POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XMU_A_ROFA101_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B
(Homo
sapiens)		5 / 12HIS A 737
ASP A 937
PRO A 941
SER A 990
PHE A 991
IBM  A2111 ( 4.8A)
MG  A2123 (-2.5A)
None
None
IBM  A2111 (-3.6A)
1.24A30.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XMU_A_ROFA101_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B
(Homo
sapiens)		8 / 12TYR A 736
HIS A 737
ASP A 937
PRO A 941
TRP A 951
ILE A 955
PHE A 959
PHE A 991
IBM  A2111 (-4.5A)
IBM  A2111 ( 4.8A)
MG  A2123 (-2.5A)
None
None
IBM  A2111 (-4.2A)
None
IBM  A2111 (-3.6A)
0.57A30.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XMU_A_ROFA101_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens)		7 / 12TYR A 211
HIS A 212
ASP A 362
PRO A 366
TRP A 376
PHE A 384
PHE A 416
IBM  A 503 (-4.6A)
None
ZN  A 501 (-2.5A)
None
None
IBM  A 503 (-4.5A)
IBM  A 503 (-3.4A)
0.34A34.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XMU_A_ROFA101_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		2qyk CYCLIC AMP-SPECIFIC
PHOSPHODIESTERASE
HSPDE4A10
(Homo
sapiens)		11 / 12TYR A 371
HIS A 372
ASP A 530
LEU A 531
PRO A 534
TYR A 541
TRP A 544
ILE A 548
MET A 569
SER A 580
PHE A 584
NPV  A   3 (-4.4A)
NPV  A   3 (-4.6A)
ZN  A   1 (-2.5A)
None
None
None
None
NPV  A   3 (-3.8A)
NPV  A   3 (-3.1A)
NPV  A   3 (-4.5A)
NPV  A   3 (-3.3A)
0.49A87.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XMU_A_ROFA101_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		2qyk CYCLIC AMP-SPECIFIC
PHOSPHODIESTERASE
HSPDE4A10
(Homo
sapiens)		11 / 12TYR A 371
HIS A 372
ASP A 530
LEU A 531
PRO A 534
TYR A 541
TRP A 544
ILE A 548
PHE A 552
SER A 580
PHE A 584
NPV  A   3 (-4.4A)
NPV  A   3 (-4.6A)
ZN  A   1 (-2.5A)
None
None
None
None
NPV  A   3 (-3.8A)
NPV  A   3 (-4.8A)
NPV  A   3 (-4.5A)
NPV  A   3 (-3.3A)
0.38A87.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XMU_A_ROFA101_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		2qym PHOSPHODIESTERASE 4C
(Homo
sapiens)		9 / 12TYR A 281
HIS A 282
ASP A 440
LEU A 441
PRO A 444
TYR A 451
TRP A 454
ILE A 458
PHE A 494
None
None
ZN  A   1 (-2.5A)
None
None
None
None
None
None
0.59A75.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_A_ROFA101_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens)		6 / 12TYR A 612
HIS A 613
ASP A 764
LEU A 765
PHE A 786
PHE A 820
VDN  A   1 (-4.8A)
VDN  A   1 (-4.3A)
None
VDN  A   1 ( 4.7A)
None
VDN  A   1 (-3.6A)
0.77A28.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_A_ROFA101_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens)		6 / 12TYR A 612
HIS A 613
ASP A 764
LEU A 765
PHE A 786
PHE A 820
None
MG  A 877 (-4.4A)
ZN  A 876 (-2.5A)
WAN  A 901 ( 4.7A)
WAN  A 901 (-4.8A)
WAN  A 901 (-3.7A)
0.68A17.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XMU_A_ROFA101_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A
(Homo
sapiens)		8 / 12TYR A 555
HIS A 556
ASP A 726
PRO A 730
TRP A 740
ILE A 744
SER A 777
PHE A 781
None
None
ZN  A   1 (-2.6A)
None
None
IBM  A   3 (-4.3A)
None
IBM  A   3 (-3.5A)
0.37A34.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XMU_A_ROFA101_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		9 / 12TYR A 325
HIS A 326
ASP A 484
LEU A 485
ILE A 502
PHE A 506
MET A 523
SER A 534
PHE A 538
None
D71  A 901 (-4.5A)
ZN  A 801 (-2.6A)
None
D71  A 901 (-4.1A)
D71  A 901 (-4.8A)
D71  A 901 ( 4.0A)
D71  A 901 (-3.4A)
D71  A 901 (-3.9A)
0.97A66.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XMU_A_ROFA101_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		11 / 12TYR A 325
HIS A 326
ASP A 484
LEU A 485
PRO A 488
TYR A 495
TRP A 498
ILE A 502
PHE A 506
MET A 523
PHE A 538
None
D71  A 901 (-4.5A)
ZN  A 801 (-2.6A)
None
None
None
None
D71  A 901 (-4.1A)
D71  A 901 (-4.8A)
D71  A 901 ( 4.0A)
D71  A 901 (-3.9A)
0.71A66.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_A_ROFA101_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		3hym ANAPHASE-PROMOTING
COMPLEX SUBUNIT
CDC26
CELL DIVISION CYCLE
PROTEIN 16 HOMOLOG
(Homo
sapiens;
Homo
sapiens)		5 / 12LEU A   2
PRO B 335
TRP B 337
SER B 301
PHE B 303
None
1.44A6.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_A_ROFA101_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens)		6 / 12TYR A 655
HIS A 656
ASP A 808
LEU A 809
ILE A 826
PHE A 862
None
None
ZN  A   1 (-2.7A)
None
None
None
0.95A19.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XMU_A_ROFA101_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		3o57 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		12 / 12TYR A 233
HIS A 234
ASP A 392
LEU A 393
PRO A 396
TYR A 403
TRP A 406
ILE A 410
PHE A 414
MET A 431
SER A 442
PHE A 446
None
None
ZN  A   1 (-2.6A)
None
ZG2  A 506 ( 4.5A)
None
None
ZG2  A 506 (-4.4A)
ZG2  A 506 (-4.4A)
ZG2  A 506 (-3.4A)
None
ZG2  A 506 (-3.6A)
0.55A93.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XMU_A_ROFA101_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		12 / 12TYR A 159
HIS A 160
ASP A 318
LEU A 319
PRO A 322
TYR A 329
TRP A 332
ILE A 336
PHE A 340
MET A 357
SER A 368
PHE A 372
TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
ASP  A 318 (-0.5A)
LEU  A 319 ( 0.6A)
PRO  A 322 (-1.1A)
TYR  A 329 (-1.3A)
TRP  A 332 ( 0.5A)
ILE  A 336 ( 0.4A)
PHE  A 340 (-1.3A)
MET  A 357 (-0.0A)
SER  A 368 (-0.0A)
PHE  A 372 (-1.3A)
0.61A84.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_A_ROFA101_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		3ui7 CAMP AND
CAMP-INHIBITED CGMP
3',5'-CYCLIC
PHOSPHODIESTERASE
10A
(Homo
sapiens)		7 / 12TYR A 524
HIS A 525
ASP A 674
LEU A 675
ILE A 692
PHE A 696
PHE A 729
C1L  A   1 ( 4.8A)
C1L  A   1 (-4.1A)
ZN  A 772 (-2.4A)
C1L  A   1 (-4.3A)
C1L  A   1 (-4.3A)
C1L  A   1 ( 4.7A)
C1L  A   1 (-3.5A)
0.83A27.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_A_ROFA101_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		3ui7 CAMP AND
CAMP-INHIBITED CGMP
3',5'-CYCLIC
PHOSPHODIESTERASE
10A
(Homo
sapiens)		6 / 12TYR A 524
HIS A 525
LEU A 635
ILE A 692
PHE A 696
PHE A 729
C1L  A   1 ( 4.8A)
C1L  A   1 (-4.1A)
None
C1L  A   1 (-4.3A)
C1L  A   1 ( 4.7A)
C1L  A   1 (-3.5A)
1.49A27.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_A_ROFA101_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		4dy0 GLIA-DERIVED NEXIN
(Homo
sapiens)		5 / 12ASP A 284
LEU A 321
ILE A 155
PHE A 124
SER A 133
None
1.29A24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_A_ROFA101_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens)		7 / 12TYR A 655
HIS A 656
ASP A 808
LEU A 809
ILE A 826
PHE A 830
PHE A 862
None
None
ZN  A1001 (-2.5A)
None
None
None
None
0.64A27.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_A_ROFA101_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		4um8 INTEGRIN ALPHA-V
(Homo
sapiens)		5 / 12ASP A  24
LEU A  37
TYR A  11
ILE A 414
SER A  62
None
1.17A19.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XMU_A_ROFA101_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		11 / 12TYR A 405
HIS A 406
ASP A 564
LEU A 565
PRO A 568
TYR A 575
TRP A 578
ILE A 582
PHE A 586
SER A 614
PHE A 618
None
MG  A 804 ( 4.9A)
ZN  A 801 (-2.5A)
None
None
None
None
None
None
None
None
0.53A61.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XMU_A_ROFA101_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		10 / 12TYR A 405
HIS A 406
ASP A 564
PRO A 568
TYR A 575
TRP A 578
ILE A 582
PHE A 586
MET A 603
SER A 614
None
MG  A 804 ( 4.9A)
ZN  A 801 (-2.5A)
None
None
None
None
None
None
None
1.00A61.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XMU_A_ROFA101_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		5b25 CALCIUM/CALMODULIN-D
EPENDENT
3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 1B
(Homo
sapiens)		8 / 12TYR A 222
HIS A 223
ASP A 370
PRO A 374
TRP A 384
PHE A 392
SER A 420
PHE A 424
None
4QJ  A 603 ( 4.9A)
ZN  A 601 (-2.5A)
None
None
GOL  A 607 (-3.9A)
4QJ  A 603 (-4.7A)
4QJ  A 603 (-3.5A)
0.59A35.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_A_ROFA101_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		5in7 NEURONAL MIGRATION
PROTEIN DOUBLECORTIN
(Homo
sapiens)		5 / 12ASP A 167
LEU A 164
ILE A 149
SER A 205
PHE A 138
None
1.33A16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_A_ROFA101_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		5neu INTEGRIN ALPHA-V
(Homo
sapiens)		5 / 12ASP A  24
LEU A  37
TYR A  11
ILE A 414
SER A  62
None
0.97A20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_A_ROFA101_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		5ohj CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		11 / 12TYR A 405
HIS A 406
ASP A 564
LEU A 565
PRO A 568
TYR A 575
TRP A 578
ILE A 582
PHE A 586
SER A 614
PHE A 618
None
None
ZN  A 699 ( 2.6A)
9VE  A 801 (-4.7A)
9VE  A 801 (-3.9A)
9VE  A 801 (-4.6A)
None
9VE  A 801 (-4.1A)
9VE  A 801 (-3.6A)
9VE  A 801 (-4.7A)
9VE  A 801 (-3.9A)
0.26Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_A_ROFA101_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		5ohj CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		8 / 12TYR A 405
LEU A 565
PRO A 568
TYR A 575
TRP A 578
ILE A 582
MET A 603
PHE A 618
None
9VE  A 801 (-4.7A)
9VE  A 801 (-3.9A)
9VE  A 801 (-4.6A)
None
9VE  A 801 (-4.1A)
9VE  A 801 (-3.6A)
9VE  A 801 (-3.9A)
0.67Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_A_ROFA101_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		5u09 CANNABINOID RECEPTOR
1,GLGA GLYCOGEN
SYNTHASE
(Homo
sapiens;
Pyrococcus
abyssi)		5 / 12LEU A 341
TYR A 294
ILE A 348
SER A 206
PHE A 155
None
1.21A20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_A_ROFA101_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		5wh6 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		11 / 12TYR A 159
HIS A 160
ASP A 318
LEU A 319
PRO A 322
TYR A 329
TRP A 332
ILE A 336
MET A 357
SER A 368
PHE A 372
AKJ  A 601 ( 4.7A)
None
ZN  A 602 (-2.5A)
AKJ  A 601 ( 4.6A)
AKJ  A 601 (-3.9A)
AKJ  A 601 (-4.8A)
None
AKJ  A 601 (-3.8A)
AKJ  A 601 (-3.4A)
AKJ  A 601 (-2.5A)
AKJ  A 601 (-4.1A)
0.67Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_A_ROFA101_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		5wh6 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		10 / 12TYR A 159
HIS A 160
ASP A 318
LEU A 319
PRO A 322
TYR A 329
TRP A 332
ILE A 336
PHE A 340
PHE A 372
AKJ  A 601 ( 4.7A)
None
ZN  A 602 (-2.5A)
AKJ  A 601 ( 4.6A)
AKJ  A 601 (-3.9A)
AKJ  A 601 (-4.8A)
None
AKJ  A 601 (-3.8A)
AKJ  A 601 (-4.5A)
AKJ  A 601 (-4.1A)
0.39Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_A_ROFA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		1b4j ANTIBODY
(Homo
sapiens)		4 / 5ASN L   1
THR L  97
MET L   4
GLN L  90
None
1.46A19.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XMU_A_ROFA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		2qyk CYCLIC AMP-SPECIFIC
PHOSPHODIESTERASE
HSPDE4A10
(Homo
sapiens)		5 / 5MET A 485
ASN A 533
THR A 545
MET A 549
GLN A 581
None
NPV  A   3 (-4.4A)
NPV  A   3 ( 4.7A)
NPV  A   3 ( 4.7A)
NPV  A   3 (-3.1A)
0.21A87.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XMU_A_ROFA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		5 / 5MET A 439
ASN A 487
THR A 499
MET A 503
GLN A 535
D71  A 901 ( 4.0A)
D71  A 901 (-4.5A)
D71  A 901 (-3.6A)
D71  A 901 (-3.6A)
D71  A 901 (-3.1A)
0.55A66.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XMU_A_ROFA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		3o57 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		5 / 5MET A 347
ASN A 395
THR A 407
MET A 411
GLN A 443
ZG2  A 506 (-3.9A)
ZG2  A 506 (-4.3A)
ZG2  A 506 (-4.3A)
None
ZG2  A 506 (-3.3A)
0.23A93.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XMU_A_ROFA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		5 / 5MET A 273
ASN A 321
THR A 333
MET A 337
GLN A 369
MET  A 273 (-0.0A)
ASN  A 321 (-0.6A)
THR  A 333 ( 0.8A)
MET  A 337 ( 0.0A)
GLN  A 369 (-0.6A)
0.26A84.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XMU_A_ROFA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		5 / 5MET A 519
ASN A 567
THR A 579
MET A 583
GLN A 615
None
0.42A61.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_A_ROFA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		5ohj CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		5 / 5MET A 519
ASN A 567
THR A 579
MET A 583
GLN A 615
9VE  A 801 (-3.8A)
9VE  A 801 (-4.1A)
9VE  A 801 (-4.1A)
9VE  A 801 ( 4.0A)
9VE  A 801 (-3.2A)
0.28Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_A_ROFA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		5wh6 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		5 / 5MET A 273
ASN A 321
THR A 333
MET A 337
GLN A 369
AKJ  A 601 ( 3.9A)
AKJ  A 601 (-4.3A)
AKJ  A 601 (-4.1A)
AKJ  A 601 ( 3.7A)
AKJ  A 601 (-3.0A)
0.23Aundetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XMU_B_ROFB102_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B
(Homo
sapiens)		7 / 12TYR A 736
HIS A 737
ASP A 937
PRO A 941
TRP A 951
ILE A 955
PHE A 959
IBM  A2111 (-4.5A)
IBM  A2111 ( 4.8A)
MG  A2123 (-2.5A)
None
None
IBM  A2111 (-4.2A)
None
0.48A30.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XMU_B_ROFB102_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens)		6 / 12TYR A 211
HIS A 212
ASP A 362
PRO A 366
TRP A 376
PHE A 384
IBM  A 503 (-4.6A)
None
ZN  A 501 (-2.5A)
None
None
IBM  A 503 (-4.5A)
0.24A34.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XMU_B_ROFB102_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		2qyk CYCLIC AMP-SPECIFIC
PHOSPHODIESTERASE
HSPDE4A10
(Homo
sapiens)		12 / 12TYR A 371
HIS A 372
MET A 485
ASP A 530
LEU A 531
PRO A 534
TYR A 541
TRP A 544
ILE A 548
PHE A 552
MET A 569
SER A 580
NPV  A   3 (-4.4A)
NPV  A   3 (-4.6A)
None
ZN  A   1 (-2.5A)
None
None
None
None
NPV  A   3 (-3.8A)
NPV  A   3 (-4.8A)
NPV  A   3 (-3.1A)
NPV  A   3 (-4.5A)
0.45A87.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XMU_B_ROFB102_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		2qym PHOSPHODIESTERASE 4C
(Homo
sapiens)		9 / 12TYR A 281
HIS A 282
MET A 395
ASP A 440
LEU A 441
PRO A 444
TYR A 451
TRP A 454
ILE A 458
None
None
None
ZN  A   1 (-2.5A)
None
None
None
None
None
0.54A75.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_B_ROFB102_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens)		5 / 12TYR A 612
HIS A 613
ASP A 764
LEU A 765
PHE A 786
VDN  A   1 (-4.8A)
VDN  A   1 (-4.3A)
None
VDN  A   1 ( 4.7A)
None
0.73A28.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_B_ROFB102_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens)		5 / 12TYR A 612
HIS A 613
ASP A 764
LEU A 765
PHE A 786
None
MG  A 877 (-4.4A)
ZN  A 876 (-2.5A)
WAN  A 901 ( 4.7A)
WAN  A 901 (-4.8A)
0.57A17.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XMU_B_ROFB102_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A
(Homo
sapiens)		8 / 12TYR A 555
HIS A 556
MET A 670
ASP A 726
PRO A 730
TRP A 740
ILE A 744
SER A 777
None
None
IBM  A   3 (-4.5A)
ZN  A   1 (-2.6A)
None
None
IBM  A   3 (-4.3A)
None
0.38A34.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XMU_B_ROFB102_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		5 / 12ASP A 484
LEU A 485
PRO A 488
TYR A 495
PHE A 196
 ZN  A 801 (-2.6A)
None
None
None
D71  A 901 (-3.9A)
1.13A66.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XMU_B_ROFB102_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		6 / 12MET A 439
ASP A 484
LEU A 485
ILE A 502
PHE A 506
SER A 534
D71  A 901 ( 4.0A)
ZN  A 801 (-2.6A)
None
D71  A 901 (-4.1A)
D71  A 901 (-4.8A)
D71  A 901 (-3.4A)
0.93A66.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XMU_B_ROFB102_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		7 / 12MET A 439
ASP A 484
LEU A 485
PRO A 488
TYR A 495
ILE A 502
PHE A 506
D71  A 901 ( 4.0A)
ZN  A 801 (-2.6A)
None
None
None
D71  A 901 (-4.1A)
D71  A 901 (-4.8A)
0.61A66.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XMU_B_ROFB102_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		7 / 12TYR A 325
HIS A 326
ASP A 484
ILE A 502
PHE A 506
MET A 523
SER A 534
None
D71  A 901 (-4.5A)
ZN  A 801 (-2.6A)
D71  A 901 (-4.1A)
D71  A 901 (-4.8A)
D71  A 901 ( 4.0A)
D71  A 901 (-3.4A)
1.05A66.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XMU_B_ROFB102_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		7 / 12TYR A 325
HIS A 326
ASP A 484
LEU A 485
ILE A 502
PHE A 506
SER A 534
None
D71  A 901 (-4.5A)
ZN  A 801 (-2.6A)
None
D71  A 901 (-4.1A)
D71  A 901 (-4.8A)
D71  A 901 (-3.4A)
0.65A66.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XMU_B_ROFB102_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		9 / 12TYR A 325
HIS A 326
ASP A 484
LEU A 485
PRO A 488
TYR A 495
TRP A 498
ILE A 502
PHE A 506
None
D71  A 901 (-4.5A)
ZN  A 801 (-2.6A)
None
None
None
None
D71  A 901 (-4.1A)
D71  A 901 (-4.8A)
0.28A66.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XMU_B_ROFB102_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		9 / 12TYR A 325
HIS A 326
ASP A 484
PRO A 488
TYR A 495
TRP A 498
ILE A 502
PHE A 506
MET A 523
None
D71  A 901 (-4.5A)
ZN  A 801 (-2.6A)
None
None
None
D71  A 901 (-4.1A)
D71  A 901 (-4.8A)
D71  A 901 ( 4.0A)
0.69A66.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_B_ROFB102_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens)		5 / 12TYR A 655
HIS A 656
ASP A 808
LEU A 809
ILE A 826
None
None
ZN  A   1 (-2.7A)
None
None
0.68A19.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XMU_B_ROFB102_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		3o57 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		12 / 12TYR A 233
HIS A 234
MET A 347
ASP A 392
LEU A 393
PRO A 396
TYR A 403
TRP A 406
ILE A 410
PHE A 414
MET A 431
SER A 442
None
None
ZG2  A 506 (-3.9A)
ZN  A   1 (-2.6A)
None
ZG2  A 506 ( 4.5A)
None
None
ZG2  A 506 (-4.4A)
ZG2  A 506 (-4.4A)
ZG2  A 506 (-3.4A)
None
0.39A93.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XMU_B_ROFB102_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		12 / 12TYR A 159
HIS A 160
MET A 273
ASP A 318
LEU A 319
PRO A 322
TYR A 329
TRP A 332
ILE A 336
PHE A 340
MET A 357
SER A 368
TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
MET  A 273 (-0.0A)
ASP  A 318 (-0.5A)
LEU  A 319 ( 0.6A)
PRO  A 322 (-1.1A)
TYR  A 329 (-1.3A)
TRP  A 332 ( 0.5A)
ILE  A 336 ( 0.4A)
PHE  A 340 (-1.3A)
MET  A 357 (-0.0A)
SER  A 368 (-0.0A)
0.44A84.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_B_ROFB102_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		3ui7 CAMP AND
CAMP-INHIBITED CGMP
3',5'-CYCLIC
PHOSPHODIESTERASE
10A
(Homo
sapiens)		6 / 12TYR A 524
HIS A 525
ASP A 674
LEU A 675
ILE A 692
PHE A 696
C1L  A   1 ( 4.8A)
C1L  A   1 (-4.1A)
ZN  A 772 (-2.4A)
C1L  A   1 (-4.3A)
C1L  A   1 (-4.3A)
C1L  A   1 ( 4.7A)
0.58A27.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_B_ROFB102_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		3ui7 CAMP AND
CAMP-INHIBITED CGMP
3',5'-CYCLIC
PHOSPHODIESTERASE
10A
(Homo
sapiens)		5 / 12TYR A 524
HIS A 525
LEU A 635
ILE A 692
PHE A 696
C1L  A   1 ( 4.8A)
C1L  A   1 (-4.1A)
None
C1L  A   1 (-4.3A)
C1L  A   1 ( 4.7A)
1.49A27.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_B_ROFB102_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		4dy0 GLIA-DERIVED NEXIN
(Homo
sapiens)		5 / 12ASP A 284
LEU A 321
ILE A 155
PHE A 124
SER A 133
None
1.25A24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_B_ROFB102_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens)		6 / 12TYR A 655
HIS A 656
ASP A 808
LEU A 809
ILE A 826
PHE A 830
None
None
ZN  A1001 (-2.5A)
None
None
None
0.54A27.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_B_ROFB102_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		4um8 INTEGRIN ALPHA-V
(Homo
sapiens)		5 / 12ASP A  24
LEU A  37
TYR A  11
ILE A 414
SER A  62
None
1.16A19.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XMU_B_ROFB102_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		10 / 12TYR A 405
HIS A 406
ASP A 564
PRO A 568
TYR A 575
TRP A 578
ILE A 582
PHE A 586
MET A 603
SER A 614
None
MG  A 804 ( 4.9A)
ZN  A 801 (-2.5A)
None
None
None
None
None
None
None
1.03A61.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XMU_B_ROFB102_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		11 / 12TYR A 405
HIS A 406
MET A 519
ASP A 564
LEU A 565
PRO A 568
TYR A 575
TRP A 578
ILE A 582
PHE A 586
SER A 614
None
MG  A 804 ( 4.9A)
None
ZN  A 801 (-2.5A)
None
None
None
None
None
None
None
0.67A61.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XMU_B_ROFB102_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		5b25 CALCIUM/CALMODULIN-D
EPENDENT
3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 1B
(Homo
sapiens)		8 / 12TYR A 222
HIS A 223
MET A 336
ASP A 370
PRO A 374
TRP A 384
PHE A 392
SER A 420
None
4QJ  A 603 ( 4.9A)
4QJ  A 603 ( 3.9A)
ZN  A 601 (-2.5A)
None
None
GOL  A 607 (-3.9A)
4QJ  A 603 (-4.7A)
0.52A35.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_B_ROFB102_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		5neu INTEGRIN ALPHA-V
(Homo
sapiens)		5 / 12ASP A  24
LEU A  37
TYR A  11
ILE A 414
SER A  62
None
0.98A20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_B_ROFB102_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		5ohj CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		11 / 12TYR A 405
HIS A 406
MET A 519
ASP A 564
LEU A 565
PRO A 568
TYR A 575
TRP A 578
ILE A 582
PHE A 586
SER A 614
None
None
9VE  A 801 (-3.8A)
ZN  A 699 ( 2.6A)
9VE  A 801 (-4.7A)
9VE  A 801 (-3.9A)
9VE  A 801 (-4.6A)
None
9VE  A 801 (-4.1A)
9VE  A 801 (-3.6A)
9VE  A 801 (-4.7A)
0.30Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_B_ROFB102_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		5ohj CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		10 / 12TYR A 405
MET A 519
ASP A 564
LEU A 565
PRO A 568
TYR A 575
TRP A 578
ILE A 582
MET A 603
SER A 614
None
9VE  A 801 (-3.8A)
ZN  A 699 ( 2.6A)
9VE  A 801 (-4.7A)
9VE  A 801 (-3.9A)
9VE  A 801 (-4.6A)
None
9VE  A 801 (-4.1A)
9VE  A 801 (-3.6A)
9VE  A 801 (-4.7A)
0.65Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_B_ROFB102_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		5wh6 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		11 / 12TYR A 159
HIS A 160
MET A 273
ASP A 318
LEU A 319
PRO A 322
TYR A 329
TRP A 332
ILE A 336
MET A 357
SER A 368
AKJ  A 601 ( 4.7A)
None
AKJ  A 601 ( 3.9A)
ZN  A 602 (-2.5A)
AKJ  A 601 ( 4.6A)
AKJ  A 601 (-3.9A)
AKJ  A 601 (-4.8A)
None
AKJ  A 601 (-3.8A)
AKJ  A 601 (-3.4A)
AKJ  A 601 (-2.5A)
0.65Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_B_ROFB102_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		5wh6 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		10 / 12TYR A 159
HIS A 160
MET A 273
ASP A 318
LEU A 319
PRO A 322
TYR A 329
TRP A 332
ILE A 336
PHE A 340
AKJ  A 601 ( 4.7A)
None
AKJ  A 601 ( 3.9A)
ZN  A 602 (-2.5A)
AKJ  A 601 ( 4.6A)
AKJ  A 601 (-3.9A)
AKJ  A 601 (-4.8A)
None
AKJ  A 601 (-3.8A)
AKJ  A 601 (-4.5A)
0.37Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_B_ROFB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		1b4j ANTIBODY
(Homo
sapiens)		4 / 5ASN L   1
THR L  97
MET L   4
GLN L  90
None
1.48A19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_B_ROFB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		2a30 DEOXYCYTIDINE KINASE
(Homo
sapiens)		4 / 5ASN A 140
MET A  85
GLN A  97
PHE A 137
None
DCZ  A 302 ( 4.3A)
DCZ  A 302 (-3.2A)
DCZ  A 302 (-3.8A)
1.32A19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_B_ROFB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		2ocp DEOXYGUANOSINE
KINASE
(Homo
sapiens)		4 / 5ASN A 154
MET A  99
GLN A 111
PHE A 151
None
DTP  A 301 ( 3.9A)
DTP  A 301 (-2.9A)
DTP  A 301 (-3.3A)
1.48A21.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XMU_B_ROFB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		2qyk CYCLIC AMP-SPECIFIC
PHOSPHODIESTERASE
HSPDE4A10
(Homo
sapiens)		5 / 5ASN A 533
THR A 545
MET A 549
GLN A 581
PHE A 584
NPV  A   3 (-4.4A)
NPV  A   3 ( 4.7A)
NPV  A   3 ( 4.7A)
NPV  A   3 (-3.1A)
NPV  A   3 (-3.3A)
0.26A87.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XMU_B_ROFB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		5 / 5ASN A 487
THR A 499
MET A 503
GLN A 535
PHE A 538
D71  A 901 (-4.5A)
D71  A 901 (-3.6A)
D71  A 901 (-3.6A)
D71  A 901 (-3.1A)
D71  A 901 (-3.9A)
0.34A66.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XMU_B_ROFB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		3o57 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		5 / 5ASN A 395
THR A 407
MET A 411
GLN A 443
PHE A 446
ZG2  A 506 (-4.3A)
ZG2  A 506 (-4.3A)
None
ZG2  A 506 (-3.3A)
ZG2  A 506 (-3.6A)
0.56A93.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XMU_B_ROFB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		5 / 5ASN A 321
THR A 333
MET A 337
GLN A 369
PHE A 372
ASN  A 321 (-0.6A)
THR  A 333 ( 0.8A)
MET  A 337 ( 0.0A)
GLN  A 369 (-0.6A)
PHE  A 372 (-1.3A)
0.51A84.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_B_ROFB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		3ue2 POLY(U)-BINDING-SPLI
CING FACTOR PUF60
(Homo
sapiens)		4 / 5ASN A 494
THR A 462
GLN A 549
PHE A 552
None
1.48A14.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XMU_B_ROFB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		5 / 5ASN A 567
THR A 579
MET A 583
GLN A 615
PHE A 618
None
0.29A61.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_B_ROFB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		5ohj CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		5 / 5ASN A 567
THR A 579
MET A 583
GLN A 615
PHE A 618
9VE  A 801 (-4.1A)
9VE  A 801 (-4.1A)
9VE  A 801 ( 4.0A)
9VE  A 801 (-3.2A)
9VE  A 801 (-3.9A)
0.15Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_B_ROFB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		5wh6 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		5 / 5ASN A 321
THR A 333
MET A 337
GLN A 369
PHE A 372
AKJ  A 601 (-4.3A)
AKJ  A 601 (-4.1A)
AKJ  A 601 ( 3.7A)
AKJ  A 601 (-3.0A)
AKJ  A 601 (-4.1A)
0.18Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_B_ROFB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		6d6q EXOSOME COMPLEX
EXONUCLEASE RRP44
(Homo
sapiens)		4 / 5ASN K 419
THR K 392
GLN K 389
PHE K 416
None
1.31Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		1je6 MHC CLASS I
CHAIN-RELATED
PROTEIN
(Homo
sapiens)		5 / 12HIS A 156
ASP A  72
LEU A  73
THR A 143
PHE A 110
None
1.28A21.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B
(Homo
sapiens)		5 / 12HIS A 737
ASP A 937
PRO A 941
SER A 990
PHE A 991
IBM  A2111 ( 4.8A)
MG  A2123 (-2.5A)
None
None
IBM  A2111 (-3.6A)
1.24A31.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B
(Homo
sapiens)		7 / 12TYR A 736
HIS A 737
ASP A 937
PRO A 941
THR A 952
ILE A 955
PHE A 991
IBM  A2111 (-4.5A)
IBM  A2111 ( 4.8A)
MG  A2123 (-2.5A)
None
IBM  A2111 ( 4.8A)
IBM  A2111 (-4.2A)
IBM  A2111 (-3.6A)
0.52A31.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		1um1 KIAA1849 PROTEIN
(Homo
sapiens)		5 / 12ASP A  27
LEU A  38
THR A  99
ILE A 103
SER A  56
None
1.49A15.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens)		5 / 12TYR A 211
HIS A 212
ASP A 362
PRO A 366
PHE A 416
IBM  A 503 (-4.6A)
None
ZN  A 501 (-2.5A)
None
IBM  A 503 (-3.4A)
0.37A33.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		2h18 ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
8A
(Homo
sapiens)		5 / 12LEU A 128
THR A  24
ILE A  67
MET A  21
SER A  90
None
1.27A24.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		2qyk CYCLIC AMP-SPECIFIC
PHOSPHODIESTERASE
HSPDE4A10
(Homo
sapiens)		12 / 12TYR A 371
HIS A 372
MET A 485
ASP A 530
LEU A 531
PRO A 534
TYR A 541
THR A 545
ILE A 548
MET A 569
SER A 580
PHE A 584
NPV  A   3 (-4.4A)
NPV  A   3 (-4.6A)
None
ZN  A   1 (-2.5A)
None
None
None
NPV  A   3 ( 4.7A)
NPV  A   3 (-3.8A)
NPV  A   3 (-3.1A)
NPV  A   3 (-4.5A)
NPV  A   3 (-3.3A)
0.52A82.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		2qym PHOSPHODIESTERASE 4C
(Homo
sapiens)		10 / 12TYR A 281
HIS A 282
MET A 395
ASP A 440
LEU A 441
PRO A 444
TYR A 451
THR A 455
ILE A 458
PHE A 494
None
None
None
ZN  A   1 (-2.5A)
None
None
None
None
None
None
0.60A82.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3a98 DEDICATOR OF
CYTOKINESIS PROTEIN
2
(Homo
sapiens)		5 / 12ASP A 162
LEU A 163
THR A 149
ILE A 152
MET A 120
None
1.50A20.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens)		5 / 12TYR A 612
HIS A 613
ASP A 764
LEU A 765
PHE A 820
VDN  A   1 (-4.8A)
VDN  A   1 (-4.3A)
None
VDN  A   1 ( 4.7A)
VDN  A   1 (-3.6A)
0.67A31.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens)		5 / 12TYR A 612
HIS A 613
ASP A 764
LEU A 765
PHE A 820
None
MG  A 877 (-4.4A)
ZN  A 876 (-2.5A)
WAN  A 901 ( 4.7A)
WAN  A 901 (-3.7A)
0.65A17.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A
(Homo
sapiens)		5 / 12MET A 670
ASP A 726
PRO A 730
SER A 780
PHE A 781
IBM  A   3 (-4.5A)
ZN  A   1 (-2.6A)
None
None
IBM  A   3 (-3.5A)
1.12A33.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A
(Homo
sapiens)		8 / 12TYR A 555
HIS A 556
MET A 670
ASP A 726
PRO A 730
ILE A 744
SER A 777
PHE A 781
None
None
IBM  A   3 (-4.5A)
ZN  A   1 (-2.6A)
None
IBM  A   3 (-4.3A)
None
IBM  A   3 (-3.5A)
0.41A33.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		7 / 12HIS A 326
MET A 439
ASP A 484
LEU A 485
MET A 523
SER A 534
PHE A 538
D71  A 901 (-4.5A)
D71  A 901 ( 4.0A)
ZN  A 801 (-2.6A)
None
D71  A 901 ( 4.0A)
D71  A 901 (-3.4A)
D71  A 901 (-3.9A)
0.98A81.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		5 / 12HIS A 330
MET A 439
LEU A 485
MET A 503
PHE A 538
 ZN  A 801 (-3.4A)
D71  A 901 ( 4.0A)
None
D71  A 901 (-3.6A)
D71  A 901 (-3.9A)
1.21A81.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		5 / 12HIS A 330
MET A 439
LEU A 485
SER A 534
PHE A 538
 ZN  A 801 (-3.4A)
D71  A 901 ( 4.0A)
None
D71  A 901 (-3.4A)
D71  A 901 (-3.9A)
1.22A81.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		5 / 12MET A 439
ASP A 484
LEU A 485
MET A 503
PHE A 538
D71  A 901 ( 4.0A)
ZN  A 801 (-2.6A)
None
D71  A 901 (-3.6A)
D71  A 901 (-3.9A)
1.40A81.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		11 / 12TYR A 325
HIS A 326
MET A 439
ASP A 484
LEU A 485
PRO A 488
TYR A 495
THR A 499
ILE A 502
MET A 523
PHE A 538
None
D71  A 901 (-4.5A)
D71  A 901 ( 4.0A)
ZN  A 801 (-2.6A)
None
None
None
D71  A 901 (-3.6A)
D71  A 901 (-4.1A)
D71  A 901 ( 4.0A)
D71  A 901 (-3.9A)
0.67A81.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3hoc FILAMIN-A
(Homo
sapiens)		5 / 12LEU A 172
THR A 186
ILE A 185
SER A 189
PHE A 188
None
1.34A23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens)		6 / 12TYR A 655
HIS A 656
ASP A 808
LEU A 809
ILE A 826
PHE A 862
None
None
ZN  A   1 (-2.7A)
None
None
None
0.95A18.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3o57 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		12 / 12TYR A 233
HIS A 234
MET A 347
ASP A 392
LEU A 393
PRO A 396
TYR A 403
THR A 407
ILE A 410
MET A 431
SER A 442
PHE A 446
None
None
ZG2  A 506 (-3.9A)
ZN  A   1 (-2.6A)
None
ZG2  A 506 ( 4.5A)
None
ZG2  A 506 (-4.3A)
ZG2  A 506 (-4.4A)
ZG2  A 506 (-3.4A)
None
ZG2  A 506 (-3.6A)
0.59A82.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3puc TITIN
(Homo
sapiens)		5 / 12TYR A  53
ASP A  73
LEU A  94
THR A  41
ILE A  47
None
1.42A13.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		11 / 12TYR A 159
HIS A 160
MET A 273
ASP A 318
LEU A 319
PRO A 322
TYR A 329
THR A 333
ILE A 336
MET A 357
SER A 368
TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
MET  A 273 (-0.0A)
ASP  A 318 (-0.5A)
LEU  A 319 ( 0.6A)
PRO  A 322 (-1.1A)
TYR  A 329 (-1.3A)
THR  A 333 ( 0.8A)
ILE  A 336 ( 0.4A)
MET  A 357 (-0.0A)
SER  A 368 (-0.0A)
0.54A94.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		11 / 12TYR A 159
HIS A 160
MET A 273
ASP A 318
LEU A 319
PRO A 322
TYR A 329
THR A 333
ILE A 336
SER A 368
PHE A 372
TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
MET  A 273 (-0.0A)
ASP  A 318 (-0.5A)
LEU  A 319 ( 0.6A)
PRO  A 322 (-1.1A)
TYR  A 329 (-1.3A)
THR  A 333 ( 0.8A)
ILE  A 336 ( 0.4A)
SER  A 368 (-0.0A)
PHE  A 372 (-1.3A)
0.52A94.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3ui7 CAMP AND
CAMP-INHIBITED CGMP
3',5'-CYCLIC
PHOSPHODIESTERASE
10A
(Homo
sapiens)		6 / 12TYR A 524
HIS A 525
ASP A 674
LEU A 675
ILE A 692
PHE A 729
C1L  A   1 ( 4.8A)
C1L  A   1 (-4.1A)
ZN  A 772 (-2.4A)
C1L  A   1 (-4.3A)
C1L  A   1 (-4.3A)
C1L  A   1 (-3.5A)
0.87A28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3ui7 CAMP AND
CAMP-INHIBITED CGMP
3',5'-CYCLIC
PHOSPHODIESTERASE
10A
(Homo
sapiens)		5 / 12TYR A 524
HIS A 525
LEU A 635
ILE A 692
PHE A 729
C1L  A   1 ( 4.8A)
C1L  A   1 (-4.1A)
None
C1L  A   1 (-4.3A)
C1L  A   1 (-3.5A)
1.44A28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens)		6 / 12TYR A 655
HIS A 656
ASP A 808
LEU A 809
ILE A 826
PHE A 862
None
None
ZN  A1001 (-2.5A)
None
None
None
0.64A28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		4um8 INTEGRIN ALPHA-V
(Homo
sapiens)		5 / 12ASP A  24
LEU A  37
TYR A  11
ILE A 414
SER A  62
None
1.20A18.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		5 / 12HIS A 410
MET A 519
LEU A 565
MET A 583
PHE A 618
 ZN  A 801 (-3.2A)
None
None
None
None
1.30A48.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		10 / 12TYR A 405
HIS A 406
ASP A 564
LEU A 565
PRO A 568
THR A 579
ILE A 582
MET A 603
SER A 614
PHE A 618
None
MG  A 804 ( 4.9A)
ZN  A 801 (-2.5A)
None
None
None
None
None
None
None
0.78A48.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		10 / 12TYR A 405
HIS A 406
ASP A 564
LEU A 565
PRO A 568
TYR A 575
THR A 579
MET A 603
SER A 614
PHE A 618
None
MG  A 804 ( 4.9A)
ZN  A 801 (-2.5A)
None
None
None
None
None
None
None
0.66A48.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		10 / 12TYR A 405
HIS A 406
MET A 519
ASP A 564
LEU A 565
PRO A 568
THR A 579
ILE A 582
SER A 614
PHE A 618
None
MG  A 804 ( 4.9A)
None
ZN  A 801 (-2.5A)
None
None
None
None
None
None
0.56A48.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		10 / 12TYR A 405
HIS A 406
MET A 519
ASP A 564
LEU A 565
PRO A 568
TYR A 575
THR A 579
SER A 614
PHE A 618
None
MG  A 804 ( 4.9A)
None
ZN  A 801 (-2.5A)
None
None
None
None
None
None
0.38A48.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		4z0x ANTIBODY HC26AM
HEAVY CHAIN VARIABLE
DOMAIN
(Homo
sapiens)		5 / 12HIS B  54
LEU B 126
TYR B 131
THR B  60
ILE B  59
None
1.16A16.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		5b25 CALCIUM/CALMODULIN-D
EPENDENT
3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 1B
(Homo
sapiens)		8 / 12TYR A 222
HIS A 223
MET A 336
ASP A 370
PRO A 374
THR A 385
SER A 420
PHE A 424
None
4QJ  A 603 ( 4.9A)
4QJ  A 603 ( 3.9A)
ZN  A 601 (-2.5A)
None
None
4QJ  A 603 (-4.7A)
4QJ  A 603 (-3.5A)
0.44A38.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		5neu INTEGRIN ALPHA-V
(Homo
sapiens)		5 / 12ASP A  24
LEU A  37
TYR A  11
ILE A 414
SER A  62
None
0.97A20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		5ohj CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		11 / 12TYR A 405
HIS A 406
MET A 519
ASP A 564
LEU A 565
PRO A 568
TYR A 575
THR A 579
ILE A 582
SER A 614
PHE A 618
None
None
9VE  A 801 (-3.8A)
ZN  A 699 ( 2.6A)
9VE  A 801 (-4.7A)
9VE  A 801 (-3.9A)
9VE  A 801 (-4.6A)
9VE  A 801 (-4.1A)
9VE  A 801 (-4.1A)
9VE  A 801 (-4.7A)
9VE  A 801 (-3.9A)
0.25Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		5ohj CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		9 / 12TYR A 405
LEU A 565
PRO A 568
TYR A 575
THR A 579
ILE A 582
MET A 603
SER A 614
PHE A 618
None
9VE  A 801 (-4.7A)
9VE  A 801 (-3.9A)
9VE  A 801 (-4.6A)
9VE  A 801 (-4.1A)
9VE  A 801 (-4.1A)
9VE  A 801 (-3.6A)
9VE  A 801 (-4.7A)
9VE  A 801 (-3.9A)
0.56Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		5u09 CANNABINOID RECEPTOR
1,GLGA GLYCOGEN
SYNTHASE
(Homo
sapiens;
Pyrococcus
abyssi)		5 / 12LEU A 341
TYR A 294
ILE A 348
SER A 206
PHE A 155
None
1.24A19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		5wh6 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		7 / 12LEU A 319
PRO A 322
TYR A 329
THR A 333
ILE A 336
MET A 357
SER A 368
AKJ  A 601 ( 4.6A)
AKJ  A 601 (-3.9A)
AKJ  A 601 (-4.8A)
AKJ  A 601 (-4.1A)
AKJ  A 601 (-3.8A)
AKJ  A 601 (-3.4A)
AKJ  A 601 (-2.5A)
0.75Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		5wh6 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		11 / 12TYR A 159
HIS A 160
MET A 273
ASP A 318
LEU A 319
PRO A 322
TYR A 329
THR A 333
ILE A 336
MET A 357
PHE A 372
AKJ  A 601 ( 4.7A)
None
AKJ  A 601 ( 3.9A)
ZN  A 602 (-2.5A)
AKJ  A 601 ( 4.6A)
AKJ  A 601 (-3.9A)
AKJ  A 601 (-4.8A)
AKJ  A 601 (-4.1A)
AKJ  A 601 (-3.8A)
AKJ  A 601 (-3.4A)
AKJ  A 601 (-4.1A)
0.46Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)
(Homo
sapiens)		5 / 12LEU A 832
TYR A 997
THR A1001
SER A 695
PHE A 696
None
1.11Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		1wh0 UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 19
(Homo
sapiens)		3 / 3ASN A  87
TRP A 115
GLN A 111
None
1.43A15.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_A_ROFA502_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens)		3 / 3ASN A 365
TRP A 376
GLN A 413
IBM  A 503 ( 4.7A)
None
IBM  A 503 (-3.0A)
0.20A33.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		2m9a E3 UBIQUITIN-PROTEIN
LIGASE ZFP91
(Homo
sapiens)		3 / 3ASN A  58
TRP A  59
GLN A  53
None
1.08A18.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_A_ROFA502_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		2qyk CYCLIC AMP-SPECIFIC
PHOSPHODIESTERASE
HSPDE4A10
(Homo
sapiens)		3 / 3ASN A 533
TRP A 544
GLN A 581
NPV  A   3 (-4.4A)
None
NPV  A   3 (-3.1A)
0.13A82.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		2z6h CATENIN BETA-1
(Homo
sapiens)		3 / 3ASN A 380
TRP A 338
GLN A 375
None
1.43A19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3c49 POLY(ADP-RIBOSE)
POLYMERASE 3
(Homo
sapiens)		3 / 3ASN A 419
TRP A 383
GLN A 512
None
1.13A21.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_A_ROFA502_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A
(Homo
sapiens)		3 / 3ASN A 729
TRP A 740
GLN A 778
None
None
IBM  A   3 (-3.4A)
0.16A33.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_A_ROFA502_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		3 / 3ASN A 487
TRP A 498
GLN A 535
D71  A 901 (-4.5A)
None
D71  A 901 (-3.1A)
0.37A81.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_A_ROFA502_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3n3z HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A
(Homo
sapiens)		3 / 3ASN A 405
TRP A 416
GLN A 453
IBM  A   1 (-3.5A)
None
IBM  A   1 (-3.5A)
0.86A30.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_A_ROFA502_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3o57 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		3 / 3ASN A 395
TRP A 406
GLN A 443
ZG2  A 506 (-4.3A)
None
ZG2  A 506 (-3.3A)
0.11A82.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3otd TRNA(HIS)
GUANYLYLTRANSFERASE
(Homo
sapiens)		3 / 3ASN A 137
TRP A  23
GLN A 138
None
1.08A22.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_A_ROFA502_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		3 / 3ASN A 321
TRP A 332
GLN A 369
ASN  A 321 (-0.6A)
TRP  A 332 ( 0.5A)
GLN  A 369 (-0.6A)
0.25A94.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		4fme ADP-RIBOSYLATION
FACTOR 6
(Homo
sapiens)		3 / 3ASN C  60
TRP C  62
GLN C  82
None
0.96A19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		4ofe METHYL-CPG-BINDING
DOMAIN PROTEIN 4
(Homo
sapiens)		3 / 3ASN A 551
TRP A 438
GLN A 555
None
1.31A23.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_A_ROFA502_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		3 / 3ASN A 567
TRP A 578
GLN A 615
None
0.15A48.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		4yjz SCFV H2526
(Homo
sapiens)		3 / 3ASN L  97
TRP L  92
GLN L 262
None
1.39A16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		5ohj CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		3 / 3ASN A 567
TRP A 578
GLN A 615
9VE  A 801 (-4.1A)
None
9VE  A 801 (-3.2A)
0.10Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		5w21 KLOTHO
(Homo
sapiens)		3 / 3ASN A 304
TRP A 302
GLN A 388
None
1.44Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		5wh6 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		3 / 3ASN A 321
TRP A 332
GLN A 369
AKJ  A 601 (-4.3A)
None
AKJ  A 601 (-3.0A)
0.04Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		6bbp CYTOHESIN-3,ADP-RIBO
SYLATION FACTOR 6
(Homo
sapiens;
Mus
musculus)		3 / 3ASN A 458
TRP A 460
GLN A 480
None
0.78Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		1je6 MHC CLASS I
CHAIN-RELATED
PROTEIN
(Homo
sapiens)		5 / 12HIS A 156
ASP A  72
LEU A  73
THR A 143
PHE A 110
None
1.30A21.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B
(Homo
sapiens)		5 / 12HIS A 737
ASP A 937
PRO A 941
SER A 990
PHE A 991
IBM  A2111 ( 4.8A)
MG  A2123 (-2.5A)
None
None
IBM  A2111 (-3.6A)
1.25A31.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B
(Homo
sapiens)		8 / 12TYR A 736
HIS A 737
ASP A 937
PRO A 941
TRP A 951
THR A 952
ILE A 955
PHE A 991
IBM  A2111 (-4.5A)
IBM  A2111 ( 4.8A)
MG  A2123 (-2.5A)
None
None
IBM  A2111 ( 4.8A)
IBM  A2111 (-4.2A)
IBM  A2111 (-3.6A)
0.52A31.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		1um1 KIAA1849 PROTEIN
(Homo
sapiens)		5 / 12ASP A  27
LEU A  38
THR A  99
ILE A 103
SER A  56
None
1.48A15.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens)		6 / 12TYR A 211
HIS A 212
ASP A 362
PRO A 366
TRP A 376
PHE A 416
IBM  A 503 (-4.6A)
None
ZN  A 501 (-2.5A)
None
None
IBM  A 503 (-3.4A)
0.36A33.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		2h18 ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
8A
(Homo
sapiens)		5 / 12LEU A 128
THR A  24
ILE A  67
MET A  21
SER A  90
None
1.25A24.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		2qyk CYCLIC AMP-SPECIFIC
PHOSPHODIESTERASE
HSPDE4A10
(Homo
sapiens)		12 / 12TYR A 371
HIS A 372
ASP A 530
LEU A 531
PRO A 534
TYR A 541
TRP A 544
THR A 545
ILE A 548
MET A 569
SER A 580
PHE A 584
NPV  A   3 (-4.4A)
NPV  A   3 (-4.6A)
ZN  A   1 (-2.5A)
None
None
None
None
NPV  A   3 ( 4.7A)
NPV  A   3 (-3.8A)
NPV  A   3 (-3.1A)
NPV  A   3 (-4.5A)
NPV  A   3 (-3.3A)
0.49A82.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		2qym PHOSPHODIESTERASE 4C
(Homo
sapiens)		10 / 12TYR A 281
HIS A 282
ASP A 440
LEU A 441
PRO A 444
TYR A 451
TRP A 454
THR A 455
ILE A 458
PHE A 494
None
None
ZN  A   1 (-2.5A)
None
None
None
None
None
None
None
0.60A82.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens)		5 / 12TYR A 612
HIS A 613
ASP A 764
LEU A 765
PHE A 820
VDN  A   1 (-4.8A)
VDN  A   1 (-4.3A)
None
VDN  A   1 ( 4.7A)
VDN  A   1 (-3.6A)
0.68A31.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens)		5 / 12TYR A 612
HIS A 613
ASP A 764
LEU A 765
PHE A 820
None
MG  A 877 (-4.4A)
ZN  A 876 (-2.5A)
WAN  A 901 ( 4.7A)
WAN  A 901 (-3.7A)
0.67A17.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A
(Homo
sapiens)		8 / 12TYR A 555
HIS A 556
ASP A 726
PRO A 730
TRP A 740
ILE A 744
SER A 777
PHE A 781
None
None
ZN  A   1 (-2.6A)
None
None
IBM  A   3 (-4.3A)
None
IBM  A   3 (-3.5A)
0.37A33.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		6 / 12HIS A 326
ASP A 484
LEU A 485
MET A 523
SER A 534
PHE A 538
D71  A 901 (-4.5A)
ZN  A 801 (-2.6A)
None
D71  A 901 ( 4.0A)
D71  A 901 (-3.4A)
D71  A 901 (-3.9A)
0.90A81.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		11 / 12TYR A 325
HIS A 326
ASP A 484
LEU A 485
PRO A 488
TYR A 495
TRP A 498
THR A 499
ILE A 502
MET A 523
PHE A 538
None
D71  A 901 (-4.5A)
ZN  A 801 (-2.6A)
None
None
None
None
D71  A 901 (-3.6A)
D71  A 901 (-4.1A)
D71  A 901 ( 4.0A)
D71  A 901 (-3.9A)
0.49A81.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3hoc FILAMIN-A
(Homo
sapiens)		5 / 12LEU A 172
THR A 186
ILE A 185
SER A 189
PHE A 188
None
1.32A23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3hym ANAPHASE-PROMOTING
COMPLEX SUBUNIT
CDC26
CELL DIVISION CYCLE
PROTEIN 16 HOMOLOG
(Homo
sapiens;
Homo
sapiens)		5 / 12LEU A   2
PRO B 335
TRP B 337
SER B 301
PHE B 303
None
1.45A6.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens)		6 / 12TYR A 655
HIS A 656
ASP A 808
LEU A 809
ILE A 826
PHE A 862
None
None
ZN  A   1 (-2.7A)
None
None
None
0.98A18.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3o57 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		12 / 12TYR A 233
HIS A 234
ASP A 392
LEU A 393
PRO A 396
TYR A 403
TRP A 406
THR A 407
ILE A 410
MET A 431
SER A 442
PHE A 446
None
None
ZN  A   1 (-2.6A)
None
ZG2  A 506 ( 4.5A)
None
None
ZG2  A 506 (-4.3A)
ZG2  A 506 (-4.4A)
ZG2  A 506 (-3.4A)
None
ZG2  A 506 (-3.6A)
0.58A82.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		11 / 12TYR A 159
HIS A 160
ASP A 318
LEU A 319
PRO A 322
TYR A 329
TRP A 332
THR A 333
ILE A 336
MET A 357
SER A 368
TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
ASP  A 318 (-0.5A)
LEU  A 319 ( 0.6A)
PRO  A 322 (-1.1A)
TYR  A 329 (-1.3A)
TRP  A 332 ( 0.5A)
THR  A 333 ( 0.8A)
ILE  A 336 ( 0.4A)
MET  A 357 (-0.0A)
SER  A 368 (-0.0A)
0.49A94.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		11 / 12TYR A 159
HIS A 160
ASP A 318
LEU A 319
PRO A 322
TYR A 329
TRP A 332
THR A 333
ILE A 336
SER A 368
PHE A 372
TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
ASP  A 318 (-0.5A)
LEU  A 319 ( 0.6A)
PRO  A 322 (-1.1A)
TYR  A 329 (-1.3A)
TRP  A 332 ( 0.5A)
THR  A 333 ( 0.8A)
ILE  A 336 ( 0.4A)
SER  A 368 (-0.0A)
PHE  A 372 (-1.3A)
0.50A94.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3ui7 CAMP AND
CAMP-INHIBITED CGMP
3',5'-CYCLIC
PHOSPHODIESTERASE
10A
(Homo
sapiens)		6 / 12TYR A 524
HIS A 525
ASP A 674
LEU A 675
ILE A 692
PHE A 729
C1L  A   1 ( 4.8A)
C1L  A   1 (-4.1A)
ZN  A 772 (-2.4A)
C1L  A   1 (-4.3A)
C1L  A   1 (-4.3A)
C1L  A   1 (-3.5A)
0.90A28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3ui7 CAMP AND
CAMP-INHIBITED CGMP
3',5'-CYCLIC
PHOSPHODIESTERASE
10A
(Homo
sapiens)		5 / 12TYR A 524
HIS A 525
LEU A 635
ILE A 692
PHE A 729
C1L  A   1 ( 4.8A)
C1L  A   1 (-4.1A)
None
C1L  A   1 (-4.3A)
C1L  A   1 (-3.5A)
1.46A28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens)		6 / 12TYR A 655
HIS A 656
ASP A 808
LEU A 809
ILE A 826
PHE A 862
None
None
ZN  A1001 (-2.5A)
None
None
None
0.66A28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens)		5 / 12TYR A 655
LEU A 809
ILE A 826
MET A 847
PHE A 862
None
1.11A28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		4um8 INTEGRIN ALPHA-V
(Homo
sapiens)		5 / 12ASP A  24
LEU A  37
TYR A  11
ILE A 414
SER A  62
None
1.18A18.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		11 / 12TYR A 405
HIS A 406
ASP A 564
LEU A 565
PRO A 568
TRP A 578
THR A 579
ILE A 582
MET A 603
SER A 614
PHE A 618
None
MG  A 804 ( 4.9A)
ZN  A 801 (-2.5A)
None
None
None
None
None
None
None
None
0.73A48.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		11 / 12TYR A 405
HIS A 406
ASP A 564
LEU A 565
PRO A 568
TYR A 575
TRP A 578
THR A 579
MET A 603
SER A 614
PHE A 618
None
MG  A 804 ( 4.9A)
ZN  A 801 (-2.5A)
None
None
None
None
None
None
None
None
0.61A48.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		4yge MULTIPLE COAGULATION
FACTOR DEFICIENCY
PROTEIN 2
(Homo
sapiens)		5 / 12ASP B  89
LEU B  91
THR B  98
ILE B  97
SER B 113
 CA  B 502 ( 4.7A)
None
None
None
None
1.47A20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		4z0x ANTIBODY HC26AM
HEAVY CHAIN VARIABLE
DOMAIN
(Homo
sapiens)		5 / 12HIS B  54
LEU B 126
TYR B 131
THR B  60
ILE B  59
None
1.14A16.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		5b25 CALCIUM/CALMODULIN-D
EPENDENT
3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 1B
(Homo
sapiens)		8 / 12TYR A 222
HIS A 223
ASP A 370
PRO A 374
TRP A 384
THR A 385
SER A 420
PHE A 424
None
4QJ  A 603 ( 4.9A)
ZN  A 601 (-2.5A)
None
None
None
4QJ  A 603 (-4.7A)
4QJ  A 603 (-3.5A)
0.47A38.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		5dc4 AS25 MONOBODY
(Homo
sapiens)		5 / 12PRO B  27
TRP B  24
THR B   8
ILE B  89
SER B   4
None
1.35A15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		5in7 NEURONAL MIGRATION
PROTEIN DOUBLECORTIN
(Homo
sapiens)		5 / 12ASP A 167
LEU A 164
ILE A 149
SER A 205
PHE A 138
None
1.35A15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		5neu INTEGRIN ALPHA-V
(Homo
sapiens)		5 / 12ASP A  24
LEU A  37
TYR A  11
ILE A 414
SER A  62
None
0.96A20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		5ohj CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		11 / 12TYR A 405
HIS A 406
ASP A 564
LEU A 565
PRO A 568
TYR A 575
TRP A 578
THR A 579
ILE A 582
SER A 614
PHE A 618
None
None
ZN  A 699 ( 2.6A)
9VE  A 801 (-4.7A)
9VE  A 801 (-3.9A)
9VE  A 801 (-4.6A)
None
9VE  A 801 (-4.1A)
9VE  A 801 (-4.1A)
9VE  A 801 (-4.7A)
9VE  A 801 (-3.9A)
0.15Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		5ohj CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		9 / 12TYR A 405
LEU A 565
PRO A 568
TYR A 575
TRP A 578
THR A 579
ILE A 582
MET A 603
PHE A 618
None
9VE  A 801 (-4.7A)
9VE  A 801 (-3.9A)
9VE  A 801 (-4.6A)
None
9VE  A 801 (-4.1A)
9VE  A 801 (-4.1A)
9VE  A 801 (-3.6A)
9VE  A 801 (-3.9A)
0.55Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		5u09 CANNABINOID RECEPTOR
1,GLGA GLYCOGEN
SYNTHASE
(Homo
sapiens;
Pyrococcus
abyssi)		5 / 12LEU A 341
TYR A 294
ILE A 348
SER A 206
PHE A 155
None
1.24A19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		5wh6 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		9 / 12HIS A 160
LEU A 319
PRO A 322
TYR A 329
TRP A 332
THR A 333
ILE A 336
MET A 357
SER A 368
None
AKJ  A 601 ( 4.6A)
AKJ  A 601 (-3.9A)
AKJ  A 601 (-4.8A)
None
AKJ  A 601 (-4.1A)
AKJ  A 601 (-3.8A)
AKJ  A 601 (-3.4A)
AKJ  A 601 (-2.5A)
0.65Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		5wh6 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		11 / 12TYR A 159
HIS A 160
ASP A 318
LEU A 319
PRO A 322
TYR A 329
TRP A 332
THR A 333
ILE A 336
MET A 357
PHE A 372
AKJ  A 601 ( 4.7A)
None
ZN  A 602 (-2.5A)
AKJ  A 601 ( 4.6A)
AKJ  A 601 (-3.9A)
AKJ  A 601 (-4.8A)
None
AKJ  A 601 (-4.1A)
AKJ  A 601 (-3.8A)
AKJ  A 601 (-3.4A)
AKJ  A 601 (-4.1A)
0.42Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)
(Homo
sapiens)		5 / 12LEU A 832
TYR A 997
THR A1001
SER A 695
PHE A 696
None
1.12Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		2cqg TAR DNA-BINDING
PROTEIN-43
(Homo
sapiens)		3 / 3MET A 162
ASN A 179
GLN A 182
None
1.01A14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		2hi8 SULFATASE-MODIFYING
FACTOR 1
(Homo
sapiens)		3 / 3MET X 161
ASN X 259
GLN X 262
None
CA  X1017 (-3.3A)
CA  X1017 (-4.1A)
0.93A18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		2nzt HEXOKINASE-2
(Homo
sapiens)		3 / 3MET A 491
ASN A 683
GLN A 739
None
GLC  A1003 (-3.6A)
GLC  A1003 (-4.3A)
0.82A16.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		2qyk CYCLIC AMP-SPECIFIC
PHOSPHODIESTERASE
HSPDE4A10
(Homo
sapiens)		3 / 3MET A 485
ASN A 533
GLN A 581
None
NPV  A   3 (-4.4A)
NPV  A   3 (-3.1A)
0.32A82.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		2xa7 AP-2 COMPLEX SUBUNIT
BETA
(Homo
sapiens)		3 / 3MET B 110
ASN B  89
GLN B  59
None
1.00A19.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A
(Homo
sapiens)		3 / 3MET A 670
ASN A 729
GLN A 778
IBM  A   3 (-4.5A)
None
IBM  A   3 (-3.4A)
0.34A33.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3fhx PYRIDOXAL KINASE
(Homo
sapiens)		3 / 3MET A 221
ASN A 251
GLN A 205
None
0.97A20.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		3 / 3MET A 439
ASN A 487
GLN A 535
D71  A 901 ( 4.0A)
D71  A 901 (-4.5A)
D71  A 901 (-3.1A)
0.58A81.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3h1v GLUCOKINASE
(Homo
sapiens)		3 / 3MET X  37
ASN X 231
GLN X 287
None
GLC  X 500 (-3.8A)
GLC  X 500 (-4.2A)
0.90A20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3hm8 HEXOKINASE-3
(Homo
sapiens)		3 / 3MET A 504
ASN A 689
GLN A 745
None
GLC  A1001 (-3.8A)
GLC  A1001 (-3.8A)
0.93A23.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3n3z HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A
(Homo
sapiens)		3 / 3MET A 365
ASN A 405
GLN A 453
None
IBM  A   1 (-3.5A)
IBM  A   1 (-3.5A)
0.88A30.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3o57 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		3 / 3MET A 347
ASN A 395
GLN A 443
ZG2  A 506 (-3.9A)
ZG2  A 506 (-4.3A)
ZG2  A 506 (-3.3A)
0.29A82.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		3 / 3MET A 273
ASN A 321
GLN A 369
MET  A 273 (-0.0A)
ASN  A 321 (-0.6A)
GLN  A 369 (-0.6A)
0.31A94.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3v8d CHOLESTEROL
7-ALPHA-MONOOXYGENAS
E
(Homo
sapiens)		3 / 3MET A 435
ASN A  81
GLN A  60
None
SO4  A 603 (-3.7A)
None
0.92A20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		4cyf PANTETHEINASE
(Homo
sapiens)		3 / 3MET A 239
ASN A  86
GLN A 187
None
0.82A20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		4f9o HEXOKINASE-1
(Homo
sapiens)		3 / 3MET A 491
ASN A 683
GLN A 739
None
BGC  A1003 (-3.9A)
BGC  A1003 (-4.4A)
0.78A16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		4jzn ANTI-HCV E2 FAB
HC84-1 HEAVY CHAIN
(Homo
sapiens)		3 / 3MET A  81
ASN A  85
GLN A  65
None
1.05A21.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		3 / 3MET A 519
ASN A 567
GLN A 615
None
0.43A48.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		5epg ALDEHYDE OXIDASE
(Homo
sapiens)		3 / 3MET A 753
ASN A 436
GLN A1235
FES  A3001 (-4.9A)
None
None
1.03A13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		5ls6 HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2,HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2,HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2
POLYCOMB PROTEIN
SUZ12
(Homo
sapiens;
Homo
sapiens)		3 / 3MET A 439
ASN C 651
GLN C 685
None
0.98A18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		5ohj CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		3 / 3MET A 519
ASN A 567
GLN A 615
9VE  A 801 (-3.8A)
9VE  A 801 (-4.1A)
9VE  A 801 (-3.2A)
0.31Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		5wh6 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		3 / 3MET A 273
ASN A 321
GLN A 369
AKJ  A 601 ( 3.9A)
AKJ  A 601 (-4.3A)
AKJ  A 601 (-3.0A)
0.11Aundetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_A_ROFA901_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B
(Homo
sapiens)		5 / 12TYR A 736
HIS A 737
PRO A 941
SER A 990
PHE A 991
IBM  A2111 (-4.5A)
IBM  A2111 ( 4.8A)
None
None
IBM  A2111 (-3.6A)
1.25A32.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_A_ROFA901_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B
(Homo
sapiens)		7 / 12TYR A 736
HIS A 737
PRO A 941
TRP A 951
THR A 952
ILE A 955
PHE A 991
IBM  A2111 (-4.5A)
IBM  A2111 ( 4.8A)
None
None
IBM  A2111 ( 4.8A)
IBM  A2111 (-4.2A)
IBM  A2111 (-3.6A)
0.53A32.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_A_ROFA901_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens)		6 / 12TYR A 211
HIS A 212
ASN A 365
PRO A 366
TRP A 376
PHE A 416
IBM  A 503 (-4.6A)
None
IBM  A 503 ( 4.7A)
None
None
IBM  A 503 (-3.4A)
0.42A33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_A_ROFA901_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		2qyk CYCLIC AMP-SPECIFIC
PHOSPHODIESTERASE
HSPDE4A10
(Homo
sapiens)		12 / 12TYR A 371
HIS A 372
MET A 485
ASN A 533
PRO A 534
TYR A 541
TRP A 544
THR A 545
ILE A 548
MET A 569
SER A 580
PHE A 584
NPV  A   3 (-4.4A)
NPV  A   3 (-4.6A)
None
NPV  A   3 (-4.4A)
None
None
None
NPV  A   3 ( 4.7A)
NPV  A   3 (-3.8A)
NPV  A   3 (-3.1A)
NPV  A   3 (-4.5A)
NPV  A   3 (-3.3A)
0.49A85.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_A_ROFA901_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		2qym PHOSPHODIESTERASE 4C
(Homo
sapiens)		9 / 12TYR A 281
HIS A 282
MET A 395
ASN A 443
PRO A 444
TRP A 454
THR A 455
ILE A 458
PHE A 494
None
0.59A83.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_A_ROFA901_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		2qym PHOSPHODIESTERASE 4C
(Homo
sapiens)		9 / 12TYR A 281
HIS A 282
MET A 395
ASN A 443
PRO A 444
TYR A 451
TRP A 454
THR A 455
PHE A 494
None
0.60A83.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_A_ROFA901_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A
(Homo
sapiens)		5 / 12MET A 670
ASN A 729
PRO A 730
SER A 780
PHE A 781
IBM  A   3 (-4.5A)
None
None
None
IBM  A   3 (-3.5A)
1.01A32.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_A_ROFA901_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A
(Homo
sapiens)		9 / 12TYR A 555
HIS A 556
MET A 670
ASN A 729
PRO A 730
TRP A 740
ILE A 744
SER A 777
PHE A 781
None
None
IBM  A   3 (-4.5A)
None
None
None
IBM  A   3 (-4.3A)
None
IBM  A   3 (-3.5A)
0.43A32.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_A_ROFA901_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		5 / 12HIS A 326
MET A 439
MET A 523
SER A 534
PHE A 538
D71  A 901 (-4.5A)
D71  A 901 ( 4.0A)
D71  A 901 ( 4.0A)
D71  A 901 (-3.4A)
D71  A 901 (-3.9A)
1.03A74.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_A_ROFA901_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		11 / 12TYR A 325
HIS A 326
MET A 439
ASN A 487
PRO A 488
TYR A 495
TRP A 498
THR A 499
ILE A 502
MET A 523
PHE A 538
None
D71  A 901 (-4.5A)
D71  A 901 ( 4.0A)
D71  A 901 (-4.5A)
None
None
None
D71  A 901 (-3.6A)
D71  A 901 (-4.1A)
D71  A 901 ( 4.0A)
D71  A 901 (-3.9A)
0.61A74.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_A_ROFA901_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3o57 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		12 / 12TYR A 233
HIS A 234
MET A 347
ASN A 395
PRO A 396
TYR A 403
TRP A 406
THR A 407
ILE A 410
MET A 431
SER A 442
PHE A 446
None
None
ZG2  A 506 (-3.9A)
ZG2  A 506 (-4.3A)
ZG2  A 506 ( 4.5A)
None
None
ZG2  A 506 (-4.3A)
ZG2  A 506 (-4.4A)
ZG2  A 506 (-3.4A)
None
ZG2  A 506 (-3.6A)
0.53A80.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_A_ROFA901_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3qi3 HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A
(Homo
sapiens)		5 / 12HIS A 252
MET A 365
ASN A 405
TRP A 416
PHE A 456
PDB  A 600 (-4.6A)
PDB  A 600 ( 4.7A)
PDB  A 600 (-4.4A)
None
PDB  A 600 (-3.5A)
0.58A24.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_A_ROFA901_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		10 / 12TYR A 159
HIS A 160
ASN A 321
PRO A 322
TYR A 329
TRP A 332
THR A 333
ILE A 336
MET A 357
SER A 368
TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
ASN  A 321 (-0.6A)
PRO  A 322 (-1.1A)
TYR  A 329 (-1.3A)
TRP  A 332 ( 0.5A)
THR  A 333 ( 0.8A)
ILE  A 336 ( 0.4A)
MET  A 357 (-0.0A)
SER  A 368 (-0.0A)
0.52A98.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_A_ROFA901_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		11 / 12TYR A 159
HIS A 160
MET A 273
ASN A 321
PRO A 322
TYR A 329
TRP A 332
THR A 333
ILE A 336
SER A 368
PHE A 372
TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
MET  A 273 (-0.0A)
ASN  A 321 (-0.6A)
PRO  A 322 (-1.1A)
TYR  A 329 (-1.3A)
TRP  A 332 ( 0.5A)
THR  A 333 ( 0.8A)
ILE  A 336 ( 0.4A)
SER  A 368 (-0.0A)
PHE  A 372 (-1.3A)
0.44A98.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_A_ROFA901_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		11 / 12TYR A 405
HIS A 406
MET A 519
ASN A 567
PRO A 568
TRP A 578
THR A 579
ILE A 582
MET A 603
SER A 614
PHE A 618
None
MG  A 804 ( 4.9A)
None
None
None
None
None
None
None
None
None
0.74A47.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_A_ROFA901_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		11 / 12TYR A 405
HIS A 406
MET A 519
ASN A 567
PRO A 568
TYR A 575
TRP A 578
THR A 579
MET A 603
SER A 614
PHE A 618
None
MG  A 804 ( 4.9A)
None
None
None
None
None
None
None
None
None
0.60A47.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_A_ROFA901_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		5b25 CALCIUM/CALMODULIN-D
EPENDENT
3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 1B
(Homo
sapiens)		8 / 12TYR A 222
HIS A 223
MET A 336
PRO A 374
TRP A 384
THR A 385
SER A 420
PHE A 424
None
4QJ  A 603 ( 4.9A)
4QJ  A 603 ( 3.9A)
None
None
None
4QJ  A 603 (-4.7A)
4QJ  A 603 (-3.5A)
0.43A37.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_A_ROFA901_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		5ohj CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		9 / 12TYR A 405
ASN A 567
PRO A 568
TYR A 575
TRP A 578
THR A 579
ILE A 582
MET A 603
PHE A 618
None
9VE  A 801 (-4.1A)
9VE  A 801 (-3.9A)
9VE  A 801 (-4.6A)
None
9VE  A 801 (-4.1A)
9VE  A 801 (-4.1A)
9VE  A 801 (-3.6A)
9VE  A 801 (-3.9A)
0.68Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_A_ROFA901_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		5ohj CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		11 / 12TYR A 405
HIS A 406
MET A 519
ASN A 567
PRO A 568
TYR A 575
TRP A 578
THR A 579
ILE A 582
SER A 614
PHE A 618
None
None
9VE  A 801 (-3.8A)
9VE  A 801 (-4.1A)
9VE  A 801 (-3.9A)
9VE  A 801 (-4.6A)
None
9VE  A 801 (-4.1A)
9VE  A 801 (-4.1A)
9VE  A 801 (-4.7A)
9VE  A 801 (-3.9A)
0.27Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_A_ROFA901_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		5wh6 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		11 / 12TYR A 159
HIS A 160
MET A 273
ASN A 321
PRO A 322
TYR A 329
TRP A 332
THR A 333
ILE A 336
MET A 357
PHE A 372
AKJ  A 601 ( 4.7A)
None
AKJ  A 601 ( 3.9A)
AKJ  A 601 (-4.3A)
AKJ  A 601 (-3.9A)
AKJ  A 601 (-4.8A)
None
AKJ  A 601 (-4.1A)
AKJ  A 601 (-3.8A)
AKJ  A 601 (-3.4A)
AKJ  A 601 (-4.1A)
0.42Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_A_ROFA901_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		5wh6 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		9 / 12TYR A 159
HIS A 160
PRO A 322
TYR A 329
TRP A 332
THR A 333
ILE A 336
MET A 357
SER A 368
AKJ  A 601 ( 4.7A)
None
AKJ  A 601 (-3.9A)
AKJ  A 601 (-4.8A)
None
AKJ  A 601 (-4.1A)
AKJ  A 601 (-3.8A)
AKJ  A 601 (-3.4A)
AKJ  A 601 (-2.5A)
0.66Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_A_ROFA901_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		1eak 72 KDA TYPE IV
COLLAGENASE
(Homo
sapiens)		3 / 3ASP A 249
LEU A 257
GLN A 219
None
0.82A21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_A_ROFA901_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		1qgr PROTEIN (IMPORTIN
BETA SUBUNIT)
(Homo
sapiens)		3 / 3ASP A 579
LEU A 583
GLN A 589
None
0.78A19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_A_ROFA901_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		1tzs CATHEPSIN E
(Homo
sapiens)		3 / 3ASP A 290
LEU A 288
GLN A 245
None
0.67A21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_A_ROFA901_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		2coc FYVE, RHOGEF AND PH
DOMAIN CONTAINING
PROTEIN 3
(Homo
sapiens)		3 / 3ASP A  46
LEU A  49
GLN A  82
None
0.76A15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_A_ROFA901_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		2oew PROGRAMMED CELL
DEATH 6-INTERACTING
PROTEIN
(Homo
sapiens)		3 / 3ASP A  59
LEU A  58
GLN A   8
None
0.81A21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_A_ROFA901_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		2pk2 CYCLIN-T1, PROTEIN
TAT
(Homo
sapiens;
Equine
infectious
anemia
virus)		3 / 3ASP A  32
LEU A  35
GLN A 190
ASP  A  32 ( 0.6A)
LEU  A  35 ( 0.6A)
GLN  A 190 ( 0.6A)
0.59A21.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_A_ROFA901_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		2qyk CYCLIC AMP-SPECIFIC
PHOSPHODIESTERASE
HSPDE4A10
(Homo
sapiens)		3 / 3ASP A 530
LEU A 531
GLN A 581
 ZN  A   1 (-2.5A)
None
NPV  A   3 (-3.1A)
0.35A85.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_A_ROFA901_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		2qym PHOSPHODIESTERASE 4C
(Homo
sapiens)		3 / 3ASP A 220
LEU A 226
GLN A 453
None
0.79A83.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_A_ROFA901_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		2xub DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC3
(Homo
sapiens)		3 / 3ASP A 318
LEU A 320
GLN A 371
None
0.79A21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_A_ROFA901_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		2zqq METHYLGLUTACONYL-COA
HYDRATASE
(Homo
sapiens)		3 / 3ASP A 273
LEU A 274
GLN A 281
None
0.80A24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_A_ROFA901_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens)		3 / 3ASP A 764
LEU A 765
GLN A 775
None
VDN  A   1 ( 4.7A)
VDN  A   1 ( 4.4A)
0.68A27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_A_ROFA901_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens)		3 / 3ASP A 764
LEU A 765
GLN A 817
None
VDN  A   1 ( 4.7A)
VDN  A   1 (-3.0A)
0.50A27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_A_ROFA901_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens)		3 / 3ASP A 764
LEU A 765
GLN A 775
 ZN  A 876 (-2.5A)
WAN  A 901 ( 4.7A)
WAN  A 901 ( 4.6A)
0.61A19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_A_ROFA901_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens)		3 / 3ASP A 764
LEU A 765
GLN A 817
 ZN  A 876 (-2.5A)
WAN  A 901 ( 4.7A)
WAN  A 901 (-3.1A)
0.48A19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_A_ROFA901_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3f1i HEPATOCYTE GROWTH
FACTOR-REGULATED
TYROSINE KINASE
SUBSTRATE
(Homo
sapiens)		3 / 3ASP H 461
LEU H 465
GLN H 471
None
0.67A15.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_A_ROFA901_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		3 / 3ASP A 484
LEU A 485
GLN A 535
 ZN  A 801 (-2.6A)
None
D71  A 901 (-3.1A)
0.29A74.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_A_ROFA901_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3o57 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		3 / 3ASP A 392
LEU A 393
GLN A 443
 ZN  A   1 (-2.6A)
None
ZG2  A 506 (-3.3A)
0.27A80.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_A_ROFA901_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3ohm 1-PHOSPHATIDYLINOSIT
OL-4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3
(Homo
sapiens)		3 / 3ASP B 227
LEU B 231
GLN B 245
None
0.80A17.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_A_ROFA901_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		3 / 3ASP A 318
LEU A 319
GLN A 369
ASP  A 318 (-0.5A)
LEU  A 319 ( 0.6A)
GLN  A 369 (-0.6A)
0.34A98.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_A_ROFA901_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3tni CYCLIN-T1
(Homo
sapiens)		3 / 3ASP B  32
LEU B  35
GLN B 190
None
0.73A21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_A_ROFA901_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3ui7 CAMP AND
CAMP-INHIBITED CGMP
3',5'-CYCLIC
PHOSPHODIESTERASE
10A
(Homo
sapiens)		3 / 3ASP A 674
LEU A 675
GLN A 726
 ZN  A 772 (-2.4A)
C1L  A   1 (-4.3A)
C1L  A   1 (-2.9A)
0.41A27.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_A_ROFA901_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens)		3 / 3ASP A 808
LEU A 809
GLN A 859
 ZN  A1001 (-2.5A)
None
None
0.45A27.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_A_ROFA901_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		4igm 2-AMINO-3-CARBOXYMUC
ONATE-6-SEMIALDEHYDE
DECARBOXYLASE
(Homo
sapiens)		3 / 3ASP A  99
LEU A  96
GLN A 142
None
0.76A22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_A_ROFA901_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		4n3y RAB GTPASE-BINDING
EFFECTOR PROTEIN 1
(Homo
sapiens)		3 / 3ASP B 577
LEU B 581
GLN B 587
None
0.81A14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_A_ROFA901_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		4nfd PAIRED
IMMUNOGLOBULIN-LIKE
TYPE 2 RECEPTOR BETA
(Homo
sapiens)		3 / 3ASP A  89
LEU A 117
GLN A   7
None
0.83A14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_A_ROFA901_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		4pj3 INTRON-BINDING
PROTEIN AQUARIUS
(Homo
sapiens)		3 / 3ASP A1269
LEU A1299
GLN A1136
None
0.69A14.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_A_ROFA901_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		3 / 3ASP A 564
LEU A 565
GLN A 615
 ZN  A 801 (-2.5A)
None
None
0.17A47.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_B_ROFB902_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B
(Homo
sapiens)		8 / 12TYR A 736
HIS A 737
ASP A 937
PRO A 941
TRP A 951
THR A 952
ILE A 955
PHE A 991
IBM  A2111 (-4.5A)
IBM  A2111 ( 4.8A)
MG  A2123 (-2.5A)
None
None
IBM  A2111 ( 4.8A)
IBM  A2111 (-4.2A)
IBM  A2111 (-3.6A)
0.48A32.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_B_ROFB902_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens)		6 / 12TYR A 211
HIS A 212
ASP A 362
PRO A 366
TRP A 376
PHE A 416
IBM  A 503 (-4.6A)
None
ZN  A 501 (-2.5A)
None
None
IBM  A 503 (-3.4A)
0.44A33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_B_ROFB902_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		2qyk CYCLIC AMP-SPECIFIC
PHOSPHODIESTERASE
HSPDE4A10
(Homo
sapiens)		12 / 12TYR A 371
HIS A 372
MET A 485
ASP A 530
LEU A 531
PRO A 534
TRP A 544
THR A 545
ILE A 548
MET A 549
MET A 569
PHE A 584
NPV  A   3 (-4.4A)
NPV  A   3 (-4.6A)
None
ZN  A   1 (-2.5A)
None
None
None
NPV  A   3 ( 4.7A)
NPV  A   3 (-3.8A)
NPV  A   3 ( 4.7A)
NPV  A   3 (-3.1A)
NPV  A   3 (-3.3A)
0.41A85.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_B_ROFB902_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		2qym PHOSPHODIESTERASE 4C
(Homo
sapiens)		10 / 12TYR A 281
HIS A 282
MET A 395
ASP A 440
LEU A 441
PRO A 444
TRP A 454
THR A 455
ILE A 458
PHE A 494
None
None
None
ZN  A   1 (-2.5A)
None
None
None
None
None
None
0.55A83.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_B_ROFB902_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		2qym PHOSPHODIESTERASE 4C
(Homo
sapiens)		5 / 12TYR A 281
PRO A 444
TRP A 454
THR A 455
MET A 459
None
0.96A83.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_B_ROFB902_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3a98 DEDICATOR OF
CYTOKINESIS PROTEIN
2
(Homo
sapiens)		5 / 12ASP A 162
LEU A 163
THR A 149
ILE A 152
MET A 120
None
1.47A17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_B_ROFB902_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens)		5 / 12TYR A 612
HIS A 613
ASP A 764
LEU A 765
PHE A 820
VDN  A   1 (-4.8A)
VDN  A   1 (-4.3A)
None
VDN  A   1 ( 4.7A)
VDN  A   1 (-3.6A)
0.61A27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_B_ROFB902_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens)		5 / 12TYR A 612
HIS A 613
ASP A 764
LEU A 765
PHE A 820
None
MG  A 877 (-4.4A)
ZN  A 876 (-2.5A)
WAN  A 901 ( 4.7A)
WAN  A 901 (-3.7A)
0.59A19.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_B_ROFB902_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A
(Homo
sapiens)		8 / 12TYR A 555
HIS A 556
MET A 670
ASP A 726
PRO A 730
TRP A 740
ILE A 744
PHE A 781
None
None
IBM  A   3 (-4.5A)
ZN  A   1 (-2.6A)
None
None
IBM  A   3 (-4.3A)
IBM  A   3 (-3.5A)
0.33A32.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_B_ROFB902_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		5 / 12HIS A 330
MET A 439
LEU A 485
MET A 503
PHE A 538
 ZN  A 801 (-3.4A)
D71  A 901 ( 4.0A)
None
D71  A 901 (-3.6A)
D71  A 901 (-3.9A)
1.24A74.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_B_ROFB902_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		11 / 12TYR A 325
HIS A 326
ASP A 484
LEU A 485
PRO A 488
TRP A 498
THR A 499
ILE A 502
MET A 503
MET A 523
PHE A 538
None
D71  A 901 (-4.5A)
ZN  A 801 (-2.6A)
None
None
None
D71  A 901 (-3.6A)
D71  A 901 (-4.1A)
D71  A 901 (-3.6A)
D71  A 901 ( 4.0A)
D71  A 901 (-3.9A)
0.58A74.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_B_ROFB902_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		11 / 12TYR A 325
HIS A 326
MET A 439
ASP A 484
LEU A 485
PRO A 488
TRP A 498
THR A 499
ILE A 502
MET A 503
PHE A 538
None
D71  A 901 (-4.5A)
D71  A 901 ( 4.0A)
ZN  A 801 (-2.6A)
None
None
None
D71  A 901 (-3.6A)
D71  A 901 (-4.1A)
D71  A 901 (-3.6A)
D71  A 901 (-3.9A)
0.59A74.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_B_ROFB902_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens)		6 / 12TYR A 655
HIS A 656
ASP A 808
LEU A 809
ILE A 826
PHE A 862
None
None
ZN  A   1 (-2.7A)
None
None
None
0.92A17.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_B_ROFB902_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3n3z HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A
(Homo
sapiens)		5 / 12HIS A 252
MET A 365
ASP A 402
TRP A 416
PHE A 456
None
None
ZN  A 507 (-2.9A)
None
IBM  A   1 (-3.4A)
0.60A30.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_B_ROFB902_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3o57 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		12 / 12TYR A 233
HIS A 234
MET A 347
ASP A 392
LEU A 393
PRO A 396
TRP A 406
THR A 407
ILE A 410
MET A 411
MET A 431
PHE A 446
None
None
ZG2  A 506 (-3.9A)
ZN  A   1 (-2.6A)
None
ZG2  A 506 ( 4.5A)
None
ZG2  A 506 (-4.3A)
ZG2  A 506 (-4.4A)
None
ZG2  A 506 (-3.4A)
ZG2  A 506 (-3.6A)
0.50A80.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_B_ROFB902_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3pb9 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE-LIK
E PROTEIN
(Homo
sapiens)		5 / 12LEU X 368
PRO X 276
THR X 344
ILE X 342
PHE X 278
None
1.49A21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_B_ROFB902_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3qi3 HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A
(Homo
sapiens)		5 / 12HIS A 252
MET A 365
ASP A 402
TRP A 416
PHE A 456
PDB  A 600 (-4.6A)
PDB  A 600 ( 4.7A)
ZN  A 534 (-2.7A)
None
PDB  A 600 (-3.5A)
0.59A24.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_B_ROFB902_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		12 / 12TYR A 159
HIS A 160
MET A 273
ASP A 318
LEU A 319
PRO A 322
TRP A 332
THR A 333
ILE A 336
MET A 337
MET A 357
PHE A 372
TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
MET  A 273 (-0.0A)
ASP  A 318 (-0.5A)
LEU  A 319 ( 0.6A)
PRO  A 322 (-1.1A)
TRP  A 332 ( 0.5A)
THR  A 333 ( 0.8A)
ILE  A 336 ( 0.4A)
MET  A 337 ( 0.0A)
MET  A 357 (-0.0A)
PHE  A 372 (-1.3A)
0.53A98.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_B_ROFB902_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3ui7 CAMP AND
CAMP-INHIBITED CGMP
3',5'-CYCLIC
PHOSPHODIESTERASE
10A
(Homo
sapiens)		6 / 12TYR A 524
HIS A 525
ASP A 674
LEU A 675
ILE A 692
PHE A 729
C1L  A   1 ( 4.8A)
C1L  A   1 (-4.1A)
ZN  A 772 (-2.4A)
C1L  A   1 (-4.3A)
C1L  A   1 (-4.3A)
C1L  A   1 (-3.5A)
0.83A27.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_B_ROFB902_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens)		6 / 12TYR A 655
HIS A 656
ASP A 808
LEU A 809
ILE A 826
PHE A 862
None
None
ZN  A1001 (-2.5A)
None
None
None
0.58A27.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_B_ROFB902_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens)		5 / 12TYR A 655
LEU A 809
ILE A 826
MET A 847
PHE A 862
None
0.99A27.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_B_ROFB902_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		4md8 CASEIN KINASE II
SUBUNIT ALPHA
(Homo
sapiens)		5 / 12HIS E 154
LEU E  85
ILE E 174
MET E 163
PHE E 113
None
1.32A22.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_B_ROFB902_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		11 / 12TYR A 405
HIS A 406
ASP A 564
LEU A 565
PRO A 568
TRP A 578
THR A 579
ILE A 582
MET A 583
MET A 603
PHE A 618
None
MG  A 804 ( 4.9A)
ZN  A 801 (-2.5A)
None
None
None
None
None
None
None
None
0.73A47.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_B_ROFB902_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		11 / 12TYR A 405
HIS A 406
MET A 519
ASP A 564
LEU A 565
PRO A 568
TRP A 578
THR A 579
ILE A 582
MET A 583
PHE A 618
None
MG  A 804 ( 4.9A)
None
ZN  A 801 (-2.5A)
None
None
None
None
None
None
None
0.58A47.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_B_ROFB902_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		5b25 CALCIUM/CALMODULIN-D
EPENDENT
3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 1B
(Homo
sapiens)		8 / 12TYR A 222
HIS A 223
MET A 336
ASP A 370
PRO A 374
TRP A 384
THR A 385
PHE A 424
None
4QJ  A 603 ( 4.9A)
4QJ  A 603 ( 3.9A)
ZN  A 601 (-2.5A)
None
None
None
4QJ  A 603 (-3.5A)
0.48A37.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_B_ROFB902_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		5mov CASEIN KINASE II
SUBUNIT ALPHA
(Homo
sapiens)		5 / 12HIS A 154
LEU A  85
ILE A 174
MET A 163
PHE A 113
None
None
HC4  A 401 ( 3.7A)
HC4  A 401 ( 4.0A)
HC4  A 401 (-3.4A)
1.41A23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_B_ROFB902_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		5ohj CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		11 / 12TYR A 405
HIS A 406
MET A 519
ASP A 564
LEU A 565
PRO A 568
TRP A 578
THR A 579
ILE A 582
MET A 583
PHE A 618
None
None
9VE  A 801 (-3.8A)
ZN  A 699 ( 2.6A)
9VE  A 801 (-4.7A)
9VE  A 801 (-3.9A)
None
9VE  A 801 (-4.1A)
9VE  A 801 (-4.1A)
9VE  A 801 ( 4.0A)
9VE  A 801 (-3.9A)
0.26Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_B_ROFB902_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		5ohj CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		11 / 12TYR A 405
HIS A 406
MET A 519
LEU A 565
PRO A 568
TRP A 578
THR A 579
ILE A 582
MET A 583
MET A 603
PHE A 618
None
None
9VE  A 801 (-3.8A)
9VE  A 801 (-4.7A)
9VE  A 801 (-3.9A)
None
9VE  A 801 (-4.1A)
9VE  A 801 (-4.1A)
9VE  A 801 ( 4.0A)
9VE  A 801 (-3.6A)
9VE  A 801 (-3.9A)
0.52Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_B_ROFB902_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		5wh6 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		12 / 12TYR A 159
HIS A 160
MET A 273
ASP A 318
LEU A 319
PRO A 322
TRP A 332
THR A 333
ILE A 336
MET A 337
MET A 357
PHE A 372
AKJ  A 601 ( 4.7A)
None
AKJ  A 601 ( 3.9A)
ZN  A 602 (-2.5A)
AKJ  A 601 ( 4.6A)
AKJ  A 601 (-3.9A)
None
AKJ  A 601 (-4.1A)
AKJ  A 601 (-3.8A)
AKJ  A 601 ( 3.7A)
AKJ  A 601 (-3.4A)
AKJ  A 601 (-4.1A)
0.43Aundetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_C_ROFC903_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B
(Homo
sapiens)		7 / 12TYR A 736
HIS A 737
ASP A 937
PRO A 941
TRP A 951
THR A 952
ILE A 955
IBM  A2111 (-4.5A)
IBM  A2111 ( 4.8A)
MG  A2123 (-2.5A)
None
None
IBM  A2111 ( 4.8A)
IBM  A2111 (-4.2A)
0.49A32.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_C_ROFC903_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		1y6n INTERLEUKIN-10
RECEPTOR ALPHA CHAIN
(Homo
sapiens)		5 / 12TYR R  70
LEU R 104
PRO R 125
THR R 135
ILE R 139
None
1.16A19.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_C_ROFC903_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens)		6 / 12TYR A 211
HIS A 212
ASP A 362
ASN A 365
PRO A 366
TRP A 376
IBM  A 503 (-4.6A)
None
ZN  A 501 (-2.5A)
IBM  A 503 ( 4.7A)
None
None
0.25A33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_C_ROFC903_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		2qyk CYCLIC AMP-SPECIFIC
PHOSPHODIESTERASE
HSPDE4A10
(Homo
sapiens)		12 / 12TYR A 371
HIS A 372
MET A 485
ASP A 530
LEU A 531
ASN A 533
PRO A 534
TYR A 541
TRP A 544
THR A 545
ILE A 548
MET A 569
NPV  A   3 (-4.4A)
NPV  A   3 (-4.6A)
None
ZN  A   1 (-2.5A)
None
NPV  A   3 (-4.4A)
None
None
None
NPV  A   3 ( 4.7A)
NPV  A   3 (-3.8A)
NPV  A   3 (-3.1A)
0.42A85.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_C_ROFC903_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		2qym PHOSPHODIESTERASE 4C
(Homo
sapiens)		11 / 12TYR A 281
HIS A 282
MET A 395
ASP A 440
LEU A 441
ASN A 443
PRO A 444
TYR A 451
TRP A 454
THR A 455
ILE A 458
None
None
None
ZN  A   1 (-2.5A)
None
None
None
None
None
None
None
0.54A83.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_C_ROFC903_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3a98 DEDICATOR OF
CYTOKINESIS PROTEIN
2
(Homo
sapiens)		5 / 12ASP A 162
LEU A 163
THR A 149
ILE A 152
MET A 120
None
1.50A17.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_C_ROFC903_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A
(Homo
sapiens)		8 / 12TYR A 555
HIS A 556
MET A 670
ASP A 726
ASN A 729
PRO A 730
TRP A 740
ILE A 744
None
None
IBM  A   3 (-4.5A)
ZN  A   1 (-2.6A)
None
None
None
IBM  A   3 (-4.3A)
0.31A32.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_C_ROFC903_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		12 / 12TYR A 325
HIS A 326
MET A 439
ASP A 484
LEU A 485
ASN A 487
PRO A 488
TYR A 495
TRP A 498
THR A 499
ILE A 502
MET A 523
None
D71  A 901 (-4.5A)
D71  A 901 ( 4.0A)
ZN  A 801 (-2.6A)
None
D71  A 901 (-4.5A)
None
None
None
D71  A 901 (-3.6A)
D71  A 901 (-4.1A)
D71  A 901 ( 4.0A)
0.66A74.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_C_ROFC903_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens)		5 / 12TYR A 655
HIS A 656
ASP A 808
LEU A 809
ILE A 826
None
None
ZN  A   1 (-2.7A)
None
None
0.72A17.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_C_ROFC903_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3n3z HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A
(Homo
sapiens)		5 / 12HIS A 252
MET A 365
ASP A 402
ASN A 405
TRP A 416
None
None
ZN  A 507 (-2.9A)
IBM  A   1 (-3.5A)
None
0.85A30.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_C_ROFC903_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3o57 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		12 / 12TYR A 233
HIS A 234
MET A 347
ASP A 392
LEU A 393
ASN A 395
PRO A 396
TYR A 403
TRP A 406
THR A 407
ILE A 410
MET A 431
None
None
ZG2  A 506 (-3.9A)
ZN  A   1 (-2.6A)
None
ZG2  A 506 (-4.3A)
ZG2  A 506 ( 4.5A)
None
None
ZG2  A 506 (-4.3A)
ZG2  A 506 (-4.4A)
ZG2  A 506 (-3.4A)
0.33A80.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_C_ROFC903_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3qi3 HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A
(Homo
sapiens)		5 / 12HIS A 252
MET A 365
ASP A 402
ASN A 405
TRP A 416
PDB  A 600 (-4.6A)
PDB  A 600 ( 4.7A)
ZN  A 534 (-2.7A)
PDB  A 600 (-4.4A)
None
0.55A24.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_C_ROFC903_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		12 / 12TYR A 159
HIS A 160
MET A 273
ASP A 318
LEU A 319
ASN A 321
PRO A 322
TYR A 329
TRP A 332
THR A 333
ILE A 336
MET A 357
TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
MET  A 273 (-0.0A)
ASP  A 318 (-0.5A)
LEU  A 319 ( 0.6A)
ASN  A 321 (-0.6A)
PRO  A 322 (-1.1A)
TYR  A 329 (-1.3A)
TRP  A 332 ( 0.5A)
THR  A 333 ( 0.8A)
ILE  A 336 ( 0.4A)
MET  A 357 (-0.0A)
0.46A98.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_C_ROFC903_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3ui7 CAMP AND
CAMP-INHIBITED CGMP
3',5'-CYCLIC
PHOSPHODIESTERASE
10A
(Homo
sapiens)		5 / 12TYR A 524
HIS A 525
ASP A 674
LEU A 675
ILE A 692
C1L  A   1 ( 4.8A)
C1L  A   1 (-4.1A)
ZN  A 772 (-2.4A)
C1L  A   1 (-4.3A)
C1L  A   1 (-4.3A)
0.59A27.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_C_ROFC903_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens)		5 / 12TYR A 655
HIS A 656
ASP A 808
LEU A 809
ILE A 826
None
None
ZN  A1001 (-2.5A)
None
None
0.52A27.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_C_ROFC903_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		10 / 12TYR A 405
HIS A 406
ASP A 564
LEU A 565
ASN A 567
PRO A 568
TRP A 578
THR A 579
ILE A 582
MET A 603
None
MG  A 804 ( 4.9A)
ZN  A 801 (-2.5A)
None
None
None
None
None
None
None
0.68A47.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_C_ROFC903_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		10 / 12TYR A 405
HIS A 406
ASP A 564
LEU A 565
ASN A 567
PRO A 568
TYR A 575
TRP A 578
THR A 579
MET A 603
None
MG  A 804 ( 4.9A)
ZN  A 801 (-2.5A)
None
None
None
None
None
None
None
0.55A47.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_C_ROFC903_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		10 / 12TYR A 405
HIS A 406
MET A 519
ASP A 564
LEU A 565
ASN A 567
PRO A 568
TRP A 578
THR A 579
ILE A 582
None
MG  A 804 ( 4.9A)
None
ZN  A 801 (-2.5A)
None
None
None
None
None
None
0.59A47.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_C_ROFC903_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		10 / 12TYR A 405
HIS A 406
MET A 519
ASP A 564
LEU A 565
ASN A 567
PRO A 568
TYR A 575
TRP A 578
THR A 579
None
MG  A 804 ( 4.9A)
None
ZN  A 801 (-2.5A)
None
None
None
None
None
None
0.41A47.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_C_ROFC903_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		4z0x ANTIBODY HC26AM
HEAVY CHAIN VARIABLE
DOMAIN
(Homo
sapiens)		5 / 12HIS B  54
LEU B 126
TYR B 131
THR B  60
ILE B  59
None
1.12A15.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_C_ROFC903_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		5b25 CALCIUM/CALMODULIN-D
EPENDENT
3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 1B
(Homo
sapiens)		7 / 12TYR A 222
HIS A 223
MET A 336
ASP A 370
PRO A 374
TRP A 384
THR A 385
None
4QJ  A 603 ( 4.9A)
4QJ  A 603 ( 3.9A)
ZN  A 601 (-2.5A)
None
None
None
0.50A37.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_C_ROFC903_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		5ohj CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		11 / 12TYR A 405
HIS A 406
MET A 519
ASP A 564
LEU A 565
ASN A 567
PRO A 568
TYR A 575
TRP A 578
THR A 579
ILE A 582
None
None
9VE  A 801 (-3.8A)
ZN  A 699 ( 2.6A)
9VE  A 801 (-4.7A)
9VE  A 801 (-4.1A)
9VE  A 801 (-3.9A)
9VE  A 801 (-4.6A)
None
9VE  A 801 (-4.1A)
9VE  A 801 (-4.1A)
0.26Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_C_ROFC903_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		5ohj CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		9 / 12TYR A 405
LEU A 565
ASN A 567
PRO A 568
TYR A 575
TRP A 578
THR A 579
ILE A 582
MET A 603
None
9VE  A 801 (-4.7A)
9VE  A 801 (-4.1A)
9VE  A 801 (-3.9A)
9VE  A 801 (-4.6A)
None
9VE  A 801 (-4.1A)
9VE  A 801 (-4.1A)
9VE  A 801 (-3.6A)
0.55Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_C_ROFC903_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		5wh6 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		12 / 12TYR A 159
HIS A 160
MET A 273
ASP A 318
LEU A 319
ASN A 321
PRO A 322
TYR A 329
TRP A 332
THR A 333
ILE A 336
MET A 357
AKJ  A 601 ( 4.7A)
None
AKJ  A 601 ( 3.9A)
ZN  A 602 (-2.5A)
AKJ  A 601 ( 4.6A)
AKJ  A 601 (-4.3A)
AKJ  A 601 (-3.9A)
AKJ  A 601 (-4.8A)
None
AKJ  A 601 (-4.1A)
AKJ  A 601 (-3.8A)
AKJ  A 601 (-3.4A)
0.45Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_C_ROFC903_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		1ioj APOC-I
(Homo
sapiens)		3 / 3SER A  43
GLN A  47
PHE A  46
None
0.76A10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_C_ROFC903_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		1jl0 S-ADENOSYLMETHIONINE
DECARBOXYLASE
PROENZYME
(Homo
sapiens)		3 / 3SER A  73
GLN A  60
PHE A  71
None
0.82A23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_C_ROFC903_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		1uff INTERSECTIN 2
(Homo
sapiens)		3 / 3SER A  46
GLN A  31
PHE A  47
None
0.72A13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_C_ROFC903_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		2ocp DEOXYGUANOSINE
KINASE
(Homo
sapiens)		3 / 3SER A 107
GLN A 111
PHE A 110
None
DTP  A 301 (-2.9A)
DTP  A 301 (-4.2A)
0.77A21.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_C_ROFC903_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		2qyk CYCLIC AMP-SPECIFIC
PHOSPHODIESTERASE
HSPDE4A10
(Homo
sapiens)		3 / 3SER A 580
GLN A 581
PHE A 584
NPV  A   3 (-4.5A)
NPV  A   3 (-3.1A)
NPV  A   3 (-3.3A)
0.22A85.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_C_ROFC903_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3d3l ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE
(Homo
sapiens)		3 / 3SER A 350
GLN A 353
PHE A 352
None
0.83A21.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_C_ROFC903_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A
(Homo
sapiens)		3 / 3SER A 777
GLN A 778
PHE A 781
None
IBM  A   3 (-3.4A)
IBM  A   3 (-3.5A)
0.22A32.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_C_ROFC903_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3ep7 S-ADENOSYLMETHIONINE
DECARBOXYLASE ALPHA
CHAIN
S-ADENOSYLMETHIONINE
DECARBOXYLASE BETA
CHAIN
(Homo
sapiens;
Homo
sapiens)		3 / 3SER A  73
GLN B  60
PHE A  71
None
0.81A22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_C_ROFC903_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3ff6 ACETYL-COA
CARBOXYLASE 2
(Homo
sapiens)		3 / 3SER A2063
GLN A2062
PHE A2036
None
0.75A18.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_C_ROFC903_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3o57 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		3 / 3SER A 442
GLN A 443
PHE A 446
None
ZG2  A 506 (-3.3A)
ZG2  A 506 (-3.6A)
0.43A80.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_C_ROFC903_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		3 / 3SER A 368
GLN A 369
PHE A 372
SER  A 368 (-0.0A)
GLN  A 369 (-0.6A)
PHE  A 372 (-1.3A)
0.45A98.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_C_ROFC903_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3w4k D-AMINO-ACID OXIDASE
(Homo
sapiens)		3 / 3SER A  68
GLN A  69
PHE A  72
None
0.82A23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_C_ROFC903_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		4cq1 POLYPYRIMIDINE
TRACT-BINDING
PROTEIN 2
(Homo
sapiens)		3 / 3SER A 354
GLN A 353
PHE A 356
None
0.84A21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_C_ROFC903_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		4d0n A-KINASE ANCHOR
PROTEIN 13
(Homo
sapiens)		3 / 3SER B2054
GLN B2058
PHE B2057
None
0.82A22.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_C_ROFC903_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		3 / 3SER A 614
GLN A 615
PHE A 618
None
0.20A47.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_C_ROFC903_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		4x4w CCA TRNA
NUCLEOTIDYLTRANSFERA
SE 1, MITOCHONDRIAL
(Homo
sapiens)		3 / 3SER A  13
GLN A  12
PHE A  15
None
0.84A24.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_C_ROFC903_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		5b25 CALCIUM/CALMODULIN-D
EPENDENT
3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 1B
(Homo
sapiens)		3 / 3SER A 420
GLN A 421
PHE A 424
4QJ  A 603 (-4.7A)
4QJ  A 603 (-3.0A)
4QJ  A 603 (-3.5A)
0.54A37.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_C_ROFC903_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		5ohj CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		3 / 3SER A 614
GLN A 615
PHE A 618
9VE  A 801 (-4.7A)
9VE  A 801 (-3.2A)
9VE  A 801 (-3.9A)
0.18Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_C_ROFC903_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
(Homo
sapiens)		3 / 3SER C2046
GLN C2042
PHE C2045
None
0.67A6.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_C_ROFC903_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		6axg RAS GUANYL-RELEASING
PROTEIN 4
(Homo
sapiens)		3 / 3SER A  71
GLN A 120
PHE A  69
None
0.50A23.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_D_ROFD904_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		1soj CGMP-INHIBITED
3',5'-CYCLIC
PHOSPHODIESTERASE B
(Homo
sapiens)		8 / 12TYR A 736
HIS A 737
ASP A 937
PRO A 941
TRP A 951
THR A 952
ILE A 955
GLN A 988
IBM  A2111 (-4.5A)
IBM  A2111 ( 4.8A)
MG  A2123 (-2.5A)
None
None
IBM  A2111 ( 4.8A)
IBM  A2111 (-4.2A)
IBM  A2111 (-3.3A)
0.51A32.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		1um1 KIAA1849 PROTEIN
(Homo
sapiens)		5 / 12ASP A  27
LEU A  38
THR A  99
ILE A 103
SER A  56
None
1.46A13.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_D_ROFD904_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens)		6 / 12TYR A 211
HIS A 212
ASP A 362
PRO A 366
TRP A 376
GLN A 413
IBM  A 503 (-4.6A)
None
ZN  A 501 (-2.5A)
None
None
IBM  A 503 (-3.0A)
0.36A33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_D_ROFD904_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		2qyk CYCLIC AMP-SPECIFIC
PHOSPHODIESTERASE
HSPDE4A10
(Homo
sapiens)		12 / 12TYR A 371
HIS A 372
MET A 485
ASP A 530
LEU A 531
PRO A 534
TRP A 544
THR A 545
ILE A 548
MET A 549
SER A 580
GLN A 581
NPV  A   3 (-4.4A)
NPV  A   3 (-4.6A)
None
ZN  A   1 (-2.5A)
None
None
None
NPV  A   3 ( 4.7A)
NPV  A   3 (-3.8A)
NPV  A   3 ( 4.7A)
NPV  A   3 (-4.5A)
NPV  A   3 (-3.1A)
0.33A85.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_D_ROFD904_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		2qyk CYCLIC AMP-SPECIFIC
PHOSPHODIESTERASE
HSPDE4A10
(Homo
sapiens)		7 / 12TYR A 371
HIS A 376
MET A 485
LEU A 531
THR A 545
SER A 580
GLN A 581
NPV  A   3 (-4.4A)
ZN  A   1 (-3.3A)
None
None
NPV  A   3 ( 4.7A)
NPV  A   3 (-4.5A)
NPV  A   3 (-3.1A)
1.49A85.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_D_ROFD904_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		2qym PHOSPHODIESTERASE 4C
(Homo
sapiens)		9 / 12TYR A 281
HIS A 282
MET A 395
ASP A 440
LEU A 441
PRO A 444
TRP A 454
THR A 455
ILE A 458
None
None
None
ZN  A   1 (-2.5A)
None
None
None
None
None
0.49A83.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_D_ROFD904_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		2qym PHOSPHODIESTERASE 4C
(Homo
sapiens)		6 / 12TYR A 281
PRO A 444
TRP A 454
THR A 455
ILE A 458
MET A 459
None
0.97A83.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens)		5 / 12TYR A 612
HIS A 613
ASP A 764
LEU A 765
GLN A 775
VDN  A   1 (-4.8A)
VDN  A   1 (-4.3A)
None
VDN  A   1 ( 4.7A)
VDN  A   1 ( 4.4A)
1.02A27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens)		5 / 12TYR A 612
HIS A 613
ASP A 764
LEU A 765
GLN A 817
VDN  A   1 (-4.8A)
VDN  A   1 (-4.3A)
None
VDN  A   1 ( 4.7A)
VDN  A   1 (-3.0A)
0.55A27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens)		5 / 12TYR A 612
HIS A 613
ASP A 764
LEU A 765
GLN A 775
None
MG  A 877 (-4.4A)
ZN  A 876 (-2.5A)
WAN  A 901 ( 4.7A)
WAN  A 901 ( 4.6A)
0.90A19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens)		5 / 12TYR A 612
HIS A 613
ASP A 764
LEU A 765
GLN A 817
None
MG  A 877 (-4.4A)
ZN  A 876 (-2.5A)
WAN  A 901 ( 4.7A)
WAN  A 901 (-3.1A)
0.53A19.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_D_ROFD904_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A
(Homo
sapiens)		9 / 12TYR A 555
HIS A 556
MET A 670
ASP A 726
PRO A 730
TRP A 740
ILE A 744
SER A 777
GLN A 778
None
None
IBM  A   3 (-4.5A)
ZN  A   1 (-2.6A)
None
None
IBM  A   3 (-4.3A)
None
IBM  A   3 (-3.4A)
0.41A32.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_D_ROFD904_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		6 / 12HIS A 326
MET A 439
ASP A 484
LEU A 485
MET A 503
SER A 534
D71  A 901 (-4.5A)
D71  A 901 ( 4.0A)
ZN  A 801 (-2.6A)
None
D71  A 901 (-3.6A)
D71  A 901 (-3.4A)
0.91A74.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_D_ROFD904_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		11 / 12TYR A 325
HIS A 326
MET A 439
ASP A 484
LEU A 485
PRO A 488
TRP A 498
THR A 499
ILE A 502
MET A 503
GLN A 535
None
D71  A 901 (-4.5A)
D71  A 901 ( 4.0A)
ZN  A 801 (-2.6A)
None
None
None
D71  A 901 (-3.6A)
D71  A 901 (-4.1A)
D71  A 901 (-3.6A)
D71  A 901 (-3.1A)
0.57A74.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens)		6 / 12TYR A 655
HIS A 656
ASP A 808
LEU A 809
ILE A 826
GLN A 859
None
None
ZN  A   1 (-2.7A)
None
None
None
0.93A17.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_D_ROFD904_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3n3z HIGH AFFINITY
CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 9A
(Homo
sapiens)		5 / 12HIS A 252
MET A 365
ASP A 402
TRP A 416
GLN A 453
None
None
ZN  A 507 (-2.9A)
None
IBM  A   1 (-3.5A)
0.62A30.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_D_ROFD904_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3o57 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		12 / 12TYR A 233
HIS A 234
MET A 347
ASP A 392
LEU A 393
PRO A 396
TRP A 406
THR A 407
ILE A 410
MET A 411
SER A 442
GLN A 443
None
None
ZG2  A 506 (-3.9A)
ZN  A   1 (-2.6A)
None
ZG2  A 506 ( 4.5A)
None
ZG2  A 506 (-4.3A)
ZG2  A 506 (-4.4A)
None
None
ZG2  A 506 (-3.3A)
0.37A80.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_D_ROFD904_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		12 / 12TYR A 159
HIS A 160
MET A 273
ASP A 318
LEU A 319
PRO A 322
TRP A 332
THR A 333
ILE A 336
MET A 337
SER A 368
GLN A 369
TYR  A 159 (-1.3A)
HIS  A 160 ( 1.0A)
MET  A 273 (-0.0A)
ASP  A 318 (-0.5A)
LEU  A 319 ( 0.6A)
PRO  A 322 (-1.1A)
TRP  A 332 ( 0.5A)
THR  A 333 ( 0.8A)
ILE  A 336 ( 0.4A)
MET  A 337 ( 0.0A)
SER  A 368 (-0.0A)
GLN  A 369 (-0.6A)
0.33A98.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3ui7 CAMP AND
CAMP-INHIBITED CGMP
3',5'-CYCLIC
PHOSPHODIESTERASE
10A
(Homo
sapiens)		6 / 12TYR A 524
HIS A 525
ASP A 674
LEU A 675
ILE A 692
GLN A 726
C1L  A   1 ( 4.8A)
C1L  A   1 (-4.1A)
ZN  A 772 (-2.4A)
C1L  A   1 (-4.3A)
C1L  A   1 (-4.3A)
C1L  A   1 (-2.9A)
0.75A27.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens)		6 / 12TYR A 655
HIS A 656
ASP A 808
LEU A 809
ILE A 826
GLN A 859
None
None
ZN  A1001 (-2.5A)
None
None
None
0.60A27.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		4p4s INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1
(Homo
sapiens)		5 / 12LEU B 179
THR B 183
ILE B 182
SER B  80
GLN B  79
None
None
None
GCP  B 701 (-4.5A)
GCP  B 701 (-3.8A)
1.42A22.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_D_ROFD904_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		12 / 12TYR A 405
HIS A 406
MET A 519
ASP A 564
LEU A 565
PRO A 568
TRP A 578
THR A 579
ILE A 582
MET A 583
SER A 614
GLN A 615
None
MG  A 804 ( 4.9A)
None
ZN  A 801 (-2.5A)
None
None
None
None
None
None
None
None
0.61A47.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_D_ROFD904_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		5b25 CALCIUM/CALMODULIN-D
EPENDENT
3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 1B
(Homo
sapiens)		9 / 12TYR A 222
HIS A 223
MET A 336
ASP A 370
PRO A 374
TRP A 384
THR A 385
SER A 420
GLN A 421
None
4QJ  A 603 ( 4.9A)
4QJ  A 603 ( 3.9A)
ZN  A 601 (-2.5A)
None
None
None
4QJ  A 603 (-4.7A)
4QJ  A 603 (-3.0A)
0.58A37.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		5ohj CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		12 / 12TYR A 405
HIS A 406
MET A 519
ASP A 564
LEU A 565
PRO A 568
TRP A 578
THR A 579
ILE A 582
MET A 583
SER A 614
GLN A 615
None
None
9VE  A 801 (-3.8A)
ZN  A 699 ( 2.6A)
9VE  A 801 (-4.7A)
9VE  A 801 (-3.9A)
None
9VE  A 801 (-4.1A)
9VE  A 801 (-4.1A)
9VE  A 801 ( 4.0A)
9VE  A 801 (-4.7A)
9VE  A 801 (-3.2A)
0.23Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		5wh6 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		11 / 12TYR A 159
HIS A 160
MET A 273
ASP A 318
LEU A 319
PRO A 322
TRP A 332
THR A 333
ILE A 336
MET A 337
GLN A 369
AKJ  A 601 ( 4.7A)
None
AKJ  A 601 ( 3.9A)
ZN  A 602 (-2.5A)
AKJ  A 601 ( 4.6A)
AKJ  A 601 (-3.9A)
None
AKJ  A 601 (-4.1A)
AKJ  A 601 (-3.8A)
AKJ  A 601 ( 3.7A)
AKJ  A 601 (-3.0A)
0.26Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		5wh6 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		11 / 12TYR A 159
HIS A 160
MET A 273
LEU A 319
PRO A 322
TRP A 332
THR A 333
ILE A 336
MET A 337
SER A 368
GLN A 369
AKJ  A 601 ( 4.7A)
None
AKJ  A 601 ( 3.9A)
AKJ  A 601 ( 4.6A)
AKJ  A 601 (-3.9A)
None
AKJ  A 601 (-4.1A)
AKJ  A 601 (-3.8A)
AKJ  A 601 ( 3.7A)
AKJ  A 601 (-2.5A)
AKJ  A 601 (-3.0A)
0.50Aundetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_D_ROFD904_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		2qyk CYCLIC AMP-SPECIFIC
PHOSPHODIESTERASE
HSPDE4A10
(Homo
sapiens)		3 / 3ASN A 533
MET A 569
PHE A 584
NPV  A   3 (-4.4A)
NPV  A   3 (-3.1A)
NPV  A   3 (-3.3A)
0.69A85.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3dw8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
55 KDA REGULATORY
SUBUNIT B ALPHA
ISOFORM
(Homo
sapiens)		3 / 3ASN B 386
MET B 368
PHE B 442
None
0.84A21.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_D_ROFD904_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3g4g CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D
(Homo
sapiens)		3 / 3ASN A 487
MET A 523
PHE A 538
D71  A 901 (-4.5A)
D71  A 901 ( 4.0A)
D71  A 901 (-3.9A)
0.67A74.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3hk0 GROWTH FACTOR
RECEPTOR-BOUND
PROTEIN 10
(Homo
sapiens)		3 / 3ASN A 309
MET A 333
PHE A 287
None
0.74A20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3nr5 REPRESSOR OF RNA
POLYMERASE III
TRANSCRIPTION MAF1
HOMOLOG
(Homo
sapiens)		3 / 3ASN A 140
MET A   1
PHE A 142
None
0.99A16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3nwn KINESIN-LIKE PROTEIN
KIF9
(Homo
sapiens)		3 / 3ASN A 146
MET A 166
PHE A 150
None
0.80A21.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_D_ROFD904_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		3o57 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		3 / 3ASN A 395
MET A 431
PHE A 446
ZG2  A 506 (-4.3A)
ZG2  A 506 (-3.4A)
ZG2  A 506 (-3.6A)
0.68A80.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		4gnk 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3
(Homo
sapiens)		3 / 3ASN B 773
MET B 178
PHE B 737
None
1.10A15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		4o7d GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL
(Homo
sapiens)		3 / 3ASN A 335
MET A 508
PHE A 318
ONL  A 601 (-3.5A)
None
None
1.14A21.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3G4L_D_ROFD904_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		4wzi CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		3 / 3ASN A 567
MET A 603
PHE A 618
None
0.89A47.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens)		3 / 3ASN A1532
MET A1024
PHE A1566
None
0.71A14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		5exr DNA PRIMASE LARGE
SUBUNIT
(Homo
sapiens)		3 / 3ASN B 374
MET B 288
PHE B 365
None
1.02A21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		5ffo TRANSFORMING GROWTH
FACTOR BETA-1
(Homo
sapiens)		3 / 3ASN C 155
MET C 104
PHE C 169
None
1.04A22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		5fhx ANTIBODY FRAGMENT
HEAVY-CHAIN
ANTIBODY FRAGMENT
LIGHT CHAIN
(Homo
sapiens;
Homo
sapiens)		3 / 3ASN H 159
MET L  37
PHE L 102
None
1.12A20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1
(Homo
sapiens)		3 / 3ASN A1532
MET A1024
PHE A1566
None
0.65A11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		5ohj CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B
(Homo
sapiens)		3 / 3ASN A 567
MET A 603
PHE A 618
9VE  A 801 (-4.1A)
9VE  A 801 (-3.6A)
9VE  A 801 (-3.9A)
0.86Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		5wea PROTEIN ARGONAUTE-2
(Homo
sapiens)		3 / 3ASN A  99
MET A 172
PHE A  94
None
0.99A18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		6b0e 1260 ANTIBODY, HEAVY
CHAIN
(Homo
sapiens)		3 / 3ASN B  76
MET B  69
PHE B  34
None
1.04A16.79