POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		1u6t SH3 DOMAIN-BINDING
GLUTAMIC
ACID-RICH-LIKE
PROTEIN
(Homo
sapiens)		4 / 7ASP A  79
ASP A  77
PRO A  66
GLN A  19
None
1.26A12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		2ckk KIN17
(Homo
sapiens)		4 / 7ASP A 122
GLN A  16
TYR A  13
GLU A 121
None
1.16A15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		2hau SEROTRANSFERRIN
(Homo
sapiens)		4 / 7ASP A 163
ASP A 166
PRO A 168
GLN A 169
None
1.18A20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		2lgp LOW-DENSITY
LIPOPROTEIN RECEPTOR
(Homo
sapiens)		4 / 7ASP A 147
ASP A 151
PRO A 150
GLU A 158
 CA  A 215 (-3.6A)
CA  A 215 (-3.2A)
None
CA  A 215 (-3.8A)
1.17A11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		2om5 CONTACTIN 2
(Homo
sapiens)		4 / 7ASP A 270
GLN A 225
PRO A 264
GLN A 262
None
1.09A23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		3f2k HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens)		4 / 7ASP A  38
ASP A 130
TYR A 157
PRO A 159
 MG  A 227 (-2.6A)
MG  A 227 (-2.5A)
None
None
0.54A20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		3o4o INTERLEUKIN-1
RECEPTOR ACCESSORY
PROTEIN
(Homo
sapiens)		4 / 7ASP B  58
ASP B  56
GLN B  55
GLU B  60
None
None
NAG  B 338 (-4.3A)
None
0.97A21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		3ovz CATHEPSIN K
(Homo
sapiens)		4 / 7GLN A  76
TYR A 110
PRO A 213
GLN A  37
None
1.24A18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		4d8o ANKYRIN-2
(Homo
sapiens)		4 / 7ASP A1113
PRO A1115
GLN A1116
GLU A1067
None
1.00A20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		5erp DESMOCOLLIN-2
(Homo
sapiens)		4 / 7ASP A 465
ASP A 434
GLN A 433
GLU A 401
 CA  A 817 ( 3.2A)
CA  A 817 (-3.0A)
None
CA  A 817 ( 2.5A)
1.10A23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		5ifm NON-POU
DOMAIN-CONTAINING
OCTAMER-BINDING
PROTEIN
(Homo
sapiens)		4 / 7ASP A 228
GLN A 229
PRO A 226
GLU A 225
None
1.25A20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		5k8r PROTOCADHERIN
GAMMA-B3
(Homo
sapiens)		4 / 7ASP A 131
ASP A  95
GLN A  94
GLU A  63
 CA  A 503 ( 3.2A)
CA  A 503 (-3.1A)
None
CA  A 503 ( 2.3A)
1.23A21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		5keg DNA DC->DU-EDITING
ENZYME APOBEC-3A
(Homo
sapiens)		4 / 7ASP A 163
GLN A 169
PRO A 172
GLN A 174
None
1.17A20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		5ms3 KALLIKREIN-8
(Homo
sapiens)		4 / 7ASP A  77
GLN A  30
PRO A  24
GLN A  23
 CA  A3001 (-3.2A)
None
None
None
0.99A12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		5myb ANGIOPOIETIN-1
RECEPTOR
(Homo
sapiens)		4 / 7ASP A 587
GLN A 588
GLN A 610
GLU A 609
None
1.08A22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		5oyl LOW-DENSITY
LIPOPROTEIN RECEPTOR
(Homo
sapiens)		4 / 7ASP D  69
ASP D  73
GLN D  81
GLU D  80
 CA  D 102 (-2.8A)
CA  D 102 (-3.1A)
None
CA  D 102 (-3.3A)
1.16A6.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		5sxg DNA DC->DU-EDITING
ENZYME APOBEC-3B
(Homo
sapiens)		4 / 7ASP A 346
GLN A 352
PRO A 355
GLN A 357
None
1.05A12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens)		4 / 7ASP A 250
TYR A  65
GLN A  61
GLU A 515
None
1.07A22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		1g5v SURVIVAL MOTOR
NEURON PROTEIN 1
(Homo
sapiens)		4 / 8PRO A 110
TYR A 109
GLN A 136
GLU A 134
None
1.13A12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		1ozn RETICULON 4 RECEPTOR
(Homo
sapiens)		4 / 8ASP A 259
PRO A 261
PRO A 286
GLU A 284
None
1.11A23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		1s9k NUCLEAR FACTOR OF
ACTIVATED T-CELLS,
CYTOPLASMIC 2
(Homo
sapiens)		4 / 8GLN C 669
PRO C 670
TYR C 659
GLN C 583
None
1.03A22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		1spj KALLIKREIN 1
(Homo
sapiens)		4 / 8ASP A 113
PRO A 111
GLN A  50
GLU A 110
None
1.10A20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		2ckk KIN17
(Homo
sapiens)		4 / 8ASP A 122
GLN A  16
TYR A  13
GLU A 121
None
1.11A15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		2d8k SYNAPTOTAGMIN VII
(Homo
sapiens)		4 / 8ASP A 103
ASP A 109
PRO A 110
GLN A  98
None
1.13A19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		2d8k SYNAPTOTAGMIN VII
(Homo
sapiens)		4 / 8ASP A 103
ASP A 109
PRO A 138
GLN A  98
None
0.79A19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		2g7i COMPLEMENT FACTOR H
(Homo
sapiens)		4 / 8ASP A1220
PRO A1166
TYR A1142
GLU A1145
None
1.10A14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		2gry KINESIN-LIKE PROTEIN
KIF2
(Homo
sapiens)		4 / 8ASP A 254
PRO A 222
TYR A 183
PRO A 185
None
1.11A21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		2om5 CONTACTIN 2
(Homo
sapiens)		4 / 8ASP A 270
GLN A 225
PRO A 264
GLN A 262
None
1.14A23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		3aqi FERROCHELATASE
(Homo
sapiens)		4 / 8ASP A 274
GLN A 193
PRO A 192
TYR A 191
None
1.10A20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		3ctz XAA-PRO
AMINOPEPTIDASE 1
(Homo
sapiens)		4 / 8PRO A 121
TYR A 296
PRO A 125
GLN A  39
None
1.09A21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		3f2k HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR
(Homo
sapiens)		5 / 8ASP A  38
ASP A 130
PRO A 156
TYR A 157
PRO A 159
 MG  A 227 (-2.6A)
MG  A 227 (-2.5A)
None
None
None
0.69A20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		3o4o INTERLEUKIN-1
RECEPTOR ACCESSORY
PROTEIN
(Homo
sapiens)		4 / 8ASP B  58
ASP B  56
GLN B  55
GLU B  60
None
None
NAG  B 338 (-4.3A)
None
1.03A21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		3sw0 COMPLEMENT FACTOR H
(Homo
sapiens)		4 / 8ASP X1220
PRO X1166
TYR X1142
GLU X1145
None
1.02A19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		5erp DESMOCOLLIN-2
(Homo
sapiens)		4 / 8ASP A 465
ASP A 434
GLN A 433
GLU A 401
 CA  A 817 ( 3.2A)
CA  A 817 (-3.0A)
None
CA  A 817 ( 2.5A)
1.12A23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		5k8r PROTOCADHERIN
GAMMA-B3
(Homo
sapiens)		5 / 8ASP A 131
ASP A  95
GLN A  94
PRO A   8
GLU A  63
 CA  A 503 ( 3.2A)
CA  A 503 (-3.1A)
None
None
CA  A 503 ( 2.3A)
1.49A21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		5vfr PROTEASOME SUBUNIT
ALPHA TYPE-4
(Homo
sapiens)		4 / 8ASP I 140
PRO I 104
GLN I 109
GLU I 108
None
1.15Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		6bdz DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 10
(Homo
sapiens)		4 / 8ASP A 472
GLN A 489
PRO A 490
GLU A 469
 CA  A 704 (-3.1A)
None
None
CA  A 704 (-2.5A)
0.87A12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		1sk4 PEPTIDOGLYCAN
RECOGNITION PROTEIN
I-ALPHA
(Homo
sapiens)		4 / 6ASP A 270
ASN A 269
ALA A 272
TYR A 203
None
0.99A20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		1ux6 THROMBOSPONDIN-1
(Homo
sapiens)		4 / 6ASP A 917
ASN A 863
TYR A1147
ASP A 926
 CA  A2002 ( 2.8A)
None
None
CA  A2001 ( 2.2A)
1.02A22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		2a2d N-ACETYLGALACTOSAMIN
E KINASE
(Homo
sapiens)		4 / 6ASP A 135
ALA A  70
TYR A  37
ASP A  66
None
0.82A18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		2fcw LOW-DENSITY
LIPOPROTEIN RECEPTOR
(Homo
sapiens)		4 / 6ASP B 112
ASP B 118
ALA B 120
ASP B 108
 CA  B3001 (-3.3A)
CA  B3001 (-3.3A)
None
CA  B3001 (-2.9A)
1.21A15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		2rhp THROMBOSPONDIN-2
(Homo
sapiens)		4 / 6ASP A 937
ASN A 883
TYR A1167
ASP A 946
 CA  A   2 ( 2.6A)
None
None
CA  A1173 ( 2.1A)
1.05A14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		3j0a TOLL-LIKE RECEPTOR 5
(Homo
sapiens)		4 / 6ASP A 390
ASP A 366
ALA A 320
TYR A 321
None
None
FUC  A1343 (-3.3A)
None
1.06A12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		4b90 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens)		4 / 6ASP A 399
ALA A 129
TYR A 128
ASP A 401
None
1.05A17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		4cns DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens)		4 / 6ASP A 406
ALA A 136
TYR A 135
ASP A 408
None
1.05A19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		4cnt DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens)		4 / 6ASP A 406
ALA A 136
TYR A 135
ASP A 408
None
0.98A17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		4jgh CULLIN-5
(Homo
sapiens)		4 / 6ASN D 267
ALA D 268
TYR D 214
ASP D 208
None
1.19A19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		5anr PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX6
(Homo
sapiens)		4 / 6ASN B 299
ALA B 138
TYR B 276
ASP B 249
None
1.18A18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		5coc IMMUNOGLOBULIN
G-BINDING PROTEIN
A,CALMODULIN
(Homo
sapiens;
Staphylococcus
aureus)		4 / 6ASP A1059
ASP A1057
ASN A1054
ASP A1065
 CA  A1101 (-2.9A)
CA  A1101 (-3.1A)
None
CA  A1101 ( 4.1A)
1.16A19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDA_A_RLTA403_1
(MARINER MOS1
TRANSPOSASE)		5mw5 PROTEIN JAGGED-2
(Homo
sapiens)		4 / 6ASP A  51
ASP A 152
ASN A 158
ASP A  68
 CA  A 403 (-2.1A)
CA  A 404 ( 2.0A)
None
CA  A 402 ( 2.4A)
1.20A20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		1hup MANNOSE-BINDING
PROTEIN
(Homo
sapiens)		4 / 6ASP A 168
ASN A 194
ALA A 196
ASP A 201
 CA  A 301 (-2.3A)
SO4  A 304 ( 3.0A)
SO4  A 304 ( 4.0A)
CA  A 303 ( 2.3A)
1.06A23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		2a2d N-ACETYLGALACTOSAMIN
E KINASE
(Homo
sapiens)		4 / 6ASP A 135
ALA A  70
TYR A  37
ASP A  66
None
0.79A18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		2fcw LOW-DENSITY
LIPOPROTEIN RECEPTOR
(Homo
sapiens)		4 / 6ASP B 112
ASP B 118
ALA B 120
ASP B 108
 CA  B3001 (-3.3A)
CA  B3001 (-3.3A)
None
CA  B3001 (-2.9A)
1.18A15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		2ik8 GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(I),
ALPHA-1 SUBUNIT
(Homo
sapiens)		4 / 6ASP A 158
ASN A 157
ALA A 153
ASP A 173
None
0.97A23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		3j0a TOLL-LIKE RECEPTOR 5
(Homo
sapiens)		4 / 6ASP A 390
ASP A 366
ALA A 320
TYR A 321
None
None
FUC  A1343 (-3.3A)
None
1.06A12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		3thc BETA-GALACTOSIDASE
(Homo
sapiens)		4 / 6ASP A 518
ASN A 587
TYR A 413
ASP A 515
None
None
EDO  A1102 (-3.5A)
None
1.10A15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		4b90 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5
(Homo
sapiens)		4 / 6ASP A 399
ALA A 129
TYR A 128
ASP A 401
None
1.05A17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		4cns DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens)		4 / 6ASP A 406
ALA A 136
TYR A 135
ASP A 408
None
1.02A19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		4cnt DIHYDROPYRIMIDINASE-
LIKE 3
(Homo
sapiens)		4 / 6ASP A 406
ALA A 136
TYR A 135
ASP A 408
None
0.95A17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		4m18 PULMONARY
SURFACTANT-ASSOCIATE
D PROTEIN D
(Homo
sapiens)		4 / 6ASP A 297
ASN A 323
ALA A 325
ASP A 330
 CA  A 402 (-2.2A)
MAN  A 406 ( 2.6A)
MAN  A 405 ( 3.7A)
CA  A 403 ( 2.2A)
1.06A20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		4n9f CULLIN-5
(Homo
sapiens)		4 / 6ASP U 200
ASN U 201
TYR U 198
ASP U 193
None
1.21A21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		5fql IDURONATE-2-SULFATAS
E
(Homo
sapiens)		4 / 6ASP A  45
ASP A  46
ALA A 346
ASP A 334
 CA  A1551 (-3.0A)
CA  A1551 (-3.0A)
None
CA  A1551 (-2.6A)
1.21A16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MDB_A_RLTA401_1
(MARINER MOS1
TRANSPOSASE)		5wkh T-CELL RECEPTOR
ALPHA VARIABLE
30,T-CELL RECEPTOR,
SP3.4 ALPHA CHAIN
(Homo
sapiens)		4 / 6ASP D 161
ASN D 197
ALA D 194
ASP D 163
None
1.19A21.15