POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4BWL_C_MN9C1297_0 (N-ACETYLNEURAMINATE LYASE)	2ymb	MIT DOMAIN-CONTAINING PROTEIN 1 (Homo sapiens)	5 / 10	ILE A  94 THR A 236 GLY A 208 GLY A 210 PHE A 107	None	1.27A	22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4BWL_C_MN9C1297_0 (N-ACETYLNEURAMINATE LYASE)	3ber	PROBABLE ATP-DEPENDENT RNA HELICASE DDX47 (Homo sapiens)	5 / 10	ILE A 108 LEU A 104 GLY A  76 GLY A  73 SER A  72	None None None AMP  A 300 (-3.3A) AMP  A 300 (-4.1A)	1.20A	23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4BWL_C_MN9C1297_0 (N-ACETYLNEURAMINATE LYASE)	3c0i	PERIPHERAL PLASMA MEMBRANE PROTEIN CASK (Homo sapiens)	5 / 10	ILE A 167 GLY A 197 TYR A 196 GLY A 173 SER A 172	None	1.00A	20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4BWL_C_MN9C1297_0 (N-ACETYLNEURAMINATE LYASE)	3ff6	ACETYL-COA CARBOXYLASE 2 (Homo sapiens)	5 / 10	LEU A1945 TYR A1810 ASP A1807 GLY A1910 SER A1911	None	1.25A	17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4BWL_C_MN9C1297_0 (N-ACETYLNEURAMINATE LYASE)	4mwt	LYSOSOMAL PROTECTIVE PROTEIN (Homo sapiens)	5 / 10	LEU A 174 GLY A 177 ASP A 380 GLY A 179 SER A 181	LEU  A 174 ( 0.5A) GLY  A 177 ( 0.0A) ASP  A 380 ( 0.5A) GLY  A 179 ( 0.0A) SER  A 181 ( 0.0A)	1.13A	20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4BWL_C_MN9C1297_0 (N-ACETYLNEURAMINATE LYASE)	5epg	ALDEHYDE OXIDASE (Homo sapiens)	5 / 10	ILE A 291 LEU A 249 GLY A 309 GLY A 307 SER A 413	None	1.20A	13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WOZ_B_MN9B401_0 (N-ACETYLNEURAMINATE LYASE)	1oki	BETA CRYSTALLIN B1 (Homo sapiens)	4 / 6	SER A 227 LEU A 228 TYR A 176 LEU A 173	None	0.88A	20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WOZ_B_MN9B401_0 (N-ACETYLNEURAMINATE LYASE)	1u71	DIHYDROFOLATE REDUCTASE (Homo sapiens)	4 / 6	SER A  92 LEU A  93 ASP A  94 LEU A  75	None	0.90A	21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WOZ_B_MN9B401_0 (N-ACETYLNEURAMINATE LYASE)	2a14	INDOLETHYLAMINE N-METHYLTRANSFERASE (Homo sapiens)	4 / 6	SER A 172 LEU A 173 ASP A 174 LEU A 216	None	0.99A	21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WOZ_B_MN9B401_0 (N-ACETYLNEURAMINATE LYASE)	2pop	MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7-INTERACTING PROTEIN 1 (Homo sapiens)	4 / 6	SER A 322 LEU A 323 ASP A 324 LEU A 369	None	0.94A	21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WOZ_B_MN9B401_0 (N-ACETYLNEURAMINATE LYASE)	3a1j	CELL CYCLE CHECKPOINT PROTEIN RAD1 (Homo sapiens)	4 / 6	SER C 191 LEU C 190 TYR C 223 LEU C 177	None	0.92A	22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WOZ_B_MN9B401_0 (N-ACETYLNEURAMINATE LYASE)	3l5h	INTERLEUKIN-6 RECEPTOR SUBUNIT BETA (Homo sapiens)	4 / 6	THR A 544 SER A 558 LEU A 557 LEU A 560	None	1.03A	20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WOZ_B_MN9B401_0 (N-ACETYLNEURAMINATE LYASE)	3sag	EXOSOME COMPONENT 10 (Homo sapiens)	4 / 6	SER A 293 LEU A 294 ASP A 295 LEU A 345	SER  A 293 ( 0.0A) LEU  A 294 ( 0.6A) ASP  A 295 ( 0.6A) LEU  A 345 ( 0.6A)	0.86A	21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WOZ_B_MN9B401_0 (N-ACETYLNEURAMINATE LYASE)	3tdu	DCN1-LIKE PROTEIN 1 (Homo sapiens)	4 / 6	SER A  99 ASP A  96 TYR A 181 LEU A 184	None	1.04A	21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WOZ_B_MN9B401_0 (N-ACETYLNEURAMINATE LYASE)	4ayz	HEME-BINDING PROTEIN 2 (Homo sapiens)	4 / 6	SER A 108 LEU A 109 TYR A  72 LEU A  69	None	1.02A	21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WOZ_B_MN9B401_0 (N-ACETYLNEURAMINATE LYASE)	4b3g	DNA-BINDING PROTEIN SMUBP-2 (Homo sapiens)	4 / 6	SER A 279 LEU A 280 ASP A 281 LEU A 263	None	0.78A	18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WOZ_B_MN9B401_0 (N-ACETYLNEURAMINATE LYASE)	4fgu	LEGUMAIN (Homo sapiens)	4 / 6	THR A 332 LEU A 339 ASP A 340 LEU A 312	None	1.02A	19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WOZ_B_MN9B401_0 (N-ACETYLNEURAMINATE LYASE)	4wzw	PUMILIO DOMAIN-CONTAINING PROTEIN KIAA0020 (Homo sapiens)	4 / 6	SER A 517 LEU A 446 ASP A 513 LEU A 483	None	0.98A	22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WOZ_B_MN9B401_0 (N-ACETYLNEURAMINATE LYASE)	5nzz	TGF-BETA-ACTIVATED KINASE 1 AND MAP3K7-BINDING PROTEIN 1 (Homo sapiens)	4 / 6	SER A 322 LEU A 323 ASP A 324 LEU A 369	None	0.82A	undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WOZ_B_MN9B401_0 (N-ACETYLNEURAMINATE LYASE)	5tja	MUCOLIPIN-1 (Homo sapiens)	4 / 6	SER A 274 LEU A 275 TYR A 109 LEU A 106	None	0.95A	18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WOZ_B_MN9B401_0 (N-ACETYLNEURAMINATE LYASE)	5vbb	RNA PSEUDOURIDYLATE SYNTHASE DOMAIN-CONTAINING PROTEIN 1 (Homo sapiens)	4 / 6	SER A 246 LEU A 247 ASP A 248 LEU A 151	None	0.71A	21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WOZ_F_MN9F401_0 (N-ACETYLNEURAMINATE LYASE)	1suv	TRANSFERRIN RECEPTOR PROTEIN 1 (Homo sapiens)	4 / 5	LEU A 625 ASP A 624 TYR A 643 LEU A 642	None	1.23A	17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WOZ_F_MN9F401_0 (N-ACETYLNEURAMINATE LYASE)	1v40	GLUTATHIONE-REQUIRIN G PROSTAGLANDIN D SYNTHASE (Homo sapiens)	4 / 5	LEU A 135 ASP A 132 LEU A 141 THR A 176	None	1.27A	21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WOZ_F_MN9F401_0 (N-ACETYLNEURAMINATE LYASE)	2yuq	TYROSINE-PROTEIN KINASE ITK/TSK (Homo sapiens)	4 / 5	LEU A  36 TYR A  28 LEU A  38 THR A  30	None	1.27A	14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WOZ_F_MN9F401_0 (N-ACETYLNEURAMINATE LYASE)	3a62	RIBOSOMAL PROTEIN S6 KINASE BETA-1 (Homo sapiens)	4 / 5	LEU A 282 ASP A 285 TYR A 198 LEU A 199	None	1.18A	22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WOZ_F_MN9F401_0 (N-ACETYLNEURAMINATE LYASE)	3nvq	SEMAPHORIN-7A (Homo sapiens)	4 / 5	LEU A 490 ASP A 491 TYR A 478 LEU A 477	None	1.22A	19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WOZ_F_MN9F401_0 (N-ACETYLNEURAMINATE LYASE)	3vzb	SPHINGOSINE KINASE 1 (Homo sapiens)	4 / 5	LEU A 116 ASP A  81 TYR A 123 LEU A 120	None None EDO  A 408 (-4.8A) EDO  A 403 (-4.5A)	1.27A	21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WOZ_F_MN9F401_0 (N-ACETYLNEURAMINATE LYASE)	3w18	AURORA KINASE A (Homo sapiens)	4 / 5	LEU A 130 ASP A 202 TYR A 148 LEU A 161	None	1.20A	20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WOZ_F_MN9F401_0 (N-ACETYLNEURAMINATE LYASE)	3zbf	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ROS (Homo sapiens)	4 / 5	LEU A2059 ASP A2062 TYR A2037 LEU A2034	None	1.25A	22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WOZ_F_MN9F401_0 (N-ACETYLNEURAMINATE LYASE)	4fgu	LEGUMAIN (Homo sapiens)	4 / 5	LEU A 339 ASP A 340 LEU A 312 THR A 332	None	1.03A	19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WOZ_F_MN9F401_0 (N-ACETYLNEURAMINATE LYASE)	4hsu	LYSINE-SPECIFIC HISTONE DEMETHYLASE 1B PUTATIVE OXIDOREDUCTASE GLYR1 (Homo sapiens; Homo sapiens)	4 / 5	LEU B 221 TYR A 809 LEU A 810 THR A 364	None	1.26A	16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WOZ_F_MN9F401_0 (N-ACETYLNEURAMINATE LYASE)	4pd3	NONMUSCLE MYOSIN HEAVY CHAIN B, ALPHA-ACTININ A CHIMERA PROTEIN (Homo sapiens; Dictyostelium discoideum)	4 / 5	LEU A 354 TYR A 285 LEU A 288 THR A 280	None	1.11A	15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WOZ_F_MN9F401_0 (N-ACETYLNEURAMINATE LYASE)	5mio	KINESIN-LIKE PROTEIN KIF2C,KIF2C FUSED TO A DARPIN,KIF2C FUSED TO A DARPIN (Homo sapiens)	4 / 5	LEU C 657 ASP C 686 LEU C 628 THR C 665	None	1.19A	18.36