POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_A_PPFA410_1
(PHOSPHONOACETATE
HYDROLASE)		1zef ALKALINE PHOSPHATASE
(Homo
sapiens)		4 / 5ASP A 316
HIS A 320
HIS A 358
HIS A 432
 ZN  A 901 ( 1.9A)
ZN  A 901 ( 3.3A)
ZN  A 902 (-3.2A)
ZN  A 901 ( 3.2A)
0.46A22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_A_PPFA410_1
(PHOSPHONOACETATE
HYDROLASE)		2ibn INOSITOL OXYGENASE
(Homo
sapiens)		4 / 5THR A 102
ASP A 253
HIS A 220
HIS A  98
None
FE  A 703 (-2.5A)
FE  A 704 ( 3.4A)
FE  A 703 (-3.2A)
1.21A16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_A_PPFA410_1
(PHOSPHONOACETATE
HYDROLASE)		3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens)		4 / 5THR A 723
ASP A 654
HIS A 613
HIS A 684
None
None
VDN  A   1 (-4.3A)
None
0.99A22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_A_PPFA410_1
(PHOSPHONOACETATE
HYDROLASE)		3e0l GUANINE DEAMINASE
(Homo
sapiens)		4 / 5ASP A 328
HIS A  84
HIS A 277
HIS A 238
 ZN  A1452 (-2.8A)
ZN  A1452 (-3.1A)
None
ZN  A1452 (-3.2A)
0.94A22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_A_PPFA410_1
(PHOSPHONOACETATE
HYDROLASE)		3oui EGL NINE HOMOLOG 1
(Homo
sapiens)		4 / 5THR A 325
ASP A 315
HIS A 313
HIS A 374
None
FE2  A   1 ( 2.5A)
FE2  A   1 ( 3.3A)
FE2  A   1 ( 3.2A)
1.22A18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_A_PPFA410_1
(PHOSPHONOACETATE
HYDROLASE)		4eih ABELSON
TYROSINE-PROTEIN
KINASE 2
(Homo
sapiens)		4 / 5THR A 233
ASP A 253
HIS A 247
HIS A 248
None
1.25A13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_A_PPFA410_1
(PHOSPHONOACETATE
HYDROLASE)		4kq8 CYTOCHROME P450 19A1
(Homo
sapiens)		4 / 5ASP A 381
HIS A 111
HIS A 105
HIS A 109
None
PO4  A 603 (-4.0A)
None
PO4  A 603 (-3.6A)
1.10A22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_A_PPFA410_1
(PHOSPHONOACETATE
HYDROLASE)		4lr2 BIS(5'-ADENOSYL)-TRI
PHOSPHATASE ENPP4
(Homo
sapiens)		5 / 5THR A  70
ASP A 189
HIS A 193
HIS A 238
HIS A 336
 ZN  A 505 ( 2.4A)
ZN  A 506 ( 2.1A)
ZN  A 506 ( 3.3A)
ZN  A 505 (-3.1A)
ZN  A 506 ( 3.3A)
0.44A23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_A_PPFA410_1
(PHOSPHONOACETATE
HYDROLASE)		4qn9 N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D
(Homo
sapiens)		4 / 5ASP A 284
HIS A 343
HIS A 185
HIS A 190
 ZN  A 502 (-2.5A)
ZN  A 502 ( 3.6A)
ZN  A 501 (-3.6A)
ZN  A 502 (-3.5A)
1.20A21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_A_PPFA410_1
(PHOSPHONOACETATE
HYDROLASE)		4zg7 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2
(Homo
sapiens)		5 / 5THR A 210
ASP A 312
HIS A 316
HIS A 360
HIS A 475
 ZN  A 904 ( 2.6A)
ZN  A 903 ( 2.0A)
ZN  A 903 ( 3.2A)
ZN  A 904 ( 3.2A)
ZN  A 903 ( 3.3A)
0.44A19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_A_PPFA410_1
(PHOSPHONOACETATE
HYDROLASE)		5deu METHYLCYTOSINE
DIOXYGENASE TET2,
CHIMERIC CONSTRUCT
(Homo
sapiens)		4 / 5THR A1393
ASP A1384
HIS A1382
HIS A1881
 CL  A2007 (-4.5A)
FE  A2003 ( 2.4A)
FE  A2003 (-3.3A)
FE  A2003 ( 3.2A)
0.98A22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_A_PPFA410_1
(PHOSPHONOACETATE
HYDROLASE)		5udy ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 7
(Homo
sapiens)		5 / 5THR A  75
ASP A 199
HIS A 203
HIS A 247
HIS A 353
 ZN  A 501 (-2.6A)
ZN  A 502 (-2.3A)
ZN  A 502 (-3.3A)
ZN  A 501 (-3.1A)
ZN  A 502 (-3.3A)
0.48A21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_A_PPFA410_1
(PHOSPHONOACETATE
HYDROLASE)		5vem ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 5
(Homo
sapiens)		5 / 5THR A  72
ASP A 191
HIS A 195
HIS A 239
HIS A 339
 ZN  A 501 (-2.4A)
ZN  A 502 (-2.0A)
ZN  A 502 (-3.2A)
ZN  A 501 (-3.1A)
ZN  A 502 (-3.2A)
0.36A21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_A_PPFA410_1
(PHOSPHONOACETATE
HYDROLASE)		6c01 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 3
(Homo
sapiens)		5 / 5THR A 205
ASP A 325
HIS A 329
HIS A 373
HIS A 483
 ZN  A 902 (-2.5A)
ZN  A 901 ( 2.1A)
ZN  A 901 ( 3.3A)
ZN  A 902 (-3.3A)
ZN  A 901 ( 3.3A)
0.44A10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_C_PPFC413_1
(PHOSPHONOACETATE
HYDROLASE)		1au8 CATHEPSIN G
(Homo
sapiens)		4 / 8PHE A 228
THR A 229
ASP A 102
HIS A  57
None
None
None
0H8  A   1 (-3.3A)
0.88A21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_C_PPFC413_1
(PHOSPHONOACETATE
HYDROLASE)		1zef ALKALINE PHOSPHATASE
(Homo
sapiens)		5 / 8ASP A  42
ASP A 316
HIS A 320
HIS A 358
HIS A 432
 ZN  A 902 ( 2.1A)
ZN  A 901 ( 1.9A)
ZN  A 901 ( 3.3A)
ZN  A 902 (-3.2A)
ZN  A 901 ( 3.2A)
0.46A22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_C_PPFC413_1
(PHOSPHONOACETATE
HYDROLASE)		1zef ALKALINE PHOSPHATASE
(Homo
sapiens)		4 / 8ASP A  42
ASP A 316
HIS A 320
HIS A 360
 ZN  A 902 ( 2.1A)
ZN  A 901 ( 1.9A)
ZN  A 901 ( 3.3A)
None
0.95A22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_C_PPFC413_1
(PHOSPHONOACETATE
HYDROLASE)		2fvz INOSITOL
MONOPHOSPHATASE 2
(Homo
sapiens)		4 / 8ASP A 179
PHE A 186
THR A 182
ILE A 174
None
0.92A21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_C_PPFC413_1
(PHOSPHONOACETATE
HYDROLASE)		4d61 EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT
ERF3A
(Homo
sapiens)		4 / 8PHE i 276
ASP i 478
HIS i 282
ILE i 285
None
0.95A22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_C_PPFC413_1
(PHOSPHONOACETATE
HYDROLASE)		4lr2 BIS(5'-ADENOSYL)-TRI
PHOSPHATASE ENPP4
(Homo
sapiens)		6 / 8ASP A  34
THR A  70
ASP A 189
HIS A 193
HIS A 238
HIS A 336
 ZN  A 505 (-2.1A)
ZN  A 505 ( 2.4A)
ZN  A 506 ( 2.1A)
ZN  A 506 ( 3.3A)
ZN  A 505 (-3.1A)
ZN  A 506 ( 3.3A)
0.44A23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_C_PPFC413_1
(PHOSPHONOACETATE
HYDROLASE)		4qkf ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE ALKB
HOMOLOG 7,
MITOCHONDRIAL
(Homo
sapiens)		4 / 8ASP A 123
HIS A 177
ILE A  70
HIS A 121
 MN  A 300 (-2.9A)
MN  A 300 ( 3.5A)
None
MN  A 300 ( 3.4A)
1.00A19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_C_PPFC413_1
(PHOSPHONOACETATE
HYDROLASE)		4zg7 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2
(Homo
sapiens)		6 / 8ASP A 172
THR A 210
ASP A 312
HIS A 316
HIS A 360
HIS A 475
 ZN  A 904 ( 2.2A)
ZN  A 904 ( 2.6A)
ZN  A 903 ( 2.0A)
ZN  A 903 ( 3.2A)
ZN  A 904 ( 3.2A)
ZN  A 903 ( 3.3A)
0.42A19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_C_PPFC413_1
(PHOSPHONOACETATE
HYDROLASE)		5aho 5' EXONUCLEASE
APOLLO
(Homo
sapiens)		4 / 8ASP A 145
ASP A 120
HIS A  31
HIS A 276
None
ZN  A1320 (-2.5A)
ZN  A1321 (-3.3A)
TLA  A1319 ( 3.9A)
1.00A22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_C_PPFC413_1
(PHOSPHONOACETATE
HYDROLASE)		5aho 5' EXONUCLEASE
APOLLO
(Homo
sapiens)		5 / 8ASP A 145
THR A 147
ASP A 120
HIS A  36
HIS A 276
None
TLA  A1319 ( 4.7A)
ZN  A1320 (-2.5A)
ZN  A1320 ( 3.4A)
TLA  A1319 ( 3.9A)
1.42A22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_C_PPFC413_1
(PHOSPHONOACETATE
HYDROLASE)		5ahr DNA CROSS-LINK
REPAIR 1A PROTEIN
(Homo
sapiens)		5 / 8ASP A 838
THR A 840
ASP A 815
HIS A 737
HIS A 994
None
None
ZN  A2041 (-3.1A)
ZN  A2041 ( 4.8A)
None
1.47A20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_C_PPFC413_1
(PHOSPHONOACETATE
HYDROLASE)		5epz ANGIOGENIN
(Homo
sapiens)		4 / 8PHE A  45
THR A  79
HIS A  47
ILE A  29
None
1.00A15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_C_PPFC413_1
(PHOSPHONOACETATE
HYDROLASE)		5i35 ATYPICAL KINASE
ADCK3, MITOCHONDRIAL
(Homo
sapiens)		4 / 8THR A 606
HIS A 559
ILE A 525
HIS A 610
None
0.84A23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_C_PPFC413_1
(PHOSPHONOACETATE
HYDROLASE)		5osh VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 29
(Homo
sapiens)		4 / 8PHE A  63
ASP A   8
HIS A 117
HIS A  10
None
0.84A11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_C_PPFC413_1
(PHOSPHONOACETATE
HYDROLASE)		5udy ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 7
(Homo
sapiens)		6 / 8ASP A  39
THR A  75
ASP A 199
HIS A 203
HIS A 247
HIS A 353
 ZN  A 501 (-2.0A)
ZN  A 501 (-2.6A)
ZN  A 502 (-2.3A)
ZN  A 502 (-3.3A)
ZN  A 501 (-3.1A)
ZN  A 502 (-3.3A)
0.43A21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_C_PPFC413_1
(PHOSPHONOACETATE
HYDROLASE)		5vem ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 5
(Homo
sapiens)		6 / 8ASP A  36
THR A  72
ASP A 191
HIS A 195
HIS A 239
HIS A 339
 ZN  A 501 (-2.0A)
ZN  A 501 (-2.4A)
ZN  A 502 (-2.0A)
ZN  A 502 (-3.2A)
ZN  A 501 (-3.1A)
ZN  A 502 (-3.2A)
0.41A21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_C_PPFC413_1
(PHOSPHONOACETATE
HYDROLASE)		5yjp HUMAN CHYMASE
(Homo
sapiens)		4 / 8PHE A 228
THR A 229
ASP A 102
HIS A  57
None
None
8W6  A 304 (-3.9A)
8W6  A 304 (-3.7A)
0.76A9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_C_PPFC413_1
(PHOSPHONOACETATE
HYDROLASE)		6c01 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 3
(Homo
sapiens)		6 / 8ASP A 167
THR A 205
ASP A 325
HIS A 329
HIS A 373
HIS A 483
 ZN  A 902 (-2.0A)
ZN  A 902 (-2.5A)
ZN  A 901 ( 2.1A)
ZN  A 901 ( 3.3A)
ZN  A 902 (-3.3A)
ZN  A 901 ( 3.3A)
0.41A10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_D_PPFD412_1
(PHOSPHONOACETATE
HYDROLASE)		1kcw CERULOPLASMIN
(Homo
sapiens)		5 / 8HIS A 980
ILE A1027
HIS A 978
HIS A1020
HIS A 163
 CU  A1050 (-3.0A)
None
CU  A1052 ( 3.2A)
CU  A1050 (-3.2A)
CU  A1050 (-3.3A)
1.14A17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_D_PPFD412_1
(PHOSPHONOACETATE
HYDROLASE)		1nmw PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
NIMA-INTERACTING 1
(Homo
sapiens)		4 / 8PHE A 151
THR A 152
ILE A 156
HIS A  59
None
0.93A14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_D_PPFD412_1
(PHOSPHONOACETATE
HYDROLASE)		1zcn PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
NIMA-INTERACTING 1
(Homo
sapiens)		4 / 8PHE A 151
THR A 152
ILE A 156
HIS A  59
None
1PE  A 400 ( 4.6A)
None
1PE  A 400 ( 4.4A)
0.83A16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_D_PPFD412_1
(PHOSPHONOACETATE
HYDROLASE)		2ibn INOSITOL OXYGENASE
(Homo
sapiens)		4 / 8ASP A 124
HIS A 123
HIS A 220
HIS A  98
 FE  A 704 (-2.5A)
FE  A 703 (-3.3A)
FE  A 704 ( 3.4A)
FE  A 703 (-3.2A)
0.75A16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_D_PPFD412_1
(PHOSPHONOACETATE
HYDROLASE)		2oy4 NEUTROPHIL
COLLAGENASE
(Homo
sapiens)		4 / 8ASP A 149
HIS A 147
ILE A 159
HIS A 175
 ZN  A 998 (-2.3A)
ZN  A 998 (-3.4A)
None
ZN  A 998 (-3.4A)
0.89A16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_D_PPFD412_1
(PHOSPHONOACETATE
HYDROLASE)		2qyk CYCLIC AMP-SPECIFIC
PHOSPHODIESTERASE
HSPDE4A10
(Homo
sapiens)		4 / 8THR A 483
ASP A 413
HIS A 372
HIS A 376
 MG  A   2 ( 4.9A)
MG  A   2 ( 2.6A)
NPV  A   3 (-4.6A)
ZN  A   1 (-3.3A)
1.03A23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_D_PPFD412_1
(PHOSPHONOACETATE
HYDROLASE)		3ba0 MACROPHAGE
METALLOELASTASE
(Homo
sapiens)		4 / 8ASP A 170
HIS A 168
ILE A 180
HIS A 196
 ZN  A 472 (-2.3A)
ZN  A 472 (-3.0A)
None
ZN  A 472 (-3.4A)
1.00A20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_D_PPFD412_1
(PHOSPHONOACETATE
HYDROLASE)		3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A
(Homo
sapiens)		4 / 8THR A 668
ASP A 597
HIS A 556
HIS A 560
 MG  A   2 ( 4.7A)
MG  A   2 ( 2.8A)
None
ZN  A   1 (-3.4A)
1.02A21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_D_PPFD412_1
(PHOSPHONOACETATE
HYDROLASE)		3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens)		4 / 8THR A 768
ASP A 697
HIS A 656
HIS A 660
 MG  A 905 (-4.3A)
ZN  A   1 ( 2.9A)
None
ZN  A   1 (-3.4A)
1.02A20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_D_PPFD412_1
(PHOSPHONOACETATE
HYDROLASE)		3rzu STAM-BINDING PROTEIN
(Homo
sapiens)		4 / 8HIS A 396
ILE A 387
HIS A 350
HIS A 398
 ZN  A   2 (-3.5A)
None
ZN  A   2 (-3.5A)
ZN  A   2 (-3.4A)
0.94A19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_D_PPFD412_1
(PHOSPHONOACETATE
HYDROLASE)		3rzv STAM-BINDING PROTEIN
(Homo
sapiens)		4 / 8HIS A 396
ILE A 387
HIS A 350
HIS A 398
 ZN  A   2 (-3.2A)
None
ZN  A   2 (-3.3A)
ZN  A   2 (-3.2A)
0.95A20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_D_PPFD412_1
(PHOSPHONOACETATE
HYDROLASE)		4igm 2-AMINO-3-CARBOXYMUC
ONATE-6-SEMIALDEHYDE
DECARBOXYLASE
(Homo
sapiens)		4 / 8ASP A 291
HIS A   6
HIS A 174
HIS A 224
 ZN  A 401 (-3.0A)
ZN  A 401 (-3.4A)
ZN  A 401 (-3.3A)
None
0.91A20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_D_PPFD412_1
(PHOSPHONOACETATE
HYDROLASE)		4lr2 BIS(5'-ADENOSYL)-TRI
PHOSPHATASE ENPP4
(Homo
sapiens)		4 / 8THR A  70
ASP A 189
HIS A 193
HIS A 336
 ZN  A 505 ( 2.4A)
ZN  A 506 ( 2.1A)
ZN  A 506 ( 3.3A)
ZN  A 506 ( 3.3A)
0.44A23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_D_PPFD412_1
(PHOSPHONOACETATE
HYDROLASE)		4tns PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
NIMA-INTERACTING 1
(Homo
sapiens)		4 / 8PHE A 151
THR A 152
ILE A 156
HIS A  59
None
None
None
REA  A 201 (-4.7A)
0.80A16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_D_PPFD412_1
(PHOSPHONOACETATE
HYDROLASE)		4tnu ASPARTOACYLASE
(Homo
sapiens)		4 / 8THR A  53
ASP A 114
HIS A 116
HIS A  21
None
None
ZN  A 401 ( 3.4A)
ZN  A 401 ( 3.2A)
1.03A20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_D_PPFD412_1
(PHOSPHONOACETATE
HYDROLASE)		4zg7 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2
(Homo
sapiens)		4 / 8THR A 210
ASP A 312
HIS A 316
HIS A 475
 ZN  A 904 ( 2.6A)
ZN  A 903 ( 2.0A)
ZN  A 903 ( 3.2A)
ZN  A 903 ( 3.3A)
0.43A19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_D_PPFD412_1
(PHOSPHONOACETATE
HYDROLASE)		5aho 5' EXONUCLEASE
APOLLO
(Homo
sapiens)		4 / 8HIS A  31
ILE A 297
HIS A  99
HIS A  36
 ZN  A1321 (-3.3A)
None
ZN  A1321 ( 3.4A)
ZN  A1320 ( 3.4A)
0.97A22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_D_PPFD412_1
(PHOSPHONOACETATE
HYDROLASE)		5b25 CALCIUM/CALMODULIN-D
EPENDENT
3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 1B
(Homo
sapiens)		4 / 8THR A 334
ASP A 264
HIS A 223
HIS A 227
 MG  A 602 ( 4.9A)
MG  A 602 ( 2.6A)
4QJ  A 603 ( 4.9A)
ZN  A 601 (-3.4A)
1.02A23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_D_PPFD412_1
(PHOSPHONOACETATE
HYDROLASE)		5i35 ATYPICAL KINASE
ADCK3, MITOCHONDRIAL
(Homo
sapiens)		4 / 8THR A 606
HIS A 559
ILE A 525
HIS A 610
None
1.00A23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_D_PPFD412_1
(PHOSPHONOACETATE
HYDROLASE)		5osh VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 29
(Homo
sapiens)		4 / 8PHE A  63
ASP A   8
HIS A 117
HIS A  10
None
0.81A11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_D_PPFD412_1
(PHOSPHONOACETATE
HYDROLASE)		5udy ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 7
(Homo
sapiens)		4 / 8THR A  75
ASP A 199
HIS A 203
HIS A 353
 ZN  A 501 (-2.6A)
ZN  A 502 (-2.3A)
ZN  A 502 (-3.3A)
ZN  A 502 (-3.3A)
0.43A21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_D_PPFD412_1
(PHOSPHONOACETATE
HYDROLASE)		5vem ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 5
(Homo
sapiens)		4 / 8THR A  72
ASP A 191
HIS A 195
HIS A 339
 ZN  A 501 (-2.4A)
ZN  A 502 (-2.0A)
ZN  A 502 (-3.2A)
ZN  A 502 (-3.2A)
0.37A21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_D_PPFD412_1
(PHOSPHONOACETATE
HYDROLASE)		6c01 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 3
(Homo
sapiens)		4 / 8THR A 205
ASP A 325
HIS A 329
HIS A 483
 ZN  A 902 (-2.5A)
ZN  A 901 ( 2.1A)
ZN  A 901 ( 3.3A)
ZN  A 901 ( 3.3A)
0.37A10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IT4_A_PPFA500_1
(CARBONIC ANHYDRASE 1)		1fq9 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(Homo
sapiens)		5 / 8HIS C 292
VAL C 308
LEU C 342
THR C 340
HIS C 351
None
1.28A20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IT4_A_PPFA500_1
(CARBONIC ANHYDRASE 1)		1ibx CHIMERA OF IGG
BINDING PROTEIN G
AND DNA
FRAGMENTATION FACTOR
45
(Homo
sapiens;
Streptococcus
sp.)		4 / 8ALA B  89
VAL B  59
LEU B  50
HIS B  32
None
0.79A24.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IT4_A_PPFA500_1
(CARBONIC ANHYDRASE 1)		1jd0 CARBONIC ANHYDRASE
XII
(Homo
sapiens)		6 / 8HIS A  94
HIS A  96
HIS A 119
VAL A 143
LEU A 198
THR A 199
 ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.1A)
AZM  A1400 ( 4.9A)
AZM  A1400 (-3.9A)
AZM  A1400 (-3.6A)
0.26A36.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IT4_A_PPFA500_1
(CARBONIC ANHYDRASE 1)		1jd0 CARBONIC ANHYDRASE
XII
(Homo
sapiens)		4 / 8HIS A  96
VAL A 121
LEU A 198
THR A 199
 ZN  A 901 ( 3.2A)
AZM  A1400 (-4.6A)
AZM  A1400 (-3.9A)
AZM  A1400 (-3.6A)
0.82A36.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IT4_A_PPFA500_1
(CARBONIC ANHYDRASE 1)		1mk3 APOPTOSIS REGULATOR
BCL-W
(Homo
sapiens)		4 / 8ALA A  97
VAL A 100
LEU A  63
THR A  59
None
0.87A19.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IT4_A_PPFA500_1
(CARBONIC ANHYDRASE 1)		2w2j CARBONIC
ANHYDRASE-RELATED
PROTEIN
(Homo
sapiens)		4 / 8HIS A 118
HIS A 141
LEU A 222
THR A 223
 CL  A 401 (-4.2A)
CL  A 401 (-4.1A)
None
CL  A 401 ( 4.8A)
0.29A39.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IT4_A_PPFA500_1
(CARBONIC ANHYDRASE 1)		3da2 CARBONIC ANHYDRASE
13
(Homo
sapiens)		6 / 8HIS A  95
HIS A  97
HIS A 120
VAL A 144
LEU A 199
THR A 200
 ZN  A 301 ( 3.6A)
ZN  A 301 ( 3.5A)
ZN  A 301 ( 3.2A)
4MD  A 401 ( 4.4A)
4MD  A 401 (-4.2A)
4MD  A 401 (-3.2A)
0.47A60.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IT4_A_PPFA500_1
(CARBONIC ANHYDRASE 1)		3da2 CARBONIC ANHYDRASE
13
(Homo
sapiens)		4 / 8HIS A  97
VAL A 122
LEU A 199
THR A 200
 ZN  A 301 ( 3.5A)
4MD  A 401 ( 4.6A)
4MD  A 401 (-4.2A)
4MD  A 401 (-3.2A)
0.74A60.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IT4_A_PPFA500_1
(CARBONIC ANHYDRASE 1)		3fe4 CARBONIC ANHYDRASE 6
(Homo
sapiens)		6 / 8HIS A 111
HIS A 113
HIS A 138
VAL A 161
LEU A 219
THR A 220
 MG  A 901 (-3.4A)
MG  A 901 (-3.4A)
MG  A 901 (-3.2A)
None
None
None
0.85A34.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IT4_A_PPFA500_1
(CARBONIC ANHYDRASE 1)		3kci PROBABLE E3
UBIQUITIN-PROTEIN
LIGASE HERC2
(Homo
sapiens)		5 / 8HIS A4260
ALA A4255
VAL A4262
LEU A4314
HIS A4312
None
1.44A22.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IT4_A_PPFA500_1
(CARBONIC ANHYDRASE 1)		3ml5 CARBONIC ANHYDRASE 7
(Homo
sapiens)		6 / 8HIS A  94
HIS A  96
HIS A 119
VAL A 143
LEU A 198
THR A 199
 ZN  A 263 ( 3.2A)
ZN  A 263 ( 3.2A)
ZN  A 263 ( 3.1A)
AZM  A 264 ( 4.9A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.4A)
0.28A51.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IT4_A_PPFA500_1
(CARBONIC ANHYDRASE 1)		3ml5 CARBONIC ANHYDRASE 7
(Homo
sapiens)		4 / 8HIS A  96
VAL A 121
LEU A 198
THR A 199
 ZN  A 263 ( 3.2A)
AZM  A 264 (-4.7A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.4A)
0.86A51.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IT4_A_PPFA500_1
(CARBONIC ANHYDRASE 1)		3pkj NAD-DEPENDENT
DEACETYLASE
SIRTUIN-6
(Homo
sapiens)		4 / 8HIS A 117
HIS A  93
ALA A  95
LEU A 211
None
0.91A21.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IT4_A_PPFA500_1
(CARBONIC ANHYDRASE 1)		3uyq CARBONIC ANHYDRASE 3
(Homo
sapiens)		5 / 8HIS A  94
HIS A  96
HIS A 119
VAL A 142
THR A 198
 ZN  A 261 (-3.3A)
ZN  A 261 (-3.3A)
ZN  A 261 (-3.2A)
None
ZN  A 261 ( 4.4A)
0.28A55.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IT4_A_PPFA500_1
(CARBONIC ANHYDRASE 1)		4lg8 PRE-MRNA-PROCESSING
FACTOR 19
(Homo
sapiens)		4 / 8HIS A 217
ALA A 258
LEU A 238
THR A 239
None
0.80A20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IT4_A_PPFA500_1
(CARBONIC ANHYDRASE 1)		4pju COHESIN SUBUNIT SA-2
DOUBLE-STRAND-BREAK
REPAIR PROTEIN RAD21
HOMOLOG
(Homo
sapiens)		4 / 8HIS A 421
ALA A 425
VAL A 424
LEU B 351
None
0.73A13.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IT4_A_PPFA500_1
(CARBONIC ANHYDRASE 1)		4qk3 CARBONIC ANHYDRASE 2
(Homo
sapiens)		6 / 8HIS A  94
HIS A  96
HIS A 119
VAL A 143
LEU A 198
THR A 199
 ZN  A 301 (-3.2A)
ZN  A 301 (-3.2A)
ZN  A 301 (-3.1A)
None
None
ZN  A 301 ( 4.4A)
0.21A59.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IT4_A_PPFA500_1
(CARBONIC ANHYDRASE 1)		4qk3 CARBONIC ANHYDRASE 2
(Homo
sapiens)		5 / 8HIS A  96
HIS A 119
VAL A 121
LEU A 198
THR A 199
 ZN  A 301 (-3.2A)
ZN  A 301 (-3.1A)
None
None
ZN  A 301 ( 4.4A)
1.02A59.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IT4_A_PPFA500_1
(CARBONIC ANHYDRASE 1)		5cjf CARBONIC ANHYDRASE
14
(Homo
sapiens)		6 / 8HIS A  94
HIS A  96
HIS A 119
VAL A 143
LEU A 198
THR A 199
 ZN  A 301 (-3.2A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.1A)
520  A 302 ( 4.9A)
520  A 302 (-3.6A)
520  A 302 (-3.4A)
0.27A35.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IT4_A_PPFA500_1
(CARBONIC ANHYDRASE 1)		5cjf CARBONIC ANHYDRASE
14
(Homo
sapiens)		4 / 8HIS A  96
VAL A 121
LEU A 198
THR A 199
 ZN  A 301 ( 3.2A)
520  A 302 ( 4.9A)
520  A 302 (-3.6A)
520  A 302 (-3.4A)
0.81A35.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IT4_A_PPFA500_1
(CARBONIC ANHYDRASE 1)		5ffo INTEGRIN BETA-6
(Homo
sapiens)		4 / 8ALA B 312
VAL B 252
LEU B 138
THR B 134
None
0.91A21.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2IT4_A_PPFA500_1
(CARBONIC ANHYDRASE 1)		5jn9 CARBONIC ANHYDRASE 4
(Homo
sapiens)		6 / 8HIS A  94
HIS A  96
HIS A 119
VAL A 143
LEU A 198
THR A 199
 ZN  A 301 ( 3.3A)
ZN  A 301 ( 3.3A)
ZN  A 301 ( 3.2A)
EZL  A 302 ( 4.7A)
EZL  A 302 (-3.5A)
EZL  A 302 (-3.4A)
0.39A31.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IT4_A_PPFA500_1
(CARBONIC ANHYDRASE 1)		5nnz DYNEIN ASSEMBLY
FACTOR WITH WDR
REPEAT DOMAINS 1
(Homo
sapiens)		4 / 8HIS B 260
ALA B 297
LEU B 277
THR B 278
None
0.84A21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IT4_A_PPFA500_1
(CARBONIC ANHYDRASE 1)		6fe1 CARBONIC ANHYDRASE 9
(Homo
sapiens)		6 / 8HIS A  94
HIS A  96
HIS A 119
VAL A 143
LEU A 198
THR A 199
 ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.1A)
None
V14  A 302 (-3.6A)
V14  A 302 (-3.2A)
0.42A15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_A_PPFA3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		1fyh INTERFERON GAMMA
INTERFERON GAMMA
RECEPTOR 1
(Homo
sapiens)		4 / 8ARG B 106
HIS A 311
SER B  80
ALA B 103
None
0.86A14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_A_PPFA3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		1fyh INTERFERON GAMMA
INTERFERON GAMMA
RECEPTOR 1
(Homo
sapiens)		4 / 8LYS A  12
HIS A 311
SER B  80
ALA B 103
None
1.32A17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_A_PPFA3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		2l7b APOLIPOPROTEIN E
(Homo
sapiens)		4 / 8LYS A 242
ASP A 110
ARG A 103
ALA A 102
None
1.40A19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_A_PPFA3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		2xub DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC3
(Homo
sapiens)		4 / 8SER A 279
ASP A 240
ARG A 247
ALA A 282
None
1.18A23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_A_PPFA3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		3ll8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens)		4 / 8ARG A 254
HIS A 199
ASP A 118
ARG A 122
PO4  A 500 (-3.1A)
ZN  A 505 (-3.3A)
ZN  A 505 (-2.7A)
PO4  A 500 (-2.9A)
1.36A20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_A_PPFA3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		3n9v TYPE II
INOSITOL-1,4,5-TRISP
HOSPHATE
5-PHOSPHATASE
(Homo
sapiens)		4 / 8ARG A 451
HIS A 549
ASP A 524
ALA A 403
None
0.87A19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_A_PPFA3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		3t2n SERINE PROTEASE
HEPSIN
(Homo
sapiens)		4 / 8HIS A 262
SER A 408
ASP A 196
ARG A  97
None
1.41A19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_A_PPFA3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		4cmn INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE OCRL-1
(Homo
sapiens)		4 / 8ARG A 426
HIS A 524
ASP A 499
ALA A 378
None
PO4  A1560 (-3.8A)
None
GOL  A1562 ( 4.4A)
0.93A18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_A_PPFA3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		4ga7 LEUKOCYTE ELASTASE
INHIBITOR
(Homo
sapiens)		4 / 8HIS A 364
SER A 367
ASP A  76
ARG A  69
None
1.21A18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_A_PPFA3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		4h1s 5'-NUCLEOTIDASE
(Homo
sapiens)		4 / 8ARG A  40
SER A 396
ASP A  47
ALA A 413
None
1.27A21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_A_PPFA3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		4nho PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX23
(Homo
sapiens)		4 / 8SER A 378
ASP A 376
ARG A 757
ALA A 632
None
CXS  A 908 (-3.9A)
None
None
1.29A21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_A_PPFA3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		5cni METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens)		4 / 8ARG A 183
SER A 173
ASP A 444
ALA A 170
None
1.32A22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_A_PPFA3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		5dgo CELL DIVISION
CONTROL PROTEIN 45
HOMOLOG
(Homo
sapiens)		4 / 8LYS A 232
HIS A 101
ASP A 543
ALA A  29
None
1.36A20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_A_PPFA3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		5kzn METABOTROPIC
GLUTAMATE RECEPTOR 2
(Homo
sapiens)		4 / 8ARG A 183
SER A 173
ASP A 444
ALA A 170
None
1.38A23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_A_PPFA3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		5t5w INTERFERON LAMBDA
RECEPTOR 1
INTERFERON LAMBDA-3
(Homo
sapiens)		4 / 8LYS C  21
LYS C  24
SER B  42
ASP B  98
None
1.34A13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_A_PPFA3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		6b0t FASCIN
(Homo
sapiens)		4 / 8HIS A 154
SER A 156
ASP A 166
ALA A 160
None
1.23A9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_B_PPFB3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		3ll8 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM
(Homo
sapiens)		4 / 7ARG A 254
HIS A 199
ASP A 118
ARG A 122
PO4  A 500 (-3.1A)
ZN  A 505 (-3.3A)
ZN  A 505 (-2.7A)
PO4  A 500 (-2.9A)
1.31A20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_B_PPFB3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		3t2n SERINE PROTEASE
HEPSIN
(Homo
sapiens)		4 / 7HIS A 262
SER A 408
ASP A 196
ARG A  97
None
1.34A19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_B_PPFB3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		4ga7 LEUKOCYTE ELASTASE
INHIBITOR
(Homo
sapiens)		4 / 7HIS A 364
SER A 367
ASP A  76
ARG A  69
None
1.19A18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_B_PPFB3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		4jnc BIFUNCTIONAL EPOXIDE
HYDROLASE 2
(Homo
sapiens)		4 / 7LYS A 530
SER A 412
ASP A 521
ARG A 440
None
1.49A19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RK8_B_PPFB3969_1
(PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP])		5t5w INTERFERON LAMBDA
RECEPTOR 1
INTERFERON LAMBDA-3
(Homo
sapiens)		4 / 7LYS C  21
LYS C  24
SER B  42
ASP B  98
None
1.37A13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T01_A_PPFA503_1
(PHOSPHONOACETATE
HYDROLASE)		2iuw ALKYLATED REPAIR
PROTEIN ALKB HOMOLOG
3
(Homo
sapiens)		4 / 7ASN A 271
ASP A 193
HIS A 191
HIS A 257
AKG  A 700 (-3.4A)
FE  A 500 ( 2.6A)
FE  A 500 ( 3.3A)
FE  A 500 ( 3.3A)
1.00A21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T01_A_PPFA503_1
(PHOSPHONOACETATE
HYDROLASE)		3b2z ADAMTS-4
(Homo
sapiens)		4 / 7ASN A 373
ASP A 328
HIS A 365
HIS A 361
None
ZN  A   1 (-1.9A)
ZN  A   1 (-3.3A)
ZN  A   1 (-3.0A)
0.93A20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T01_A_PPFA503_1
(PHOSPHONOACETATE
HYDROLASE)		3btz ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE ALKB
HOMOLOG 2
(Homo
sapiens)		4 / 7ASN A 159
ASP A 173
ILE A 168
HIS A 236
None
0.96A17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T01_A_PPFA503_1
(PHOSPHONOACETATE
HYDROLASE)		3btz ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE ALKB
HOMOLOG 2
(Homo
sapiens)		4 / 7ASN A 250
ASP A 173
HIS A 171
HIS A 236
None
0.97A17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T01_A_PPFA503_1
(PHOSPHONOACETATE
HYDROLASE)		3m7p FN1 PROTEIN
(Homo
sapiens)		4 / 7THR A 507
ASN A 501
ASP A 522
HIS A 539
None
None
None
ZN  A 955 (-4.9A)
1.01A19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T01_A_PPFA503_1
(PHOSPHONOACETATE
HYDROLASE)		3tht ALKYLATED DNA REPAIR
PROTEIN ALKB HOMOLOG
8
(Homo
sapiens)		4 / 7ASN A 227
ASP A 240
ILE A 235
HIS A 292
AKG  A 403 (-3.2A)
MN  A 402 ( 2.6A)
AKG  A 403 (-4.4A)
MN  A 402 ( 3.6A)
1.03A21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T01_A_PPFA503_1
(PHOSPHONOACETATE
HYDROLASE)		4lr2 BIS(5'-ADENOSYL)-TRI
PHOSPHATASE ENPP4
(Homo
sapiens)		4 / 7THR A  70
ASP A 189
HIS A 193
HIS A 336
 ZN  A 505 ( 2.4A)
ZN  A 506 ( 2.1A)
ZN  A 506 ( 3.3A)
ZN  A 506 ( 3.3A)
0.41A23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T01_A_PPFA503_1
(PHOSPHONOACETATE
HYDROLASE)		4nrq RNA DEMETHYLASE
ALKBH5
(Homo
sapiens)		4 / 7ASN A 193
ASP A 206
ILE A 201
HIS A 266
PD2  A 301 (-3.3A)
MN  A 302 ( 2.7A)
PD2  A 301 (-4.8A)
MN  A 302 ( 3.3A)
1.06A19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T01_A_PPFA503_1
(PHOSPHONOACETATE
HYDROLASE)		4zg7 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2
(Homo
sapiens)		4 / 7THR A 210
ASP A 312
HIS A 316
HIS A 475
 ZN  A 904 ( 2.6A)
ZN  A 903 ( 2.0A)
ZN  A 903 ( 3.2A)
ZN  A 903 ( 3.3A)
0.39A19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T01_A_PPFA503_1
(PHOSPHONOACETATE
HYDROLASE)		5ebb ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A
(Homo
sapiens)		4 / 7ASN A 211
ASP A  45
HIS A 295
HIS A  47
None
ZN  A 702 ( 3.0A)
ZN  A 702 ( 3.4A)
ZN  A 702 ( 3.4A)
1.03A21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T01_A_PPFA503_1
(PHOSPHONOACETATE
HYDROLASE)		5i35 ATYPICAL KINASE
ADCK3, MITOCHONDRIAL
(Homo
sapiens)		4 / 7THR A 606
HIS A 559
ILE A 525
HIS A 610
None
0.82A23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T01_A_PPFA503_1
(PHOSPHONOACETATE
HYDROLASE)		5i85 SPHINGOMYELIN
PHOSPHODIESTERASE
(Homo
sapiens)		4 / 7ASN A 325
ASP A 206
HIS A 459
HIS A 208
None
ZN  A 715 ( 3.1A)
ZN  A 715 ( 3.3A)
ZN  A 715 ( 3.4A)
0.98A22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T01_A_PPFA503_1
(PHOSPHONOACETATE
HYDROLASE)		5osh VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 29
(Homo
sapiens)		4 / 7PHE A  63
ASP A   8
HIS A 117
HIS A  10
None
0.81A11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T01_A_PPFA503_1
(PHOSPHONOACETATE
HYDROLASE)		5udy ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 7
(Homo
sapiens)		4 / 7THR A  75
ASP A 199
HIS A 203
HIS A 353
 ZN  A 501 (-2.6A)
ZN  A 502 (-2.3A)
ZN  A 502 (-3.3A)
ZN  A 502 (-3.3A)
0.39A23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T01_A_PPFA503_1
(PHOSPHONOACETATE
HYDROLASE)		5vem ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 5
(Homo
sapiens)		4 / 7THR A  72
ASP A 191
HIS A 195
HIS A 339
 ZN  A 501 (-2.4A)
ZN  A 502 (-2.0A)
ZN  A 502 (-3.2A)
ZN  A 502 (-3.2A)
0.32A21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T01_A_PPFA503_1
(PHOSPHONOACETATE
HYDROLASE)		5yjp HUMAN CHYMASE
(Homo
sapiens)		4 / 7PHE A 228
THR A 229
ASP A 102
HIS A  57
None
None
8W6  A 304 (-3.9A)
8W6  A 304 (-3.7A)
0.89A10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T01_A_PPFA503_1
(PHOSPHONOACETATE
HYDROLASE)		6bmm HUMAN DHHC20
PALMITOYLTRANSFERASE
(Homo
sapiens)		4 / 7PHE A  74
THR A  75
ASN A 161
ILE A  73
None
1.01A10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T01_A_PPFA503_1
(PHOSPHONOACETATE
HYDROLASE)		6c01 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 3
(Homo
sapiens)		4 / 7THR A 205
ASP A 325
HIS A 329
HIS A 483
 ZN  A 902 (-2.5A)
ZN  A 901 ( 2.1A)
ZN  A 901 ( 3.3A)
ZN  A 901 ( 3.3A)
0.38A9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MV7_A_PPFA501_1
(BIOTIN CARBOXYLASE)		1hzf COMPLEMENT FACTOR
C4A
(Homo
sapiens)		4 / 7ASN A1116
VAL A1114
GLU A1118
ARG A1107
None
1.10A20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MV7_A_PPFA501_1
(BIOTIN CARBOXYLASE)		2xoc E3 UBIQUITIN-PROTEIN
LIGASE CHFR
(Homo
sapiens)		4 / 7ARG A 504
VAL A 505
GLU A 498
ARG A 495
None
1.32A17.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MV7_A_PPFA501_1
(BIOTIN CARBOXYLASE)		2yl2 ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens)		4 / 7ASN A 476
ARG A 478
GLN A 480
VAL A 481
None
0.99A32.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MV7_A_PPFA501_1
(BIOTIN CARBOXYLASE)		2yl2 ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens)		4 / 7ASN A 476
ARG A 478
VAL A 481
GLU A 482
None
0.94A32.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MV7_A_PPFA501_1
(BIOTIN CARBOXYLASE)		2yl2 ACETYL-COA
CARBOXYLASE 1
(Homo
sapiens)		4 / 7LYS A 423
ASN A 476
ARG A 478
GLN A 480
None
0.95A32.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MV7_A_PPFA501_1
(BIOTIN CARBOXYLASE)		3nv3 GALECTIN 9 SHORT
ISOFORM VARIANT
(Homo
sapiens)		4 / 7ARG A 221
VAL A 246
GLU A 258
ARG A 260
None
None
NAG  A 502 ( 2.7A)
NAG  A 502 (-4.0A)
1.31A14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MV7_A_PPFA501_1
(BIOTIN CARBOXYLASE)		3u9w LEUKOTRIENE A-4
HYDROLASE
(Homo
sapiens)		4 / 7LYS A1565
ASN A1291
GLU A1533
ARG A1563
None
1.37A22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MV7_A_PPFA501_1
(BIOTIN CARBOXYLASE)		3wv6 GALECTIN-9
(Homo
sapiens)		4 / 7ARG A  44
VAL A  73
GLU A  85
ARG A  87
GAL  A 402 ( 4.9A)
None
BGC  A 403 (-2.9A)
BGC  A 403 (-4.1A)
1.32A20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MV7_A_PPFA501_1
(BIOTIN CARBOXYLASE)		3zxe GALECTIN-7
(Homo
sapiens)		4 / 7ARG A  31
VAL A  60
GLU A  72
ARG A  74
PGZ  A   1 ( 4.7A)
None
PGZ  A   1 (-3.5A)
None
1.26A15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MV7_A_PPFA501_1
(BIOTIN CARBOXYLASE)		3zyi LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4
(Homo
sapiens)		4 / 7ASN A  81
GLN A 105
VAL A 103
GLU A 129
None
1.18A21.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MV7_A_PPFA501_1
(BIOTIN CARBOXYLASE)		4hq6 ACETYL-COA
CARBOXYLASE 2
(Homo
sapiens)		5 / 7LYS A 529
ASN A 582
ARG A 584
GLN A 586
VAL A 587
None
0.95A32.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4MV7_A_PPFA501_1
(BIOTIN CARBOXYLASE)		4hq6 ACETYL-COA
CARBOXYLASE 2
(Homo
sapiens)		5 / 7LYS A 529
ASN A 582
ARG A 584
VAL A 587
GLU A 588
None
1.18A32.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MV7_A_PPFA501_1
(BIOTIN CARBOXYLASE)		4y26 GALECTIN-7
(Homo
sapiens)		4 / 7ARG A  31
VAL A  60
GLU A  72
ARG A  74
None
None
6S2  A 202 (-2.8A)
6S2  A 202 (-3.5A)
1.20A19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MV7_A_PPFA501_1
(BIOTIN CARBOXYLASE)		5nst HEAVY CHAIN OF
ANTIBODY MGD21
(Homo
sapiens)		4 / 7ASN B  32
VAL B 132
GLU B 167
ARG B 169
None
None
None
GOL  B 402 (-2.9A)
1.28A20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_A_PPFA602_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		1bci CYTOSOLIC
PHOSPHOLIPASE A2
(Homo
sapiens)		4 / 6ASP A  93
GLY A  36
ASP A  37
ASP A  43
 CA  A 140 (-3.6A)
None
None
CA  A 139 ( 2.9A)
1.19A15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_A_PPFA602_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		1ihb CYCLIN-DEPENDENT
KINASE 6 INHIBITOR
(Homo
sapiens)		4 / 6ARG A  79
ASP A  67
GLY A  70
ASP A 100
None
1.12A15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_A_PPFA602_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		1w0h 3'-5' EXONUCLEASE
ERI1
(Homo
sapiens)		4 / 6ARG A 272
ASP A 234
GLY A 231
ASP A 230
None
MG  A1000 ( 3.1A)
None
None
1.12A16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_A_PPFA602_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		2rhp THROMBOSPONDIN-2
(Homo
sapiens)		4 / 6ASP A 718
GLY A 699
ASP A1164
ASP A 696
 CA  A  29 ( 2.3A)
None
None
CA  A  28 ( 2.6A)
1.20A20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_A_PPFA602_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		3ghg FIBRINOGEN GAMMA
CHAIN
(Homo
sapiens)		4 / 6ARG C 247
ASP C 285
GLY C 284
ASP C 261
ARG  C 247 ( 0.6A)
ASP  C 285 ( 0.6A)
GLY  C 284 ( 0.0A)
ASP  C 261 ( 0.6A)
1.34A22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_A_PPFA602_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		4raf PROTEIN PHOSPHATASE
1A
(Homo
sapiens)		4 / 6ARG A  33
ASP A 239
GLY A 240
ASP A 243
None
MN  A 401 (-2.6A)
MN  A 401 ( 4.8A)
None
1.27A21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_A_PPFA602_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		4x0q DNA POLYMERASE THETA
(Homo
sapiens)		4 / 6LYS A2383
ARG A2379
ASP A2540
ASP A2330
DG3  A2604 (-2.5A)
DG3  A2604 (-3.4A)
MG  A2603 ( 2.6A)
MG  A2603 ( 2.3A)
1.29A22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_A_PPFA602_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6b0t FASCIN
(Homo
sapiens)		4 / 6ARG A 398
ASP A 473
GLY A 476
ASP A 405
None
1.30A7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_C_PPFC601_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		1pl0 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH
(Homo
sapiens)		4 / 6ARG A 307
GLY A 340
ASP A 339
LYS A 357
None
1.18A21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_C_PPFC601_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		1y8q UBIQUITIN-LIKE 2
ACTIVATING ENZYME
E1B
(Homo
sapiens)		4 / 6ARG B  59
ASP B 347
ASP B  53
LYS B 346
ATP  B 802 (-4.1A)
ATP  B 802 ( 4.3A)
None
ATP  B 802 (-2.9A)
1.22A20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_C_PPFC601_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		4nen INTEGRIN ALPHA-X
(Homo
sapiens)		4 / 6ARG A 480
GLY A 542
ASP A 449
LYS A 868
None
None
CA  A1115 (-2.9A)
None
1.21A18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_C_PPFC601_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		4x0q DNA POLYMERASE THETA
(Homo
sapiens)		4 / 6ARG A2379
ASP A2330
ASP A2540
LYS A2575
DG3  A2604 (-3.4A)
MG  A2603 ( 2.3A)
MG  A2603 ( 2.6A)
DG3  A2604 ( 3.7A)
1.06A22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_C_PPFC601_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		6b67 PROTEIN PHOSPHATASE
1A
(Homo
sapiens)		4 / 6ARG A  33
ASP A  60
GLY A  61
ASP A  38
None
CA  A 302 ( 2.8A)
CA  A 301 (-4.2A)
None
1.33A8.81