POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Seq. Identity (%)
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4WNU_A_QDNA602_1 (CYTOCHROME P450 2D6)	2f9q	CYTOCHROME P450 2D6 (Homo sapiens)	5 / 11	LEU A 110 GLY A 212 LEU A 213 PHE A 247 LEU A 248	None	0.98A	99.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4WNU_A_QDNA602_1 (CYTOCHROME P450 2D6)	2f9q	CYTOCHROME P450 2D6 (Homo sapiens)	7 / 11	LEU A 110 PHE A 120 GLY A 212 PHE A 247 LEU A 248 ALA A 300 SER A 304	None HEM A 600 (-4.6A) None None None None None	0.60A	99.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WNU_A_QDNA602_1 (CYTOCHROME P450 2D6)	2jii	SERINE/THREONINE-PRO TEIN KINASE VRK3 MOLECULE: VACCINIA RELATED KINASE 3 (Homo sapiens)	5 / 11	LEU A 290 PHE A 296 GLY A 326 ALA A 240 PHE A 217	None	1.17A	22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WNU_A_QDNA602_1 (CYTOCHROME P450 2D6)	2knh	PROTEIN CBFA2T1 (Homo sapiens)	5 / 11	LEU A 337 GLY A 302 LEU A 301 PHE A 313 LEU A 333	None	1.15A	11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WNU_A_QDNA602_1 (CYTOCHROME P450 2D6)	2pkg	SERINE/THREONINE-PRO TEIN PHOSPHATASE 2A 65 KDA REGULATORY SUBUNIT A ALPHA ISOFORM (Homo sapiens)	5 / 11	LEU A 544 PHE A 538 GLY A 530 LEU A 564 ALA A 579	None	1.22A	22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WNU_A_QDNA602_1 (CYTOCHROME P450 2D6)	3ahr	ERO1-LIKE PROTEIN ALPHA (Homo sapiens)	5 / 11	LEU A 254 GLU A 186 GLN A 404 LEU A 307 SER A 453	None	1.21A	22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WNU_A_QDNA602_1 (CYTOCHROME P450 2D6)	3f1r	FIBROBLAST GROWTH FACTOR 20 (Homo sapiens)	5 / 11	LEU A 203 GLY A 112 LEU A 117 PHE A 95 LEU A 94	None	1.16A	20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WNU_A_QDNA602_1 (CYTOCHROME P450 2D6)	3ut3	PLASMINOGEN ACTIVATOR INHIBITOR 1 (Homo sapiens)	5 / 11	LEU A 82 GLY A 38 LEU A 78 ALA A 9 SER A 13	None	1.14A	21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WNU_A_QDNA602_1 (CYTOCHROME P450 2D6)	3v4y	SERINE/THREONINE-PRO TEIN PHOSPHATASE PP1-ALPHA CATALYTIC SUBUNIT (Homo sapiens)	5 / 11	LEU A 90 LEU A 241 LEU A 88 ALA A 163 PHE A 235	None	1.12A	20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WNU_A_QDNA602_1 (CYTOCHROME P450 2D6)	3zrh	UBIQUITIN THIOESTERASE ZRANB1 (Homo sapiens)	5 / 11	LEU A 375 LEU A 363 ALA A 465 SER A 469 PHE A 370	None	1.16A	21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WNU_A_QDNA602_1 (CYTOCHROME P450 2D6)	4oe5	DELTA-1-PYRROLINE-5- CARBOXYLATE DEHYDROGENASE, MITOCHONDRIAL (Homo sapiens)	5 / 11	LEU A 453 PHE A 320 GLY A 335 ALA A 350 SER A 510	None	1.02A	20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WNU_A_QDNA602_1 (CYTOCHROME P450 2D6)	4rcd	BETA-SECRETASE 1 (Homo sapiens)	5 / 11	LEU A 133 GLY A 120 LEU A 121 PHE A 38 ALA A 97	None	1.21A	21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WNU_A_QDNA602_1 (CYTOCHROME P450 2D6)	5kre	LYSOPHOSPHOLIPASE-LI KE PROTEIN 1 (Homo sapiens)	5 / 11	LEU A 194 PHE A 150 LEU A 171 ALA A 146 PHE A 78	None NO3 A 302 (-4.4A) None None None	1.08A	18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WNU_A_QDNA602_1 (CYTOCHROME P450 2D6)	5toa	ESTROGEN RECEPTOR BETA (Homo sapiens)	5 / 11	LEU A 263 LEU A 322 GLU A 321 LEU A 268 ALA A 432	None	1.12A	20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WNU_A_QDNA602_1 (CYTOCHROME P450 2D6)	6caj	TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA (Homo sapiens)	5 / 11	LEU C 144 GLY C 40 LEU C 41 LEU C 140 PHE C 18	None	0.96A	10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WNU_A_QDNA602_1 (CYTOCHROME P450 2D6)	6ej2	BETA-SECRETASE 1 (Homo sapiens)	5 / 11	LEU A 542 GLY A 529 LEU A 530 PHE A 447 ALA A 506	None	1.21A	13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WNU_A_QDNA602_1 (CYTOCHROME P450 2D6)	6ffh	METABOTROPIC GLUTAMATE RECEPTOR 5,ENDOLYSIN (Escherichia virus T4; Homo sapiens)	5 / 11	GLY A 628 LEU A 630 LEU A1814 ALA A 593 PHE A 633	D7W A4006 (-3.4A) YCM A 634 ( 4.2A) None None OLA A4004 (-4.8A)	1.17A	9.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4WNU_B_QDNB602_1 (CYTOCHROME P450 2D6)	2f9q	CYTOCHROME P450 2D6 (Homo sapiens)	6 / 9	LEU A 110 PHE A 120 GLN A 244 ASP A 301 SER A 304 ALA A 305	None HEM A 600 (-4.6A) None None None HEM A 600 (-3.6A)	1.19A	99.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4WNU_B_QDNB602_1 (CYTOCHROME P450 2D6)	2f9q	CYTOCHROME P450 2D6 (Homo sapiens)	7 / 9	LEU A 110 PHE A 120 PHE A 247 ALA A 300 ASP A 301 SER A 304 ALA A 305	None HEM A 600 (-4.6A) None None None None HEM A 600 (-3.6A)	0.53A	99.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4WNU_B_QDNB602_1 (CYTOCHROME P450 2D6)	2f9q	CYTOCHROME P450 2D6 (Homo sapiens)	6 / 9	LEU A 248 PHE A 120 GLN A 244 ASP A 301 SER A 304 ALA A 305	None HEM A 600 (-4.6A) None None None HEM A 600 (-3.6A)	1.43A	99.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4WNU_B_QDNB602_1 (CYTOCHROME P450 2D6)	2f9q	CYTOCHROME P450 2D6 (Homo sapiens)	5 / 9	LEU A 248 PHE A 120 GLU A 216 GLN A 244 ALA A 305	None HEM A 600 (-4.6A) None None HEM A 600 (-3.6A)	1.46A	99.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WNU_B_QDNB602_1 (CYTOCHROME P450 2D6)	4zrq	TRANSCOBALAMIN-2 (Homo sapiens)	5 / 9	LEU A 388 GLU A 219 ALA A 264 SER A 259 ALA A 258	None	1.40A	23.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4WNU_C_QDNC602_1 (CYTOCHROME P450 2D6)	2f9q	CYTOCHROME P450 2D6 (Homo sapiens)	6 / 11	LEU A 110 PHE A 120 GLY A 212 GLN A 244 ASP A 301 SER A 304	None HEM A 600 (-4.6A) None None None None	1.24A	99.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4WNU_C_QDNC602_1 (CYTOCHROME P450 2D6)	2f9q	CYTOCHROME P450 2D6 (Homo sapiens)	7 / 11	LEU A 110 PHE A 120 GLY A 212 PHE A 247 ALA A 300 ASP A 301 SER A 304	None HEM A 600 (-4.6A) None None None None None	0.61A	99.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4WNU_C_QDNC602_1 (CYTOCHROME P450 2D6)	2f9q	CYTOCHROME P450 2D6 (Homo sapiens)	6 / 11	LEU A 248 PHE A 120 GLY A 212 GLN A 244 ASP A 301 SER A 304	None HEM A 600 (-4.6A) None None None None	1.47A	99.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WNU_C_QDNC602_1 (CYTOCHROME P450 2D6)	2hpa	PROTEIN (ACID PHOSPHATASE) (Homo sapiens)	5 / 11	LEU A1283 GLY A1050 LEU A1091 PHE A1010 PHE A1092	None	1.36A	20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WNU_C_QDNC602_1 (CYTOCHROME P450 2D6)	2jii	SERINE/THREONINE-PRO TEIN KINASE VRK3 MOLECULE: VACCINIA RELATED KINASE 3 (Homo sapiens)	5 / 11	LEU A 290 PHE A 296 GLY A 326 ALA A 240 PHE A 217	None	1.28A	22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WNU_C_QDNC602_1 (CYTOCHROME P450 2D6)	3e5m	NMRA-LIKE FAMILY DOMAIN-CONTAINING PROTEIN 1 (Homo sapiens)	5 / 11	GLY A 113 LEU A 114 GLU A 115 ASP A 186 PHE A 130	None	1.26A	21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WNU_C_QDNC602_1 (CYTOCHROME P450 2D6)	3k9b	LIVER CARBOXYLESTERASE 1 (Homo sapiens)	5 / 11	LEU A1230 GLY A1223 GLU A1225 ALA A1243 SER A1245	None	1.12A	22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WNU_C_QDNC602_1 (CYTOCHROME P450 2D6)	4oe5	DELTA-1-PYRROLINE-5- CARBOXYLATE DEHYDROGENASE, MITOCHONDRIAL (Homo sapiens)	5 / 11	LEU A 453 PHE A 320 GLY A 335 ALA A 350 SER A 510	None	0.98A	20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WNU_C_QDNC602_1 (CYTOCHROME P450 2D6)	4wlp	NUCLEAR FACTOR RELATED TO KAPPA-B-BINDING PROTEIN UBIQUITIN CARBOXYL-TERMINAL HYDROLASE ISOZYME L5 (Homo sapiens)	5 / 11	LEU B 146 PHE A 121 ALA A 123 ASP A 122 PHE A 114	None	1.38A	13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WNU_C_QDNC602_1 (CYTOCHROME P450 2D6)	5a1n	BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE (Homo sapiens)	5 / 11	LEU A 82 GLY A 16 LEU A 19 ALA A 59 PHE A 160	None	1.26A	18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WNU_C_QDNC602_1 (CYTOCHROME P450 2D6)	5wrr	PSEUDOKINASE FAM20A (Homo sapiens)	5 / 11	PHE A 275 GLY A 407 PHE A 435 ALA A 266 ASP A 270	None	1.21A	24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WNU_C_QDNC602_1 (CYTOCHROME P450 2D6)	5xqh	PROTEIN ROGDI HOMOLOG (Homo sapiens)	5 / 11	GLY A 79 LEU A 77 PHE A 45 ALA A 257 ASP A 256	None	1.28A	18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WNU_C_QDNC602_1 (CYTOCHROME P450 2D6)	5y3r	DNA-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT (Homo sapiens)	5 / 11	LEU C 662 GLY C 769 LEU C 773 GLU C 775 SER C 735	None	1.34A	7.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WNU_C_QDNC602_1 (CYTOCHROME P450 2D6)	5yh3	EXTRACELLULAR SERINE/THREONINE PROTEIN KINASE FAM20C (Homo sapiens)	5 / 11	PHE C 323 GLY C 455 PHE C 483 ALA C 314 ASP C 318	None	1.23A	13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WNU_D_QDND602_1 (CYTOCHROME P450 2D6)	1htn	TETRANECTIN (Homo sapiens)	5 / 10	GLY A 105 GLU A 107 LEU A 172 SER A 156 ALA A 159	None	1.29A	18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WNU_D_QDND602_1 (CYTOCHROME P450 2D6)	1hzf	COMPLEMENT FACTOR C4A (Homo sapiens)	5 / 10	LEU A1254 ALA A1263 ASP A1264 SER A1267 ALA A1268	None	1.18A	23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WNU_D_QDND602_1 (CYTOCHROME P450 2D6)	1jkw	CYCLIN H (Homo sapiens)	5 / 10	PHE A 194 LEU A 195 ALA A 216 SER A 220 ALA A 221	None	0.98A	20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WNU_D_QDND602_1 (CYTOCHROME P450 2D6)	1qu6	PROTEIN KINASE PKR (Homo sapiens)	5 / 10	PHE A 48 GLY A 13 LEU A 19 ALA A 73 ALA A 68	None	1.26A	18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WNU_D_QDND602_1 (CYTOCHROME P450 2D6)	1tn3	TETRANECTIN (Homo sapiens)	5 / 10	GLY A 105 GLU A 107 LEU A 172 SER A 156 ALA A 159	None	1.23A	18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WNU_D_QDND602_1 (CYTOCHROME P450 2D6)	1ug3	EUKARYOTIC PROTEIN SYNTHESIS INITIATION FACTOR 4G (Homo sapiens)	5 / 10	GLY A1455 LEU A1448 ALA A1486 SER A1490 ALA A1491	None	0.88A	21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WNU_D_QDND602_1 (CYTOCHROME P450 2D6)	1w8d	2,4-DIENOYL-COA REDUCTASE, MITOCHONDRIAL PRECURSOR (Homo sapiens)	5 / 10	PHE A 57 LEU A 82 ALA A 282 SER A 286 ALA A 289	GOL A1329 ( 4.2A) None None GOL A1329 (-4.3A) None	1.31A	22.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4WNU_D_QDND602_1 (CYTOCHROME P450 2D6)	2f9q	CYTOCHROME P450 2D6 (Homo sapiens)	5 / 10	PHE A 120 GLY A 212 GLN A 244 ASP A 301 ALA A 305	HEM A 600 (-4.6A) None None None HEM A 600 (-3.6A)	1.05A	99.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4WNU_D_QDND602_1 (CYTOCHROME P450 2D6)	2f9q	CYTOCHROME P450 2D6 (Homo sapiens)	5 / 10	PHE A 120 GLY A 212 GLU A 216 GLN A 244 ALA A 305	HEM A 600 (-4.6A) None None None HEM A 600 (-3.6A)	1.27A	99.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4WNU_D_QDND602_1 (CYTOCHROME P450 2D6)	2f9q	CYTOCHROME P450 2D6 (Homo sapiens)	5 / 10	PHE A 120 GLY A 212 GLU A 216 LEU A 251 ALA A 305	HEM A 600 (-4.6A) None None None HEM A 600 (-3.6A)	1.30A	99.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4WNU_D_QDND602_1 (CYTOCHROME P450 2D6)	2f9q	CYTOCHROME P450 2D6 (Homo sapiens)	8 / 10	PHE A 120 GLY A 212 PHE A 247 LEU A 248 ALA A 300 ASP A 301 SER A 304 ALA A 305	HEM A 600 (-4.6A) None None None None None None HEM A 600 (-3.6A)	0.53A	99.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WNU_D_QDND602_1 (CYTOCHROME P450 2D6)	2jbm	NICOTINATE-NUCLEOTID E PYROPHOSPHORYLASE (Homo sapiens)	5 / 10	GLY A 58 GLN A 59 PHE A 62 ALA A 90 ALA A 50	None	1.18A	23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WNU_D_QDND602_1 (CYTOCHROME P450 2D6)	2oby	PUTATIVE QUINONE OXIDOREDUCTASE (Homo sapiens)	5 / 10	GLY A 62 GLN A 95 LEU A 330 ALA A 36 ALA A 120	None	1.08A	23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WNU_D_QDND602_1 (CYTOCHROME P450 2D6)	2p2c	CASPASE-2 (Homo sapiens)	5 / 10	GLY P 124 LEU P 117 ALA P 149 SER P 153 ALA P 162	None	1.29A	14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WNU_D_QDND602_1 (CYTOCHROME P450 2D6)	2z8c	INSULIN RECEPTOR (Homo sapiens)	5 / 10	PHE A1276 LEU A1267 ALA A1114 ASP A1118 ALA A1121	None	1.27A	21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WNU_D_QDND602_1 (CYTOCHROME P450 2D6)	3f0w	NUMB-LIKE PROTEIN (Homo sapiens)	5 / 10	GLY A 86 LEU A 175 ALA A 156 ASP A 150 SER A 158	None	1.05A	17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WNU_D_QDND602_1 (CYTOCHROME P450 2D6)	3ikm	DNA POLYMERASE SUBUNIT GAMMA-1 (Homo sapiens)	5 / 10	PHE A 273 GLY A 431 PHE A 291 ASP A 274 ALA A 276	None	1.14A	17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WNU_D_QDND602_1 (CYTOCHROME P450 2D6)	4eku	PROTEIN-TYROSINE KINASE 2-BETA (Homo sapiens)	5 / 10	GLY A 282 GLU A 263 LEU A 354 ASP A 346 ALA A 345	None	1.31A	19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WNU_D_QDND602_1 (CYTOCHROME P450 2D6)	4nen	INTEGRIN ALPHA-X (Homo sapiens)	5 / 10	PHE A 361 GLY A 90 LEU A 87 ALA A 339 ALA A 350	None	1.29A	19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WNU_D_QDND602_1 (CYTOCHROME P450 2D6)	4otd	SERINE/THREONINE-PRO TEIN KINASE N1 (Homo sapiens)	5 / 10	GLY A 808 LEU A 815 ALA A 723 SER A 727 ALA A 728	None	0.64A	22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WNU_D_QDND602_1 (CYTOCHROME P450 2D6)	5e6s	INTEGRIN ALPHA-L (Homo sapiens)	5 / 10	GLY A 81 LEU A 25 ALA A 75 ASP A 332 ALA A 338	None	1.35A	21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WNU_D_QDND602_1 (CYTOCHROME P450 2D6)	5xbk	IMPORTIN-4 (Homo sapiens)	5 / 10	PHE D 921 GLY D 930 GLU D 928 LEU D 941 ALA D 883	None	1.13A	10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WNU_D_QDND602_1 (CYTOCHROME P450 2D6)	5yh3	EXTRACELLULAR SERINE/THREONINE PROTEIN KINASE FAM20C (Homo sapiens)	5 / 10	PHE C 323 GLY C 455 PHE C 483 ALA C 314 ASP C 318	None	1.26A	13.67