POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALB_L_TIQL1210_1
(MEDI2452 HEAVY CHAIN
MEDI2452 LIGHT CHAIN)		4fmf POLIOVIRUS
RECEPTOR-RELATED
PROTEIN 1
(Homo
sapiens)		5 / 11SER A 209
ILE A 208
THR A 206
SER A 181
TRP A 149
None
None
NAG  A 402 ( 4.9A)
None
None
1.13A24.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ALB_L_TIQL1210_1
(MEDI2452 HEAVY CHAIN
MEDI2452 LIGHT CHAIN)		5alc ANTI-TICAGRELOR FAB
72, HEAVY CHAIN
(Homo
sapiens)		9 / 11SER H  33
HIS H  35
TRP H  47
ILE H  52
THR H  56
SER H  58
TYR H  99
ASP H 100
LEU H 100
None
0.39A97.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALB_L_TIQL1210_1
(MEDI2452 HEAVY CHAIN
MEDI2452 LIGHT CHAIN)		5epg ALDEHYDE OXIDASE
(Homo
sapiens)		5 / 11ILE A 968
TYR A 956
PRO A 901
ASP A 895
LEU A 892
None
1.25A12.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ALB_L_TIQL1210_2
(MEDI2452 LIGHT CHAIN)		1b4j ANTIBODY
(Homo
sapiens)		4 / 8SER L  34
TYR L  36
GLY L  89
PHE L  98
None
0.28A44.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALB_L_TIQL1210_2
(MEDI2452 LIGHT CHAIN)		1gpz COMPLEMENT C1R
COMPONENT
(Homo
sapiens)		4 / 8SER A 577
GLY A 578
GLY A 470
PHE A 579
None
0.88A19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALB_L_TIQL1210_2
(MEDI2452 LIGHT CHAIN)		1md7 C1R COMPLEMENT
SERINE PROTEASE
(Homo
sapiens)		4 / 8SER A 577
GLY A 578
GLY A 470
PHE A 579
None
0.91A20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALB_L_TIQL1210_2
(MEDI2452 LIGHT CHAIN)		2c11 MEMBRANE COPPER
AMINE OXIDASE
(Homo
sapiens)		4 / 8SER A 345
GLY A 346
ALA A  61
GLY A 340
None
0.77A15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALB_L_TIQL1210_2
(MEDI2452 LIGHT CHAIN)		2qy0 COMPLEMENT C1R
SUBCOMPONENT
(Homo
sapiens)		4 / 8SER B 577
GLY B 578
GLY B 470
PHE B 579
None
0.92A20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALB_L_TIQL1210_2
(MEDI2452 LIGHT CHAIN)		2vc2 INTEGRIN ALPHA-IIB
(Homo
sapiens)		4 / 8SER A 238
GLY A 256
ALA A 286
GLY A 265
None
0.80A21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALB_L_TIQL1210_2
(MEDI2452 LIGHT CHAIN)		2vpj KELCH-LIKE PROTEIN
12
(Homo
sapiens)		4 / 8GLY A 480
TYR A 476
ALA A 469
GLY A 467
None
0.86A22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALB_L_TIQL1210_2
(MEDI2452 LIGHT CHAIN)		3v4p INTEGRIN ALPHA-4
(Homo
sapiens)		4 / 8SER A 276
GLY A 293
ALA A 332
GLY A 304
None
0.59A17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALB_L_TIQL1210_2
(MEDI2452 LIGHT CHAIN)		3vi3 INTEGRIN ALPHA-5
(Homo
sapiens)		4 / 8SER A 234
GLY A 251
ALA A 282
GLY A 260
None
0.84A19.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ALB_L_TIQL1210_2
(MEDI2452 LIGHT CHAIN)		3zl4 A17 ANTIBODY FAB
FRAGMENT LAMBDA
LIGHT CHAIN
(Homo
sapiens)		4 / 8SER L  35
TYR L  37
GLY L  90
PHE L 100
MES  L1217 ( 3.9A)
None
None
MES  L1217 ( 4.9A)
0.48A93.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALB_L_TIQL1210_2
(MEDI2452 LIGHT CHAIN)		4bc5 XYLULOSE KINASE
(Homo
sapiens)		4 / 8GLY A 279
TYR A 475
ALA A 474
GLY A  94
None
0.78A16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALB_L_TIQL1210_2
(MEDI2452 LIGHT CHAIN)		4buh CLONE M0418 SCFV
(Homo
sapiens)		4 / 8TYR A 178
TRP A 233
GLY A 240
PHE A 242
None
0.91A26.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALB_L_TIQL1210_2
(MEDI2452 LIGHT CHAIN)		4chb KELCH-LIKE PROTEIN 2
(Homo
sapiens)		4 / 8GLY A 407
TYR A 403
ALA A 396
GLY A 394
None
0.88A20.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ALB_L_TIQL1210_2
(MEDI2452 LIGHT CHAIN)		4mwf FAB AR3C HEAVY CHAIN
(Homo
sapiens)		4 / 8SER A  95
TYR A  32
TRP A  47
GLY A  50
None
0.75A30.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALB_L_TIQL1210_2
(MEDI2452 LIGHT CHAIN)		4um8 INTEGRIN ALPHA-V
(Homo
sapiens)		4 / 8SER A 225
GLY A 242
ALA A 273
GLY A 251
None
0.83A15.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ALB_L_TIQL1210_2
(MEDI2452 LIGHT CHAIN)		4uu9 MEDI7814
(Homo
sapiens)		4 / 8SER B  30
GLY B  28
ALA B   3
GLY B  25
None
0.87A62.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALB_L_TIQL1210_2
(MEDI2452 LIGHT CHAIN)		4wk4 INTEGRIN ALPHA-5
(Homo
sapiens)		4 / 8SER A 234
GLY A 251
ALA A 282
GLY A 260
None
0.87A20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALB_L_TIQL1210_2
(MEDI2452 LIGHT CHAIN)		5ccx TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRMT61A
TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
NON-CATALYTIC
SUBUNIT TRM6
(Homo
sapiens)		4 / 8SER B 455
GLY B 456
ALA A  24
PHE B 457
None
0.88A19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALB_L_TIQL1210_2
(MEDI2452 LIGHT CHAIN)		5e6s INTEGRIN ALPHA-L
(Homo
sapiens)		4 / 8SER A 330
GLY A 341
ALA A 376
GLY A 350
None
0.68A14.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ALB_L_TIQL1210_2
(MEDI2452 LIGHT CHAIN)		5jsa BROADLY NEUTRALIZING
ANTIBODY PGT128
LIGHT CHAIN
(Homo
sapiens)		4 / 8SER B  34
TYR B  36
GLY B  89
PHE B  98
None
0.41A81.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALB_L_TIQL1210_2
(MEDI2452 LIGHT CHAIN)		5neu INTEGRIN ALPHA-V
(Homo
sapiens)		4 / 8SER A 225
GLY A 242
ALA A 273
GLY A 251
None
0.84A17.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ALB_L_TIQL1210_2
(MEDI2452 LIGHT CHAIN)		5ngv ANTI-HUMAN ACTRIIB
MAB BYM338
LIGHT-CHAIN
(Homo
sapiens)		4 / 8TYR L  38
GLY L  91
GLY L 100
PHE L 102
None
0.18A37.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALB_L_TIQL1210_2
(MEDI2452 LIGHT CHAIN)		5nkp KELCH-LIKE PROTEIN 3
(Homo
sapiens)		4 / 8GLY A 401
TYR A 397
ALA A 390
GLY A 388
None
0.86A22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALC_L_TIQL1210_1
(ANTI-TICAGRELOR FAB
72, HEAVY CHAIN
ANTI-TICAGRELOR FAB
72, LIGHT CHAIN)		1zag PROTEIN
(ZINC-ALPHA-2-GLYCOP
ROTEIN)
(Homo
sapiens)		5 / 9ILE A  84
THR A  80
TYR A 124
PRO A 136
ASP A 138
None
1.50A23.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ALC_L_TIQL1210_1
(ANTI-TICAGRELOR FAB
72, HEAVY CHAIN
ANTI-TICAGRELOR FAB
72, LIGHT CHAIN)		2b4c ANTI-HIV-1 GP120
IMMUNOGLOBULIN X5
HEAVY CHAIN
(Homo
sapiens)		5 / 9TRP H  47
ILE H  52
THR H  56
TYR H 100
ASP H  95
None
1.40A80.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ALC_L_TIQL1210_2
(ANTI-TICAGRELOR FAB
72, LIGHT CHAIN)		1b4j ANTIBODY
(Homo
sapiens)		4 / 8SER L  34
TYR L  36
GLY L  89
PHE L  98
None
0.35A43.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALC_L_TIQL1210_2
(ANTI-TICAGRELOR FAB
72, LIGHT CHAIN)		1d1t ALCOHOL
DEHYDROGENASE CLASS
IV SIGMA CHAIN
(Homo
sapiens)		4 / 8SER A 213
GLY A 210
ILE A 172
GLY A 181
None
0.76A18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALC_L_TIQL1210_2
(ANTI-TICAGRELOR FAB
72, LIGHT CHAIN)		3kq4 CUBILIN
(Homo
sapiens)		4 / 8SER B1189
TRP B1193
ILE B1257
GLY B1166
None
0.80A17.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ALC_L_TIQL1210_2
(ANTI-TICAGRELOR FAB
72, LIGHT CHAIN)		3wlw ANTIBODY L CHAIN
(Homo
sapiens)		4 / 8SER L  36
TYR L  38
SER L  97
PHE L 101
None
0.77A53.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ALC_L_TIQL1210_2
(ANTI-TICAGRELOR FAB
72, LIGHT CHAIN)		3zl4 A17 ANTIBODY FAB
FRAGMENT LAMBDA
LIGHT CHAIN
(Homo
sapiens)		4 / 8SER L  35
TYR L  37
GLY L  90
PHE L 100
MES  L1217 ( 3.9A)
None
None
MES  L1217 ( 4.9A)
0.55A94.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALC_L_TIQL1210_2
(ANTI-TICAGRELOR FAB
72, LIGHT CHAIN)		4buh CLONE M0418 SCFV
(Homo
sapiens)		4 / 8TYR A 178
TRP A 233
GLY A 240
PHE A 242
None
0.50A26.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ALC_L_TIQL1210_2
(ANTI-TICAGRELOR FAB
72, LIGHT CHAIN)		4mwf FAB AR3C HEAVY CHAIN
(Homo
sapiens)		4 / 8SER A  95
TYR A  32
TRP A  47
GLY A  50
None
0.81A30.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALC_L_TIQL1210_2
(ANTI-TICAGRELOR FAB
72, LIGHT CHAIN)		4xat NOELIN
(Homo
sapiens)		4 / 8SER A 242
GLY A 243
ILE A 449
GLY A 247
None
0.73A24.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ALC_L_TIQL1210_2
(ANTI-TICAGRELOR FAB
72, LIGHT CHAIN)		5fcs DIABODY
(Homo
sapiens)		4 / 8GLY L  90
TRP L  92
SER L  97
PHE L 101
None
0.82A52.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ALC_L_TIQL1210_2
(ANTI-TICAGRELOR FAB
72, LIGHT CHAIN)		5grj AVELUMAB L CHAIN
(Homo
sapiens)		4 / 8SER L  36
TYR L  38
SER L  97
PHE L 101
None
0.69A65.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ALC_L_TIQL1210_2
(ANTI-TICAGRELOR FAB
72, LIGHT CHAIN)		5i8o HMM5 ANTIBODY LIGHT
CHAIN
(Homo
sapiens)		4 / 8TYR L  94
GLY L  92
ILE L  21
GLY L 102
None
0.83A44.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ALC_L_TIQL1210_2
(ANTI-TICAGRELOR FAB
72, LIGHT CHAIN)		5jz7 MEDI578 SCFV, LIGHT
CHAIN
(Homo
sapiens)		4 / 8TYR D  36
GLY D  89
TRP D  91
PHE D  98
None
0.64A57.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ALC_L_TIQL1210_2
(ANTI-TICAGRELOR FAB
72, LIGHT CHAIN)		5ngv ANTI-HUMAN ACTRIIB
MAB BYM338
LIGHT-CHAIN
(Homo
sapiens)		4 / 8TYR L  38
GLY L  91
GLY L 100
PHE L 102
None
0.27A37.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ALC_L_TIQL1210_2
(ANTI-TICAGRELOR FAB
72, LIGHT CHAIN)		5ocy ACPA E4 FAB FRAGMENT
- LIGHT CHAIN
(Homo
sapiens)		4 / 8SER L  35
TRP L  92
SER L  97
PHE L 101
None
0.59A72.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ALC_L_TIQL1210_2
(ANTI-TICAGRELOR FAB
72, LIGHT CHAIN)		5u0r DH270.UCA1 LIGHT
CHAIN
(Homo
sapiens)		4 / 8SER L  36
TYR L  38
SER L  97
PHE L 101
None
0.76A82.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALC_L_TIQL1210_2
(ANTI-TICAGRELOR FAB
72, LIGHT CHAIN)		6en4 SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens)		4 / 8SER A 639
GLY A 668
SER A 696
GLY A 672
None
0.84A17.93