POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.


DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAV_A_RAVA183_1
(FERRITIN LIGHT CHAIN)
1ad0 ANTIBODY A5B7 (HEAVY
CHAIN)
(Homo
sapiens)
4 / 6LEU B  48
SER B  60
TYR B  59
ALA B  61
None
0.99A19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAV_A_RAVA183_1
(FERRITIN LIGHT CHAIN)
1ex0 COAGULATION FACTOR
XIII A CHAIN
(Homo
sapiens)
4 / 6SER A 263
ALA A 264
ARG A 260
LEU A 325
None
None
PGO  A1340 (-4.3A)
None
0.85A14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAV_A_RAVA183_1
(FERRITIN LIGHT CHAIN)
1fl5 ANTIBODY GERMLINE
PRECURSOR TO
ANTIBODY 28B4
(Homo
sapiens)
4 / 6LEU H  48
SER H  60
TYR H  59
ALA H  61
None
1.02A24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAV_A_RAVA183_1
(FERRITIN LIGHT CHAIN)
1ldj CULLIN HOMOLOG 1
(Homo
sapiens)
4 / 6LEU A 559
SER A 562
TYR A 563
LEU A 555
None
0.81A14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAV_A_RAVA183_1
(FERRITIN LIGHT CHAIN)
1nug PROTEIN-GLUTAMINE
GLUTAMYLTRANSFERASE
E
(Homo
sapiens)
4 / 6LEU A 352
SER A 220
ALA A 221
ARG A 217
None
None
CA  A 703 (-4.5A)
None
1.03A14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAV_A_RAVA183_1
(FERRITIN LIGHT CHAIN)
1nug PROTEIN-GLUTAMINE
GLUTAMYLTRANSFERASE
E
(Homo
sapiens)
4 / 6LEU A 352
SER A 220
ALA A 221
LEU A 283
None
None
CA  A 703 (-4.5A)
None
1.00A14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAV_A_RAVA183_1
(FERRITIN LIGHT CHAIN)
1xwi SKD1 PROTEIN
(Homo
sapiens)
4 / 6LEU A 300
SER A 337
TYR A 336
ALA A 339
None
1.07A19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAV_A_RAVA183_1
(FERRITIN LIGHT CHAIN)
2a9u UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 8
(Homo
sapiens)
4 / 6TYR A  60
ALA A  47
ARG A  51
LEU A 109
None
0.82A22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAV_A_RAVA183_1
(FERRITIN LIGHT CHAIN)
2b25 HYPOTHETICAL PROTEIN
(Homo
sapiens)
4 / 6LEU A 119
SER A 122
ARG A 152
LEU A  73
None
0.94A19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAV_A_RAVA183_1
(FERRITIN LIGHT CHAIN)
2lm0 AF4/FMR2 FAMILY
MEMBER 1/PROTEIN
AF-9 CHIMERA
(Homo
sapiens)
4 / 6LEU A 770
SER A 771
ARG A 772
LEU A 767
None
1.02A22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAV_A_RAVA183_1
(FERRITIN LIGHT CHAIN)
2rgz HEME OXYGENASE 2
(Homo
sapiens)
4 / 6LEU A  74
TYR A  75
ALA A 127
LEU A 109
None
0.78A23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAV_A_RAVA183_1
(FERRITIN LIGHT CHAIN)
2wya HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
MITOCHONDRIAL
(Homo
sapiens)
4 / 6LEU A 372
SER A 392
TYR A 373
ALA A 391
None
1.04A18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAV_A_RAVA183_1
(FERRITIN LIGHT CHAIN)
3fcx S-FORMYLGLUTATHIONE
HYDROLASE
(Homo
sapiens)
4 / 6LEU A 207
SER A 210
TYR A 211
LEU A 160
None
1.05A21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAV_A_RAVA183_1
(FERRITIN LIGHT CHAIN)
3n5n A/G-SPECIFIC ADENINE
DNA GLYCOSYLASE
(Homo
sapiens)
4 / 6LEU X 229
ALA X 234
ARG X 233
LEU X 248
None
1.06A20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAV_A_RAVA183_1
(FERRITIN LIGHT CHAIN)
4bej DYNAMIN 1-LIKE
PROTEIN
(Homo
sapiens)
4 / 6LEU A 624
SER A 627
TYR A 628
ALA A 504
None
0.59A15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAV_A_RAVA183_1
(FERRITIN LIGHT CHAIN)
4f52 CULLIN-1
(Homo
sapiens)
4 / 6LEU A 559
SER A 562
TYR A 563
LEU A 555
None
0.92A21.51