POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HKU_A_TORA300_1
(CARBONIC ANHYDRASE 2)		1jd0 CARBONIC ANHYDRASE
XII
(Homo
sapiens)		9 / 12ASN A  62
GLN A  92
HIS A  94
HIS A  96
VAL A 121
VAL A 143
LEU A 198
THR A 200
TRP A 209
None
AZM  A1400 (-3.2A)
ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.2A)
AZM  A1400 (-4.6A)
AZM  A1400 ( 4.9A)
AZM  A1400 (-3.9A)
AZM  A1400 (-3.3A)
None
0.44A36.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HKU_A_TORA300_1
(CARBONIC ANHYDRASE 2)		1jd0 CARBONIC ANHYDRASE
XII
(Homo
sapiens)		5 / 12ASN A  62
HIS A  96
VAL A 121
LEU A 198
THR A 200
None
ZN  A 901 ( 3.2A)
AZM  A1400 (-4.6A)
AZM  A1400 (-3.9A)
AZM  A1400 (-3.3A)
0.86A36.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HKU_A_TORA300_1
(CARBONIC ANHYDRASE 2)		2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens)		6 / 12GLN A  92
HIS A  94
HIS A  96
VAL A 143
LEU A 198
TRP A 209
None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
None
0.58A60.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HKU_A_TORA300_1
(CARBONIC ANHYDRASE 2)		2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens)		5 / 12HIS A  96
PHE A  91
VAL A 143
LEU A 198
TRP A 209
 ZN  A 561 ( 3.2A)
None
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
None
1.12A60.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_1
(CARBONIC ANHYDRASE 2)		2v5y RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE MU
(Homo
sapiens)		5 / 12HIS A  75
VAL A 137
PHE A 139
VAL A  98
LEU A 125
None
1.18A16.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HKU_A_TORA300_1
(CARBONIC ANHYDRASE 2)		3da2 CARBONIC ANHYDRASE
13
(Homo
sapiens)		7 / 12ASN A  68
GLN A  93
HIS A  95
HIS A  97
VAL A 122
PHE A 132
LEU A 199
None
4MD  A 401 (-3.1A)
ZN  A 301 ( 3.6A)
ZN  A 301 ( 3.5A)
4MD  A 401 ( 4.6A)
4MD  A 401 (-4.6A)
4MD  A 401 (-4.2A)
0.95A60.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HKU_A_TORA300_1
(CARBONIC ANHYDRASE 2)		3da2 CARBONIC ANHYDRASE
13
(Homo
sapiens)		8 / 12ASN A  68
HIS A  95
HIS A  97
VAL A 122
PHE A 132
VAL A 144
LEU A 199
TRP A 210
None
ZN  A 301 ( 3.6A)
ZN  A 301 ( 3.5A)
4MD  A 401 ( 4.6A)
4MD  A 401 (-4.6A)
4MD  A 401 ( 4.4A)
4MD  A 401 (-4.2A)
None
0.56A60.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_1
(CARBONIC ANHYDRASE 2)		3e0l GUANINE DEAMINASE
(Homo
sapiens)		5 / 12GLN A  87
HIS A  84
HIS A  82
PHE A 108
VAL A 169
None
ZN  A1452 (-3.1A)
ZN  A1452 (-3.3A)
None
None
1.01A20.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HKU_A_TORA300_1
(CARBONIC ANHYDRASE 2)		3fe4 CARBONIC ANHYDRASE 6
(Homo
sapiens)		8 / 12ASN A  83
GLN A 109
HIS A 111
HIS A 113
VAL A 140
VAL A 161
LEU A 219
TRP A 230
None
None
MG  A 901 (-3.4A)
MG  A 901 (-3.4A)
None
None
None
None
0.61A34.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HKU_A_TORA300_1
(CARBONIC ANHYDRASE 2)		3fe4 CARBONIC ANHYDRASE 6
(Homo
sapiens)		6 / 12HIS A 111
HIS A 113
VAL A 140
VAL A 161
LEU A 219
THR A 220
 MG  A 901 (-3.4A)
MG  A 901 (-3.4A)
None
None
None
None
1.46A34.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HKU_A_TORA300_1
(CARBONIC ANHYDRASE 2)		3ml5 CARBONIC ANHYDRASE 7
(Homo
sapiens)		6 / 12ASN A  62
GLN A  67
HIS A  96
VAL A 121
LEU A 198
THR A 200
None
None
ZN  A 263 ( 3.2A)
AZM  A 264 (-4.7A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.5A)
1.30A55.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HKU_A_TORA300_1
(CARBONIC ANHYDRASE 2)		3ml5 CARBONIC ANHYDRASE 7
(Homo
sapiens)		10 / 12ASN A  62
GLN A  92
HIS A  94
HIS A  96
VAL A 121
PHE A 131
VAL A 143
LEU A 198
THR A 200
TRP A 209
None
AZM  A 264 (-4.1A)
ZN  A 263 ( 3.2A)
ZN  A 263 ( 3.2A)
AZM  A 264 (-4.7A)
AZM  A 264 (-4.4A)
AZM  A 264 ( 4.9A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.5A)
None
0.37A55.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HKU_A_TORA300_1
(CARBONIC ANHYDRASE 2)		3ml5 CARBONIC ANHYDRASE 7
(Homo
sapiens)		5 / 12GLN A  67
HIS A  94
HIS A  96
LEU A 198
THR A 200
None
ZN  A 263 ( 3.2A)
ZN  A 263 ( 3.2A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.5A)
1.13A55.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HKU_A_TORA300_1
(CARBONIC ANHYDRASE 2)		3ml5 CARBONIC ANHYDRASE 7
(Homo
sapiens)		7 / 12GLN A  92
HIS A  94
HIS A  96
VAL A 121
PHE A 131
LEU A 198
THR A 199
AZM  A 264 (-4.1A)
ZN  A 263 ( 3.2A)
ZN  A 263 ( 3.2A)
AZM  A 264 (-4.7A)
AZM  A 264 (-4.4A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.4A)
1.38A55.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HKU_A_TORA300_1
(CARBONIC ANHYDRASE 2)		3uyq CARBONIC ANHYDRASE 3
(Homo
sapiens)		9 / 12ASN A  62
GLN A  92
HIS A  94
HIS A  96
VAL A 121
PHE A 130
VAL A 142
THR A 199
TRP A 208
None
None
ZN  A 261 (-3.3A)
ZN  A 261 (-3.3A)
None
None
None
None
None
0.46A58.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HKU_A_TORA300_1
(CARBONIC ANHYDRASE 2)		3uyq CARBONIC ANHYDRASE 3
(Homo
sapiens)		6 / 12GLN A  92
HIS A  94
HIS A  96
VAL A 121
VAL A 142
THR A 198
None
ZN  A 261 (-3.3A)
ZN  A 261 (-3.3A)
None
None
ZN  A 261 ( 4.4A)
1.26A58.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HKU_A_TORA300_1
(CARBONIC ANHYDRASE 2)		4qk3 CARBONIC ANHYDRASE 2
(Homo
sapiens)		8 / 12ALA A  65
GLN A  92
HIS A  94
HIS A  96
VAL A 121
PHE A 131
LEU A 198
THR A 199
None
None
ZN  A 301 (-3.2A)
ZN  A 301 (-3.2A)
None
None
None
ZN  A 301 ( 4.4A)
1.41A95.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HKU_A_TORA300_1
(CARBONIC ANHYDRASE 2)		4qk3 CARBONIC ANHYDRASE 2
(Homo
sapiens)		12 / 12ASN A  62
ALA A  65
ASN A  67
GLN A  92
HIS A  94
HIS A  96
VAL A 121
PHE A 131
VAL A 143
LEU A 198
THR A 200
TRP A 209
None
None
None
None
ZN  A 301 (-3.2A)
ZN  A 301 (-3.2A)
None
None
None
None
None
None
0.35A95.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HKU_A_TORA300_1
(CARBONIC ANHYDRASE 2)		4qk3 CARBONIC ANHYDRASE 2
(Homo
sapiens)		6 / 12ASN A  67
ALA A  65
HIS A  96
VAL A 143
LEU A 198
THR A 200
None
None
ZN  A 301 (-3.2A)
None
None
None
1.30A95.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HKU_A_TORA300_1
(CARBONIC ANHYDRASE 2)		4qk3 CARBONIC ANHYDRASE 2
(Homo
sapiens)		5 / 12HIS A 119
HIS A  96
VAL A 143
LEU A 198
THR A 200
 ZN  A 301 (-3.1A)
ZN  A 301 (-3.2A)
None
None
None
1.31A95.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HKU_A_TORA300_1
(CARBONIC ANHYDRASE 2)		5cjf CARBONIC ANHYDRASE
14
(Homo
sapiens)		6 / 12ASN A  62
GLN A  67
HIS A  96
VAL A 121
LEU A 198
THR A 200
GOL  A 303 (-3.9A)
GOL  A 303 (-3.4A)
ZN  A 301 ( 3.2A)
520  A 302 ( 4.9A)
520  A 302 (-3.6A)
GOL  A 303 ( 3.5A)
1.24A36.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HKU_A_TORA300_1
(CARBONIC ANHYDRASE 2)		5cjf CARBONIC ANHYDRASE
14
(Homo
sapiens)		9 / 12ASN A  62
GLN A  92
HIS A  94
HIS A  96
VAL A 121
VAL A 143
LEU A 198
THR A 200
TRP A 209
GOL  A 303 (-3.9A)
GOL  A 303 (-3.2A)
ZN  A 301 (-3.2A)
ZN  A 301 ( 3.2A)
520  A 302 ( 4.9A)
520  A 302 ( 4.9A)
520  A 302 (-3.6A)
GOL  A 303 ( 3.5A)
None
0.26A36.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HKU_A_TORA300_1
(CARBONIC ANHYDRASE 2)		5cjf CARBONIC ANHYDRASE
14
(Homo
sapiens)		5 / 12GLN A  67
HIS A  94
HIS A  96
LEU A 198
THR A 200
GOL  A 303 (-3.4A)
ZN  A 301 (-3.2A)
ZN  A 301 ( 3.2A)
520  A 302 (-3.6A)
GOL  A 303 ( 3.5A)
1.11A36.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HKU_A_TORA300_1
(CARBONIC ANHYDRASE 2)		5jn9 CARBONIC ANHYDRASE 4
(Homo
sapiens)		9 / 12ASN A  62
GLN A  92
HIS A  94
HIS A  96
VAL A 121
VAL A 143
LEU A 198
THR A 200
TRP A 209
None
EZL  A 302 (-4.3A)
ZN  A 301 ( 3.3A)
ZN  A 301 ( 3.3A)
EZL  A 302 (-4.7A)
EZL  A 302 ( 4.7A)
EZL  A 302 (-3.5A)
EZL  A 302 (-3.9A)
None
0.46A35.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HKU_A_TORA300_1
(CARBONIC ANHYDRASE 2)		5jn9 CARBONIC ANHYDRASE 4
(Homo
sapiens)		5 / 12ASN A  62
HIS A  96
VAL A 121
LEU A 198
THR A 200
None
ZN  A 301 ( 3.3A)
EZL  A 302 (-4.7A)
EZL  A 302 (-3.5A)
EZL  A 302 (-3.9A)
1.06A35.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HKU_A_TORA300_1
(CARBONIC ANHYDRASE 2)		5jn9 CARBONIC ANHYDRASE 4
(Homo
sapiens)		6 / 12GLN A  92
HIS A  94
HIS A  96
VAL A 121
LEU A 198
THR A 199
EZL  A 302 (-4.3A)
ZN  A 301 ( 3.3A)
ZN  A 301 ( 3.3A)
EZL  A 302 (-4.7A)
EZL  A 302 (-3.5A)
EZL  A 302 (-3.4A)
1.42A35.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_1
(CARBONIC ANHYDRASE 2)		6cet GATOR COMPLEX
PROTEIN DEPDC5
(Homo
sapiens)		5 / 12ALA D 169
VAL D 334
PHE D 199
VAL D 364
LEU D 747
None
1.33A17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_1
(CARBONIC ANHYDRASE 2)		6fe1 CARBONIC ANHYDRASE 9
(Homo
sapiens)		9 / 12ASN A  62
GLN A  92
HIS A  94
HIS A  96
VAL A 121
VAL A 143
LEU A 198
THR A 200
TRP A 209
V14  A 302 (-3.4A)
V14  A 302 (-3.8A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
V14  A 302 (-4.7A)
None
V14  A 302 (-3.6A)
V14  A 302 (-3.5A)
None
0.39A14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_1
(CARBONIC ANHYDRASE 2)		6fe1 CARBONIC ANHYDRASE 9
(Homo
sapiens)		5 / 12ASN A  62
HIS A  96
VAL A 121
LEU A 198
THR A 200
V14  A 302 (-3.4A)
ZN  A 301 ( 3.2A)
V14  A 302 (-4.7A)
V14  A 302 (-3.6A)
V14  A 302 (-3.5A)
1.09A14.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HKU_A_TORA300_2
(CARBONIC ANHYDRASE 2)		1jd0 CARBONIC ANHYDRASE
XII
(Homo
sapiens)		3 / 3GLU A 106
HIS A 119
THR A 199
 ZN  A 901 ( 4.5A)
ZN  A 901 ( 3.1A)
AZM  A1400 (-3.6A)
0.09A36.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_2
(CARBONIC ANHYDRASE 2)		2ice COMPLEMENT C3 BETA
CHAIN
(Homo
sapiens)		3 / 3GLU A  23
HIS A  25
THR A 469
None
0.77A18.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HKU_A_TORA300_2
(CARBONIC ANHYDRASE 2)		2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens)		3 / 3GLU A 106
HIS A 119
THR A 199
 ZN  A 561 ( 4.9A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-3.6A)
0.29A60.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_2
(CARBONIC ANHYDRASE 2)		2qob EPHRIN RECEPTOR
(Homo
sapiens)		3 / 3GLU A 615
HIS A 610
THR A 690
None
0.81A20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_2
(CARBONIC ANHYDRASE 2)		2r2p EPHRIN TYPE-A
RECEPTOR 5
(Homo
sapiens)		3 / 3GLU A 669
HIS A 664
THR A 744
None
0.85A20.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HKU_A_TORA300_2
(CARBONIC ANHYDRASE 2)		2w2j CARBONIC
ANHYDRASE-RELATED
PROTEIN
(Homo
sapiens)		3 / 3GLU A 128
HIS A 141
THR A 223
None
CL  A 401 (-4.1A)
CL  A 401 ( 4.8A)
0.20A39.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HKU_A_TORA300_2
(CARBONIC ANHYDRASE 2)		3da2 CARBONIC ANHYDRASE
13
(Homo
sapiens)		3 / 3GLU A 107
HIS A 120
THR A 200
 ZN  A 301 ( 4.9A)
ZN  A 301 ( 3.2A)
4MD  A 401 (-3.2A)
0.21A60.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HKU_A_TORA300_2
(CARBONIC ANHYDRASE 2)		3fe4 CARBONIC ANHYDRASE 6
(Homo
sapiens)		3 / 3GLU A 125
HIS A 138
THR A 220
 MG  A 901 ( 4.4A)
MG  A 901 (-3.2A)
None
0.63A34.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HKU_A_TORA300_2
(CARBONIC ANHYDRASE 2)		3ml5 CARBONIC ANHYDRASE 7
(Homo
sapiens)		3 / 3GLU A 106
HIS A 119
THR A 199
 ZN  A 263 ( 4.6A)
ZN  A 263 ( 3.1A)
AZM  A 264 (-3.4A)
0.11A55.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HKU_A_TORA300_2
(CARBONIC ANHYDRASE 2)		3uyq CARBONIC ANHYDRASE 3
(Homo
sapiens)		3 / 3GLU A 106
HIS A 119
THR A 198
 ZN  A 261 ( 4.9A)
ZN  A 261 (-3.2A)
ZN  A 261 ( 4.4A)
0.17A58.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_2
(CARBONIC ANHYDRASE 2)		4dpg LYSINE--TRNA LIGASE
(Homo
sapiens)		3 / 3GLU A 317
HIS A 304
THR A 268
None
0.76A20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_2
(CARBONIC ANHYDRASE 2)		4fo0 ACTIN-RELATED
PROTEIN 8
(Homo
sapiens)		3 / 3GLU A 295
HIS A 300
THR A 527
None
0.71A18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_2
(CARBONIC ANHYDRASE 2)		4po6 INTERFERON
ALPHA/BETA RECEPTOR
1
NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2
(Homo
sapiens)		3 / 3GLU B 497
HIS A 474
THR A 477
None
0.63A9.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HKU_A_TORA300_2
(CARBONIC ANHYDRASE 2)		4qk3 CARBONIC ANHYDRASE 2
(Homo
sapiens)		3 / 3GLU A 106
HIS A 119
THR A 199
 ZN  A 301 ( 4.5A)
ZN  A 301 (-3.1A)
ZN  A 301 ( 4.4A)
0.18A95.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_2
(CARBONIC ANHYDRASE 2)		4y4r BIFUNCTIONAL
LYSINE-SPECIFIC
DEMETHYLASE AND
HISTIDYL-HYDROXYLASE
NO66
(Homo
sapiens)		3 / 3GLU A 352
HIS A 414
THR A 244
None
0.65A19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_2
(CARBONIC ANHYDRASE 2)		5a40 MONOBODIES
PUTATIVE FLUORIDE
ION TRANSPORTER CRCB
(Bordetella
pertussis;
Homo
sapiens)		3 / 3GLU A  88
HIS E  78
THR A  39
None
0.85A21.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HKU_A_TORA300_2
(CARBONIC ANHYDRASE 2)		5cjf CARBONIC ANHYDRASE
14
(Homo
sapiens)		3 / 3GLU A 106
HIS A 119
THR A 199
 ZN  A 301 ( 4.6A)
ZN  A 301 ( 3.1A)
520  A 302 (-3.4A)
0.10A36.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HKU_A_TORA300_2
(CARBONIC ANHYDRASE 2)		5jn9 CARBONIC ANHYDRASE 4
(Homo
sapiens)		3 / 3GLU A 106
HIS A 119
THR A 199
 ZN  A 301 ( 4.6A)
ZN  A 301 ( 3.2A)
EZL  A 302 (-3.4A)
0.09A35.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_2
(CARBONIC ANHYDRASE 2)		6chd LYSINE--TRNA LIGASE
(Homo
sapiens)		3 / 3GLU A 317
HIS A 304
THR A 268
None
0.73A18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_2
(CARBONIC ANHYDRASE 2)		6fe1 CARBONIC ANHYDRASE 9
(Homo
sapiens)		3 / 3GLU A 106
HIS A 119
THR A 199
V14  A 302 (-4.2A)
ZN  A 301 ( 3.1A)
V14  A 302 (-3.2A)
0.22A14.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LXE_A_TORA262_1
(CARBONIC ANHYDRASE 1)		1jd0 CARBONIC ANHYDRASE
XII
(Homo
sapiens)		8 / 12SER A  65
GLN A  92
HIS A  94
HIS A  96
VAL A 143
LEU A 198
THR A 199
TRP A 209
None
AZM  A1400 (-3.2A)
ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.2A)
AZM  A1400 ( 4.9A)
AZM  A1400 (-3.9A)
AZM  A1400 (-3.6A)
None
0.48A37.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LXE_A_TORA262_1
(CARBONIC ANHYDRASE 1)		2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens)		10 / 12HIS A  64
SER A  65
PHE A  91
GLN A  92
HIS A  94
HIS A  96
VAL A 143
LEU A 198
THR A 199
TRP A 209
None
None
None
None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
0.30A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LXE_A_TORA262_1
(CARBONIC ANHYDRASE 1)		3da2 CARBONIC ANHYDRASE
13
(Homo
sapiens)		5 / 12PHE A 132
HIS A  97
VAL A 122
LEU A 199
THR A 200
4MD  A 401 (-4.6A)
ZN  A 301 ( 3.5A)
4MD  A 401 ( 4.6A)
4MD  A 401 (-4.2A)
4MD  A 401 (-3.2A)
1.35A59.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LXE_A_TORA262_1
(CARBONIC ANHYDRASE 1)		3da2 CARBONIC ANHYDRASE
13
(Homo
sapiens)		7 / 12SER A  66
GLN A  93
HIS A  95
HIS A  97
VAL A 144
LEU A 199
THR A 200
None
4MD  A 401 (-3.1A)
ZN  A 301 ( 3.6A)
ZN  A 301 ( 3.5A)
4MD  A 401 ( 4.4A)
4MD  A 401 (-4.2A)
4MD  A 401 (-3.2A)
0.79A59.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LXE_A_TORA262_1
(CARBONIC ANHYDRASE 1)		3da2 CARBONIC ANHYDRASE
13
(Homo
sapiens)		8 / 12SER A  66
PHE A 132
HIS A  95
HIS A  97
VAL A 144
LEU A 199
THR A 200
TRP A 210
None
4MD  A 401 (-4.6A)
ZN  A 301 ( 3.6A)
ZN  A 301 ( 3.5A)
4MD  A 401 ( 4.4A)
4MD  A 401 (-4.2A)
4MD  A 401 (-3.2A)
None
1.04A59.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXE_A_TORA262_1
(CARBONIC ANHYDRASE 1)		3e0l GUANINE DEAMINASE
(Homo
sapiens)		5 / 12PHE A  90
GLN A  87
HIS A  84
HIS A 238
LEU A 306
None
None
ZN  A1452 (-3.1A)
ZN  A1452 (-3.2A)
None
1.49A18.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LXE_A_TORA262_1
(CARBONIC ANHYDRASE 1)		3fe4 CARBONIC ANHYDRASE 6
(Homo
sapiens)		7 / 12GLN A 109
HIS A 111
HIS A 113
VAL A 161
LEU A 219
THR A 220
TRP A 230
None
MG  A 901 (-3.4A)
MG  A 901 (-3.4A)
None
None
None
None
0.82A34.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LXE_A_TORA262_1
(CARBONIC ANHYDRASE 1)		3ml5 CARBONIC ANHYDRASE 7
(Homo
sapiens)		5 / 12GLN A  67
HIS A  94
HIS A  96
LEU A 198
THR A 199
None
ZN  A 263 ( 3.2A)
ZN  A 263 ( 3.2A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.4A)
0.87A50.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LXE_A_TORA262_1
(CARBONIC ANHYDRASE 1)		3ml5 CARBONIC ANHYDRASE 7
(Homo
sapiens)		5 / 12GLN A  67
HIS A  96
VAL A 121
LEU A 198
THR A 199
None
ZN  A 263 ( 3.2A)
AZM  A 264 (-4.7A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.4A)
1.16A50.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LXE_A_TORA262_1
(CARBONIC ANHYDRASE 1)		3ml5 CARBONIC ANHYDRASE 7
(Homo
sapiens)		8 / 12SER A  65
GLN A  92
HIS A  94
HIS A  96
VAL A 143
LEU A 198
THR A 199
TRP A 209
None
AZM  A 264 (-4.1A)
ZN  A 263 ( 3.2A)
ZN  A 263 ( 3.2A)
AZM  A 264 ( 4.9A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.4A)
None
0.56A50.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LXE_A_TORA262_1
(CARBONIC ANHYDRASE 1)		3ml5 CARBONIC ANHYDRASE 7
(Homo
sapiens)		6 / 12SER A  65
PHE A 131
HIS A  96
VAL A 143
THR A 199
TRP A 209
None
AZM  A 264 (-4.4A)
ZN  A 263 ( 3.2A)
AZM  A 264 ( 4.9A)
AZM  A 264 (-3.4A)
None
1.04A50.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LXE_A_TORA262_1
(CARBONIC ANHYDRASE 1)		3uyq CARBONIC ANHYDRASE 3
(Homo
sapiens)		6 / 12GLN A  92
HIS A  94
HIS A  96
VAL A 142
THR A 198
TRP A 208
None
ZN  A 261 (-3.3A)
ZN  A 261 (-3.3A)
None
ZN  A 261 ( 4.4A)
None
0.56A54.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LXE_A_TORA262_1
(CARBONIC ANHYDRASE 1)		4qk3 CARBONIC ANHYDRASE 2
(Homo
sapiens)		8 / 12HIS A  64
GLN A  92
HIS A  94
HIS A  96
VAL A 143
LEU A 198
THR A 199
TRP A 209
None
None
ZN  A 301 (-3.2A)
ZN  A 301 (-3.2A)
None
None
ZN  A 301 ( 4.4A)
None
0.62A58.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LXE_A_TORA262_1
(CARBONIC ANHYDRASE 1)		4qk3 CARBONIC ANHYDRASE 2
(Homo
sapiens)		6 / 12PHE A 131
GLN A  92
HIS A  96
LEU A 198
THR A 199
TRP A 209
None
None
ZN  A 301 (-3.2A)
None
ZN  A 301 ( 4.4A)
None
1.25A58.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LXE_A_TORA262_1
(CARBONIC ANHYDRASE 1)		4qk3 CARBONIC ANHYDRASE 2
(Homo
sapiens)		5 / 12PHE A 131
GLN A  92
HIS A 119
LEU A 198
THR A 199
None
None
ZN  A 301 (-3.1A)
None
ZN  A 301 ( 4.4A)
1.45A58.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LXE_A_TORA262_1
(CARBONIC ANHYDRASE 1)		4qk3 CARBONIC ANHYDRASE 2
(Homo
sapiens)		5 / 12PHE A 131
HIS A  96
VAL A 121
LEU A 198
THR A 199
None
ZN  A 301 (-3.2A)
None
None
ZN  A 301 ( 4.4A)
1.36A58.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXE_A_TORA262_1
(CARBONIC ANHYDRASE 1)		4qn9 N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D
(Homo
sapiens)		5 / 12HIS A 185
PHE A 316
GLN A 320
HIS A 321
HIS A 343
 ZN  A 501 (-3.6A)
None
3PE  A 503 (-4.1A)
3PE  A 503 (-3.8A)
ZN  A 502 ( 3.6A)
1.14A20.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LXE_A_TORA262_1
(CARBONIC ANHYDRASE 1)		5cjf CARBONIC ANHYDRASE
14
(Homo
sapiens)		7 / 12GLN A  92
HIS A  94
HIS A  96
VAL A 143
LEU A 198
THR A 199
TRP A 209
GOL  A 303 (-3.2A)
ZN  A 301 (-3.2A)
ZN  A 301 ( 3.2A)
520  A 302 ( 4.9A)
520  A 302 (-3.6A)
520  A 302 (-3.4A)
None
0.50A34.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXE_A_TORA262_1
(CARBONIC ANHYDRASE 1)		5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR
(Homo
sapiens)		5 / 12SER A1895
HIS A1791
GLN A1901
LEU A2208
THR A2207
None
1.32A7.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LXE_A_TORA262_1
(CARBONIC ANHYDRASE 1)		5jn9 CARBONIC ANHYDRASE 4
(Homo
sapiens)		9 / 12HIS A  64
SER A  65
GLN A  92
HIS A  94
HIS A  96
VAL A 143
LEU A 198
THR A 199
TRP A 209
None
None
EZL  A 302 (-4.3A)
ZN  A 301 ( 3.3A)
ZN  A 301 ( 3.3A)
EZL  A 302 ( 4.7A)
EZL  A 302 (-3.5A)
EZL  A 302 (-3.4A)
None
0.72A31.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXE_A_TORA262_1
(CARBONIC ANHYDRASE 1)		5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens)		5 / 12GLN A 263
HIS A 142
HIS A 143
LEU A 179
HIS A 201
None
None
EDO  A 410 (-4.4A)
None
None
1.35A20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXE_A_TORA262_1
(CARBONIC ANHYDRASE 1)		6bbp CYTOHESIN-3,ADP-RIBO
SYLATION FACTOR 6
(Homo
sapiens;
Mus
musculus)		5 / 12HIS A  56
HIS A  60
GLN A  65
HIS A  59
THR A 477
None
1.47A14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXE_A_TORA262_1
(CARBONIC ANHYDRASE 1)		6fe1 CARBONIC ANHYDRASE 9
(Homo
sapiens)		8 / 12SER A  65
GLN A  92
HIS A  94
HIS A  96
VAL A 143
LEU A 198
THR A 199
TRP A 209
V14  A 302 ( 4.6A)
V14  A 302 (-3.8A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
None
V14  A 302 (-3.6A)
V14  A 302 (-3.2A)
None
0.63A15.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LXE_B_TORB262_1
(CARBONIC ANHYDRASE 1)		1jd0 CARBONIC ANHYDRASE
XII
(Homo
sapiens)		8 / 12SER A  65
GLN A  92
HIS A  94
HIS A  96
VAL A 143
LEU A 198
THR A 199
TRP A 209
None
AZM  A1400 (-3.2A)
ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.2A)
AZM  A1400 ( 4.9A)
AZM  A1400 (-3.9A)
AZM  A1400 (-3.6A)
None
0.50A37.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LXE_B_TORB262_1
(CARBONIC ANHYDRASE 1)		2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens)		10 / 12HIS A  64
SER A  65
PHE A  91
GLN A  92
HIS A  94
HIS A  96
VAL A 143
LEU A 198
THR A 199
TRP A 209
None
None
None
None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
0.28A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LXE_B_TORB262_1
(CARBONIC ANHYDRASE 1)		3da2 CARBONIC ANHYDRASE
13
(Homo
sapiens)		5 / 12HIS A  65
SER A  63
PHE A 132
VAL A 122
LEU A 199
None
None
4MD  A 401 (-4.6A)
4MD  A 401 ( 4.6A)
4MD  A 401 (-4.2A)
1.18A59.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LXE_B_TORB262_1
(CARBONIC ANHYDRASE 1)		3da2 CARBONIC ANHYDRASE
13
(Homo
sapiens)		5 / 12PHE A 132
HIS A  97
VAL A 122
LEU A 199
THR A 200
4MD  A 401 (-4.6A)
ZN  A 301 ( 3.5A)
4MD  A 401 ( 4.6A)
4MD  A 401 (-4.2A)
4MD  A 401 (-3.2A)
1.35A59.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LXE_B_TORB262_1
(CARBONIC ANHYDRASE 1)		3da2 CARBONIC ANHYDRASE
13
(Homo
sapiens)		7 / 12SER A  66
GLN A  93
HIS A  95
HIS A  97
VAL A 144
LEU A 199
THR A 200
None
4MD  A 401 (-3.1A)
ZN  A 301 ( 3.6A)
ZN  A 301 ( 3.5A)
4MD  A 401 ( 4.4A)
4MD  A 401 (-4.2A)
4MD  A 401 (-3.2A)
0.83A59.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LXE_B_TORB262_1
(CARBONIC ANHYDRASE 1)		3da2 CARBONIC ANHYDRASE
13
(Homo
sapiens)		8 / 12SER A  66
PHE A 132
HIS A  95
HIS A  97
VAL A 144
LEU A 199
THR A 200
TRP A 210
None
4MD  A 401 (-4.6A)
ZN  A 301 ( 3.6A)
ZN  A 301 ( 3.5A)
4MD  A 401 ( 4.4A)
4MD  A 401 (-4.2A)
4MD  A 401 (-3.2A)
None
1.06A59.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXE_B_TORB262_1
(CARBONIC ANHYDRASE 1)		3e0l GUANINE DEAMINASE
(Homo
sapiens)		5 / 12PHE A  90
GLN A  87
HIS A  84
HIS A 238
LEU A 306
None
None
ZN  A1452 (-3.1A)
ZN  A1452 (-3.2A)
None
1.48A18.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LXE_B_TORB262_1
(CARBONIC ANHYDRASE 1)		3fe4 CARBONIC ANHYDRASE 6
(Homo
sapiens)		7 / 12GLN A 109
HIS A 111
HIS A 113
VAL A 161
LEU A 219
THR A 220
TRP A 230
None
MG  A 901 (-3.4A)
MG  A 901 (-3.4A)
None
None
None
None
0.82A34.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LXE_B_TORB262_1
(CARBONIC ANHYDRASE 1)		3ml5 CARBONIC ANHYDRASE 7
(Homo
sapiens)		5 / 12GLN A  67
HIS A  94
HIS A  96
LEU A 198
THR A 199
None
ZN  A 263 ( 3.2A)
ZN  A 263 ( 3.2A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.4A)
0.87A50.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LXE_B_TORB262_1
(CARBONIC ANHYDRASE 1)		3ml5 CARBONIC ANHYDRASE 7
(Homo
sapiens)		5 / 12GLN A  67
HIS A  96
VAL A 121
LEU A 198
THR A 199
None
ZN  A 263 ( 3.2A)
AZM  A 264 (-4.7A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.4A)
1.16A50.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LXE_B_TORB262_1
(CARBONIC ANHYDRASE 1)		3ml5 CARBONIC ANHYDRASE 7
(Homo
sapiens)		8 / 12SER A  65
GLN A  92
HIS A  94
HIS A  96
VAL A 143
LEU A 198
THR A 199
TRP A 209
None
AZM  A 264 (-4.1A)
ZN  A 263 ( 3.2A)
ZN  A 263 ( 3.2A)
AZM  A 264 ( 4.9A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.4A)
None
0.58A50.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LXE_B_TORB262_1
(CARBONIC ANHYDRASE 1)		3ml5 CARBONIC ANHYDRASE 7
(Homo
sapiens)		7 / 12SER A  65
PHE A 131
GLN A  92
HIS A  96
VAL A 143
THR A 199
TRP A 209
None
AZM  A 264 (-4.4A)
AZM  A 264 (-4.1A)
ZN  A 263 ( 3.2A)
AZM  A 264 ( 4.9A)
AZM  A 264 (-3.4A)
None
1.20A50.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXE_B_TORB262_1
(CARBONIC ANHYDRASE 1)		3sl9 CATENIN BETA-1
(Homo
sapiens)		5 / 12HIS A 223
VAL A 195
LEU A 218
THR A 217
HIS A 219
None
1.39A19.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LXE_B_TORB262_1
(CARBONIC ANHYDRASE 1)		3uyq CARBONIC ANHYDRASE 3
(Homo
sapiens)		6 / 12GLN A  92
HIS A  94
HIS A  96
VAL A 142
THR A 198
TRP A 208
None
ZN  A 261 (-3.3A)
ZN  A 261 (-3.3A)
None
ZN  A 261 ( 4.4A)
None
0.55A54.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXE_B_TORB262_1
(CARBONIC ANHYDRASE 1)		4o5l FAB F045-092 HEAVY
CHAIN
(Homo
sapiens)		5 / 12SER H 215
HIS H 217
HIS H 218
HIS H 220
HIS H 219
None
1.44A23.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LXE_B_TORB262_1
(CARBONIC ANHYDRASE 1)		4qk3 CARBONIC ANHYDRASE 2
(Homo
sapiens)		8 / 12HIS A  64
GLN A  92
HIS A  94
HIS A  96
VAL A 143
LEU A 198
THR A 199
TRP A 209
None
None
ZN  A 301 (-3.2A)
ZN  A 301 (-3.2A)
None
None
ZN  A 301 ( 4.4A)
None
0.59A58.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LXE_B_TORB262_1
(CARBONIC ANHYDRASE 1)		4qk3 CARBONIC ANHYDRASE 2
(Homo
sapiens)		6 / 12PHE A 131
GLN A  92
HIS A  96
LEU A 198
THR A 199
TRP A 209
None
None
ZN  A 301 (-3.2A)
None
ZN  A 301 ( 4.4A)
None
1.25A58.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LXE_B_TORB262_1
(CARBONIC ANHYDRASE 1)		4qk3 CARBONIC ANHYDRASE 2
(Homo
sapiens)		5 / 12PHE A 131
GLN A  92
HIS A 119
LEU A 198
THR A 199
None
None
ZN  A 301 (-3.1A)
None
ZN  A 301 ( 4.4A)
1.44A58.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LXE_B_TORB262_1
(CARBONIC ANHYDRASE 1)		4qk3 CARBONIC ANHYDRASE 2
(Homo
sapiens)		5 / 12PHE A 131
HIS A  96
VAL A 121
LEU A 198
THR A 199
None
ZN  A 301 (-3.2A)
None
None
ZN  A 301 ( 4.4A)
1.36A58.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXE_B_TORB262_1
(CARBONIC ANHYDRASE 1)		4qn9 N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D
(Homo
sapiens)		5 / 12HIS A 185
PHE A 316
GLN A 320
HIS A 321
HIS A 343
 ZN  A 501 (-3.6A)
None
3PE  A 503 (-4.1A)
3PE  A 503 (-3.8A)
ZN  A 502 ( 3.6A)
1.13A20.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LXE_B_TORB262_1
(CARBONIC ANHYDRASE 1)		5cjf CARBONIC ANHYDRASE
14
(Homo
sapiens)		7 / 12GLN A  92
HIS A  94
HIS A  96
VAL A 143
LEU A 198
THR A 199
TRP A 209
GOL  A 303 (-3.2A)
ZN  A 301 (-3.2A)
ZN  A 301 ( 3.2A)
520  A 302 ( 4.9A)
520  A 302 (-3.6A)
520  A 302 (-3.4A)
None
0.49A34.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LXE_B_TORB262_1
(CARBONIC ANHYDRASE 1)		5jn9 CARBONIC ANHYDRASE 4
(Homo
sapiens)		9 / 12HIS A  64
SER A  65
GLN A  92
HIS A  94
HIS A  96
VAL A 143
LEU A 198
THR A 199
TRP A 209
None
None
EZL  A 302 (-4.3A)
ZN  A 301 ( 3.3A)
ZN  A 301 ( 3.3A)
EZL  A 302 ( 4.7A)
EZL  A 302 (-3.5A)
EZL  A 302 (-3.4A)
None
0.72A31.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXE_B_TORB262_1
(CARBONIC ANHYDRASE 1)		5vi6 HISTONE DEACETYLASE
8
(Homo
sapiens)		5 / 12GLN A 263
HIS A 142
HIS A 143
LEU A 179
HIS A 201
None
None
EDO  A 410 (-4.4A)
None
None
1.33A20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXE_B_TORB262_1
(CARBONIC ANHYDRASE 1)		6fe1 CARBONIC ANHYDRASE 9
(Homo
sapiens)		8 / 12SER A  65
GLN A  92
HIS A  94
HIS A  96
VAL A 143
LEU A 198
THR A 199
TRP A 209
V14  A 302 ( 4.6A)
V14  A 302 (-3.8A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
None
V14  A 302 (-3.6A)
V14  A 302 (-3.2A)
None
0.63A15.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_A_TORA302_1
(CARBONIC ANHYDRASE 4)		1jd0 CARBONIC ANHYDRASE
XII
(Homo
sapiens)		12 / 12ASN A  62
SER A  65
GLN A  92
HIS A  94
HIS A  96
GLU A 106
HIS A 119
VAL A 121
VAL A 143
LEU A 198
THR A 199
THR A 200
None
None
AZM  A1400 (-3.2A)
ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.2A)
ZN  A 901 ( 4.5A)
ZN  A 901 ( 3.1A)
AZM  A1400 (-4.6A)
AZM  A1400 ( 4.9A)
AZM  A1400 (-3.9A)
AZM  A1400 (-3.6A)
AZM  A1400 (-3.3A)
0.38A35.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_A_TORA302_1
(CARBONIC ANHYDRASE 4)		1jd0 CARBONIC ANHYDRASE
XII
(Homo
sapiens)		6 / 12GLN A  92
HIS A  94
HIS A  96
VAL A 121
LEU A 198
THR A 200
AZM  A1400 (-3.2A)
ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.2A)
AZM  A1400 (-4.6A)
AZM  A1400 (-3.9A)
AZM  A1400 (-3.3A)
1.36A35.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_A_TORA302_1
(CARBONIC ANHYDRASE 4)		1jd0 CARBONIC ANHYDRASE
XII
(Homo
sapiens)		5 / 12HIS A  94
HIS A  96
VAL A 121
LEU A 198
THR A 200
 ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.2A)
AZM  A1400 (-4.6A)
AZM  A1400 (-3.9A)
AZM  A1400 (-3.3A)
1.10A35.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_A_TORA302_1
(CARBONIC ANHYDRASE 4)		1jd0 CARBONIC ANHYDRASE
XII
(Homo
sapiens)		6 / 12HIS A  96
GLU A 106
VAL A 143
LEU A 198
THR A 199
THR A 200
 ZN  A 901 ( 3.2A)
ZN  A 901 ( 4.5A)
AZM  A1400 ( 4.9A)
AZM  A1400 (-3.9A)
AZM  A1400 (-3.6A)
AZM  A1400 (-3.3A)
1.07A35.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_A_TORA302_1
(CARBONIC ANHYDRASE 4)		2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens)		5 / 12HIS A  96
GLU A 106
VAL A 143
LEU A 198
THR A 199
 ZN  A 561 ( 3.2A)
ZN  A 561 ( 4.9A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
0.99A31.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_A_TORA302_1
(CARBONIC ANHYDRASE 4)		2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens)		9 / 12SER A  65
GLN A  92
HIS A  94
HIS A  96
GLU A 106
HIS A 119
VAL A 143
LEU A 198
THR A 199
None
None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 4.9A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
0.66A31.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_A_TORA302_1
(CARBONIC ANHYDRASE 4)		2w2j CARBONIC
ANHYDRASE-RELATED
PROTEIN
(Homo
sapiens)		5 / 12HIS A 118
GLU A 128
HIS A 141
LEU A 222
THR A 223
 CL  A 401 (-4.2A)
None
CL  A 401 (-4.1A)
None
CL  A 401 ( 4.8A)
0.24A31.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_A_TORA302_1
(CARBONIC ANHYDRASE 4)		3da2 CARBONIC ANHYDRASE
13
(Homo
sapiens)		5 / 12ASN A  68
HIS A  97
GLU A 107
VAL A 144
LEU A 199
None
ZN  A 301 ( 3.5A)
ZN  A 301 ( 4.9A)
4MD  A 401 ( 4.4A)
4MD  A 401 (-4.2A)
1.00A33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_A_TORA302_1
(CARBONIC ANHYDRASE 4)		3da2 CARBONIC ANHYDRASE
13
(Homo
sapiens)		6 / 12ASN A  68
SER A  66
HIS A  97
GLU A 107
LEU A 199
THR A 200
None
None
ZN  A 301 ( 3.5A)
ZN  A 301 ( 4.9A)
4MD  A 401 (-4.2A)
4MD  A 401 (-3.2A)
1.20A33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_A_TORA302_1
(CARBONIC ANHYDRASE 4)		3da2 CARBONIC ANHYDRASE
13
(Homo
sapiens)		8 / 12SER A  66
GLN A  93
HIS A  95
HIS A  97
GLU A 107
VAL A 122
LEU A 199
THR A 200
None
4MD  A 401 (-3.1A)
ZN  A 301 ( 3.6A)
ZN  A 301 ( 3.5A)
ZN  A 301 ( 4.9A)
4MD  A 401 ( 4.6A)
4MD  A 401 (-4.2A)
4MD  A 401 (-3.2A)
0.77A33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_A_TORA302_1
(CARBONIC ANHYDRASE 4)		3da2 CARBONIC ANHYDRASE
13
(Homo
sapiens)		9 / 12SER A  66
HIS A  95
HIS A  97
GLU A 107
HIS A 120
VAL A 122
VAL A 144
LEU A 199
THR A 200
None
ZN  A 301 ( 3.6A)
ZN  A 301 ( 3.5A)
ZN  A 301 ( 4.9A)
ZN  A 301 ( 3.2A)
4MD  A 401 ( 4.6A)
4MD  A 401 ( 4.4A)
4MD  A 401 (-4.2A)
4MD  A 401 (-3.2A)
0.44A33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_A_TORA302_1
(CARBONIC ANHYDRASE 4)		3da2 CARBONIC ANHYDRASE
13
(Homo
sapiens)		5 / 12SER A  66
HIS A  97
VAL A 122
LEU A 199
THR A 200
None
ZN  A 301 ( 3.5A)
4MD  A 401 ( 4.6A)
4MD  A 401 (-4.2A)
4MD  A 401 (-3.2A)
1.05A33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_A_TORA302_1
(CARBONIC ANHYDRASE 4)		3fe4 CARBONIC ANHYDRASE 6
(Homo
sapiens)		9 / 12ASN A  83
GLN A 109
HIS A 111
HIS A 113
GLU A 125
HIS A 138
VAL A 140
VAL A 161
THR A 220
None
None
MG  A 901 (-3.4A)
MG  A 901 (-3.4A)
MG  A 901 ( 4.4A)
MG  A 901 (-3.2A)
None
None
None
0.63A32.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_A_TORA302_1
(CARBONIC ANHYDRASE 4)		3fe4 CARBONIC ANHYDRASE 6
(Homo
sapiens)		9 / 12ASN A  83
HIS A 111
HIS A 113
GLU A 125
HIS A 138
VAL A 140
VAL A 161
LEU A 219
THR A 220
None
MG  A 901 (-3.4A)
MG  A 901 (-3.4A)
MG  A 901 ( 4.4A)
MG  A 901 (-3.2A)
None
None
None
None
0.75A32.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_A_TORA302_1
(CARBONIC ANHYDRASE 4)		3fe4 CARBONIC ANHYDRASE 6
(Homo
sapiens)		6 / 12GLN A 109
HIS A 111
GLU A 136
HIS A 138
VAL A 140
VAL A 161
None
MG  A 901 (-3.4A)
None
MG  A 901 (-3.2A)
None
None
1.49A32.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_A_TORA302_1
(CARBONIC ANHYDRASE 4)		3fe4 CARBONIC ANHYDRASE 6
(Homo
sapiens)		5 / 12GLU A 125
HIS A 138
LEU A 219
THR A 220
THR A 221
 MG  A 901 ( 4.4A)
MG  A 901 (-3.2A)
None
None
None
0.74A32.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_A_TORA302_1
(CARBONIC ANHYDRASE 4)		3ml5 CARBONIC ANHYDRASE 7
(Homo
sapiens)		12 / 12ASN A  62
SER A  65
GLN A  92
HIS A  94
HIS A  96
GLU A 106
HIS A 119
VAL A 121
VAL A 143
LEU A 198
THR A 199
THR A 200
None
None
AZM  A 264 (-4.1A)
ZN  A 263 ( 3.2A)
ZN  A 263 ( 3.2A)
ZN  A 263 ( 4.6A)
ZN  A 263 ( 3.1A)
AZM  A 264 (-4.7A)
AZM  A 264 ( 4.9A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.5A)
0.43A34.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_A_TORA302_1
(CARBONIC ANHYDRASE 4)		3ml5 CARBONIC ANHYDRASE 7
(Homo
sapiens)		7 / 12GLN A  67
HIS A  94
HIS A  96
GLU A 106
HIS A 119
THR A 199
THR A 200
None
ZN  A 263 ( 3.2A)
ZN  A 263 ( 3.2A)
ZN  A 263 ( 4.6A)
ZN  A 263 ( 3.1A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.5A)
0.98A34.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_A_TORA302_1
(CARBONIC ANHYDRASE 4)		3ml5 CARBONIC ANHYDRASE 7
(Homo
sapiens)		6 / 12GLN A  67
HIS A  96
GLU A 106
VAL A 121
THR A 199
THR A 200
None
ZN  A 263 ( 3.2A)
ZN  A 263 ( 4.6A)
AZM  A 264 (-4.7A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.5A)
1.10A34.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_A_TORA302_1
(CARBONIC ANHYDRASE 4)		3ml5 CARBONIC ANHYDRASE 7
(Homo
sapiens)		6 / 12HIS A  96
GLU A 106
VAL A 121
LEU A 198
THR A 199
THR A 200
 ZN  A 263 ( 3.2A)
ZN  A 263 ( 4.6A)
AZM  A 264 (-4.7A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.5A)
1.01A34.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_A_TORA302_1
(CARBONIC ANHYDRASE 4)		3uyq CARBONIC ANHYDRASE 3
(Homo
sapiens)		10 / 12ASN A  62
GLN A  92
HIS A  94
HIS A  96
GLU A 106
HIS A 119
VAL A 121
VAL A 142
THR A 198
THR A 199
None
None
ZN  A 261 (-3.3A)
ZN  A 261 (-3.3A)
ZN  A 261 ( 4.9A)
ZN  A 261 (-3.2A)
None
None
ZN  A 261 ( 4.4A)
None
0.57A34.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_A_TORA302_1
(CARBONIC ANHYDRASE 4)		3uyq CARBONIC ANHYDRASE 3
(Homo
sapiens)		5 / 12HIS A  96
GLU A 106
VAL A 142
THR A 198
THR A 199
 ZN  A 261 (-3.3A)
ZN  A 261 ( 4.9A)
None
ZN  A 261 ( 4.4A)
None
0.79A34.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_A_TORA302_1
(CARBONIC ANHYDRASE 4)		4qk3 CARBONIC ANHYDRASE 2
(Homo
sapiens)		11 / 12ASN A  62
GLN A  92
HIS A  94
HIS A  96
GLU A 106
HIS A 119
VAL A 121
VAL A 143
LEU A 198
THR A 199
THR A 200
None
None
ZN  A 301 (-3.2A)
ZN  A 301 (-3.2A)
ZN  A 301 ( 4.5A)
ZN  A 301 (-3.1A)
None
None
None
ZN  A 301 ( 4.4A)
None
0.46A35.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_A_TORA302_1
(CARBONIC ANHYDRASE 4)		4qk3 CARBONIC ANHYDRASE 2
(Homo
sapiens)		7 / 12ASN A  67
HIS A  96
GLU A 106
VAL A 143
LEU A 198
THR A 199
THR A 200
None
ZN  A 301 (-3.2A)
ZN  A 301 ( 4.5A)
None
None
ZN  A 301 ( 4.4A)
None
1.01A35.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_A_TORA302_1
(CARBONIC ANHYDRASE 4)		4qk3 CARBONIC ANHYDRASE 2
(Homo
sapiens)		5 / 12ASN A  67
HIS A 119
VAL A 207
LEU A 198
THR A 199
None
ZN  A 301 (-3.1A)
None
None
ZN  A 301 ( 4.4A)
1.15A35.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_A_TORA302_1
(CARBONIC ANHYDRASE 4)		4qk3 CARBONIC ANHYDRASE 2
(Homo
sapiens)		5 / 12ASN A  67
VAL A 207
LEU A 198
THR A 199
THR A 200
None
None
None
ZN  A 301 ( 4.4A)
None
1.03A35.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_A_TORA302_1
(CARBONIC ANHYDRASE 4)		5cjf CARBONIC ANHYDRASE
14
(Homo
sapiens)		11 / 12ASN A  62
GLN A  92
HIS A  94
HIS A  96
GLU A 106
HIS A 119
VAL A 121
VAL A 143
LEU A 198
THR A 199
THR A 200
GOL  A 303 (-3.9A)
GOL  A 303 (-3.2A)
ZN  A 301 (-3.2A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 4.6A)
ZN  A 301 ( 3.1A)
520  A 302 ( 4.9A)
520  A 302 ( 4.9A)
520  A 302 (-3.6A)
520  A 302 (-3.4A)
GOL  A 303 ( 3.5A)
0.47A35.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_A_TORA302_1
(CARBONIC ANHYDRASE 4)		5cjf CARBONIC ANHYDRASE
14
(Homo
sapiens)		7 / 12GLN A  67
HIS A  94
HIS A  96
GLU A 106
HIS A 119
THR A 199
THR A 200
GOL  A 303 (-3.4A)
ZN  A 301 (-3.2A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 4.6A)
ZN  A 301 ( 3.1A)
520  A 302 (-3.4A)
GOL  A 303 ( 3.5A)
0.95A35.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_A_TORA302_1
(CARBONIC ANHYDRASE 4)		5cjf CARBONIC ANHYDRASE
14
(Homo
sapiens)		6 / 12GLN A  92
HIS A  94
HIS A  96
VAL A 121
LEU A 198
THR A 200
GOL  A 303 (-3.2A)
ZN  A 301 (-3.2A)
ZN  A 301 ( 3.2A)
520  A 302 ( 4.9A)
520  A 302 (-3.6A)
GOL  A 303 ( 3.5A)
1.41A35.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_A_TORA302_1
(CARBONIC ANHYDRASE 4)		5cjf CARBONIC ANHYDRASE
14
(Homo
sapiens)		6 / 12HIS A  96
GLU A 106
VAL A 143
LEU A 198
THR A 199
THR A 200
 ZN  A 301 ( 3.2A)
ZN  A 301 ( 4.6A)
520  A 302 ( 4.9A)
520  A 302 (-3.6A)
520  A 302 (-3.4A)
GOL  A 303 ( 3.5A)
1.07A35.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_A_TORA302_1
(CARBONIC ANHYDRASE 4)		5jn9 CARBONIC ANHYDRASE 4
(Homo
sapiens)		12 / 12ASN A  62
SER A  65
GLN A  92
HIS A  94
HIS A  96
GLU A 106
HIS A 119
VAL A 121
VAL A 143
LEU A 198
THR A 199
THR A 200
None
None
EZL  A 302 (-4.3A)
ZN  A 301 ( 3.3A)
ZN  A 301 ( 3.3A)
ZN  A 301 ( 4.6A)
ZN  A 301 ( 3.2A)
EZL  A 302 (-4.7A)
EZL  A 302 ( 4.7A)
EZL  A 302 (-3.5A)
EZL  A 302 (-3.4A)
EZL  A 302 (-3.9A)
0.36A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_A_TORA302_1
(CARBONIC ANHYDRASE 4)		5jn9 CARBONIC ANHYDRASE 4
(Homo
sapiens)		5 / 12SER A  65
HIS A  96
VAL A 143
LEU A 198
THR A 200
None
ZN  A 301 ( 3.3A)
EZL  A 302 ( 4.7A)
EZL  A 302 (-3.5A)
EZL  A 302 (-3.9A)
1.12A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_A_TORA302_1
(CARBONIC ANHYDRASE 4)		6fe1 CARBONIC ANHYDRASE 9
(Homo
sapiens)		12 / 12ASN A  62
SER A  65
GLN A  92
HIS A  94
HIS A  96
GLU A 106
HIS A 119
VAL A 121
VAL A 143
LEU A 198
THR A 199
THR A 200
V14  A 302 (-3.4A)
V14  A 302 ( 4.6A)
V14  A 302 (-3.8A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
V14  A 302 (-4.2A)
ZN  A 301 ( 3.1A)
V14  A 302 (-4.7A)
None
V14  A 302 (-3.6A)
V14  A 302 (-3.2A)
V14  A 302 (-3.5A)
0.44A16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_A_TORA302_1
(CARBONIC ANHYDRASE 4)		6fe1 CARBONIC ANHYDRASE 9
(Homo
sapiens)		7 / 12SER A  65
HIS A  96
GLU A 106
VAL A 143
LEU A 198
THR A 199
THR A 200
V14  A 302 ( 4.6A)
ZN  A 301 ( 3.2A)
V14  A 302 (-4.2A)
None
V14  A 302 (-3.6A)
V14  A 302 (-3.2A)
V14  A 302 (-3.5A)
1.14A16.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_B_TORB302_1
(CARBONIC ANHYDRASE 4)		1jd0 CARBONIC ANHYDRASE
XII
(Homo
sapiens)		12 / 12ASN A  62
SER A  65
GLN A  92
HIS A  94
HIS A  96
HIS A 119
VAL A 121
VAL A 143
LEU A 198
THR A 199
THR A 200
TRP A 209
None
None
AZM  A1400 (-3.2A)
ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.1A)
AZM  A1400 (-4.6A)
AZM  A1400 ( 4.9A)
AZM  A1400 (-3.9A)
AZM  A1400 (-3.6A)
AZM  A1400 (-3.3A)
None
0.36A35.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_B_TORB302_1
(CARBONIC ANHYDRASE 4)		1jd0 CARBONIC ANHYDRASE
XII
(Homo
sapiens)		6 / 12GLN A  92
HIS A  94
HIS A  96
VAL A 121
LEU A 198
THR A 200
AZM  A1400 (-3.2A)
ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.2A)
AZM  A1400 (-4.6A)
AZM  A1400 (-3.9A)
AZM  A1400 (-3.3A)
1.32A35.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_B_TORB302_1
(CARBONIC ANHYDRASE 4)		1jd0 CARBONIC ANHYDRASE
XII
(Homo
sapiens)		5 / 12HIS A  94
VAL A 207
THR A 199
THR A 200
TRP A 209
 ZN  A 901 ( 3.2A)
None
AZM  A1400 (-3.6A)
AZM  A1400 (-3.3A)
None
1.36A35.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_B_TORB302_1
(CARBONIC ANHYDRASE 4)		1jd0 CARBONIC ANHYDRASE
XII
(Homo
sapiens)		6 / 12HIS A 119
HIS A  96
VAL A 143
LEU A 198
THR A 199
THR A 200
 ZN  A 901 ( 3.1A)
ZN  A 901 ( 3.2A)
AZM  A1400 ( 4.9A)
AZM  A1400 (-3.9A)
AZM  A1400 (-3.6A)
AZM  A1400 (-3.3A)
1.48A35.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_B_TORB302_1
(CARBONIC ANHYDRASE 4)		2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens)		9 / 12SER A  65
GLN A  92
HIS A  94
HIS A  96
HIS A 119
VAL A 143
LEU A 198
THR A 199
TRP A 209
None
None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
0.63A31.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_B_TORB302_1
(CARBONIC ANHYDRASE 4)		2w2j CARBONIC
ANHYDRASE-RELATED
PROTEIN
(Homo
sapiens)		5 / 12HIS A 118
HIS A 141
LEU A 222
THR A 223
TRP A 233
 CL  A 401 (-4.2A)
CL  A 401 (-4.1A)
None
CL  A 401 ( 4.8A)
None
0.26A31.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_B_TORB302_1
(CARBONIC ANHYDRASE 4)		3da2 CARBONIC ANHYDRASE
13
(Homo
sapiens)		5 / 12ASN A  68
SER A  66
HIS A  97
LEU A 199
THR A 200
None
None
ZN  A 301 ( 3.5A)
4MD  A 401 (-4.2A)
4MD  A 401 (-3.2A)
1.24A33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_B_TORB302_1
(CARBONIC ANHYDRASE 4)		3da2 CARBONIC ANHYDRASE
13
(Homo
sapiens)		8 / 12SER A  66
GLN A  93
HIS A  95
HIS A  97
VAL A 122
VAL A 144
LEU A 199
THR A 200
None
4MD  A 401 (-3.1A)
ZN  A 301 ( 3.6A)
ZN  A 301 ( 3.5A)
4MD  A 401 ( 4.6A)
4MD  A 401 ( 4.4A)
4MD  A 401 (-4.2A)
4MD  A 401 (-3.2A)
0.77A33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_B_TORB302_1
(CARBONIC ANHYDRASE 4)		3da2 CARBONIC ANHYDRASE
13
(Homo
sapiens)		9 / 12SER A  66
HIS A  95
HIS A  97
HIS A 120
VAL A 122
VAL A 144
LEU A 199
THR A 200
TRP A 210
None
ZN  A 301 ( 3.6A)
ZN  A 301 ( 3.5A)
ZN  A 301 ( 3.2A)
4MD  A 401 ( 4.6A)
4MD  A 401 ( 4.4A)
4MD  A 401 (-4.2A)
4MD  A 401 (-3.2A)
None
0.47A33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_B_TORB302_1
(CARBONIC ANHYDRASE 4)		3fe4 CARBONIC ANHYDRASE 6
(Homo
sapiens)		10 / 12ASN A  83
GLN A 109
HIS A 111
HIS A 113
HIS A 138
VAL A 140
VAL A 161
LEU A 219
THR A 220
TRP A 230
None
None
MG  A 901 (-3.4A)
MG  A 901 (-3.4A)
MG  A 901 (-3.2A)
None
None
None
None
None
0.75A32.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_B_TORB302_1
(CARBONIC ANHYDRASE 4)		3fe4 CARBONIC ANHYDRASE 6
(Homo
sapiens)		5 / 12HIS A 138
LEU A 219
THR A 220
THR A 221
TRP A 230
 MG  A 901 (-3.2A)
None
None
None
None
0.66A32.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_B_TORB302_1
(CARBONIC ANHYDRASE 4)		3ml5 CARBONIC ANHYDRASE 7
(Homo
sapiens)		12 / 12ASN A  62
SER A  65
GLN A  92
HIS A  94
HIS A  96
HIS A 119
VAL A 121
VAL A 143
LEU A 198
THR A 199
THR A 200
TRP A 209
None
None
AZM  A 264 (-4.1A)
ZN  A 263 ( 3.2A)
ZN  A 263 ( 3.2A)
ZN  A 263 ( 3.1A)
AZM  A 264 (-4.7A)
AZM  A 264 ( 4.9A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.5A)
None
0.43A34.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_B_TORB302_1
(CARBONIC ANHYDRASE 4)		3ml5 CARBONIC ANHYDRASE 7
(Homo
sapiens)		6 / 12GLN A  67
HIS A  94
HIS A  96
HIS A 119
THR A 199
THR A 200
None
ZN  A 263 ( 3.2A)
ZN  A 263 ( 3.2A)
ZN  A 263 ( 3.1A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.5A)
1.02A34.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_B_TORB302_1
(CARBONIC ANHYDRASE 4)		3ml5 CARBONIC ANHYDRASE 7
(Homo
sapiens)		5 / 12GLN A  67
HIS A  96
VAL A 121
THR A 199
THR A 200
None
ZN  A 263 ( 3.2A)
AZM  A 264 (-4.7A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.5A)
1.11A34.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_B_TORB302_1
(CARBONIC ANHYDRASE 4)		3ml5 CARBONIC ANHYDRASE 7
(Homo
sapiens)		5 / 12HIS A  96
HIS A  94
VAL A 121
LEU A 198
THR A 199
 ZN  A 263 ( 3.2A)
ZN  A 263 ( 3.2A)
AZM  A 264 (-4.7A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.4A)
1.34A34.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_B_TORB302_1
(CARBONIC ANHYDRASE 4)		3ml5 CARBONIC ANHYDRASE 7
(Homo
sapiens)		6 / 12HIS A 119
HIS A  96
VAL A 143
LEU A 198
THR A 199
THR A 200
 ZN  A 263 ( 3.1A)
ZN  A 263 ( 3.2A)
AZM  A 264 ( 4.9A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.5A)
1.47A34.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_B_TORB302_1
(CARBONIC ANHYDRASE 4)		3uyq CARBONIC ANHYDRASE 3
(Homo
sapiens)		10 / 12ASN A  62
GLN A  92
HIS A  94
HIS A  96
HIS A 119
VAL A 121
VAL A 142
THR A 198
THR A 199
TRP A 208
None
None
ZN  A 261 (-3.3A)
ZN  A 261 (-3.3A)
ZN  A 261 (-3.2A)
None
None
ZN  A 261 ( 4.4A)
None
None
0.56A34.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_B_TORB302_1
(CARBONIC ANHYDRASE 4)		4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens)		5 / 12SER A   1
VAL A  39
VAL A  83
THR A  77
THR A  78
None
1.28A21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_B_TORB302_1
(CARBONIC ANHYDRASE 4)		4n40 PROTEIN ECT2
(Homo
sapiens)		5 / 12HIS A 279
VAL A 281
VAL A 301
THR A 262
TRP A 305
None
1.31A22.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_B_TORB302_1
(CARBONIC ANHYDRASE 4)		4qk3 CARBONIC ANHYDRASE 2
(Homo
sapiens)		11 / 12ASN A  62
GLN A  92
HIS A  94
HIS A  96
HIS A 119
VAL A 121
VAL A 143
LEU A 198
THR A 199
THR A 200
TRP A 209
None
None
ZN  A 301 (-3.2A)
ZN  A 301 (-3.2A)
ZN  A 301 (-3.1A)
None
None
None
ZN  A 301 ( 4.4A)
None
None
0.44A35.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_B_TORB302_1
(CARBONIC ANHYDRASE 4)		4qk3 CARBONIC ANHYDRASE 2
(Homo
sapiens)		6 / 12ASN A  67
HIS A  96
VAL A 143
LEU A 198
THR A 199
THR A 200
None
ZN  A 301 (-3.2A)
None
None
ZN  A 301 ( 4.4A)
None
1.05A35.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_B_TORB302_1
(CARBONIC ANHYDRASE 4)		4qk3 CARBONIC ANHYDRASE 2
(Homo
sapiens)		6 / 12HIS A  94
HIS A  96
VAL A 121
LEU A 198
THR A 199
THR A 200
 ZN  A 301 (-3.2A)
ZN  A 301 (-3.2A)
None
None
ZN  A 301 ( 4.4A)
None
1.13A35.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_B_TORB302_1
(CARBONIC ANHYDRASE 4)		4qk3 CARBONIC ANHYDRASE 2
(Homo
sapiens)		5 / 12HIS A  96
HIS A  94
VAL A 121
LEU A 198
THR A 199
 ZN  A 301 (-3.2A)
ZN  A 301 (-3.2A)
None
None
ZN  A 301 ( 4.4A)
1.32A35.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_B_TORB302_1
(CARBONIC ANHYDRASE 4)		5cjf CARBONIC ANHYDRASE
14
(Homo
sapiens)		11 / 12ASN A  62
GLN A  92
HIS A  94
HIS A  96
HIS A 119
VAL A 121
VAL A 143
LEU A 198
THR A 199
THR A 200
TRP A 209
GOL  A 303 (-3.9A)
GOL  A 303 (-3.2A)
ZN  A 301 (-3.2A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.1A)
520  A 302 ( 4.9A)
520  A 302 ( 4.9A)
520  A 302 (-3.6A)
520  A 302 (-3.4A)
GOL  A 303 ( 3.5A)
None
0.47A35.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_B_TORB302_1
(CARBONIC ANHYDRASE 4)		5cjf CARBONIC ANHYDRASE
14
(Homo
sapiens)		6 / 12GLN A  67
HIS A  94
HIS A  96
HIS A 119
THR A 199
THR A 200
GOL  A 303 (-3.4A)
ZN  A 301 (-3.2A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.1A)
520  A 302 (-3.4A)
GOL  A 303 ( 3.5A)
1.00A35.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_B_TORB302_1
(CARBONIC ANHYDRASE 4)		5cjf CARBONIC ANHYDRASE
14
(Homo
sapiens)		5 / 12HIS A  94
VAL A 207
THR A 199
THR A 200
TRP A 209
 ZN  A 301 (-3.2A)
None
520  A 302 (-3.4A)
GOL  A 303 ( 3.5A)
None
1.37A35.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_B_TORB302_1
(CARBONIC ANHYDRASE 4)		5cjf CARBONIC ANHYDRASE
14
(Homo
sapiens)		5 / 12HIS A  96
VAL A 143
LEU A 198
THR A 199
THR A 200
 ZN  A 301 ( 3.2A)
520  A 302 ( 4.9A)
520  A 302 (-3.6A)
520  A 302 (-3.4A)
GOL  A 303 ( 3.5A)
1.08A35.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_B_TORB302_1
(CARBONIC ANHYDRASE 4)		5jn9 CARBONIC ANHYDRASE 4
(Homo
sapiens)		12 / 12ASN A  62
SER A  65
GLN A  92
HIS A  94
HIS A  96
HIS A 119
VAL A 121
VAL A 143
LEU A 198
THR A 199
THR A 200
TRP A 209
None
None
EZL  A 302 (-4.3A)
ZN  A 301 ( 3.3A)
ZN  A 301 ( 3.3A)
ZN  A 301 ( 3.2A)
EZL  A 302 (-4.7A)
EZL  A 302 ( 4.7A)
EZL  A 302 (-3.5A)
EZL  A 302 (-3.4A)
EZL  A 302 (-3.9A)
None
0.36A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_B_TORB302_1
(CARBONIC ANHYDRASE 4)		5jn9 CARBONIC ANHYDRASE 4
(Homo
sapiens)		6 / 12HIS A 119
HIS A  96
VAL A 143
LEU A 198
THR A 199
THR A 200
 ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.3A)
EZL  A 302 ( 4.7A)
EZL  A 302 (-3.5A)
EZL  A 302 (-3.4A)
EZL  A 302 (-3.9A)
1.45A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_B_TORB302_1
(CARBONIC ANHYDRASE 4)		5jn9 CARBONIC ANHYDRASE 4
(Homo
sapiens)		6 / 12SER A  65
HIS A  96
VAL A 143
LEU A 198
THR A 199
THR A 200
None
ZN  A 301 ( 3.3A)
EZL  A 302 ( 4.7A)
EZL  A 302 (-3.5A)
EZL  A 302 (-3.4A)
EZL  A 302 (-3.9A)
1.14A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_B_TORB302_1
(CARBONIC ANHYDRASE 4)		6fe1 CARBONIC ANHYDRASE 9
(Homo
sapiens)		12 / 12ASN A  62
SER A  65
GLN A  92
HIS A  94
HIS A  96
HIS A 119
VAL A 121
VAL A 143
LEU A 198
THR A 199
THR A 200
TRP A 209
V14  A 302 (-3.4A)
V14  A 302 ( 4.6A)
V14  A 302 (-3.8A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.1A)
V14  A 302 (-4.7A)
None
V14  A 302 (-3.6A)
V14  A 302 (-3.2A)
V14  A 302 (-3.5A)
None
0.42A16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_B_TORB302_1
(CARBONIC ANHYDRASE 4)		6fe1 CARBONIC ANHYDRASE 9
(Homo
sapiens)		6 / 12SER A  65
HIS A  96
VAL A 143
LEU A 198
THR A 199
THR A 200
V14  A 302 ( 4.6A)
ZN  A 301 ( 3.2A)
None
V14  A 302 (-3.6A)
V14  A 302 (-3.2A)
V14  A 302 (-3.5A)
1.10A16.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_C_TORC302_1
(CARBONIC ANHYDRASE 4)		1jd0 CARBONIC ANHYDRASE
XII
(Homo
sapiens)		11 / 11ASN A  62
SER A  65
GLN A  92
HIS A  94
HIS A  96
HIS A 119
VAL A 121
VAL A 143
LEU A 198
THR A 199
THR A 200
None
None
AZM  A1400 (-3.2A)
ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.1A)
AZM  A1400 (-4.6A)
AZM  A1400 ( 4.9A)
AZM  A1400 (-3.9A)
AZM  A1400 (-3.6A)
AZM  A1400 (-3.3A)
0.41A35.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_C_TORC302_1
(CARBONIC ANHYDRASE 4)		1jd0 CARBONIC ANHYDRASE
XII
(Homo
sapiens)		6 / 11GLN A  92
HIS A  94
HIS A  96
VAL A 121
LEU A 198
THR A 200
AZM  A1400 (-3.2A)
ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.2A)
AZM  A1400 (-4.6A)
AZM  A1400 (-3.9A)
AZM  A1400 (-3.3A)
1.33A35.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_C_TORC302_1
(CARBONIC ANHYDRASE 4)		1jd0 CARBONIC ANHYDRASE
XII
(Homo
sapiens)		5 / 11HIS A  94
HIS A  96
VAL A 121
LEU A 198
THR A 200
 ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.2A)
AZM  A1400 (-4.6A)
AZM  A1400 (-3.9A)
AZM  A1400 (-3.3A)
1.10A35.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_C_TORC302_1
(CARBONIC ANHYDRASE 4)		1jd0 CARBONIC ANHYDRASE
XII
(Homo
sapiens)		6 / 11SER A  65
HIS A  96
VAL A 143
LEU A 198
THR A 199
THR A 200
None
ZN  A 901 ( 3.2A)
AZM  A1400 ( 4.9A)
AZM  A1400 (-3.9A)
AZM  A1400 (-3.6A)
AZM  A1400 (-3.3A)
1.19A35.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_C_TORC302_1
(CARBONIC ANHYDRASE 4)		2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens)		8 / 11SER A  65
GLN A  92
HIS A  94
HIS A  96
HIS A 119
VAL A 143
LEU A 198
THR A 199
None
None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
0.67A31.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_C_TORC302_1
(CARBONIC ANHYDRASE 4)		3da2 CARBONIC ANHYDRASE
13
(Homo
sapiens)		5 / 11ASN A  68
SER A  66
HIS A  97
LEU A 199
THR A 200
None
None
ZN  A 301 ( 3.5A)
4MD  A 401 (-4.2A)
4MD  A 401 (-3.2A)
1.24A33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_C_TORC302_1
(CARBONIC ANHYDRASE 4)		3da2 CARBONIC ANHYDRASE
13
(Homo
sapiens)		5 / 11ASN A  68
SER A  66
HIS A  97
VAL A 144
LEU A 199
None
None
ZN  A 301 ( 3.5A)
4MD  A 401 ( 4.4A)
4MD  A 401 (-4.2A)
1.13A33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_C_TORC302_1
(CARBONIC ANHYDRASE 4)		3da2 CARBONIC ANHYDRASE
13
(Homo
sapiens)		7 / 11SER A  66
GLN A  93
HIS A  95
HIS A  97
VAL A 122
LEU A 199
THR A 200
None
4MD  A 401 (-3.1A)
ZN  A 301 ( 3.6A)
ZN  A 301 ( 3.5A)
4MD  A 401 ( 4.6A)
4MD  A 401 (-4.2A)
4MD  A 401 (-3.2A)
0.83A33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_C_TORC302_1
(CARBONIC ANHYDRASE 4)		3da2 CARBONIC ANHYDRASE
13
(Homo
sapiens)		8 / 11SER A  66
HIS A  95
HIS A  97
HIS A 120
VAL A 122
VAL A 144
LEU A 199
THR A 200
None
ZN  A 301 ( 3.6A)
ZN  A 301 ( 3.5A)
ZN  A 301 ( 3.2A)
4MD  A 401 ( 4.6A)
4MD  A 401 ( 4.4A)
4MD  A 401 (-4.2A)
4MD  A 401 (-3.2A)
0.47A33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_C_TORC302_1
(CARBONIC ANHYDRASE 4)		3fe4 CARBONIC ANHYDRASE 6
(Homo
sapiens)		8 / 11ASN A  83
GLN A 109
HIS A 111
HIS A 113
HIS A 138
VAL A 140
VAL A 161
THR A 220
None
None
MG  A 901 (-3.4A)
MG  A 901 (-3.4A)
MG  A 901 (-3.2A)
None
None
None
0.61A32.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_C_TORC302_1
(CARBONIC ANHYDRASE 4)		3fe4 CARBONIC ANHYDRASE 6
(Homo
sapiens)		8 / 11ASN A  83
HIS A 111
HIS A 113
HIS A 138
VAL A 140
VAL A 161
LEU A 219
THR A 220
None
MG  A 901 (-3.4A)
MG  A 901 (-3.4A)
MG  A 901 (-3.2A)
None
None
None
None
0.74A32.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_C_TORC302_1
(CARBONIC ANHYDRASE 4)		3ml5 CARBONIC ANHYDRASE 7
(Homo
sapiens)		11 / 11ASN A  62
SER A  65
GLN A  92
HIS A  94
HIS A  96
HIS A 119
VAL A 121
VAL A 143
LEU A 198
THR A 199
THR A 200
None
None
AZM  A 264 (-4.1A)
ZN  A 263 ( 3.2A)
ZN  A 263 ( 3.2A)
ZN  A 263 ( 3.1A)
AZM  A 264 (-4.7A)
AZM  A 264 ( 4.9A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.5A)
0.45A34.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_C_TORC302_1
(CARBONIC ANHYDRASE 4)		3ml5 CARBONIC ANHYDRASE 7
(Homo
sapiens)		6 / 11GLN A  67
HIS A  94
HIS A  96
HIS A 119
THR A 199
THR A 200
None
ZN  A 263 ( 3.2A)
ZN  A 263 ( 3.2A)
ZN  A 263 ( 3.1A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.5A)
1.04A34.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_C_TORC302_1
(CARBONIC ANHYDRASE 4)		3ml5 CARBONIC ANHYDRASE 7
(Homo
sapiens)		5 / 11GLN A  67
HIS A  96
VAL A 121
THR A 199
THR A 200
None
ZN  A 263 ( 3.2A)
AZM  A 264 (-4.7A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.5A)
1.08A34.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_C_TORC302_1
(CARBONIC ANHYDRASE 4)		3ml5 CARBONIC ANHYDRASE 7
(Homo
sapiens)		5 / 11HIS A  96
VAL A 121
LEU A 198
THR A 199
THR A 200
 ZN  A 263 ( 3.2A)
AZM  A 264 (-4.7A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.5A)
0.97A34.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_C_TORC302_1
(CARBONIC ANHYDRASE 4)		3ml5 CARBONIC ANHYDRASE 7
(Homo
sapiens)		5 / 11SER A  65
HIS A  96
VAL A 143
LEU A 198
THR A 200
None
ZN  A 263 ( 3.2A)
AZM  A 264 ( 4.9A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.5A)
1.12A34.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_C_TORC302_1
(CARBONIC ANHYDRASE 4)		3uyq CARBONIC ANHYDRASE 3
(Homo
sapiens)		9 / 11ASN A  62
GLN A  92
HIS A  94
HIS A  96
HIS A 119
VAL A 121
VAL A 142
THR A 198
THR A 199
None
None
ZN  A 261 (-3.3A)
ZN  A 261 (-3.3A)
ZN  A 261 (-3.2A)
None
None
ZN  A 261 ( 4.4A)
None
0.56A34.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_C_TORC302_1
(CARBONIC ANHYDRASE 4)		4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens)		5 / 11SER A   1
VAL A  39
VAL A  83
THR A  77
THR A  78
None
1.27A21.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_C_TORC302_1
(CARBONIC ANHYDRASE 4)		4qk3 CARBONIC ANHYDRASE 2
(Homo
sapiens)		10 / 11ASN A  62
GLN A  92
HIS A  94
HIS A  96
HIS A 119
VAL A 121
VAL A 143
LEU A 198
THR A 199
THR A 200
None
None
ZN  A 301 (-3.2A)
ZN  A 301 (-3.2A)
ZN  A 301 (-3.1A)
None
None
None
ZN  A 301 ( 4.4A)
None
0.49A35.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_C_TORC302_1
(CARBONIC ANHYDRASE 4)		4qk3 CARBONIC ANHYDRASE 2
(Homo
sapiens)		6 / 11ASN A  67
HIS A  96
VAL A 143
LEU A 198
THR A 199
THR A 200
None
ZN  A 301 (-3.2A)
None
None
ZN  A 301 ( 4.4A)
None
1.08A35.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_C_TORC302_1
(CARBONIC ANHYDRASE 4)		4qk3 CARBONIC ANHYDRASE 2
(Homo
sapiens)		5 / 11ASN A  67
HIS A 119
VAL A 207
LEU A 198
THR A 199
None
ZN  A 301 (-3.1A)
None
None
ZN  A 301 ( 4.4A)
1.14A35.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_C_TORC302_1
(CARBONIC ANHYDRASE 4)		4qk3 CARBONIC ANHYDRASE 2
(Homo
sapiens)		5 / 11ASN A  67
VAL A 207
LEU A 198
THR A 199
THR A 200
None
None
None
ZN  A 301 ( 4.4A)
None
1.01A35.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_C_TORC302_1
(CARBONIC ANHYDRASE 4)		4qk3 CARBONIC ANHYDRASE 2
(Homo
sapiens)		6 / 11HIS A  94
HIS A  96
VAL A 121
LEU A 198
THR A 199
THR A 200
 ZN  A 301 (-3.2A)
ZN  A 301 (-3.2A)
None
None
ZN  A 301 ( 4.4A)
None
1.12A35.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_C_TORC302_1
(CARBONIC ANHYDRASE 4)		5cjf CARBONIC ANHYDRASE
14
(Homo
sapiens)		10 / 11ASN A  62
GLN A  92
HIS A  94
HIS A  96
HIS A 119
VAL A 121
VAL A 143
LEU A 198
THR A 199
THR A 200
GOL  A 303 (-3.9A)
GOL  A 303 (-3.2A)
ZN  A 301 (-3.2A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.1A)
520  A 302 ( 4.9A)
520  A 302 ( 4.9A)
520  A 302 (-3.6A)
520  A 302 (-3.4A)
GOL  A 303 ( 3.5A)
0.50A35.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_C_TORC302_1
(CARBONIC ANHYDRASE 4)		5cjf CARBONIC ANHYDRASE
14
(Homo
sapiens)		6 / 11GLN A  67
HIS A  94
HIS A  96
HIS A 119
THR A 199
THR A 200
GOL  A 303 (-3.4A)
ZN  A 301 (-3.2A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.1A)
520  A 302 (-3.4A)
GOL  A 303 ( 3.5A)
1.01A35.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_C_TORC302_1
(CARBONIC ANHYDRASE 4)		5cjf CARBONIC ANHYDRASE
14
(Homo
sapiens)		6 / 11GLN A  92
HIS A  94
HIS A  96
VAL A 121
LEU A 198
THR A 200
GOL  A 303 (-3.2A)
ZN  A 301 (-3.2A)
ZN  A 301 ( 3.2A)
520  A 302 ( 4.9A)
520  A 302 (-3.6A)
GOL  A 303 ( 3.5A)
1.39A35.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_C_TORC302_1
(CARBONIC ANHYDRASE 4)		5cjf CARBONIC ANHYDRASE
14
(Homo
sapiens)		5 / 11HIS A  96
VAL A 143
LEU A 198
THR A 199
THR A 200
 ZN  A 301 ( 3.2A)
520  A 302 ( 4.9A)
520  A 302 (-3.6A)
520  A 302 (-3.4A)
GOL  A 303 ( 3.5A)
1.10A35.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_C_TORC302_1
(CARBONIC ANHYDRASE 4)		5jn9 CARBONIC ANHYDRASE 4
(Homo
sapiens)		11 / 11ASN A  62
SER A  65
GLN A  92
HIS A  94
HIS A  96
HIS A 119
VAL A 121
VAL A 143
LEU A 198
THR A 199
THR A 200
None
None
EZL  A 302 (-4.3A)
ZN  A 301 ( 3.3A)
ZN  A 301 ( 3.3A)
ZN  A 301 ( 3.2A)
EZL  A 302 (-4.7A)
EZL  A 302 ( 4.7A)
EZL  A 302 (-3.5A)
EZL  A 302 (-3.4A)
EZL  A 302 (-3.9A)
0.39A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_C_TORC302_1
(CARBONIC ANHYDRASE 4)		5jn9 CARBONIC ANHYDRASE 4
(Homo
sapiens)		5 / 11SER A  65
HIS A  96
VAL A 143
LEU A 198
THR A 200
None
ZN  A 301 ( 3.3A)
EZL  A 302 ( 4.7A)
EZL  A 302 (-3.5A)
EZL  A 302 (-3.9A)
1.10A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_C_TORC302_1
(CARBONIC ANHYDRASE 4)		6fe1 CARBONIC ANHYDRASE 9
(Homo
sapiens)		11 / 11ASN A  62
SER A  65
GLN A  92
HIS A  94
HIS A  96
HIS A 119
VAL A 121
VAL A 143
LEU A 198
THR A 199
THR A 200
V14  A 302 (-3.4A)
V14  A 302 ( 4.6A)
V14  A 302 (-3.8A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.1A)
V14  A 302 (-4.7A)
None
V14  A 302 (-3.6A)
V14  A 302 (-3.2A)
V14  A 302 (-3.5A)
0.46A16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_C_TORC302_1
(CARBONIC ANHYDRASE 4)		6fe1 CARBONIC ANHYDRASE 9
(Homo
sapiens)		6 / 11SER A  65
HIS A  96
VAL A 143
LEU A 198
THR A 199
THR A 200
V14  A 302 ( 4.6A)
ZN  A 301 ( 3.2A)
None
V14  A 302 (-3.6A)
V14  A 302 (-3.2A)
V14  A 302 (-3.5A)
1.08A16.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_D_TORD302_1
(CARBONIC ANHYDRASE 4)		1jd0 CARBONIC ANHYDRASE
XII
(Homo
sapiens)		12 / 12ASN A  62
SER A  65
GLN A  92
HIS A  94
HIS A  96
HIS A 119
VAL A 121
VAL A 143
LEU A 198
THR A 199
THR A 200
TRP A 209
None
None
AZM  A1400 (-3.2A)
ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.1A)
AZM  A1400 (-4.6A)
AZM  A1400 ( 4.9A)
AZM  A1400 (-3.9A)
AZM  A1400 (-3.6A)
AZM  A1400 (-3.3A)
None
0.35A35.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_D_TORD302_1
(CARBONIC ANHYDRASE 4)		1jd0 CARBONIC ANHYDRASE
XII
(Homo
sapiens)		6 / 12GLN A  92
HIS A  94
HIS A  96
VAL A 121
LEU A 198
THR A 200
AZM  A1400 (-3.2A)
ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.2A)
AZM  A1400 (-4.6A)
AZM  A1400 (-3.9A)
AZM  A1400 (-3.3A)
1.37A35.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_D_TORD302_1
(CARBONIC ANHYDRASE 4)		1jd0 CARBONIC ANHYDRASE
XII
(Homo
sapiens)		6 / 12HIS A  94
HIS A  96
VAL A 121
LEU A 198
THR A 199
THR A 200
 ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.2A)
AZM  A1400 (-4.6A)
AZM  A1400 (-3.9A)
AZM  A1400 (-3.6A)
AZM  A1400 (-3.3A)
1.06A35.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_D_TORD302_1
(CARBONIC ANHYDRASE 4)		2it4 CARBONIC ANHYDRASE 1
(Homo
sapiens)		9 / 12SER A  65
GLN A  92
HIS A  94
HIS A  96
HIS A 119
VAL A 143
LEU A 198
THR A 199
TRP A 209
None
None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
0.60A31.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_D_TORD302_1
(CARBONIC ANHYDRASE 4)		2w2j CARBONIC
ANHYDRASE-RELATED
PROTEIN
(Homo
sapiens)		5 / 12HIS A 118
HIS A 141
LEU A 222
THR A 223
TRP A 233
 CL  A 401 (-4.2A)
CL  A 401 (-4.1A)
None
CL  A 401 ( 4.8A)
None
0.26A31.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_D_TORD302_1
(CARBONIC ANHYDRASE 4)		3da2 CARBONIC ANHYDRASE
13
(Homo
sapiens)		5 / 12ASN A  68
SER A  66
HIS A  97
LEU A 199
THR A 200
None
None
ZN  A 301 ( 3.5A)
4MD  A 401 (-4.2A)
4MD  A 401 (-3.2A)
1.18A33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_D_TORD302_1
(CARBONIC ANHYDRASE 4)		3da2 CARBONIC ANHYDRASE
13
(Homo
sapiens)		5 / 12ASN A  68
SER A  66
HIS A  97
VAL A 144
LEU A 199
None
None
ZN  A 301 ( 3.5A)
4MD  A 401 ( 4.4A)
4MD  A 401 (-4.2A)
1.13A33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_D_TORD302_1
(CARBONIC ANHYDRASE 4)		3da2 CARBONIC ANHYDRASE
13
(Homo
sapiens)		7 / 12SER A  66
GLN A  93
HIS A  95
HIS A  97
VAL A 122
LEU A 199
THR A 200
None
4MD  A 401 (-3.1A)
ZN  A 301 ( 3.6A)
ZN  A 301 ( 3.5A)
4MD  A 401 ( 4.6A)
4MD  A 401 (-4.2A)
4MD  A 401 (-3.2A)
0.81A33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_D_TORD302_1
(CARBONIC ANHYDRASE 4)		3da2 CARBONIC ANHYDRASE
13
(Homo
sapiens)		9 / 12SER A  66
HIS A  95
HIS A  97
HIS A 120
VAL A 122
VAL A 144
LEU A 199
THR A 200
TRP A 210
None
ZN  A 301 ( 3.6A)
ZN  A 301 ( 3.5A)
ZN  A 301 ( 3.2A)
4MD  A 401 ( 4.6A)
4MD  A 401 ( 4.4A)
4MD  A 401 (-4.2A)
4MD  A 401 (-3.2A)
None
0.46A33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_D_TORD302_1
(CARBONIC ANHYDRASE 4)		3fe4 CARBONIC ANHYDRASE 6
(Homo
sapiens)		10 / 12ASN A  83
GLN A 109
HIS A 111
HIS A 113
HIS A 138
VAL A 140
VAL A 161
LEU A 219
THR A 220
TRP A 230
None
None
MG  A 901 (-3.4A)
MG  A 901 (-3.4A)
MG  A 901 (-3.2A)
None
None
None
None
None
0.69A32.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_D_TORD302_1
(CARBONIC ANHYDRASE 4)		3ml5 CARBONIC ANHYDRASE 7
(Homo
sapiens)		12 / 12ASN A  62
SER A  65
GLN A  92
HIS A  94
HIS A  96
HIS A 119
VAL A 121
VAL A 143
LEU A 198
THR A 199
THR A 200
TRP A 209
None
None
AZM  A 264 (-4.1A)
ZN  A 263 ( 3.2A)
ZN  A 263 ( 3.2A)
ZN  A 263 ( 3.1A)
AZM  A 264 (-4.7A)
AZM  A 264 ( 4.9A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.5A)
None
0.40A34.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_D_TORD302_1
(CARBONIC ANHYDRASE 4)		3ml5 CARBONIC ANHYDRASE 7
(Homo
sapiens)		6 / 12GLN A  67
HIS A  94
HIS A  96
HIS A 119
THR A 199
THR A 200
None
ZN  A 263 ( 3.2A)
ZN  A 263 ( 3.2A)
ZN  A 263 ( 3.1A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.5A)
1.03A34.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_D_TORD302_1
(CARBONIC ANHYDRASE 4)		3ml5 CARBONIC ANHYDRASE 7
(Homo
sapiens)		5 / 12GLN A  67
HIS A  96
VAL A 121
THR A 199
THR A 200
None
ZN  A 263 ( 3.2A)
AZM  A 264 (-4.7A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.5A)
1.06A34.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_D_TORD302_1
(CARBONIC ANHYDRASE 4)		3ml5 CARBONIC ANHYDRASE 7
(Homo
sapiens)		5 / 12HIS A  96
VAL A 121
LEU A 198
THR A 199
THR A 200
 ZN  A 263 ( 3.2A)
AZM  A 264 (-4.7A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.5A)
0.94A34.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_D_TORD302_1
(CARBONIC ANHYDRASE 4)		3uyq CARBONIC ANHYDRASE 3
(Homo
sapiens)		10 / 12ASN A  62
GLN A  92
HIS A  94
HIS A  96
HIS A 119
VAL A 121
VAL A 142
THR A 198
THR A 199
TRP A 208
None
None
ZN  A 261 (-3.3A)
ZN  A 261 (-3.3A)
ZN  A 261 (-3.2A)
None
None
ZN  A 261 ( 4.4A)
None
None
0.54A34.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_D_TORD302_1
(CARBONIC ANHYDRASE 4)		4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1
(Homo
sapiens)		5 / 12SER A   1
VAL A  39
VAL A  83
THR A  77
THR A  78
None
1.29A21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_D_TORD302_1
(CARBONIC ANHYDRASE 4)		4n40 PROTEIN ECT2
(Homo
sapiens)		5 / 12HIS A 279
VAL A 281
VAL A 301
THR A 262
TRP A 305
None
1.32A22.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_D_TORD302_1
(CARBONIC ANHYDRASE 4)		4qk3 CARBONIC ANHYDRASE 2
(Homo
sapiens)		11 / 12ASN A  62
GLN A  92
HIS A  94
HIS A  96
HIS A 119
VAL A 121
VAL A 143
LEU A 198
THR A 199
THR A 200
TRP A 209
None
None
ZN  A 301 (-3.2A)
ZN  A 301 (-3.2A)
ZN  A 301 (-3.1A)
None
None
None
ZN  A 301 ( 4.4A)
None
None
0.43A35.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_D_TORD302_1
(CARBONIC ANHYDRASE 4)		4qk3 CARBONIC ANHYDRASE 2
(Homo
sapiens)		5 / 12ASN A  67
HIS A  96
LEU A 198
THR A 199
THR A 200
None
ZN  A 301 (-3.2A)
None
ZN  A 301 ( 4.4A)
None
1.01A35.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_D_TORD302_1
(CARBONIC ANHYDRASE 4)		4qk3 CARBONIC ANHYDRASE 2
(Homo
sapiens)		5 / 12ASN A  67
HIS A  96
VAL A 143
LEU A 198
THR A 200
None
ZN  A 301 (-3.2A)
None
None
None
0.96A35.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_D_TORD302_1
(CARBONIC ANHYDRASE 4)		4qk3 CARBONIC ANHYDRASE 2
(Homo
sapiens)		6 / 12HIS A  94
HIS A  96
VAL A 121
LEU A 198
THR A 199
THR A 200
 ZN  A 301 (-3.2A)
ZN  A 301 (-3.2A)
None
None
ZN  A 301 ( 4.4A)
None
1.09A35.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_D_TORD302_1
(CARBONIC ANHYDRASE 4)		4qk3 CARBONIC ANHYDRASE 2
(Homo
sapiens)		5 / 12HIS A  96
HIS A  94
VAL A 121
LEU A 198
THR A 199
 ZN  A 301 (-3.2A)
ZN  A 301 (-3.2A)
None
None
ZN  A 301 ( 4.4A)
1.31A35.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_D_TORD302_1
(CARBONIC ANHYDRASE 4)		5cjf CARBONIC ANHYDRASE
14
(Homo
sapiens)		11 / 12ASN A  62
GLN A  92
HIS A  94
HIS A  96
HIS A 119
VAL A 121
VAL A 143
LEU A 198
THR A 199
THR A 200
TRP A 209
GOL  A 303 (-3.9A)
GOL  A 303 (-3.2A)
ZN  A 301 (-3.2A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.1A)
520  A 302 ( 4.9A)
520  A 302 ( 4.9A)
520  A 302 (-3.6A)
520  A 302 (-3.4A)
GOL  A 303 ( 3.5A)
None
0.43A35.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_D_TORD302_1
(CARBONIC ANHYDRASE 4)		5cjf CARBONIC ANHYDRASE
14
(Homo
sapiens)		6 / 12GLN A  67
HIS A  94
HIS A  96
HIS A 119
THR A 199
THR A 200
GOL  A 303 (-3.4A)
ZN  A 301 (-3.2A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.1A)
520  A 302 (-3.4A)
GOL  A 303 ( 3.5A)
1.01A35.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_D_TORD302_1
(CARBONIC ANHYDRASE 4)		5cjf CARBONIC ANHYDRASE
14
(Homo
sapiens)		5 / 12HIS A  96
VAL A 143
LEU A 198
THR A 199
THR A 200
 ZN  A 301 ( 3.2A)
520  A 302 ( 4.9A)
520  A 302 (-3.6A)
520  A 302 (-3.4A)
GOL  A 303 ( 3.5A)
1.09A35.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_D_TORD302_1
(CARBONIC ANHYDRASE 4)		5jn9 CARBONIC ANHYDRASE 4
(Homo
sapiens)		12 / 12ASN A  62
SER A  65
GLN A  92
HIS A  94
HIS A  96
HIS A 119
VAL A 121
VAL A 143
LEU A 198
THR A 199
THR A 200
TRP A 209
None
None
EZL  A 302 (-4.3A)
ZN  A 301 ( 3.3A)
ZN  A 301 ( 3.3A)
ZN  A 301 ( 3.2A)
EZL  A 302 (-4.7A)
EZL  A 302 ( 4.7A)
EZL  A 302 (-3.5A)
EZL  A 302 (-3.4A)
EZL  A 302 (-3.9A)
None
0.32A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JNA_D_TORD302_1
(CARBONIC ANHYDRASE 4)		5jn9 CARBONIC ANHYDRASE 4
(Homo
sapiens)		6 / 12SER A  65
HIS A  94
HIS A  96
VAL A 143
LEU A 198
THR A 200
None
ZN  A 301 ( 3.3A)
ZN  A 301 ( 3.3A)
EZL  A 302 ( 4.7A)
EZL  A 302 (-3.5A)
EZL  A 302 (-3.9A)
1.21A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_D_TORD302_1
(CARBONIC ANHYDRASE 4)		6fe1 CARBONIC ANHYDRASE 9
(Homo
sapiens)		12 / 12ASN A  62
SER A  65
GLN A  92
HIS A  94
HIS A  96
HIS A 119
VAL A 121
VAL A 143
LEU A 198
THR A 199
THR A 200
TRP A 209
V14  A 302 (-3.4A)
V14  A 302 ( 4.6A)
V14  A 302 (-3.8A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.1A)
V14  A 302 (-4.7A)
None
V14  A 302 (-3.6A)
V14  A 302 (-3.2A)
V14  A 302 (-3.5A)
None
0.40A16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_D_TORD302_1
(CARBONIC ANHYDRASE 4)		6fe1 CARBONIC ANHYDRASE 9
(Homo
sapiens)		6 / 12SER A  65
HIS A  94
HIS A  96
VAL A 121
LEU A 198
THR A 199
V14  A 302 ( 4.6A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
V14  A 302 (-4.7A)
V14  A 302 (-3.6A)
V14  A 302 (-3.2A)
1.50A16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_D_TORD302_1
(CARBONIC ANHYDRASE 4)		6fe1 CARBONIC ANHYDRASE 9
(Homo
sapiens)		6 / 12SER A  65
HIS A  96
VAL A 143
LEU A 198
THR A 199
THR A 200
V14  A 302 ( 4.6A)
ZN  A 301 ( 3.2A)
None
V14  A 302 (-3.6A)
V14  A 302 (-3.2A)
V14  A 302 (-3.5A)
1.10A16.24