POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HWK_A_SFYA807_0 (SEPIAPTERIN REDUCTASE)	2ad1	SULFOTRANSFERASE 1C2 (Homo sapiens)	5 / 11	LEU A 164 PHE A 160 TRP A 156 TYR A 159 PRO A 133	None	1.10A	21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HWK_A_SFYA807_0 (SEPIAPTERIN REDUCTASE)	2rhz	LETHAL(3)MALIGNANT BRAIN TUMOR-LIKE PROTEIN (Homo sapiens)	5 / 11	SER A 394 CYH A 390 PHE A 375 TYR A 388 ALA A 365	None	1.16A	20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4HWK_A_SFYA807_0 (SEPIAPTERIN REDUCTASE)	4z3k	SEPIAPTERIN REDUCTASE (Homo sapiens)	11 / 11	SER A 154 LEU A 155 CYH A 156 PHE A 161 TRP A 164 TYR A 167 PRO A 197 MET A 202 GLN A 203 ALA A 206 MET A 215	4KL  A 802 (-2.6A) 4KL  A 802 (-4.0A) 4KL  A 802 ( 4.2A) None None 4KL  A 802 ( 4.1A) 4KL  A 802 (-4.0A) NAP  A 801 (-3.5A) 4KL  A 802 ( 3.2A) 4KL  A 802 ( 4.3A) None	0.55A	94.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HWK_B_SFYB806_0 (SEPIAPTERIN REDUCTASE)	1m1l	SUPPRESSOR OF FUSED (Homo sapiens)	5 / 11	LEU A 120 LEU A  98 MET A 141 GLN A 142 ALA A 145	None	1.43A	23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HWK_B_SFYB806_0 (SEPIAPTERIN REDUCTASE)	1x3a	SYNAPSE ASSOCIATED PROTEIN 1 (Homo sapiens)	5 / 11	LEU A  53 SER A  22 LEU A  21 TRP A  77 ALA A  49	None	1.39A	17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HWK_B_SFYB806_0 (SEPIAPTERIN REDUCTASE)	2ad1	SULFOTRANSFERASE 1C2 (Homo sapiens)	5 / 11	LEU A 164 PHE A 160 TRP A 156 TYR A 159 PRO A 133	None	1.08A	21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HWK_B_SFYB806_0 (SEPIAPTERIN REDUCTASE)	2rhz	LETHAL(3)MALIGNANT BRAIN TUMOR-LIKE PROTEIN (Homo sapiens)	5 / 11	SER A 394 CYH A 390 PHE A 375 TYR A 388 ALA A 365	None	1.18A	20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HWK_B_SFYB806_0 (SEPIAPTERIN REDUCTASE)	4bla	MALTOSE-BINDING PERIPLASMIC PROTEIN, SUPPRESSOR OF FUSED HOMOLOG (Escherichia coli; Homo sapiens)	5 / 11	LEU A 460 LEU A 438 MET A 481 GLN A 482 ALA A 485	None	1.48A	17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HWK_B_SFYB806_0 (SEPIAPTERIN REDUCTASE)	4gtu	GLUTATHIONE S-TRANSFERASE (Homo sapiens)	5 / 11	LEU A 207 CYH A 114 PHE A 119 TRP A 214 TYR A 208	None	1.43A	24.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4HWK_B_SFYB806_0 (SEPIAPTERIN REDUCTASE)	4z3k	SEPIAPTERIN REDUCTASE (Homo sapiens)	5 / 11	LEU A 101 CYH A 168 PHE A 161 TRP A 164 MET A 202	None None None None NAP  A 801 (-3.5A)	1.43A	94.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4HWK_B_SFYB806_0 (SEPIAPTERIN REDUCTASE)	4z3k	SEPIAPTERIN REDUCTASE (Homo sapiens)	11 / 11	LEU A 101 SER A 154 LEU A 155 CYH A 156 PHE A 161 TRP A 164 TYR A 167 PRO A 197 MET A 202 GLN A 203 ALA A 206	None 4KL  A 802 (-2.6A) 4KL  A 802 (-4.0A) 4KL  A 802 ( 4.2A) None None 4KL  A 802 ( 4.1A) 4KL  A 802 (-4.0A) NAP  A 801 (-3.5A) 4KL  A 802 ( 3.2A) 4KL  A 802 ( 4.3A)	0.32A	94.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HWK_B_SFYB806_0 (SEPIAPTERIN REDUCTASE)	6au8	GOLGI TO ER TRAFFIC PROTEIN 4 HOMOLOG LARGE PROLINE-RICH PROTEIN BAG6 (Homo sapiens; Homo sapiens)	5 / 11	LEU A 179 SER C1038 LEU C1037 GLN A 202 ALA A 199	None None None GOL  A 401 ( 3.3A) None	1.40A	22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HWK_B_SFYB806_0 (SEPIAPTERIN REDUCTASE)	6au8	GOLGI TO ER TRAFFIC PROTEIN 4 HOMOLOG LARGE PROLINE-RICH PROTEIN BAG6 (Homo sapiens; Homo sapiens)	5 / 11	LEU A 179 SER C1038 LEU C1037 TYR A 182 GLN A 202	None None None None GOL  A 401 ( 3.3A)	1.43A	22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HWK_B_SFYB806_0 (SEPIAPTERIN REDUCTASE)	6co1	TUDOR-INTERACTING REPAIR REGULATOR PROTEIN (Homo sapiens)	5 / 11	LEU A 192 LEU A  60 PHE A 160 GLN A 199 ALA A 195	None	1.31A	undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HWK_C_SFYC804_0 (SEPIAPTERIN REDUCTASE)	1x3a	SYNAPSE ASSOCIATED PROTEIN 1 (Homo sapiens)	5 / 12	LEU A  53 SER A  22 LEU A  21 TRP A  77 ALA A  49	None	1.41A	17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HWK_C_SFYC804_0 (SEPIAPTERIN REDUCTASE)	2ad1	SULFOTRANSFERASE 1C2 (Homo sapiens)	5 / 12	LEU A 164 PHE A 160 TRP A 156 TYR A 159 PRO A 133	None	1.08A	21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HWK_C_SFYC804_0 (SEPIAPTERIN REDUCTASE)	2rhz	LETHAL(3)MALIGNANT BRAIN TUMOR-LIKE PROTEIN (Homo sapiens)	5 / 12	SER A 394 CYH A 390 PHE A 375 TYR A 388 ALA A 365	None	1.16A	20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HWK_C_SFYC804_0 (SEPIAPTERIN REDUCTASE)	4gtu	GLUTATHIONE S-TRANSFERASE (Homo sapiens)	5 / 12	LEU A 207 CYH A 114 PHE A 119 TRP A 214 TYR A 208	None	1.43A	24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HWK_C_SFYC804_0 (SEPIAPTERIN REDUCTASE)	4l59	LETHAL(3)MALIGNANT BRAIN TUMOR-LIKE PROTEIN 3 (Homo sapiens)	5 / 12	SER A 420 CYH A 416 PHE A 401 TYR A 414 ALA A 391	None	1.19A	21.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4HWK_C_SFYC804_0 (SEPIAPTERIN REDUCTASE)	4z3k	SEPIAPTERIN REDUCTASE (Homo sapiens)	5 / 12	LEU A 101 CYH A 168 PHE A 161 TRP A 164 MET A 202	None None None None NAP  A 801 (-3.5A)	1.43A	94.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4HWK_C_SFYC804_0 (SEPIAPTERIN REDUCTASE)	4z3k	SEPIAPTERIN REDUCTASE (Homo sapiens)	12 / 12	LEU A 101 SER A 154 LEU A 155 CYH A 156 PHE A 161 TRP A 164 TYR A 167 PRO A 197 MET A 202 GLN A 203 ALA A 206 MET A 215	None 4KL  A 802 (-2.6A) 4KL  A 802 (-4.0A) 4KL  A 802 ( 4.2A) None None 4KL  A 802 ( 4.1A) 4KL  A 802 (-4.0A) NAP  A 801 (-3.5A) 4KL  A 802 ( 3.2A) 4KL  A 802 ( 4.3A) None	0.50A	94.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HWK_C_SFYC804_0 (SEPIAPTERIN REDUCTASE)	6au8	GOLGI TO ER TRAFFIC PROTEIN 4 HOMOLOG LARGE PROLINE-RICH PROTEIN BAG6 (Homo sapiens; Homo sapiens)	5 / 12	LEU A 179 SER C1038 LEU C1037 GLN A 202 ALA A 199	None None None GOL  A 401 ( 3.3A) None	1.38A	22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HWK_C_SFYC804_0 (SEPIAPTERIN REDUCTASE)	6au8	GOLGI TO ER TRAFFIC PROTEIN 4 HOMOLOG LARGE PROLINE-RICH PROTEIN BAG6 (Homo sapiens; Homo sapiens)	5 / 12	LEU A 179 SER C1038 LEU C1037 TYR A 182 GLN A 202	None None None None GOL  A 401 ( 3.3A)	1.42A	22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HWK_C_SFYC804_0 (SEPIAPTERIN REDUCTASE)	6co1	TUDOR-INTERACTING REPAIR REGULATOR PROTEIN (Homo sapiens)	5 / 12	LEU A 192 LEU A  60 PHE A 160 GLN A 199 ALA A 195	None	1.31A	undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HWK_D_SFYD803_0 (SEPIAPTERIN REDUCTASE)	1x3a	SYNAPSE ASSOCIATED PROTEIN 1 (Homo sapiens)	5 / 11	LEU A  53 SER A  22 LEU A  21 TRP A  77 ALA A  49	None	1.40A	17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HWK_D_SFYD803_0 (SEPIAPTERIN REDUCTASE)	2ad1	SULFOTRANSFERASE 1C2 (Homo sapiens)	5 / 11	LEU A 164 PHE A 160 TRP A 156 TYR A 159 PRO A 133	None	1.12A	21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HWK_D_SFYD803_0 (SEPIAPTERIN REDUCTASE)	2rhz	LETHAL(3)MALIGNANT BRAIN TUMOR-LIKE PROTEIN (Homo sapiens)	5 / 11	SER A 394 CYH A 390 PHE A 375 TYR A 388 ALA A 365	None	1.15A	20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HWK_D_SFYD803_0 (SEPIAPTERIN REDUCTASE)	4l59	LETHAL(3)MALIGNANT BRAIN TUMOR-LIKE PROTEIN 3 (Homo sapiens)	5 / 11	SER A 420 CYH A 416 PHE A 401 TYR A 414 ALA A 391	None	1.19A	21.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4HWK_D_SFYD803_0 (SEPIAPTERIN REDUCTASE)	4z3k	SEPIAPTERIN REDUCTASE (Homo sapiens)	11 / 11	LEU A 101 SER A 154 LEU A 155 CYH A 156 PHE A 161 TRP A 164 TYR A 167 PRO A 197 MET A 202 GLN A 203 ALA A 206	None 4KL  A 802 (-2.6A) 4KL  A 802 (-4.0A) 4KL  A 802 ( 4.2A) None None 4KL  A 802 ( 4.1A) 4KL  A 802 (-4.0A) NAP  A 801 (-3.5A) 4KL  A 802 ( 3.2A) 4KL  A 802 ( 4.3A)	0.27A	94.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HWK_D_SFYD803_0 (SEPIAPTERIN REDUCTASE)	6au8	GOLGI TO ER TRAFFIC PROTEIN 4 HOMOLOG LARGE PROLINE-RICH PROTEIN BAG6 (Homo sapiens; Homo sapiens)	5 / 11	LEU A 179 SER C1038 LEU C1037 GLN A 202 ALA A 199	None None None GOL  A 401 ( 3.3A) None	1.39A	22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HWK_D_SFYD803_0 (SEPIAPTERIN REDUCTASE)	6au8	GOLGI TO ER TRAFFIC PROTEIN 4 HOMOLOG LARGE PROLINE-RICH PROTEIN BAG6 (Homo sapiens; Homo sapiens)	5 / 11	LEU A 179 SER C1038 LEU C1037 TYR A 182 GLN A 202	None None None None GOL  A 401 ( 3.3A)	1.45A	22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HWK_D_SFYD803_0 (SEPIAPTERIN REDUCTASE)	6co1	TUDOR-INTERACTING REPAIR REGULATOR PROTEIN (Homo sapiens)	5 / 11	LEU A 192 LEU A  60 PHE A 160 GLN A 199 ALA A 195	None	1.33A	undetectable