POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Seq. Identity (%)	View	Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3D91_A_REMA350_1 (RENIN)	1htr	GASTRICSIN (Homo sapiens)	5 / 12	ASP B  32 GLY B  34 PHE B  15 ASP B 217 SER B 221	None	0.78A	36.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3D91_A_REMA350_1 (RENIN)	1htr	GASTRICSIN (Homo sapiens)	5 / 12	ASP B 217 GLY B 219 LEU B  30 ASP B  32 SER B  36	None	0.83A	36.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3D91_A_REMA350_1 (RENIN)	1m54	CYSTATHIONINE BETA-SYNTHASE (Homo sapiens)	5 / 12	GLY A 307 THR A 296 LEU A 287 ASP A 281 ALA A 288	None	1.24A	22.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3D91_A_REMA350_1 (RENIN)	1qrp	PEPSIN 3A (Homo sapiens)	6 / 12	ASP E  32 GLY E  34 THR E  77 PHE E 117 ASP E 215 SER E 219	HH0  E 327 (-2.7A) HH0  E 327 (-4.1A) HH0  E 327 (-3.2A) HH0  E 327 ( 4.8A) HH0  E 327 (-2.5A) HH0  E 327 (-3.0A)	0.77A	38.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3D91_A_REMA350_1 (RENIN)	2ewy	BETA-SECRETASE 2 (Homo sapiens)	5 / 12	ASP A 241 GLY A 243 LEU A  46 ASP A  48 SER A  52	DBO  A1001 (-3.2A) DBO  A1001 (-4.2A) None DBO  A1001 (-2.7A) None	0.86A	27.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3D91_A_REMA350_1 (RENIN)	2g1s	RENIN (Homo sapiens)	8 / 12	ASP A  33 GLY A  35 SER A  79 PHE A 119 LEU A 219 ASP A 221 SER A 228 ALA A 309	4IG  A 885 (-2.7A) 4IG  A 885 (-3.5A) 4IG  A 885 (-3.0A) None None 4IG  A 885 (-2.6A) None None	0.73A	100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3D91_A_REMA350_1 (RENIN)	2g1s	RENIN (Homo sapiens)	10 / 12	GLN A  14 ASP A  33 GLY A  35 THR A  80 PHE A 119 LEU A 219 ASP A 221 SER A 225 SER A 228 ALA A 309	4IG  A 885 (-3.2A) 4IG  A 885 (-2.7A) 4IG  A 885 (-3.5A) 4IG  A 885 (-3.5A) None None 4IG  A 885 (-2.6A) 4IG  A 885 (-3.1A) None None	0.46A	100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3D91_A_REMA350_1 (RENIN)	2g1s	RENIN (Homo sapiens)	5 / 12	GLY A  35 PHE A 114 LEU A 219 SER A 228 ALA A 309	4IG  A 885 (-3.5A) 4IG  A 885 ( 4.8A) None None None	1.12A	100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3D91_A_REMA350_1 (RENIN)	2iik	3-KETOACYL-COA THIOLASE, PEROXISOMAL (Homo sapiens)	5 / 12	GLY A 248 SER A 280 LEU A 376 SER A 276 ALA A 373	None	1.28A	24.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3D91_A_REMA350_1 (RENIN)	3oad	RENIN (Homo sapiens)	6 / 12	LEU B 224 ASP B 226 SER B 230 SER B 233 HIS B 301 ALA B 314	None	0.36A	100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3D91_A_REMA350_1 (RENIN)	4amt	RENIN (Homo sapiens)	7 / 12	ASP A  81 GLY A  83 LEU A 267 ASP A 269 SER A 273 SER A 276 ALA A 357	None None None None SO4  A1387 (-3.8A) None None	0.42A	88.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3D91_A_REMA350_1 (RENIN)	4amt	RENIN (Homo sapiens)	7 / 12	ASP A  81 GLY A  83 PHE A 167 LEU A 267 ASP A 269 SER A 276 ALA A 357	None	0.70A	88.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3D91_A_REMA350_1 (RENIN)	4amt	RENIN (Homo sapiens)	6 / 12	GLN A  62 ASP A  81 GLY A  83 LEU A 267 ASP A 269 SER A 273	None None None None None SO4  A1387 (-3.8A)	1.32A	88.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3D91_A_REMA350_1 (RENIN)	4h1s	5'-NUCLEOTIDASE (Homo sapiens)	5 / 12	ASP A 226 GLY A 241 LEU A 218 SER A 178 ALA A 114	None	1.29A	21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3D91_A_REMA350_1 (RENIN)	4rcd	BETA-SECRETASE 1 (Homo sapiens)	5 / 12	ASP A 228 GLY A 230 LEU A  30 ASP A  32 SER A  36	3LL  A 501 (-2.6A) 3LL  A 501 (-3.0A) 3LL  A 501 (-4.2A) 3LL  A 501 (-2.8A) None	0.73A	26.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3D91_A_REMA350_1 (RENIN)	4rcd	BETA-SECRETASE 1 (Homo sapiens)	5 / 12	ASP A 228 GLY A 230 THR A  72 LEU A  30 ASP A  32	3LL  A 501 (-2.6A) 3LL  A 501 (-3.0A) None 3LL  A 501 (-4.2A) 3LL  A 501 (-2.8A)	1.08A	26.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3D91_A_REMA350_1 (RENIN)	5f9s	SERINE--PYRUVATE AMINOTRANSFERASE (Homo sapiens)	5 / 12	GLN A  65 SER A 218 LEU A 242 SER A 221 ALA A  88	None	1.25A	22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3D91_A_REMA350_1 (RENIN)	5iaa	UBIQUITIN-FOLD MODIFIER 1 UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME 5 (Homo sapiens)	5 / 12	GLY A 214 SER C  12 THR C  11 ASP C  80 SER C  47	None	1.17A	24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3D91_A_REMA350_1 (RENIN)	5mov	CASEIN KINASE II SUBUNIT ALPHA (Homo sapiens)	5 / 12	GLN A  40 GLY A  34 THR A  60 ASP A  99 ALA A  98	None	1.25A	22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3D91_A_REMA350_1 (RENIN)	5v1b	EGL NINE HOMOLOG 2 (Homo sapiens)	5 / 12	GLY A 305 PHE A 350 LEU A 389 ASP A 304 ALA A 390	None	1.20A	18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3D91_A_REMA350_1 (RENIN)	6ej2	BETA-SECRETASE 1 (Homo sapiens)	5 / 12	ASP A 637 GLY A 639 LEU A 439 ASP A 441 SER A 445	B7E  A 901 (-2.6A) B7E  A 901 (-3.8A) B7E  A 901 (-4.6A) B7E  A 901 (-2.9A) None	0.70A	13.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3D91_A_REMA350_2 (RENIN)	2g1s	RENIN (Homo sapiens)	4 / 5	ALA A 117 ALA A 224 TYR A 226 MET A 298	4IG  A 885 ( 4.6A) 4IG  A 885 ( 4.7A) None None	0.72A	100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3D91_A_REMA350_2 (RENIN)	2g1s	RENIN (Homo sapiens)	4 / 5	TYR A  78 ALA A 117 ALA A 224 MET A 298	4IG  A 885 (-4.0A) 4IG  A 885 ( 4.6A) 4IG  A 885 ( 4.7A) None	0.49A	100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3D91_A_REMA350_2 (RENIN)	2nmp	CYSTATHIONINE GAMMA-LYASE (Homo sapiens)	4 / 5	TYR A 208 ALA A 203 ALA A  76 TYR A  83	None	1.25A	23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3D91_A_REMA350_2 (RENIN)	2xyd	ANGIOTENSIN-CONVERTI NG ENZYME (Homo sapiens)	4 / 5	TYR A 237 ALA A 250 ALA A 154 TYR A 607	None	1.11A	19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3D91_A_REMA350_2 (RENIN)	3fht	ATP-DEPENDENT RNA HELICASE DDX19B (Homo sapiens)	4 / 5	ALA A 334 ALA A 439 TYR A 310 MET A 442	None	1.21A	20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3D91_A_REMA350_2 (RENIN)	3iuy	PROBABLE ATP-DEPENDENT RNA HELICASE DDX53 (Homo sapiens)	4 / 5	TYR A 285 ALA A 387 ALA A 275 TYR A 438	None	1.22A	21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3D91_A_REMA350_2 (RENIN)	5npr	UDP-N-ACETYLGLUCOSAM INE--PEPTIDE N-ACETYLGLUCOSAMINYL TRANSFERASE 110 KDA SUBUNIT (Homo sapiens)	4 / 5	ALA A 597 ALA A 582 TYR A 581 MET A 629	None	1.10A	13.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3D91_B_REMB350_1 (RENIN)	1htr	GASTRICSIN (Homo sapiens)	5 / 12	ASP B 217 GLY B 219 LEU B  30 ASP B  32 SER B  36	None	0.88A	36.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3D91_B_REMB350_1 (RENIN)	1qrp	PEPSIN 3A (Homo sapiens)	5 / 12	ASP E  32 GLY E  34 THR E  77 ASP E 215 SER E 219	HH0  E 327 (-2.7A) HH0  E 327 (-4.1A) HH0  E 327 (-3.2A) HH0  E 327 (-2.5A) HH0  E 327 (-3.0A)	0.46A	38.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3D91_B_REMB350_1 (RENIN)	1qrp	PEPSIN 3A (Homo sapiens)	5 / 12	ASP E  32 GLY E  34 THR E  77 VAL E  30 ASP E 215	HH0  E 327 (-2.7A) HH0  E 327 (-4.1A) HH0  E 327 (-3.2A) HH0  E 327 ( 4.7A) HH0  E 327 (-2.5A)	1.07A	38.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3D91_B_REMB350_1 (RENIN)	2ewy	BETA-SECRETASE 2 (Homo sapiens)	5 / 12	ASP A 241 GLY A 243 LEU A  46 ASP A  48 SER A  52	DBO  A1001 (-3.2A) DBO  A1001 (-4.2A) None DBO  A1001 (-2.7A) None	0.89A	27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3D91_B_REMB350_1 (RENIN)	2ewy	BETA-SECRETASE 2 (Homo sapiens)	5 / 12	ASP A 241 GLY A 243 VAL A 344 LEU A  46 ASP A  48	DBO  A1001 (-3.2A) DBO  A1001 (-4.2A) None None DBO  A1001 (-2.7A)	1.01A	27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3D91_B_REMB350_1 (RENIN)	2fy2	CHOLINE O-ACETYLTRANSFERASE (Homo sapiens)	5 / 12	GLY A 292 SER A 237 THR A 236 VAL A 321 ALA A 300	None	1.25A	21.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3D91_B_REMB350_1 (RENIN)	2g1s	RENIN (Homo sapiens)	8 / 12	ASP A  33 GLY A  35 SER A  79 THR A  80 VAL A  31 LEU A 219 ASP A 221 SER A 228	4IG  A 885 (-2.7A) 4IG  A 885 (-3.5A) 4IG  A 885 (-3.0A) 4IG  A 885 (-3.5A) 4IG  A 885 (-4.3A) None 4IG  A 885 (-2.6A) None	1.36A	100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3D91_B_REMB350_1 (RENIN)	2g1s	RENIN (Homo sapiens)	11 / 12	GLN A  14 ASP A  33 GLY A  35 SER A  79 THR A  80 VAL A 122 LEU A 219 ASP A 221 ALA A 224 SER A 225 SER A 228	4IG  A 885 (-3.2A) 4IG  A 885 (-2.7A) 4IG  A 885 (-3.5A) 4IG  A 885 (-3.0A) 4IG  A 885 (-3.5A) 4IG  A 885 ( 4.4A) None 4IG  A 885 (-2.6A) 4IG  A 885 ( 4.7A) 4IG  A 885 (-3.1A) None	0.55A	100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3D91_B_REMB350_1 (RENIN)	2ger	PYRROLINE-5-CARBOXYL ATE REDUCTASE 1 (Homo sapiens)	5 / 12	GLN A  10 GLY A   4 SER A  33 LEU A  66 ALA A  69	None	1.26A	22.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3D91_B_REMB350_1 (RENIN)	3oad	RENIN (Homo sapiens)	6 / 12	LEU B 224 ASP B 226 ALA B 229 SER B 230 SER B 233 HIS B 301	None	0.37A	100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3D91_B_REMB350_1 (RENIN)	3vzb	SPHINGOSINE KINASE 1 (Homo sapiens)	5 / 12	GLN A 128 GLY A  80 ASP A  81 ALA A 115 SER A 168	None None None SQS  A 401 ( 4.8A) SQS  A 401 (-3.1A)	1.19A	17.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3D91_B_REMB350_1 (RENIN)	4amt	RENIN (Homo sapiens)	8 / 12	ASP A  81 GLY A  83 VAL A 170 LEU A 267 ASP A 269 ALA A 272 SER A 273 SER A 276	None None None None None SO4  A1387 (-3.4A) SO4  A1387 (-3.8A) None	0.57A	88.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3D91_B_REMB350_1 (RENIN)	4amt	RENIN (Homo sapiens)	8 / 12	GLN A  62 ASP A  81 GLY A  83 LEU A 267 ASP A 269 ALA A 272 SER A 273 SER A 276	None None None None None SO4  A1387 (-3.4A) SO4  A1387 (-3.8A) None	1.35A	88.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3D91_B_REMB350_1 (RENIN)	4amt	RENIN (Homo sapiens)	8 / 12	GLN A  62 ASP A  81 GLY A  83 VAL A  79 LEU A 267 ASP A 269 ALA A 272 SER A 276	None None None None None None SO4  A1387 (-3.4A) None	1.33A	88.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3D91_B_REMB350_1 (RENIN)	4rcd	BETA-SECRETASE 1 (Homo sapiens)	5 / 12	ASP A 228 GLY A 230 LEU A  30 ASP A  32 SER A  36	3LL  A 501 (-2.6A) 3LL  A 501 (-3.0A) 3LL  A 501 (-4.2A) 3LL  A 501 (-2.8A) None	0.72A	26.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3D91_B_REMB350_1 (RENIN)	4rcd	BETA-SECRETASE 1 (Homo sapiens)	6 / 12	ASP A 228 GLY A 230 THR A  72 VAL A 332 LEU A  30 ASP A  32	3LL  A 501 (-2.6A) 3LL  A 501 (-3.0A) None None 3LL  A 501 (-4.2A) 3LL  A 501 (-2.8A)	1.06A	26.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3D91_B_REMB350_1 (RENIN)	5knm	LEUKOCYTE IMMUNOGLOBULIN-LIKE RECEPTOR SUBFAMILY B MEMBER 1 (Homo sapiens)	5 / 12	GLY D  97 SER D 189 VAL D  15 ALA D 176 SER D 124	None	1.16A	21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3D91_B_REMB350_1 (RENIN)	6ej2	BETA-SECRETASE 1 (Homo sapiens)	5 / 12	ASP A 637 GLY A 639 LEU A 439 ASP A 441 SER A 445	B7E  A 901 (-2.6A) B7E  A 901 (-3.8A) B7E  A 901 (-4.6A) B7E  A 901 (-2.9A) None	0.71A	13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3D91_B_REMB350_1 (RENIN)	6ej2	BETA-SECRETASE 1 (Homo sapiens)	5 / 12	ASP A 637 GLY A 639 VAL A 741 LEU A 439 ASP A 441	B7E  A 901 (-2.6A) B7E  A 901 (-3.8A) None B7E  A 901 (-4.6A) B7E  A 901 (-2.9A)	0.79A	13.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3D91_B_REMB350_2 (RENIN)	2g1s	RENIN (Homo sapiens)	4 / 4	VAL A  31 TYR A  78 PRO A 113 PHE A 119	4IG  A 885 (-4.3A) 4IG  A 885 (-4.0A) 4IG  A 885 (-4.7A) None	0.57A	100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3D91_B_REMB350_2 (RENIN)	3ceg	BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 6 (Homo sapiens)	4 / 4	VAL A4625 TYR A4699 PRO A4592 PHE A4627	None	1.23A	21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3D91_B_REMB350_2 (RENIN)	6ejb	XYLOSYLTRANSFERASE 1 (Homo sapiens)	4 / 4	VAL A 839 TYR A 867 PRO A 810 PHE A 837	None	1.28A	12.61