)
AZM  A1400 (-3.3A)
None
1.48A36.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZGF_A_TRUA300_1
(CARBONIC ANHYDRASE
II)		2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens)		9 / 12HIS A  64
GLN A  92
HIS A  94
HIS A  96
HIS A 119
VAL A 143
LEU A 198
THR A 199
TRP A 209
None
None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
0.53A60.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZGF_A_TRUA300_1
(CARBONIC ANHYDRASE
II)		2w2j CARBONIC
ANHYDRASE-RELATED
PROTEIN
(Homo
sapiens)		5 / 12HIS A 118
HIS A 141
LEU A 222
THR A 223
TRP A 233
 CL  A 401 (-4.2A)
CL  A 401 (-4.1A)
None
CL  A 401 ( 4.8A)
None
0.36A38.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZGF_A_TRUA300_1
(CARBONIC ANHYDRASE
II)		3da2 CARBONIC ANHYDRASE
13
(Homo
sapiens)		7 / 12ASN A  68
GLN A  93
HIS A  95
HIS A  97
VAL A 122
LEU A 199
THR A 200
None
4MD  A 401 (-3.1A)
ZN  A 301 ( 3.6A)
ZN  A 301 ( 3.5A)
4MD  A 401 ( 4.6A)
4MD  A 401 (-4.2A)
4MD  A 401 (-3.2A)
0.89A59.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZGF_A_TRUA300_1
(CARBONIC ANHYDRASE
II)		3da2 CARBONIC ANHYDRASE
13
(Homo
sapiens)		9 / 12ASN A  68
HIS A  95
HIS A  97
HIS A 120
VAL A 122
VAL A 144
LEU A 199
THR A 200
TRP A 210
None
ZN  A 301 ( 3.6A)
ZN  A 301 ( 3.5A)
ZN  A 301 ( 3.2A)
4MD  A 401 ( 4.6A)
4MD  A 401 ( 4.4A)
4MD  A 401 (-4.2A)
4MD  A 401 (-3.2A)
None
0.55A59.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZGF_A_TRUA300_1
(CARBONIC ANHYDRASE
II)		3fe4 CARBONIC ANHYDRASE 6
(Homo
sapiens)		9 / 12GLN A 109
HIS A 111
HIS A 113
HIS A 138
VAL A 140
VAL A 161
LEU A 219
THR A 220
TRP A 230
None
MG  A 901 (-3.4A)
MG  A 901 (-3.4A)
MG  A 901 (-3.2A)
None
None
None
None
None
0.63A34.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZGF_A_TRUA300_1
(CARBONIC ANHYDRASE
II)		3fe4 CARBONIC ANHYDRASE 6
(Homo
sapiens)		6 / 12HIS A 111
HIS A 113
VAL A 140
VAL A 161
LEU A 219
THR A 220
 MG  A 901 (-3.4A)
MG  A 901 (-3.4A)
None
None
None
None
1.46A34.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZGF_A_TRUA300_1
(CARBONIC ANHYDRASE
II)		3ml5 CARBONIC ANHYDRASE 7
(Homo
sapiens)		6 / 12ASN A  62
GLN A  67
HIS A  96
VAL A 121
THR A 199
THR A 200
None
None
ZN  A 263 ( 3.2A)
AZM  A 264 (-4.7A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.5A)
1.27A55.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZGF_A_TRUA300_1
(CARBONIC ANHYDRASE
II)		3ml5 CARBONIC ANHYDRASE 7
(Homo
sapiens)		6 / 12ASN A  62
HIS A  96
VAL A 121
LEU A 198
THR A 199
THR A 200
None
ZN  A 263 ( 3.2A)
AZM  A 264 (-4.7A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.5A)
1.01A55.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZGF_A_TRUA300_1
(CARBONIC ANHYDRASE
II)		3ml5 CARBONIC ANHYDRASE 7
(Homo
sapiens)		5 / 12GLN A  67
HIS A  94
HIS A  96
THR A 199
THR A 200
None
ZN  A 263 ( 3.2A)
ZN  A 263 ( 3.2A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.5A)
1.02A55.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZGF_A_TRUA300_1
(CARBONIC ANHYDRASE
II)		3ml5 CARBONIC ANHYDRASE 7
(Homo
sapiens)		10 / 12GLN A  92
HIS A  94
HIS A  96
HIS A 119
VAL A 121
VAL A 143
LEU A 198
THR A 199
THR A 200
TRP A 209
AZM  A 264 (-4.1A)
ZN  A 263 ( 3.2A)
ZN  A 263 ( 3.2A)
ZN  A 263 ( 3.1A)
AZM  A 264 (-4.7A)
AZM  A 264 ( 4.9A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.5A)
None
0.26A55.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZGF_A_TRUA300_1
(CARBONIC ANHYDRASE
II)		3uyq CARBONIC ANHYDRASE 3
(Homo
sapiens)		9 / 12GLN A  92
HIS A  94
HIS A  96
HIS A 119
VAL A 121
VAL A 142
THR A 198
THR A 199
TRP A 208
None
ZN  A 261 (-3.3A)
ZN  A 261 (-3.3A)
ZN  A 261 (-3.2A)
None
None
ZN  A 261 ( 4.4A)
None
None
0.34A58.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZGF_A_TRUA300_1
(CARBONIC ANHYDRASE
II)		3uyq CARBONIC ANHYDRASE 3
(Homo
sapiens)		5 / 12HIS A  94
HIS A  96
VAL A 121
VAL A 142
THR A 198
 ZN  A 261 (-3.3A)
ZN  A 261 (-3.3A)
None
None
ZN  A 261 ( 4.4A)
1.18A58.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGF_A_TRUA300_1
(CARBONIC ANHYDRASE
II)		4gga CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG
(Homo
sapiens)		5 / 12HIS A 301
HIS A 267
VAL A 312
LEU A 305
THR A 304
None
1.28A21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGF_A_TRUA300_1
(CARBONIC ANHYDRASE
II)		4n14 CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG
(Homo
sapiens)		5 / 12HIS A 301
HIS A 267
VAL A 312
LEU A 305
THR A 304
None
1.24A20.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZGF_A_TRUA300_1
(CARBONIC ANHYDRASE
II)		4qk3 CARBONIC ANHYDRASE 2
(Homo
sapiens)		6 / 12ASN A  62
HIS A  96
VAL A 121
LEU A 198
THR A 199
THR A 200
None
ZN  A 301 (-3.2A)
None
None
ZN  A 301 ( 4.4A)
None
0.95A95.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZGF_A_TRUA300_1
(CARBONIC ANHYDRASE
II)		4qk3 CARBONIC ANHYDRASE 2
(Homo
sapiens)		12 / 12HIS A  64
ASN A  67
GLN A  92
HIS A  94
HIS A  96
HIS A 119
VAL A 121
VAL A 143
LEU A 198
THR A 199
THR A 200
TRP A 209
None
None
None
ZN  A 301 (-3.2A)
ZN  A 301 (-3.2A)
ZN  A 301 (-3.1A)
None
None
None
ZN  A 301 ( 4.4A)
None
None
0.35A95.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZGF_A_TRUA300_1
(CARBONIC ANHYDRASE
II)		4qk3 CARBONIC ANHYDRASE 2
(Homo
sapiens)		6 / 12HIS A  64
HIS A  94
VAL A 207
THR A 199
THR A 200
TRP A 209
None
ZN  A 301 (-3.2A)
None
ZN  A 301 ( 4.4A)
None
None
1.39A95.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZGF_A_TRUA300_1
(CARBONIC ANHYDRASE
II)		5cjf CARBONIC ANHYDRASE
14
(Homo
sapiens)		7 / 12ASN A  62
GLN A  67
HIS A  96
VAL A 121
LEU A 198
THR A 199
THR A 200
GOL  A 303 (-3.9A)
GOL  A 303 (-3.4A)
ZN  A 301 ( 3.2A)
520  A 302 ( 4.9A)
520  A 302 (-3.6A)
520  A 302 (-3.4A)
GOL  A 303 ( 3.5A)
1.30A36.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZGF_A_TRUA300_1
(CARBONIC ANHYDRASE
II)		5cjf CARBONIC ANHYDRASE
14
(Homo
sapiens)		6 / 12GLN A  67
HIS A  94
HIS A  96
LEU A 198
THR A 199
THR A 200
GOL  A 303 (-3.4A)
ZN  A 301 (-3.2A)
ZN  A 301 ( 3.2A)
520  A 302 (-3.6A)
520  A 302 (-3.4A)
GOL  A 303 ( 3.5A)
1.07A36.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZGF_A_TRUA300_1
(CARBONIC ANHYDRASE
II)		5cjf CARBONIC ANHYDRASE
14
(Homo
sapiens)		10 / 12GLN A  92
HIS A  94
HIS A  96
HIS A 119
VAL A 121
VAL A 143
LEU A 198
THR A 199
THR A 200
TRP A 209
GOL  A 303 (-3.2A)
ZN  A 301 (-3.2A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.1A)
520  A 302 ( 4.9A)
520  A 302 ( 4.9A)
520  A 302 (-3.6A)
520  A 302 (-3.4A)
GOL  A 303 ( 3.5A)
None
0.24A36.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZGF_A_TRUA300_1
(CARBONIC ANHYDRASE
II)		5cjf CARBONIC ANHYDRASE
14
(Homo
sapiens)		6 / 12HIS A  96
HIS A  94
VAL A 121
LEU A 198
THR A 199
THR A 200
 ZN  A 301 ( 3.2A)
ZN  A 301 (-3.2A)
520  A 302 ( 4.9A)
520  A 302 (-3.6A)
520  A 302 (-3.4A)
GOL  A 303 ( 3.5A)
1.34A36.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZGF_A_TRUA300_1
(CARBONIC ANHYDRASE
II)		5cjf CARBONIC ANHYDRASE
14
(Homo
sapiens)		6 / 12HIS A  96
HIS A 119
LEU A 198
THR A 199
THR A 200
TRP A 209
 ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.1A)
520  A 302 (-3.6A)
520  A 302 (-3.4A)
GOL  A 303 ( 3.5A)
None
1.47A36.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZGF_A_TRUA300_1
(CARBONIC ANHYDRASE
II)		5jn9 CARBONIC ANHYDRASE 4
(Homo
sapiens)		6 / 12ASN A  62
HIS A  96
VAL A 121
LEU A 198
THR A 199
THR A 200
None
ZN  A 301 ( 3.3A)
EZL  A 302 (-4.7A)
EZL  A 302 (-3.5A)
EZL  A 302 (-3.4A)
EZL  A 302 (-3.9A)
1.09A35.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ZGF_A_TRUA300_1
(CARBONIC ANHYDRASE
II)		5jn9 CARBONIC ANHYDRASE 4
(Homo
sapiens)		11 / 12HIS A  64
GLN A  92
HIS A  94
HIS A  96
HIS A 119
VAL A 121
VAL A 143
LEU A 198
THR A 199
THR A 200
TRP A 209
None
EZL  A 302 (-4.3A)
ZN  A 301 ( 3.3A)
ZN  A 301 ( 3.3A)
ZN  A 301 ( 3.2A)
EZL  A 302 (-4.7A)
EZL  A 302 ( 4.7A)
EZL  A 302 (-3.5A)
EZL  A 302 (-3.4A)
EZL  A 302 (-3.9A)
None
0.45A35.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGF_A_TRUA300_1
(CARBONIC ANHYDRASE
II)		5lcw CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG
(Homo
sapiens)		5 / 12HIS Q 301
HIS Q 267
VAL Q 312
LEU Q 305
THR Q 304
None
1.21A20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGF_A_TRUA300_1
(CARBONIC ANHYDRASE
II)		5lcw CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG
(Homo
sapiens)		5 / 12HIS R 301
HIS R 267
VAL R 312
LEU R 305
THR R 304
None
1.22A20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGF_A_TRUA300_1
(CARBONIC ANHYDRASE
II)		6fe1 CARBONIC ANHYDRASE 9
(Homo
sapiens)		6 / 12ASN A  62
HIS A  96
VAL A 121
LEU A 198
THR A 199
THR A 200
V14  A 302 (-3.4A)
ZN  A 301 ( 3.2A)
V14  A 302 (-4.7A)
V14  A 302 (-3.6A)
V14  A 302 (-3.2A)
V14  A 302 (-3.5A)
1.16A14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGF_A_TRUA300_1
(CARBONIC ANHYDRASE
II)		6fe1 CARBONIC ANHYDRASE 9
(Homo
sapiens)		10 / 12GLN A  92
HIS A  94
HIS A  96
HIS A 119
VAL A 121
VAL A 143
LEU A 198
THR A 199
THR A 200
TRP A 209
V14  A 302 (-3.8A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.1A)
V14  A 302 (-4.7A)
None
V14  A 302 (-3.6A)
V14  A 302 (-3.2A)
V14  A 302 (-3.5A)
None
0.40A14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGF_A_TRUA300_1
(CARBONIC ANHYDRASE
II)		6fe1 CARBONIC ANHYDRASE 9
(Homo
sapiens)		5 / 12HIS A 119
HIS A  96
VAL A 143
LEU A 198
THR A 199
 ZN  A 301 ( 3.1A)
ZN  A 301 ( 3.2A)
None
V14  A 302 (-3.6A)
V14  A 302 (-3.2A)
1.30A14.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ILT_B_TRUB800_1
(GLUTAMATE RECEPTOR 2)		2zns GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 1
(Homo
sapiens)		6 / 12LYS A 516
PRO A 517
MET A 519
LEU A 768
LEU A 776
LYS A 780
None
0.90A51.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILT_B_TRUB800_1
(GLUTAMATE RECEPTOR 2)		3eo3 BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE
(Homo
sapiens)		5 / 12LYS A 433
LEU A 706
LEU A 410
ILE A 430
SER A 408
None
1.45A19.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ILT_B_TRUB800_1
(GLUTAMATE RECEPTOR 2)		3qxm GLUTAMATE RECEPTOR
IONOTROPIC, KAINATE
2
(Homo
sapiens)		5 / 12LYS A 500
MET A 503
LEU A 752
LEU A 760
LYS A 764
None
0.86A51.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ILT_B_TRUB800_1
(GLUTAMATE RECEPTOR 2)		3qxm GLUTAMATE RECEPTOR
IONOTROPIC, KAINATE
2
(Homo
sapiens)		5 / 12LYS A 500
PRO A 501
MET A 503
LEU A 752
LEU A 760
None
0.75A51.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILT_B_TRUB800_1
(GLUTAMATE RECEPTOR 2)		4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens)		5 / 12SER A 316
LEU A 345
SER A 416
ILE A 380
SER A 348
None
1.39A19.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ILT_E_TRUE800_1
(GLUTAMATE RECEPTOR 2)		2zns GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 1
(Homo
sapiens)		6 / 10LYS A 516
PRO A 517
MET A 519
LEU A 768
LEU A 776
LYS A 780
None
0.82A51.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILT_E_TRUE800_1
(GLUTAMATE RECEPTOR 2)		3eo3 BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE
(Homo
sapiens)		5 / 10ILE A 430
SER A 408
LYS A 433
LEU A 706
LEU A 410
None
1.42A19.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ILT_E_TRUE800_1
(GLUTAMATE RECEPTOR 2)		3qxm GLUTAMATE RECEPTOR
IONOTROPIC, KAINATE
2
(Homo
sapiens)		6 / 10LYS A 500
PRO A 501
MET A 503
LEU A 752
LEU A 760
LYS A 764
None
0.80A51.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILT_E_TRUE800_1
(GLUTAMATE RECEPTOR 2)		4gwn MEPRIN A SUBUNIT
BETA
(Homo
sapiens)		5 / 10ILE A 380
SER A 348
SER A 316
LEU A 345
SER A 416
None
1.30A19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILT_H_TRUH800_1
(GLUTAMATE RECEPTOR 2)		1d4v TNF-RELATED
APOPTOSIS INDUCING
LIGAND
(Homo
sapiens)		3 / 3ILE B 126
SER B 186
SER B 273
None
0.50A18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILT_H_TRUH800_1
(GLUTAMATE RECEPTOR 2)		1dg6 APO2L/TNF-RELATED
APOPOTIS INDUCING
LIGAND (TRAIL)
(Homo
sapiens)		3 / 3ILE A 126
SER A 186
SER A 273
None
0.53A20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILT_H_TRUH800_1
(GLUTAMATE RECEPTOR 2)		1wtl BENCE-JONES PROTEIN
MCG (LIGHT CHAIN)
(Homo
sapiens)		3 / 3ILE A  83
SER A  12
SER A  14
None
0.43A15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILT_H_TRUH800_1
(GLUTAMATE RECEPTOR 2)		1xks NUCLEAR PORE COMPLEX
PROTEIN NUP133
(Homo
sapiens)		3 / 3ILE A 221
SER A 288
SER A 227
None
0.61A18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILT_H_TRUH800_1
(GLUTAMATE RECEPTOR 2)		1yb5 QUINONE
OXIDOREDUCTASE
(Homo
sapiens)		3 / 3ILE A 221
SER A 235
SER A 231
None
0.60A22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILT_H_TRUH800_1
(GLUTAMATE RECEPTOR 2)		3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens)		3 / 3ILE A 757
SER A 597
SER A 762
None
0.51A20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILT_H_TRUH800_1
(GLUTAMATE RECEPTOR 2)		3cdf IMMUNOGLOBULIN LIGHT
CHAIN
(Homo
sapiens)		3 / 3ILE A  83
SER A  12
SER A  14
None
0.56A16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILT_H_TRUH800_1
(GLUTAMATE RECEPTOR 2)		3ntc FAB LIGHT CHAIN
(Homo
sapiens;
Mus
musculus)		3 / 3ILE L  83
SER L  12
SER L  14
None
0.48A23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILT_H_TRUH800_1
(GLUTAMATE RECEPTOR 2)		3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1
(Homo
sapiens)		3 / 3ILE A 757
SER A 597
SER A 762
None
0.50A19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILT_H_TRUH800_1
(GLUTAMATE RECEPTOR 2)		4auo INTERSTITIAL
COLLAGENASE
(Homo
sapiens)		3 / 3ILE A 234
SER A 244
SER A 123
None
0.61A21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILT_H_TRUH800_1
(GLUTAMATE RECEPTOR 2)		4nef AQUAPORIN-2
(Homo
sapiens)		3 / 3ILE A  52
SER A 167
SER A 163
None
None
CD  A 301 ( 4.4A)
0.57A21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILT_H_TRUH800_1
(GLUTAMATE RECEPTOR 2)		4oe5 DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE,
MITOCHONDRIAL
(Homo
sapiens)		3 / 3ILE A 415
SER A 454
SER A 436
None
0.40A19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILT_H_TRUH800_1
(GLUTAMATE RECEPTOR 2)		4oj2 AQUAPORIN-2
(Homo
sapiens)		3 / 3ILE X  52
SER X 167
SER X 163
None
0.60A20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILT_H_TRUH800_1
(GLUTAMATE RECEPTOR 2)		5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B
(Homo
sapiens)		3 / 3ILE A 757
SER A 597
SER A 762
None
0.63A20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILT_H_TRUH800_1
(GLUTAMATE RECEPTOR 2)		5c5x AQUAPORIN-5
(Homo
sapiens)		3 / 3ILE A  53
SER A 168
SER A 164
None
0.51A21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILT_H_TRUH800_1
(GLUTAMATE RECEPTOR 2)		5fpn HEAT SHOCK-RELATED
70 KDA PROTEIN 2
(Homo
sapiens)		3 / 3ILE A  67
SER A 120
SER A  40
None
0.55A18.72