POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Seq. Identity (%)	View	Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1TNL_A_TPAA900_1 (TRYPSIN)	1elv	COMPLEMENT C1S COMPONENT (Homo sapiens)	6 / 6	ASP A 611 SER A 612 SER A 617 VAL A 638 GLY A 641 GLY A 648	None None SO4  A2001 ( 2.7A) None None None	0.29A	30.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1TNL_A_TPAA900_1 (TRYPSIN)	1fq3	GRANZYME B (Homo sapiens)	4 / 6	SER A 190 SER A 195 VAL A 213 GLY A 216	None SO4  A 800 (-2.4A) None None	0.69A	36.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1TNL_A_TPAA900_1 (TRYPSIN)	1fxy	COAGULATION FACTOR XA-TRYPSIN CHIMERA (Homo sapiens)	6 / 6	ASP A 189 SER A 190 SER A 195 VAL A 213 GLY A 216 GLY A 226	0G6  A   1 (-2.8A) 0G6  A   1 (-2.8A) 0G6  A   1 (-1.4A) None 0G6  A   1 (-3.9A) 0G6  A   1 (-3.3A)	0.29A	55.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1TNL_A_TPAA900_1 (TRYPSIN)	1gvl	KALLIKREIN 6 (Homo sapiens)	4 / 6	SER A 195 VAL A 213 GLY A 216 GLY A 226	None	0.55A	44.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1TNL_A_TPAA900_1 (TRYPSIN)	1h4w	TRYPSIN IVA (Homo sapiens)	6 / 6	ASP A 189 SER A 190 SER A 195 VAL A 213 GLY A 216 GLY A 226	BEN  A 250 (-2.9A) BEN  A 250 (-2.9A) BEN  A 250 (-3.6A) None BEN  A 250 (-3.9A) BEN  A 250 (-3.3A)	0.20A	72.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1TNL_A_TPAA900_1 (TRYPSIN)	1o5f	SERINE PROTEASE HEPSIN (Homo sapiens)	5 / 6	ASP H 189 SER H 195 VAL H 213 GLY H 216 GLY H 226	CR9  H 256 (-2.4A) CR9  H 256 (-1.5A) CR9  H 256 (-4.3A) CR9  H 256 ( 3.8A) CR9  H 256 (-3.0A)	0.23A	41.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1TNL_A_TPAA900_1 (TRYPSIN)	1orf	GRANZYME A (Homo sapiens)	5 / 6	ASP A 189 SER A 190 SER A 195 GLY A 216 GLY A 226	0G6  A   1 (-2.9A) 0G6  A   1 (-2.9A) 0G6  A   1 (-1.3A) 0G6  A   1 (-3.3A) 0G6  A   1 (-3.5A)	0.31A	35.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1TNL_A_TPAA900_1 (TRYPSIN)	1q3x	MANNAN-BINDING LECTIN SERINE PROTEASE 2 (Homo sapiens)	6 / 6	ASP A 627 SER A 628 SER A 633 VAL A 653 GLY A 656 GLY A 667	NA  A 800 ( 4.6A) GOL  A 701 (-3.4A) GOL  A 701 (-3.0A) GOL  A 701 (-4.9A) GOL  A 701 ( 4.1A) GOL  A 701 ( 4.0A)	0.31A	30.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1TNL_A_TPAA900_1 (TRYPSIN)	1zjk	MANNAN-BINDING LECTIN SERINE PROTEASE 2 (Homo sapiens)	4 / 6	SER A 633 VAL A 653 GLY A 656 GLY A 667	None	0.66A	26.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1TNL_A_TPAA900_1 (TRYPSIN)	1zlr	COAGULATION FACTOR XI (Homo sapiens)	4 / 6	ASP A 189 SER A 195 GLY A 216 GLY A 226	368  A 901 (-2.8A) 368  A 901 (-1.4A) 368  A 901 (-3.6A) 368  A 901 (-3.5A)	0.27A	39.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1TNL_A_TPAA900_1 (TRYPSIN)	2b5n	DAMAGE-SPECIFIC DNA BINDING PROTEIN 1 (Homo sapiens)	4 / 6	ASP A 654 SER A 653 GLY A 609 GLY A 632	None	0.75A	20.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1TNL_A_TPAA900_1 (TRYPSIN)	2ei8	COAGULATION FACTOR X, HEAVY CHAIN (Homo sapiens)	5 / 6	ASP A 189 SER A 195 VAL A 213 GLY A 216 GLY A 226	DT8  A 700 (-3.5A) DT8  A 700 ( 3.9A) DT8  A 700 ( 4.1A) DT8  A 700 (-3.5A) DT8  A 700 (-3.5A)	0.45A	38.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1TNL_A_TPAA900_1 (TRYPSIN)	2ipp	CATHEPSIN B (Homo sapiens)	4 / 6	SER A  39 VAL B  52 GLY B  92 GLY B  99	None	0.77A	12.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1TNL_A_TPAA900_1 (TRYPSIN)	2oq5	TRANSMEMBRANE PROTEASE, SERINE 11E (Homo sapiens)	5 / 6	ASP A 189 SER A 195 VAL A 213 GLY A 216 GLY A 226	BEN  A 245 (-3.0A) BEN  A 245 (-3.3A) None BEN  A 245 ( 3.8A) BEN  A 245 (-3.4A)	0.25A	37.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1TNL_A_TPAA900_1 (TRYPSIN)	2pks	THROMBIN HEAVY CHAIN FRAGMENT (Homo sapiens)	5 / 6	ASP C 229 SER C 235 VAL C 255 GLY C 258 GLY C 268	G44  C 101 (-2.6A) G44  C 101 (-3.5A) None G44  C 101 (-3.3A) G44  C 101 (-3.0A)	0.33A	21.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1TNL_A_TPAA900_1 (TRYPSIN)	2psy	KALLIKREIN-5 (Homo sapiens)	6 / 6	ASP A 189 SER A 190 SER A 195 VAL A 213 GLY A 216 GLY A 226	None	0.34A	47.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1TNL_A_TPAA900_1 (TRYPSIN)	2qy0	COMPLEMENT C1R SUBCOMPONENT (Homo sapiens)	5 / 6	ASP B 631 SER B 637 VAL B 657 GLY B 660 GLY B 668	None	0.47A	32.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1TNL_A_TPAA900_1 (TRYPSIN)	2r0l	HEPATOCYTE GROWTH FACTOR ACTIVATOR (Homo sapiens)	4 / 6	ASP A 189 SER A 195 GLY A 216 GLY A 226	None	0.33A	37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1TNL_A_TPAA900_1 (TRYPSIN)	2r2w	PLASMINOGEN ACTIVATOR, UROKINASE (Homo sapiens)	6 / 6	ASP U 189 SER U 190 SER U 195 VAL U 213 GLY U 216 GLY U 226	4PG  U 300 (-2.8A) 4PG  U 300 (-2.7A) 4PG  U 300 (-3.5A) None 4PG  U 300 (-3.3A) 4PG  U 300 (-3.2A)	0.64A	38.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1TNL_A_TPAA900_1 (TRYPSIN)	2wpm	COAGULATION FACTOR IXA HEAVY CHAIN (Homo sapiens)	5 / 6	ASP S 189 SER S 190 SER S 195 GLY S 216 GLY S 226	None	0.25A	41.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1TNL_A_TPAA900_1 (TRYPSIN)	2zec	TRYPTASE BETA 2 (Homo sapiens)	6 / 6	ASP A 203 SER A 204 SER A 209 VAL A 227 GLY A 230 GLY A 240	11N  A   1 (-2.6A) 11N  A   1 (-3.5A) 11N  A   1 (-3.3A) None 11N  A   1 (-3.9A) 11N  A   1 (-3.6A)	0.36A	40.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1TNL_A_TPAA900_1 (TRYPSIN)	3f6u	VITAMIN K-DEPENDENT PROTEIN C HEAVY CHAIN (Homo sapiens)	5 / 6	ASP H 189 SER H 195 VAL H 213 GLY H 216 GLY H 226	0G6  H   1 (-2.8A) 0G6  H   1 (-1.8A) None 0G6  H   1 (-3.8A) 0G6  H   1 ( 3.9A)	0.40A	35.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1TNL_A_TPAA900_1 (TRYPSIN)	3gov	MASP-1 (Homo sapiens)	5 / 6	ASP B 640 SER B 646 VAL B 666 GLY B 669 GLY B 679	None	0.47A	35.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1TNL_A_TPAA900_1 (TRYPSIN)	3gym	PROSTASIN (Homo sapiens)	5 / 6	ASP A 189 SER A 195 VAL A 213 GLY A 216 GLY A 226	None	0.31A	40.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1TNL_A_TPAA900_1 (TRYPSIN)	3r3g	THROMBIN HEAVY CHAIN (Homo sapiens)	5 / 6	ASP B 189 SER B 195 VAL B 213 GLY B 216 GLY B 226	None	0.47A	37.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1TNL_A_TPAA900_1 (TRYPSIN)	3zjc	GTPASE IMAP FAMILY MEMBER 7 (Homo sapiens)	4 / 6	SER A  19 SER A  22 GLY A  66 GLY A  15	GNP  A1297 (-3.9A) MG  A1296 ( 2.4A) GNP  A1297 ( 4.3A) None	0.72A	19.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1TNL_A_TPAA900_1 (TRYPSIN)	4d9r	COMPLEMENT FACTOR D (Homo sapiens)	5 / 6	ASP A 189 SER A 190 SER A 195 VAL A 213 GLY A 226	None	0.61A	37.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1TNL_A_TPAA900_1 (TRYPSIN)	4dgj	ENTEROPEPTIDASE CATALYTIC LIGHT CHAIN (Homo sapiens)	5 / 6	ASP A 181 SER A 182 SER A 187 GLY A 208 GLY A 218	None	0.57A	37.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1TNL_A_TPAA900_1 (TRYPSIN)	4fxg	MANNAN-BINDING LECTIN SERINE PROTEASE 2 B CHAIN (Homo sapiens)	5 / 6	ASP H 627 SER H 628 VAL H 653 GLY H 656 GLY H 667	None	0.38A	36.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1TNL_A_TPAA900_1 (TRYPSIN)	4iw4	MANNAN-BINDING LECTIN SERINE PROTEASE 3 (Homo sapiens)	5 / 6	ASP E 639 SER E 645 VAL E 665 GLY E 668 GLY E 680	None	0.42A	34.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1TNL_A_TPAA900_1 (TRYPSIN)	4k8y	KALLIKREIN-4 (Homo sapiens)	6 / 6	ASP A 189 SER A 190 SER A 195 VAL A 213 GLY A 216 GLY A 226	None	0.38A	40.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1TNL_A_TPAA900_1 (TRYPSIN)	4r0i	SUPPRESSOR OF TUMORIGENICITY 14 PROTEIN (Homo sapiens)	6 / 6	ASP A 189 SER A 190 SER A 195 VAL A 213 GLY A 216 GLY A 226	3KM  A 900 (-2.9A) 3KM  A 900 (-2.9A) 3KM  A 900 (-3.6A) None 3KM  A 900 (-3.4A) 3KM  A 900 (-3.2A)	0.22A	39.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1TNL_A_TPAA900_1 (TRYPSIN)	4wwy	TRYPSIN-1 (Homo sapiens)	6 / 6	ASP A 189 SER A 190 SER A 195 VAL A 213 GLY A 216 GLY A 226	None	0.25A	74.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1TNL_A_TPAA900_1 (TRYPSIN)	4ylq	COAGULATION FACTOR VII (Homo sapiens)	6 / 6	ASP H 189 SER H 190 SER H 195 VAL H 213 GLY H 216 GLY H 226	0Z7  H 501 (-2.3A) 0Z7  H 501 (-2.3A) 0Z7  H 501 (-1.4A) 0Z7  H 501 ( 4.7A) 0Z7  H 501 (-3.4A) 0Z7  H 501 (-3.0A)	0.26A	40.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1TNL_A_TPAA900_1 (TRYPSIN)	5f8z	PLASMA KALLIKREIN LIGHT CHAIN (Homo sapiens)	4 / 6	ASP A 189 SER A 195 GLY A 216 GLY A 226	None	0.41A	41.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1TNL_A_TPAA900_1 (TRYPSIN)	5fah	KALLIKREIN-7 (Homo sapiens)	4 / 6	SER A 195 VAL A 213 GLY A 216 GLY A 226	5VT  A 302 (-4.0A) None 5VT  A 302 (-3.4A) 5VT  A 302 ( 4.3A)	0.74A	41.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1TNL_A_TPAA900_1 (TRYPSIN)	5ms3	KALLIKREIN-8 (Homo sapiens)	4 / 6	ASP A 189 SER A 195 GLY A 216 GLY A 226	None	0.35A	33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1TNL_A_TPAA900_1 (TRYPSIN)	5to3	PROTHROMBIN,THROMBOM ODULIN (Homo sapiens)	5 / 6	ASP B 214 SER B 220 VAL B 240 GLY B 243 GLY B 253	0G6  B 501 (-2.9A) 0G6  B 501 (-1.3A) None 0G6  B 501 (-3.7A) 0G6  B 501 (-3.6A)	0.25A	27.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1TNL_A_TPAA900_1 (TRYPSIN)	5ubm	COMPLEMENT C1S SUBCOMPONENT (Homo sapiens)	6 / 6	ASP A 626 SER A 627 SER A 632 VAL A 653 GLY A 656 GLY A 663	None	0.42A	33.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1TNL_A_TPAA900_1 (TRYPSIN)	6au6	GUANINE NUCLEOTIDE-BINDING PROTEIN G(S) SUBUNIT ALPHA ISOFORMS SHORT (Homo sapiens)	4 / 6	SER A  51 SER A  54 GLY A 226 GLY A  47	GDP  A 401 (-3.4A) MG  A 402 ( 2.1A) None None	0.68A	21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1TNL_A_TPAA900_1 (TRYPSIN)	6b74	COAGULATION FACTOR XII (Homo sapiens)	4 / 6	ASP B 189 SER B 195 GLY B 216 GLY B 226	BEN  B 301 (-2.7A) SO4  B 304 ( 2.5A) BEN  B 301 (-3.3A) BEN  B 301 (-3.1A)	0.23A	16.74