POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_1
(AAC(6')-IB)		1a27 17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE
(Homo
sapiens)		5 / 12GLY A 145
TYR A 275
VAL A 283
TYR A 218
SER A 222
None
1.35A22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_1
(AAC(6')-IB)		2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA
(Homo
sapiens)		5 / 12GLY I 250
LEU I 127
VAL I  96
TYR A  48
SER A  52
None
1.08A20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_1
(AAC(6')-IB)		2ybx PHOSPHATIDYLINOSITOL
-5-PHOSPHATE
4-KINASE TYPE-2
ALPHA
(Homo
sapiens)		5 / 12GLY A 106
TYR A 142
LEU A 116
VAL A  45
ASP A 109
None
1.44A19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_1
(AAC(6')-IB)		3zyj LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 4C
(Homo
sapiens)		5 / 12GLU A 271
VAL A 270
GLN A 246
TRP A 249
ASP A 222
None
1.48A19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_1
(AAC(6')-IB)		5wy0 SMALL RNA
2'-O-METHYLTRANSFERA
SE
(Homo
sapiens)		5 / 12GLY A  94
LEU A  24
VAL A  47
TYR A  81
ASP A  89
None
1.35A18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_2
(AAC(6')-IB)		1wfg REGULATING SYNAPTIC
MEMBRANE EXOCYTOSIS
PROTEIN 2
(Homo
sapiens)		3 / 3TRP A  93
GLN A 118
TRP A  18
None
1.35A18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_2
(AAC(6')-IB)		2dk7 TRANSCRIPTION
ELONGATION REGULATOR
1
(Homo
sapiens)		3 / 3TRP A  26
GLN A  61
TRP A  22
None
1.33A17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_2
(AAC(6')-IB)		3fxt NUCLEOSIDE
DIPHOSPHATE-LINKED
MOIETY X MOTIF 6
(Homo
sapiens)		3 / 3TRP A  85
GLN A  83
TRP A 128
None
0.81A18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_2
(AAC(6')-IB)		3j2s COAGULATION FACTOR
VIII LIGHT CHAIN
(Homo
sapiens)		3 / 3TRP B2219
GLN B2222
TRP B2271
None
1.14A15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_2
(AAC(6')-IB)		3lrh ANTI-HUNTINGTIN VL
DOMAIN
(Homo
sapiens)		3 / 3TRP A  36
GLN A  38
TRP A  99
None
1.36A18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_2
(AAC(6')-IB)		4m8g TUMOR SUPPRESSOR
CANDIDATE 3
(Homo
sapiens)		3 / 3TRP A 140
GLN A 136
TRP A  75
None
1.02A20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_2
(AAC(6')-IB)		4wrl MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
(Homo
sapiens)		3 / 3TRP A  58
GLN A  77
TRP A 159
None
FUC  A 402 (-4.0A)
None
1.08A19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VQY_A_PARA1201_2
(AAC(6')-IB)		4wrm MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
(Homo
sapiens)		3 / 3TRP A  58
GLN A  77
TRP A 159
None
0.94A18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR2_A_PARA1609_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		1oki BETA CRYSTALLIN B1
(Homo
sapiens)		3 / 3TYR A 197
ARG A 131
SER A 129
None
1.18A22.64
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR2_A_PARA1609_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		1ow0 IMMUNOGLOBULIN ALPHA
FC RECEPTOR
(Homo
sapiens)		3 / 3TYR C 173
ARG C 171
SER C 187
None
1.09A18.98
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR2_A_PARA1609_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		2dl2 PROTEIN (MHC CLASS I
NK CELL RECEPTOR
PRECURSOR (P58
NATURAL KILLER CELL
RECEPTOR CLONE
CL-43))
(Homo
sapiens)		3 / 3TYR A  80
ARG A  78
SER A  94
None
0.94A19.40
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR2_A_PARA1609_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		2y0n MALE-SPECIFIC LETHAL
3 HOMOLOG
(Homo
sapiens)		3 / 3TYR A 449
ARG A 262
SER A 448
None
1.17A20.56
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR2_A_PARA1609_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		2z6h CATENIN BETA-1
(Homo
sapiens)		3 / 3TYR A 254
ARG A 212
SER A 250
None
1.14A11.03
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR2_A_PARA1609_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		3e9l PRE-MRNA-PROCESSING-
SPLICING FACTOR 8
(Homo
sapiens)		3 / 3TYR A1768
ARG A2008
SER A1765
None
0.93A22.71
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR2_A_PARA1609_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		3lgg ADENOSINE DEAMINASE
CECR1
(Homo
sapiens)		3 / 3TYR A 264
ARG A 222
SER A 265
None
0.96A14.14
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR2_A_PARA1609_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		3w5k ZINC FINGER PROTEIN
SNAI1
(Homo
sapiens)		3 / 3TYR B 236
ARG B 247
SER B 246
None
1.12A17.95
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR2_A_PARA1609_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		4h6j ARYL HYDROCARBON
NUCLEAR TRANSLOCATOR
(Homo
sapiens)		3 / 3TYR B 386
ARG B 430
SER B 431
None
1.17A16.92
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR2_A_PARA1609_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		4jvs RAS-RELATED PROTEIN
RAB-1A
(Homo
sapiens)		3 / 3TYR B  81
ARG B  74
SER B  78
None
1.18A23.33
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR2_A_PARA1609_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		4nqe MAJOR
HISTOCOMPATIBILITY
COMPLEX CLASS
I-RELATED GENE
PROTEIN
(Homo
sapiens)		3 / 3TYR A  36
ARG A  41
SER A  38
None
1.18A18.18
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR2_A_PARA1609_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		4nzm INOSITOL
HEXAKISPHOSPHATE AND
DIPHOSPHOINOSITOL-PE
NTAKISPHOSPHATE
KINASE 2
(Homo
sapiens)		3 / 3TYR A 234
ARG A 156
SER A 233
None
1.15A16.92
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR2_A_PARA1609_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens)		3 / 3TYR A 441
ARG A 421
SER A 422
None
1.13A20.22
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR2_A_PARA1609_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		5odb D10 FAB FRAGMENT -
LIGHT CHAIN
(Homo
sapiens)		3 / 3TYR B 192
ARG B 209
SER B 190
None
0.58A17.56
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR2_A_PARA1609_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		5v3g PR DOMAIN ZINC
FINGER PROTEIN 9
(Homo
sapiens)		3 / 3TYR D 803
ARG D 795
SER D 813
None
1.08A20.22
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR2_A_PARA1609_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		5zal ENDORIBONUCLEASE
DICER
(Homo
sapiens)		3 / 3TYR A1757
ARG A  86
SER A1664
None
1.15A19.53
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KHP_A_PARA1606_1
(16S RIBOSOMAL RNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		2emy ZINC FINGER PROTEIN
268
(Homo
sapiens)		3 / 3TYR A  13
ARG A  24
SER A  23
None
1.00A16.19
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KHP_A_PARA1606_1
(16S RIBOSOMAL RNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		2id5 LEUCINE RICH REPEAT
NEURONAL 6A
(Homo
sapiens)		3 / 3TYR A 456
ARG A 423
SER A 421
None
0.81A14.26
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KHP_A_PARA1606_1
(16S RIBOSOMAL RNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		2j2s ZINC FINGER PROTEIN
HRX
(Homo
sapiens)		3 / 3TYR A1205
ARG A1150
SER A1202
None
1.07A17.39
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KHP_A_PARA1606_1
(16S RIBOSOMAL RNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		2z6h CATENIN BETA-1
(Homo
sapiens)		3 / 3TYR A 254
ARG A 212
SER A 250
None
0.96A11.03
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KHP_A_PARA1606_1
(16S RIBOSOMAL RNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		3ifq PLAKOGLOBIN
(Homo
sapiens)		3 / 3TYR A 245
ARG A 203
SER A 241
None
1.07A12.22
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KHP_A_PARA1606_1
(16S RIBOSOMAL RNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		3lgg ADENOSINE DEAMINASE
CECR1
(Homo
sapiens)		3 / 3TYR A 264
ARG A 222
SER A 265
None
0.95A13.48
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KHP_A_PARA1606_1
(16S RIBOSOMAL RNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		3sl9 CATENIN BETA-1
(Homo
sapiens)		3 / 3TYR A 254
ARG A 212
SER A 250
None
1.11A21.66
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KHP_A_PARA1606_1
(16S RIBOSOMAL RNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		4cak INTEGRIN ALPHA-IIB
(Homo
sapiens)		3 / 3TYR A 645
ARG A 512
SER A 568
None
1.11A9.51
6.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KHP_A_PARA1606_1
(16S RIBOSOMAL RNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		4giz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
UBIQUITIN LIGASE
EA6P: CHIMERIC
PROTEIN
PROTEIN E6
(Alphapapillomavi
rus
9;
Escherichia
coli;
Homo
sapiens)		3 / 3TYR A 342
ARG C 129
SER A 338
CEY  A 400 (-4.5A)
None
None
1.04A15.18
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KHP_A_PARA1606_1
(16S RIBOSOMAL RNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		4mxw LYMPHOTOXIN-BETA
(Homo
sapiens)		3 / 3TYR Y 220
ARG Y 160
SER Y 162
None
1.03A20.48
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KHP_A_PARA1606_1
(16S RIBOSOMAL RNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1
(Homo
sapiens)		3 / 3TYR A 441
ARG A 421
SER A 422
None
0.98A20.30
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KHP_A_PARA1606_1
(16S RIBOSOMAL RNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		5odb D10 FAB FRAGMENT -
LIGHT CHAIN
(Homo
sapiens)		3 / 3TYR B 192
ARG B 209
SER B 190
None
1.09A17.69
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KHP_A_PARA1606_1
(16S RIBOSOMAL RNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		5t0i 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 8
(Homo
sapiens)		3 / 3TYR d  74
ARG d  65
SER d  70
None
0.84A17.17
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KHP_A_PARA1606_1
(16S RIBOSOMAL RNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		5wiv D(4) DOPAMINE
RECEPTOR, SOLUBLE
CYTOCHROME B562
CHIMERA
(Escherichia
coli;
Homo
sapiens)		3 / 3TYR A 143
ARG A 151
SER A 149
PO4  A1202 (-4.2A)
PO4  A1202 ( 3.8A)
PO4  A1202 (-2.6A)
0.92A15.53
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KHP_A_PARA1606_1
(16S RIBOSOMAL RNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		6ez8 HUNTINGTIN
(Homo
sapiens)		3 / 3TYR A2784
ARG A2528
SER A2614
None
0.90A16.39
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF7_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		1ow0 IMMUNOGLOBULIN ALPHA
FC RECEPTOR
(Homo
sapiens)		3 / 3TYR C 173
ARG C 171
SER C 187
None
1.11A18.98
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF7_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		2cqc ARGININE/SERINE-RICH
SPLICING FACTOR 10
(Homo
sapiens)		3 / 3TYR A 128
ARG A 187
SER A 126
None
1.09A20.49
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF7_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		2d96 NUCLEAR FACTOR
NF-KAPPA-B P100
SUBUNIT
(Homo
sapiens)		3 / 3TYR A  49
ARG A  61
SER A  58
None
0.98A19.70
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF7_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		2fc9 NCL PROTEIN
(Homo
sapiens)		3 / 3TYR A  25
ARG A  81
SER A  24
None
1.05A19.70
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF7_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		2kxn TRANSFORMER-2
PROTEIN HOMOLOG BETA
(Homo
sapiens)		3 / 3TYR B 128
ARG B 187
SER B 126
None
A  A   1 ( 4.4A)
None
1.20A21.28
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF7_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		3ctz XAA-PRO
AMINOPEPTIDASE 1
(Homo
sapiens)		3 / 3TYR A 296
ARG A 307
SER A 299
None
1.08A11.41
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF7_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		3e9l PRE-MRNA-PROCESSING-
SPLICING FACTOR 8
(Homo
sapiens)		3 / 3TYR A1768
ARG A2008
SER A1765
None
1.18A22.71
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF7_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		3keh GLUCOCEREBROSIDASE
(Homo
sapiens)		3 / 3TYR A  11
ARG A 359
SER A 356
SO4  A1504 (-4.7A)
None
SO4  A1504 (-2.6A)
1.01A15.29
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF7_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		3lgg ADENOSINE DEAMINASE
CECR1
(Homo
sapiens)		3 / 3TYR A 264
ARG A 222
SER A 265
None
0.89A14.14
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF7_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		4cak INTEGRIN ALPHA-IIB
(Homo
sapiens)		3 / 3TYR A 645
ARG A 512
SER A 568
None
1.17A9.41
7.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF7_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		5eh2 HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9
(Homo
sapiens)		3 / 3TYR E 803
ARG E 795
SER E 813
None
1.21A22.82
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF7_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		5m32 PROTEASOME SUBUNIT
ALPHA TYPE-7
(Homo
sapiens)		3 / 3TYR C 110
ARG C 117
SER C 113
None
1.03A22.55
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF7_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		5odb D10 FAB FRAGMENT -
LIGHT CHAIN
(Homo
sapiens)		3 / 3TYR B 192
ARG B 209
SER B 190
None
0.54A17.56
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF7_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		5v3g PR DOMAIN ZINC
FINGER PROTEIN 9
(Homo
sapiens)		3 / 3TYR D 803
ARG D 795
SER D 813
None
1.20A20.22
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF7_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		5zal ENDORIBONUCLEASE
DICER
(Homo
sapiens)		3 / 3TYR A1757
ARG A  86
SER A1664
None
1.15A19.53
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF8_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		1ow0 IMMUNOGLOBULIN ALPHA
FC RECEPTOR
(Homo
sapiens)		3 / 3TYR C 173
ARG C 171
SER C 187
None
1.11A18.98
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF8_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		2cqc ARGININE/SERINE-RICH
SPLICING FACTOR 10
(Homo
sapiens)		3 / 3TYR A 128
ARG A 187
SER A 126
None
1.09A20.49
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF8_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		2d96 NUCLEAR FACTOR
NF-KAPPA-B P100
SUBUNIT
(Homo
sapiens)		3 / 3TYR A  49
ARG A  61
SER A  58
None
0.98A19.70
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF8_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		2fc9 NCL PROTEIN
(Homo
sapiens)		3 / 3TYR A  25
ARG A  81
SER A  24
None
1.05A19.70
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF8_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		2kxn TRANSFORMER-2
PROTEIN HOMOLOG BETA
(Homo
sapiens)		3 / 3TYR B 128
ARG B 187
SER B 126
None
A  A   1 ( 4.4A)
None
1.20A21.28
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF8_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		3ctz XAA-PRO
AMINOPEPTIDASE 1
(Homo
sapiens)		3 / 3TYR A 296
ARG A 307
SER A 299
None
1.08A11.41
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF8_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		3e9l PRE-MRNA-PROCESSING-
SPLICING FACTOR 8
(Homo
sapiens)		3 / 3TYR A1768
ARG A2008
SER A1765
None
1.18A22.71
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF8_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		3keh GLUCOCEREBROSIDASE
(Homo
sapiens)		3 / 3TYR A  11
ARG A 359
SER A 356
SO4  A1504 (-4.7A)
None
SO4  A1504 (-2.6A)
1.01A15.29
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF8_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		3lgg ADENOSINE DEAMINASE
CECR1
(Homo
sapiens)		3 / 3TYR A 264
ARG A 222
SER A 265
None
0.89A14.14
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF8_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		4cak INTEGRIN ALPHA-IIB
(Homo
sapiens)		3 / 3TYR A 645
ARG A 512
SER A 568
None
1.17A9.41
7.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF8_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		5eh2 HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9
(Homo
sapiens)		3 / 3TYR E 803
ARG E 795
SER E 813
None
1.21A22.82
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF8_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		5m32 PROTEASOME SUBUNIT
ALPHA TYPE-7
(Homo
sapiens)		3 / 3TYR C 110
ARG C 117
SER C 113
None
1.03A22.55
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF8_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		5odb D10 FAB FRAGMENT -
LIGHT CHAIN
(Homo
sapiens)		3 / 3TYR B 192
ARG B 209
SER B 190
None
0.54A17.56
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF8_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		5v3g PR DOMAIN ZINC
FINGER PROTEIN 9
(Homo
sapiens)		3 / 3TYR D 803
ARG D 795
SER D 813
None
1.20A20.22
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LF8_A_PARA1817_1
(16S RRNA
RIBOSOMAL PROTEIN S9
RIBOSOMAL PROTEIN
S10)		5zal ENDORIBONUCLEASE
DICER
(Homo
sapiens)		3 / 3TYR A1757
ARG A  86
SER A1664
None
1.15A19.53
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_A_PARA500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens)		5 / 10PHE A 707
PHE A 831
THR A 703
GLU A 727
TYR A 719
None
1.26A20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_A_PARA500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		4q80 SERINE PROTEASE 57
(Homo
sapiens)		5 / 10SER A 145
PHE A 148
SER A 192
ASP A 226
GLY A 221
None
None
2YS  A 304 (-4.4A)
None
None
1.44A22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_A_PARA500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		4wuu IMMUNOGLOBULIN HEAVY
CHAIN
(Homo
sapiens)		5 / 10SER E  28
PHE E  32
SER E  77
TYR E  55
GLY E  54
None
1.48A17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_B_PARB500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		2hq6 SEROLOGICALLY
DEFINED COLON CANCER
ANTIGEN 10
(Homo
sapiens)		5 / 9THR A 137
GLU A  27
ARG A  95
ASP A  25
GLY A 135
None
1.47A21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_C_PARC500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		2jxy MACROPHAGE
METALLOELASTASE
(Homo
sapiens)		5 / 10PHE A 453
TYR A 400
ASP A 411
ASP A 404
TYR A 390
None
1.33A15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_C_PARC500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		2pxx UNCHARACTERIZED
PROTEIN MGC2408
(Homo
sapiens)		5 / 10SER A 176
PHE A 206
SER A 173
TYR A 186
TYR A  20
None
1.32A19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_D_PARD500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		1xap RETINOIC ACID
RECEPTOR BETA
(Homo
sapiens)		4 / 8PHE A 305
THR A 319
ASP A 315
ASP A 316
None
1.29A23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_D_PARD500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		1zef ALKALINE PHOSPHATASE
(Homo
sapiens)		4 / 8SER A 363
SER A 322
GLU A 413
TYR A 388
None
1.18A23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_D_PARD500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		2dw4 LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1
(Homo
sapiens)		4 / 8SER A 393
GLU A 559
ASP A 557
ASP A 556
None
1.31A20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_D_PARD500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		2hk5 TYROSINE-PROTEIN
KINASE HCK
(Homo
sapiens)		4 / 8PHE A 487
SER A 425
GLU A 288
ASP A 382
None
None
1BM  A 499 (-3.2A)
1BM  A 499 (-4.4A)
1.40A19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_D_PARD500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		2qob EPHRIN RECEPTOR
(Homo
sapiens)		4 / 8PHE A 871
SER A 809
GLU A 670
ASP A 764
None
1.41A21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_D_PARD500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		2z8c INSULIN RECEPTOR
(Homo
sapiens)		4 / 8PHE A1256
SER A1194
GLU A1047
ASP A1150
None
1.39A21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_D_PARD500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		2znv AMSH-LIKE PROTEASE
(Homo
sapiens)		4 / 8THR A 363
SER A 366
ASP A 360
TYR A 322
None
EDO  A   2 (-3.4A)
None
None
1.43A17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_D_PARD500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		3s95 LIM DOMAIN KINASE 1
(Homo
sapiens)		4 / 8PHE A 597
SER A 534
GLU A 384
ASP A 478
None
None
STU  A   1 (-3.7A)
STU  A   1 ( 4.2A)
1.31A22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_D_PARD500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		3smt HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3
(Homo
sapiens)		4 / 8SER A 180
SER A 249
ASP A 274
TYR A  77
None
1.20A20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_D_PARD500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		4kfz ANTI-LMO2 VH
LMO-2
(Homo
sapiens)		4 / 8PHE C  27
SER C  32
GLU A  52
ASP A  53
None
1.13A15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_D_PARD500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens)		4 / 8PHE A 191
THR A 263
SER A 268
ASP A 265
None
1.07A21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_D_PARD500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		4ol0 TRANSPORTIN-3
(Homo
sapiens)		4 / 8PHE B  62
SER B  47
GLU B 153
ASP B 114
None
1.40A18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_D_PARD500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		4r3z ARGININE--TRNA
LIGASE, CYTOPLASMIC
(Homo
sapiens)		4 / 8PHE B 198
SER B 329
SER B 222
ASP B 650
None
1.36A22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_D_PARD500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		5k13 RETINOIC ACID
RECEPTOR ALPHA
(Homo
sapiens)		4 / 8PHE A 312
THR A 326
ASP A 322
ASP A 323
None
1.37A20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_D_PARD500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		5uan RETINOIC ACID
RECEPTOR BETA
(Homo
sapiens)		4 / 8PHE B 305
THR B 319
ASP B 315
ASP B 316
None
1.30A24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_D_PARD500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		6en4 SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens)		4 / 8PHE A 741
SER A 507
SER A 743
ASP A 471
None
1.40A11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_E_PARE500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		1suv TRANSFERRIN RECEPTOR
PROTEIN 1
(Homo
sapiens)		5 / 12PHE A 433
PHE A 450
LEU A 601
THR A 602
ASP A 604
None
1.41A21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_E_PARE500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens)		5 / 12LEU A 259
GLU A 436
ASP A 266
TYR A 687
GLY A 263
None
1.28A19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_E_PARE500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		2pxx UNCHARACTERIZED
PROTEIN MGC2408
(Homo
sapiens)		5 / 12SER A 176
PHE A 206
SER A 173
TYR A 186
TYR A  20
None
1.43A19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_E_PARE500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens)		5 / 12PHE A 707
PHE A 831
THR A 703
GLU A 727
TYR A 719
None
1.26A20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_E_PARE500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		4auo INTERSTITIAL
COLLAGENASE
(Homo
sapiens)		5 / 12LEU A 263
THR A 264
ASP A 266
ASP A 408
GLY A 422
None
1.10A20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_E_PARE500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		4cak INTEGRIN ALPHA-IIB
INTEGRIN BETA-3
(Homo
sapiens)		5 / 12SER B 291
LEU A 352
THR B 230
ASP B 233
GLY A 382
None
1.24A18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_E_PARE500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		4nux INTERLEUKIN-17
RECEPTOR A
(Homo
sapiens)		5 / 12PHE A 574
SER A 448
LEU A 446
GLU A 417
ASP A 413
None
1.31A18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_F_PARF500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		1cee GTP-BINDING RHO-LIKE
PROTEIN
WISKOTT-ALDRICH
SYNDROME PROTEIN
WASP
(Homo
sapiens)		5 / 11PHE B  42
THR A  58
SER A  71
GLU A 100
GLY A  60
None
1.49A8.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_F_PARF500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		1w6j LANOSTEROL SYNTHASE
(Homo
sapiens)		5 / 11PHE A 195
SER A 241
GLU A 504
ASP A 327
ASP A 326
None
1.24A21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_F_PARF500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		2z8c INSULIN RECEPTOR
(Homo
sapiens)		5 / 11PHE A1256
SER A1194
GLU A1047
GLU A1043
ASP A1150
None
None
None
PTR  A1163 ( 4.6A)
None
1.47A21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_F_PARF500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		3pb9 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE-LIK
E PROTEIN
(Homo
sapiens)		5 / 11PHE X 174
ASP X 269
ASP X 327
TYR X 238
GLY X 224
None
1BN  X 390 (-3.3A)
None
None
None
1.45A23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_F_PARF500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		4yu9 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE
(Homo
sapiens)		5 / 11PHE A 146
ASP A 248
ASP A 306
TYR A 214
GLY A 200
None
1.44A22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11801_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
EL18)		1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
(Homo
sapiens)		4 / 4ARG A 221
ARG A 192
GLY A 111
ARG A 107
None
1.49A11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11802_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
UL4
RIBOSOMAL PROTEIN
UL15
RIBOSOMAL PROTEIN
EL15)		1skx ORPHAN NUCLEAR
RECEPTOR PXR
(Homo
sapiens)		3 / 3ARG A 410
LYS A 210
ARG A 413
RFP  A   1 ( 4.2A)
RFP  A   1 (-3.5A)
None
1.29A10.53
13.85
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11802_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
UL4
RIBOSOMAL PROTEIN
UL15
RIBOSOMAL PROTEIN
EL15)		2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE
(Homo
sapiens)		3 / 3ARG A 133
LYS A 151
ARG A 237
None
GRG  A 500 (-2.8A)
None
1.25A13.60
13.06
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11802_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
UL4
RIBOSOMAL PROTEIN
UL15
RIBOSOMAL PROTEIN
EL15)		3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2
(Homo
sapiens)		3 / 3ARG A1032
LYS A 868
ARG A1066
None
1.40A13.50
12.72
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11802_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
UL4
RIBOSOMAL PROTEIN
UL15
RIBOSOMAL PROTEIN
EL15)		4rlv ANKYRIN-1, ANKYRIN-2
(Homo
sapiens;
Mus
musculus)		3 / 3ARG A2506
LYS A1584
ARG A2539
None
1.20A7.03
6.66
5.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11803_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
EL18)		1uju SCRIBBLE
(Homo
sapiens)		3 / 3SER A  26
LYS A  50
SER A  49
None
0.70A17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11803_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
EL18)		1whl CYLINDROMATOSIS
TUMOR SUPPRESSOR
CYLD
(Homo
sapiens)		3 / 3SER A   3
LYS A   1
SER A   5
None
0.74A18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11803_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
EL18)		2c9a RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE MU
(Homo
sapiens)		3 / 3SER A 107
LYS A 106
SER A 105
None
0.74A16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11803_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
EL18)		2p5s RAS AND EF-HAND
DOMAIN CONTAINING
(Homo
sapiens)		3 / 3SER A 555
LYS A 554
SER A 556
GDP  A1001 ( 2.5A)
GDP  A1001 ( 2.8A)
GDP  A1001 ( 2.6A)
0.84A20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11803_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
EL18)		2p82 CYSTEINE PROTEASE
ATG4A
(Homo
sapiens)		3 / 3SER A  43
LYS A  44
SER A  47
None
0.67A12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11803_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
EL18)		3eh1 PROTEIN TRANSPORT
PROTEIN SEC24B
(Homo
sapiens)		3 / 3SER A1036
LYS A 836
SER A1034
None
0.59A8.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11803_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
EL18)		3lbx SPECTRIN BETA CHAIN,
ERYTHROCYTE
(Homo
sapiens)		3 / 3SER B1956
LYS B1957
SER B1960
None
0.67A15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11803_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
EL18)		5f0k VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 35
(Homo
sapiens)		3 / 3SER A  62
LYS A  61
SER A  59
None
0.74A11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11803_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
EL18)		5yew MITOFUSIN-1,MITOFUSI
N-1 FUSION PROTEIN
(Homo
sapiens)		3 / 3SER B  89
LYS B  88
SER B  90
 MG  B 804 ( 2.1A)
BEF  B 802 ( 2.5A)
GDP  B 801 (-2.5A)
0.83A18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11803_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
EL18)		6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)
(Homo
sapiens)		3 / 3SER A1530
LYS A1531
SER A1534
None
0.84A0.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11803_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
EL18)		6bql CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2
(Homo
sapiens)		3 / 3SER A 400
LYS A 401
SER A 404
None
0.67A21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB7_A_PARA900_0
(AAC(3)-IIIB PROTEIN)		2feb APOLIPOPROTEIN(A)
(Homo
sapiens)		5 / 10ASP A  17
THR A   9
HIS A   5
GLY A  36
ASP A  82
None
1.42A17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB7_A_PARA900_0
(AAC(3)-IIIB PROTEIN)		2ggz GUANYLYL
CYCLASE-ACTIVATING
PROTEIN 3
(Homo
sapiens)		5 / 10ASP A  57
THR A  62
GLY A  69
ASP A  68
GLU A  75
None
None
None
CA  A 500 (-2.4A)
CA  A 500 (-2.0A)
1.29A17.33