POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		1b72 PROTEIN (HOMEOBOX
PROTEIN HOX-B1)
(Homo
sapiens)		5 / 7VAL A 247
LEU A 218
GLU A 244
ALA A 237
LEU A 228
None
1.20A14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		1ln1 PHOSPHATIDYLCHOLINE
TRANSFER PROTEIN
(Homo
sapiens)		4 / 7VAL A 132
LEU A 134
ALA A 160
LEU A 123
None
0.62A18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		1lpe APOLIPOPROTEIN E3
(Homo
sapiens)		5 / 7ARG A 114
VAL A 111
LEU A  60
LEU A 141
LEU A 137
None
1.24A18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		2dno TRINUCLEOTIDE REPEAT
CONTAINING 4 VARIANT
(Homo
sapiens)		4 / 7VAL A  75
ALA A 114
LEU A 144
LEU A 137
None
0.67A17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		2l9r HOMEOBOX PROTEIN
NKX-3.1
(Homo
sapiens)		5 / 7VAL A  48
LEU A  19
GLU A  45
ALA A  38
LEU A  29
None
1.29A11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		2nq3 ITCHY HOMOLOG E3
UBIQUITIN PROTEIN
LIGASE
(Homo
sapiens)		4 / 7VAL A 118
LEU A 120
LEU A 139
LEU A 113
None
0.57A18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		2z7x TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens)		4 / 7VAL A 464
LEU A 469
LEU A 482
LEU A 479
None
0.66A19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		2zfu CEREBRAL PROTEIN 1
(Homo
sapiens)		4 / 7VAL A 390
LEU A 388
LEU A 366
LEU A 448
None
0.69A21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		3l43 DYNAMIN-3
(Homo
sapiens)		4 / 7VAL A 124
ALA A  81
LEU A  71
LEU A  69
None
0.56A20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		3vzg ZYMOGEN GRANULE
MEMBRANE PROTEIN 16
(Homo
sapiens)		5 / 7VAL A  97
LEU A 139
ALA A 130
LEU A 108
LEU A 105
None
0.88A17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		4n68 CONTACTIN-5
(Homo
sapiens)		4 / 7VAL A 894
ALA A 884
LEU A 937
LEU A 940
None
0.65A19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		5a3f DYNAMIN 3
(Homo
sapiens)		4 / 7VAL A 124
ALA A  81
LEU A  71
LEU A  69
None
0.57A16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		5c7o GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
TESTIS-SPECIFIC
(Homo
sapiens)		4 / 7VAL O 380
LEU O 382
ALA O 374
LEU O 321
None
0.59A21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		5d3q DYNAMIN-1,DYNAMIN-1
(Homo
sapiens)		4 / 7VAL A 124
ALA A  81
LEU A  71
LEU A  69
None
0.50A22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		5ggg PROTEIN
O-LINKED-MANNOSE
BETA-1,2-N-ACETYLGLU
COSAMINYLTRANSFERASE
1
(Homo
sapiens)		4 / 7ARG A 616
VAL A 623
ALA A 577
LEU A 597
None
0.59A20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_2
(ENVELOPE
GLYCOPROTEIN 2)		2v40 ADENYLOSUCCINATE
SYNTHETASE ISOZYME 2
(Homo
sapiens)		4 / 7LEU A 343
THR A 301
THR A 302
LEU A 436
None
0.90A15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_2
(ENVELOPE
GLYCOPROTEIN 2)		3fk2 GLUCOCORTICOID
RECEPTOR DNA-BINDING
FACTOR 1
(Homo
sapiens)		4 / 7LEU A1341
THR A1403
MET A1337
LEU A1361
None
1.07A17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_2
(ENVELOPE
GLYCOPROTEIN 2)		3u3z MICROCEPHALIN
(Homo
sapiens)		4 / 7LEU A 781
THR A 683
THR A 649
LEU A 778
None
1.13A18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_2
(ENVELOPE
GLYCOPROTEIN 2)		4bkx HISTONE DEACETYLASE
1
METASTASIS-ASSOCIATE
D PROTEIN MTA1
(Homo
sapiens)		4 / 7TYR B 336
THR A 332
THR A 333
LEU B  41
None
1.12A14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_2
(ENVELOPE
GLYCOPROTEIN 2)		4cek REGULATOR OF
NONSENSE TRANSCRIPTS
2
(Homo
sapiens)		4 / 7LEU A 673
ASP A 585
MET A 678
LEU A 640
None
1.09A17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_2
(ENVELOPE
GLYCOPROTEIN 2)		5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 5
(Homo
sapiens)		4 / 7LEU O 567
TYR O 545
ASP O 517
LEU O 563
None
1.02A11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_2
(ENVELOPE
GLYCOPROTEIN 2)		5d1x IRON-REGULATED
SURFACE DETERMINANT
PROTEIN B
P5 HEAVY CHAIN
(Homo
sapiens;
Staphylococcus
aureus)		4 / 7LEU E 345
TYR C 100
THR C  97
ASP C 101
None
1.13A20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_2
(ENVELOPE
GLYCOPROTEIN 2)		5lf9 NUCLEOSIDE
DIPHOSPHATE-LINKED
MOIETY X MOTIF 22
(Homo
sapiens)		4 / 7LEU A 208
TYR A 225
THR A 129
ASP A 132
None
0.98A18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_2
(ENVELOPE
GLYCOPROTEIN 2)		5ve9 MICROTUBULE-ACTIN
CROSS-LINKING FACTOR
1, ISOFORMS 1/2/3/5
(Homo
sapiens)		4 / 7THR A7077
THR A7078
MET A7039
LEU A7106
None
0.98A23.36