POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3L4W_A_MIGA1001_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		3ctt MALTASE-GLUCOAMYLASE
(Homo
sapiens)		11 / 12TYR A 299
ASP A 327
ILE A 328
ILE A 364
TRP A 406
TRP A 441
ASP A 443
MET A 444
ASP A 542
PHE A 575
HIS A 600
3CU  A1001 (-3.6A)
3CU  A1001 (-2.7A)
3CU  A1001 ( 3.9A)
3CU  A1001 (-4.5A)
None
3CU  A1001 (-4.9A)
3CU  A1001 (-2.7A)
3CU  A1001 ( 3.9A)
3CU  A1001 ( 2.5A)
3CU  A1001 (-4.5A)
3CU  A1001 (-3.9A)
0.49A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3L4W_A_MIGA1001_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		3ctt MALTASE-GLUCOAMYLASE
(Homo
sapiens)		11 / 12TYR A 299
ASP A 327
ILE A 328
ILE A 364
TRP A 441
ASP A 443
MET A 444
TRP A 539
ASP A 542
PHE A 575
HIS A 600
3CU  A1001 (-3.6A)
3CU  A1001 (-2.7A)
3CU  A1001 ( 3.9A)
3CU  A1001 (-4.5A)
3CU  A1001 (-4.9A)
3CU  A1001 (-2.7A)
3CU  A1001 ( 3.9A)
3CU  A1001 (-4.6A)
3CU  A1001 ( 2.5A)
3CU  A1001 (-4.5A)
3CU  A1001 (-3.9A)
0.19A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3L4W_A_MIGA1001_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		3lpp SUCRASE-ISOMALTASE
(Homo
sapiens)		11 / 12ASP A 355
ILE A 356
ILE A 392
TRP A 435
TRP A 470
ASP A 472
MET A 473
TRP A 568
ASP A 571
PHE A 604
HIS A 629
TRS  A6001 (-2.9A)
TRS  A6001 ( 4.0A)
None
TRS  A6001 ( 4.6A)
None
TRS  A6001 (-3.2A)
TRS  A6001 ( 3.7A)
None
TRS  A6001 ( 3.7A)
TRS  A6001 (-4.4A)
TRS  A6001 (-4.2A)
0.50A57.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3L4W_A_MIGA1001_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens)		6 / 12ASP A1279
ILE A1280
MET A1421
ASP A1526
PHE A1559
HIS A1584
ACR  A   1 (-3.2A)
ACR  A   1 (-4.1A)
ACR  A   1 (-3.5A)
ACR  A   1 (-2.8A)
ACR  A   1 (-4.3A)
ACR  A   1 (-3.9A)
1.42A43.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3L4W_A_MIGA1001_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens)		12 / 12TYR A1251
ASP A1279
ILE A1280
ILE A1315
TRP A1355
TRP A1418
ASP A1420
MET A1421
TRP A1523
ASP A1526
PHE A1559
HIS A1584
ACR  A   1 ( 4.1A)
ACR  A   1 (-3.2A)
ACR  A   1 (-4.1A)
None
ACR  A   1 (-4.4A)
None
ACR  A   1 (-3.6A)
ACR  A   1 (-3.5A)
ACR  A   1 (-4.5A)
ACR  A   1 (-2.8A)
ACR  A   1 (-4.3A)
ACR  A   1 (-3.9A)
0.62A43.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3L4W_A_MIGA1001_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens)		10 / 12ASP A 404
ILE A 441
TRP A 481
TRP A 516
ASP A 518
MET A 519
TRP A 613
ASP A 616
PHE A 649
HIS A 674
ACR  A1015 (-3.0A)
ACR  A1015 (-4.3A)
ACR  A1015 ( 4.6A)
None
ACR  A1015 (-3.1A)
ACR  A1015 (-3.3A)
ACR  A1015 (-4.8A)
ACR  A1015 (-2.7A)
ACR  A1015 (-4.3A)
ACR  A1015 (-4.0A)
0.50A44.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NN6_A_MIGA1013_1
(LYSOSOMAL
ALPHA-GLUCOSIDASE)		3ctt MALTASE-GLUCOAMYLASE
(Homo
sapiens)		10 / 12ASP A 327
ILE A 364
TRP A 406
TRP A 441
ASP A 443
MET A 444
TRP A 539
ASP A 542
PHE A 575
HIS A 600
3CU  A1001 (-2.7A)
3CU  A1001 (-4.5A)
None
3CU  A1001 (-4.9A)
3CU  A1001 (-2.7A)
3CU  A1001 ( 3.9A)
3CU  A1001 (-4.6A)
3CU  A1001 ( 2.5A)
3CU  A1001 (-4.5A)
3CU  A1001 (-3.9A)
0.71A44.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NN6_A_MIGA1013_1
(LYSOSOMAL
ALPHA-GLUCOSIDASE)		3lpp SUCRASE-ISOMALTASE
(Homo
sapiens)		10 / 12TRP A 327
ASP A 355
ILE A 392
TRP A 435
TRP A 470
ASP A 472
MET A 473
TRP A 568
PHE A 604
HIS A 629
TRS  A6001 ( 3.8A)
TRS  A6001 (-2.9A)
None
TRS  A6001 ( 4.6A)
None
TRS  A6001 (-3.2A)
TRS  A6001 ( 3.7A)
None
TRS  A6001 (-4.4A)
TRS  A6001 (-4.2A)
0.68A42.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NN6_A_MIGA1013_1
(LYSOSOMAL
ALPHA-GLUCOSIDASE)		3lpp SUCRASE-ISOMALTASE
(Homo
sapiens)		10 / 12TRP A 327
ASP A 355
ILE A 392
TRP A 435
TRP A 470
ASP A 472
TRP A 568
ASP A 571
PHE A 604
HIS A 629
TRS  A6001 ( 3.8A)
TRS  A6001 (-2.9A)
None
TRS  A6001 ( 4.6A)
None
TRS  A6001 (-3.2A)
None
TRS  A6001 ( 3.7A)
TRS  A6001 (-4.4A)
TRS  A6001 (-4.2A)
0.62A42.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NN6_A_MIGA1013_1
(LYSOSOMAL
ALPHA-GLUCOSIDASE)		3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens)		10 / 12ASP A1279
ILE A1315
TRP A1355
TRP A1418
ASP A1420
MET A1421
TRP A1523
ASP A1526
PHE A1559
HIS A1584
ACR  A   1 (-3.2A)
None
ACR  A   1 (-4.4A)
None
ACR  A   1 (-3.6A)
ACR  A   1 (-3.5A)
ACR  A   1 (-4.5A)
ACR  A   1 (-2.8A)
ACR  A   1 (-4.3A)
ACR  A   1 (-3.9A)
0.71A39.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NN6_A_MIGA1013_1
(LYSOSOMAL
ALPHA-GLUCOSIDASE)		5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens)		12 / 12TRP A 376
ASP A 404
LEU A 405
ILE A 441
TRP A 481
TRP A 516
ASP A 518
MET A 519
TRP A 613
ASP A 616
PHE A 649
HIS A 674
ACR  A1015 ( 4.6A)
ACR  A1015 (-3.0A)
ACR  A1015 (-4.0A)
ACR  A1015 (-4.3A)
ACR  A1015 ( 4.6A)
None
ACR  A1015 (-3.1A)
ACR  A1015 (-3.3A)
ACR  A1015 (-4.8A)
ACR  A1015 (-2.7A)
ACR  A1015 (-4.3A)
ACR  A1015 (-4.0A)
0.63A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA1_A_MIGA701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		3ctt MALTASE-GLUCOAMYLASE
(Homo
sapiens)		10 / 12ASP A 327
ILE A 328
ILE A 364
ASP A 443
MET A 444
ARG A 526
TRP A 539
ASP A 542
PHE A 575
HIS A 600
3CU  A1001 (-2.7A)
3CU  A1001 ( 3.9A)
3CU  A1001 (-4.5A)
3CU  A1001 (-2.7A)
3CU  A1001 ( 3.9A)
3CU  A1001 ( 3.5A)
3CU  A1001 (-4.6A)
3CU  A1001 ( 2.5A)
3CU  A1001 (-4.5A)
3CU  A1001 (-3.9A)
0.40A6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA1_A_MIGA701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		3ctt MALTASE-GLUCOAMYLASE
(Homo
sapiens)		6 / 12ASP A 327
ILE A 328
ILE A 364
TRP A 441
PHE A 575
HIS A 600
3CU  A1001 (-2.7A)
3CU  A1001 ( 3.9A)
3CU  A1001 (-4.5A)
3CU  A1001 (-4.9A)
3CU  A1001 (-4.5A)
3CU  A1001 (-3.9A)
0.77A6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA1_A_MIGA701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		3ctt MALTASE-GLUCOAMYLASE
(Homo
sapiens)		7 / 12ASP A 327
ILE A 364
MET A 444
ARG A 526
ASP A 542
PHE A 575
HIS A 600
3CU  A1001 (-2.7A)
3CU  A1001 (-4.5A)
3CU  A1001 ( 3.9A)
3CU  A1001 ( 3.5A)
3CU  A1001 ( 2.5A)
3CU  A1001 (-4.5A)
3CU  A1001 (-3.9A)
1.41A6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA1_A_MIGA701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		3lpp SUCRASE-ISOMALTASE
(Homo
sapiens)		7 / 12ASP A 355
ILE A 392
MET A 473
ARG A 555
ASP A 571
PHE A 604
HIS A 629
TRS  A6001 (-2.9A)
None
TRS  A6001 ( 3.7A)
TRS  A6001 ( 4.6A)
TRS  A6001 ( 3.7A)
TRS  A6001 (-4.4A)
TRS  A6001 (-4.2A)
1.40A9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA1_A_MIGA701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		3lpp SUCRASE-ISOMALTASE
(Homo
sapiens)		11 / 12TRP A 327
ASP A 355
ILE A 356
ILE A 392
ASP A 472
MET A 473
ARG A 555
TRP A 568
ASP A 571
PHE A 604
HIS A 629
TRS  A6001 ( 3.8A)
TRS  A6001 (-2.9A)
TRS  A6001 ( 4.0A)
None
TRS  A6001 (-3.2A)
TRS  A6001 ( 3.7A)
TRS  A6001 ( 4.6A)
None
TRS  A6001 ( 3.7A)
TRS  A6001 (-4.4A)
TRS  A6001 (-4.2A)
0.40A9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA1_A_MIGA701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		3lpp SUCRASE-ISOMALTASE
(Homo
sapiens)		8 / 12TRP A 327
ASP A 355
ILE A 356
ILE A 392
TRP A 470
TRP A 568
PHE A 604
HIS A 629
TRS  A6001 ( 3.8A)
TRS  A6001 (-2.9A)
TRS  A6001 ( 4.0A)
None
None
None
TRS  A6001 (-4.4A)
TRS  A6001 (-4.2A)
0.83A9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA1_A_MIGA701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens)		10 / 12ASP A1279
ILE A1280
ILE A1315
ASP A1420
MET A1421
ARG A1510
TRP A1523
ASP A1526
PHE A1559
HIS A1584
ACR  A   1 (-3.2A)
ACR  A   1 (-4.1A)
None
ACR  A   1 (-3.6A)
ACR  A   1 (-3.5A)
ACR  A   1 (-2.9A)
ACR  A   1 (-4.5A)
ACR  A   1 (-2.8A)
ACR  A   1 (-4.3A)
ACR  A   1 (-3.9A)
0.45A6.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA1_A_MIGA701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens)		6 / 12ASP A1279
ILE A1280
ILE A1315
TRP A1418
PHE A1559
HIS A1584
ACR  A   1 (-3.2A)
ACR  A   1 (-4.1A)
None
None
ACR  A   1 (-4.3A)
ACR  A   1 (-3.9A)
0.85A6.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA1_A_MIGA701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens)		8 / 12ASP A1279
ILE A1315
ASP A1420
MET A1421
ARG A1510
ASP A1526
PHE A1559
HIS A1584
ACR  A   1 (-3.2A)
None
ACR  A   1 (-3.6A)
ACR  A   1 (-3.5A)
ACR  A   1 (-2.9A)
ACR  A   1 (-2.8A)
ACR  A   1 (-4.3A)
ACR  A   1 (-3.9A)
1.46A6.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA1_A_MIGA701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens)		6 / 12ASP A 404
ILE A 441
MET A 519
ARG A 600
ASP A 616
PHE A 649
ACR  A1015 (-3.0A)
ACR  A1015 (-4.3A)
ACR  A1015 (-3.3A)
ACR  A1015 (-3.1A)
ACR  A1015 (-2.7A)
ACR  A1015 (-4.3A)
1.45A8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA1_A_MIGA701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens)		10 / 12TRP A 376
ASP A 404
ILE A 441
ASP A 518
MET A 519
ARG A 600
TRP A 613
ASP A 616
PHE A 649
HIS A 674
ACR  A1015 ( 4.6A)
ACR  A1015 (-3.0A)
ACR  A1015 (-4.3A)
ACR  A1015 (-3.1A)
ACR  A1015 (-3.3A)
ACR  A1015 (-3.1A)
ACR  A1015 (-4.8A)
ACR  A1015 (-2.7A)
ACR  A1015 (-4.3A)
ACR  A1015 (-4.0A)
0.69A8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA1_A_MIGA701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens)		6 / 12TRP A 376
ASP A 404
ILE A 441
TRP A 516
PHE A 649
HIS A 674
ACR  A1015 ( 4.6A)
ACR  A1015 (-3.0A)
ACR  A1015 (-4.3A)
None
ACR  A1015 (-4.3A)
ACR  A1015 (-4.0A)
0.97A8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA1_B_MIGB701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		3ctt MALTASE-GLUCOAMYLASE
(Homo
sapiens)		10 / 12ASP A 327
ILE A 328
ILE A 364
ASP A 443
MET A 444
ARG A 526
TRP A 539
ASP A 542
PHE A 575
HIS A 600
3CU  A1001 (-2.7A)
3CU  A1001 ( 3.9A)
3CU  A1001 (-4.5A)
3CU  A1001 (-2.7A)
3CU  A1001 ( 3.9A)
3CU  A1001 ( 3.5A)
3CU  A1001 (-4.6A)
3CU  A1001 ( 2.5A)
3CU  A1001 (-4.5A)
3CU  A1001 (-3.9A)
0.40A6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA1_B_MIGB701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		3ctt MALTASE-GLUCOAMYLASE
(Homo
sapiens)		6 / 12ASP A 327
ILE A 328
ILE A 364
TRP A 441
PHE A 575
HIS A 600
3CU  A1001 (-2.7A)
3CU  A1001 ( 3.9A)
3CU  A1001 (-4.5A)
3CU  A1001 (-4.9A)
3CU  A1001 (-4.5A)
3CU  A1001 (-3.9A)
0.79A6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA1_B_MIGB701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		3ctt MALTASE-GLUCOAMYLASE
(Homo
sapiens)		7 / 12ASP A 327
ILE A 364
MET A 444
ARG A 526
ASP A 542
PHE A 575
HIS A 600
3CU  A1001 (-2.7A)
3CU  A1001 (-4.5A)
3CU  A1001 ( 3.9A)
3CU  A1001 ( 3.5A)
3CU  A1001 ( 2.5A)
3CU  A1001 (-4.5A)
3CU  A1001 (-3.9A)
1.44A6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA1_B_MIGB701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		3lpp SUCRASE-ISOMALTASE
(Homo
sapiens)		7 / 12ASP A 355
ILE A 392
MET A 473
ARG A 555
ASP A 571
PHE A 604
HIS A 629
TRS  A6001 (-2.9A)
None
TRS  A6001 ( 3.7A)
TRS  A6001 ( 4.6A)
TRS  A6001 ( 3.7A)
TRS  A6001 (-4.4A)
TRS  A6001 (-4.2A)
1.42A9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA1_B_MIGB701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		3lpp SUCRASE-ISOMALTASE
(Homo
sapiens)		11 / 12TRP A 327
ASP A 355
ILE A 356
ILE A 392
ASP A 472
MET A 473
ARG A 555
TRP A 568
ASP A 571
PHE A 604
HIS A 629
TRS  A6001 ( 3.8A)
TRS  A6001 (-2.9A)
TRS  A6001 ( 4.0A)
None
TRS  A6001 (-3.2A)
TRS  A6001 ( 3.7A)
TRS  A6001 ( 4.6A)
None
TRS  A6001 ( 3.7A)
TRS  A6001 (-4.4A)
TRS  A6001 (-4.2A)
0.39A9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA1_B_MIGB701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		3lpp SUCRASE-ISOMALTASE
(Homo
sapiens)		8 / 12TRP A 327
ASP A 355
ILE A 356
ILE A 392
TRP A 470
TRP A 568
PHE A 604
HIS A 629
TRS  A6001 ( 3.8A)
TRS  A6001 (-2.9A)
TRS  A6001 ( 4.0A)
None
None
None
TRS  A6001 (-4.4A)
TRS  A6001 (-4.2A)
0.83A9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA1_B_MIGB701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens)		10 / 12ASP A1279
ILE A1280
ILE A1315
ASP A1420
MET A1421
ARG A1510
TRP A1523
ASP A1526
PHE A1559
HIS A1584
ACR  A   1 (-3.2A)
ACR  A   1 (-4.1A)
None
ACR  A   1 (-3.6A)
ACR  A   1 (-3.5A)
ACR  A   1 (-2.9A)
ACR  A   1 (-4.5A)
ACR  A   1 (-2.8A)
ACR  A   1 (-4.3A)
ACR  A   1 (-3.9A)
0.44A6.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA1_B_MIGB701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens)		6 / 12ASP A1279
ILE A1280
ILE A1315
TRP A1418
PHE A1559
HIS A1584
ACR  A   1 (-3.2A)
ACR  A   1 (-4.1A)
None
None
ACR  A   1 (-4.3A)
ACR  A   1 (-3.9A)
0.87A6.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA1_B_MIGB701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens)		6 / 12ASP A 404
ILE A 441
MET A 519
ARG A 600
ASP A 616
PHE A 649
ACR  A1015 (-3.0A)
ACR  A1015 (-4.3A)
ACR  A1015 (-3.3A)
ACR  A1015 (-3.1A)
ACR  A1015 (-2.7A)
ACR  A1015 (-4.3A)
1.47A8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA1_B_MIGB701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens)		10 / 12TRP A 376
ASP A 404
ILE A 441
ASP A 518
MET A 519
ARG A 600
TRP A 613
ASP A 616
PHE A 649
HIS A 674
ACR  A1015 ( 4.6A)
ACR  A1015 (-3.0A)
ACR  A1015 (-4.3A)
ACR  A1015 (-3.1A)
ACR  A1015 (-3.3A)
ACR  A1015 (-3.1A)
ACR  A1015 (-4.8A)
ACR  A1015 (-2.7A)
ACR  A1015 (-4.3A)
ACR  A1015 (-4.0A)
0.64A8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA1_B_MIGB701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens)		6 / 12TRP A 376
ASP A 404
ILE A 441
TRP A 516
PHE A 649
HIS A 674
ACR  A1015 ( 4.6A)
ACR  A1015 (-3.0A)
ACR  A1015 (-4.3A)
None
ACR  A1015 (-4.3A)
ACR  A1015 (-4.0A)
0.96A8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA3_A_MIGA701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		3ctt MALTASE-GLUCOAMYLASE
(Homo
sapiens)		6 / 12ASP A 327
ILE A 364
MET A 444
ARG A 526
ASP A 542
PHE A 575
3CU  A1001 (-2.7A)
3CU  A1001 (-4.5A)
3CU  A1001 ( 3.9A)
3CU  A1001 ( 3.5A)
3CU  A1001 ( 2.5A)
3CU  A1001 (-4.5A)
1.47A6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA3_A_MIGA701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		3ctt MALTASE-GLUCOAMYLASE
(Homo
sapiens)		11 / 12TYR A 299
ASP A 327
ILE A 328
ILE A 364
ASP A 443
MET A 444
ARG A 526
TRP A 539
ASP A 542
PHE A 575
HIS A 600
3CU  A1001 (-3.6A)
3CU  A1001 (-2.7A)
3CU  A1001 ( 3.9A)
3CU  A1001 (-4.5A)
3CU  A1001 (-2.7A)
3CU  A1001 ( 3.9A)
3CU  A1001 ( 3.5A)
3CU  A1001 (-4.6A)
3CU  A1001 ( 2.5A)
3CU  A1001 (-4.5A)
3CU  A1001 (-3.9A)
0.47A6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA3_A_MIGA701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		3ctt MALTASE-GLUCOAMYLASE
(Homo
sapiens)		7 / 12TYR A 299
ASP A 327
ILE A 328
ILE A 364
TRP A 441
PHE A 575
HIS A 600
3CU  A1001 (-3.6A)
3CU  A1001 (-2.7A)
3CU  A1001 ( 3.9A)
3CU  A1001 (-4.5A)
3CU  A1001 (-4.9A)
3CU  A1001 (-4.5A)
3CU  A1001 (-3.9A)
0.89A6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA3_A_MIGA701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		3lpp SUCRASE-ISOMALTASE
(Homo
sapiens)		10 / 12ASP A 355
ILE A 356
ILE A 392
ASP A 472
MET A 473
ARG A 555
TRP A 568
ASP A 571
PHE A 604
HIS A 629
TRS  A6001 (-2.9A)
TRS  A6001 ( 4.0A)
None
TRS  A6001 (-3.2A)
TRS  A6001 ( 3.7A)
TRS  A6001 ( 4.6A)
None
TRS  A6001 ( 3.7A)
TRS  A6001 (-4.4A)
TRS  A6001 (-4.2A)
0.43A9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA3_A_MIGA701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		3lpp SUCRASE-ISOMALTASE
(Homo
sapiens)		7 / 12ASP A 355
ILE A 356
ILE A 392
TRP A 470
TRP A 568
PHE A 604
HIS A 629
TRS  A6001 (-2.9A)
TRS  A6001 ( 4.0A)
None
None
None
TRS  A6001 (-4.4A)
TRS  A6001 (-4.2A)
0.90A9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA3_A_MIGA701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens)		11 / 12TYR A1251
ASP A1279
ILE A1280
ILE A1315
ASP A1420
MET A1421
ARG A1510
TRP A1523
ASP A1526
PHE A1559
HIS A1584
ACR  A   1 ( 4.1A)
ACR  A   1 (-3.2A)
ACR  A   1 (-4.1A)
None
ACR  A   1 (-3.6A)
ACR  A   1 (-3.5A)
ACR  A   1 (-2.9A)
ACR  A   1 (-4.5A)
ACR  A   1 (-2.8A)
ACR  A   1 (-4.3A)
ACR  A   1 (-3.9A)
0.42A6.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA3_A_MIGA701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens)		7 / 12TYR A1251
ASP A1279
ILE A1280
ILE A1315
TRP A1418
PHE A1559
HIS A1584
ACR  A   1 ( 4.1A)
ACR  A   1 (-3.2A)
ACR  A   1 (-4.1A)
None
None
ACR  A   1 (-4.3A)
ACR  A   1 (-3.9A)
0.91A6.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA3_A_MIGA701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens)		9 / 12ASP A 404
ILE A 441
ASP A 518
MET A 519
ARG A 600
TRP A 613
ASP A 616
PHE A 649
HIS A 674
ACR  A1015 (-3.0A)
ACR  A1015 (-4.3A)
ACR  A1015 (-3.1A)
ACR  A1015 (-3.3A)
ACR  A1015 (-3.1A)
ACR  A1015 (-4.8A)
ACR  A1015 (-2.7A)
ACR  A1015 (-4.3A)
ACR  A1015 (-4.0A)
0.41A8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA3_A_MIGA701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens)		6 / 12ASP A 404
ILE A 441
MET A 519
ARG A 600
ASP A 616
PHE A 649
ACR  A1015 (-3.0A)
ACR  A1015 (-4.3A)
ACR  A1015 (-3.3A)
ACR  A1015 (-3.1A)
ACR  A1015 (-2.7A)
ACR  A1015 (-4.3A)
1.44A8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA3_A_MIGA701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens)		5 / 12ASP A 404
ILE A 441
TRP A 516
PHE A 649
HIS A 674
ACR  A1015 (-3.0A)
ACR  A1015 (-4.3A)
None
ACR  A1015 (-4.3A)
ACR  A1015 (-4.0A)
0.89A8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA3_B_MIGB701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		3ctt MALTASE-GLUCOAMYLASE
(Homo
sapiens)		10 / 12ASP A 327
ILE A 328
ILE A 364
ASP A 443
MET A 444
ARG A 526
TRP A 539
ASP A 542
PHE A 575
HIS A 600
3CU  A1001 (-2.7A)
3CU  A1001 ( 3.9A)
3CU  A1001 (-4.5A)
3CU  A1001 (-2.7A)
3CU  A1001 ( 3.9A)
3CU  A1001 ( 3.5A)
3CU  A1001 (-4.6A)
3CU  A1001 ( 2.5A)
3CU  A1001 (-4.5A)
3CU  A1001 (-3.9A)
0.42A6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA3_B_MIGB701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		3ctt MALTASE-GLUCOAMYLASE
(Homo
sapiens)		8 / 12ASP A 327
ILE A 328
ILE A 364
TRP A 406
ASP A 443
ASP A 542
PHE A 575
HIS A 600
3CU  A1001 (-2.7A)
3CU  A1001 ( 3.9A)
3CU  A1001 (-4.5A)
None
3CU  A1001 (-2.7A)
3CU  A1001 ( 2.5A)
3CU  A1001 (-4.5A)
3CU  A1001 (-3.9A)
0.78A6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA3_B_MIGB701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		3ctt MALTASE-GLUCOAMYLASE
(Homo
sapiens)		7 / 12ASP A 327
ILE A 328
ILE A 364
TRP A 406
TRP A 441
PHE A 575
HIS A 600
3CU  A1001 (-2.7A)
3CU  A1001 ( 3.9A)
3CU  A1001 (-4.5A)
None
3CU  A1001 (-4.9A)
3CU  A1001 (-4.5A)
3CU  A1001 (-3.9A)
1.25A6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA3_B_MIGB701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		3ctt MALTASE-GLUCOAMYLASE
(Homo
sapiens)		6 / 12ASP A 327
ILE A 364
MET A 444
ARG A 526
ASP A 542
PHE A 575
3CU  A1001 (-2.7A)
3CU  A1001 (-4.5A)
3CU  A1001 ( 3.9A)
3CU  A1001 ( 3.5A)
3CU  A1001 ( 2.5A)
3CU  A1001 (-4.5A)
1.47A6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA3_B_MIGB701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		3lpp SUCRASE-ISOMALTASE
(Homo
sapiens)		10 / 12ASP A 355
ILE A 356
ILE A 392
ASP A 472
MET A 473
ARG A 555
TRP A 568
ASP A 571
PHE A 604
HIS A 629
TRS  A6001 (-2.9A)
TRS  A6001 ( 4.0A)
None
TRS  A6001 (-3.2A)
TRS  A6001 ( 3.7A)
TRS  A6001 ( 4.6A)
None
TRS  A6001 ( 3.7A)
TRS  A6001 (-4.4A)
TRS  A6001 (-4.2A)
0.43A9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA3_B_MIGB701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		3lpp SUCRASE-ISOMALTASE
(Homo
sapiens)		8 / 12ASP A 355
ILE A 356
ILE A 392
TRP A 435
ASP A 472
TRP A 568
PHE A 604
HIS A 629
TRS  A6001 (-2.9A)
TRS  A6001 ( 4.0A)
None
TRS  A6001 ( 4.6A)
TRS  A6001 (-3.2A)
None
TRS  A6001 (-4.4A)
TRS  A6001 (-4.2A)
0.67A9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA3_B_MIGB701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		3lpp SUCRASE-ISOMALTASE
(Homo
sapiens)		8 / 12ASP A 355
ILE A 356
ILE A 392
TRP A 435
TRP A 470
TRP A 568
PHE A 604
HIS A 629
TRS  A6001 (-2.9A)
TRS  A6001 ( 4.0A)
None
TRS  A6001 ( 4.6A)
None
None
TRS  A6001 (-4.4A)
TRS  A6001 (-4.2A)
1.12A9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA3_B_MIGB701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens)		10 / 12ASP A1279
ILE A1280
ILE A1315
ASP A1420
MET A1421
ARG A1510
TRP A1523
ASP A1526
PHE A1559
HIS A1584
ACR  A   1 (-3.2A)
ACR  A   1 (-4.1A)
None
ACR  A   1 (-3.6A)
ACR  A   1 (-3.5A)
ACR  A   1 (-2.9A)
ACR  A   1 (-4.5A)
ACR  A   1 (-2.8A)
ACR  A   1 (-4.3A)
ACR  A   1 (-3.9A)
0.43A6.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA3_B_MIGB701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens)		9 / 12ASP A1279
ILE A1280
ILE A1315
TRP A1355
ASP A1420
TRP A1523
ASP A1526
PHE A1559
HIS A1584
ACR  A   1 (-3.2A)
ACR  A   1 (-4.1A)
None
ACR  A   1 (-4.4A)
ACR  A   1 (-3.6A)
ACR  A   1 (-4.5A)
ACR  A   1 (-2.8A)
ACR  A   1 (-4.3A)
ACR  A   1 (-3.9A)
0.70A6.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA3_B_MIGB701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		3top MALTASE-GLUCOAMYLASE
, INTESTINAL
(Homo
sapiens)		7 / 12ASP A1279
ILE A1280
ILE A1315
TRP A1355
TRP A1418
PHE A1559
HIS A1584
ACR  A   1 (-3.2A)
ACR  A   1 (-4.1A)
None
ACR  A   1 (-4.4A)
None
ACR  A   1 (-4.3A)
ACR  A   1 (-3.9A)
1.23A6.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA3_B_MIGB701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens)		6 / 12ASP A 404
ILE A 441
MET A 519
ARG A 600
ASP A 616
PHE A 649
ACR  A1015 (-3.0A)
ACR  A1015 (-4.3A)
ACR  A1015 (-3.3A)
ACR  A1015 (-3.1A)
ACR  A1015 (-2.7A)
ACR  A1015 (-4.3A)
1.44A8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA3_B_MIGB701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens)		10 / 12ASP A 404
ILE A 441
TRP A 481
ASP A 518
MET A 519
ARG A 600
TRP A 613
ASP A 616
PHE A 649
HIS A 674
ACR  A1015 (-3.0A)
ACR  A1015 (-4.3A)
ACR  A1015 ( 4.6A)
ACR  A1015 (-3.1A)
ACR  A1015 (-3.3A)
ACR  A1015 (-3.1A)
ACR  A1015 (-4.8A)
ACR  A1015 (-2.7A)
ACR  A1015 (-4.3A)
ACR  A1015 (-4.0A)
0.61A8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA3_B_MIGB701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE
(Homo
sapiens)		6 / 12ASP A 404
ILE A 441
TRP A 481
TRP A 516
PHE A 649
HIS A 674
ACR  A1015 (-3.0A)
ACR  A1015 (-4.3A)
ACR  A1015 ( 4.6A)
None
ACR  A1015 (-4.3A)
ACR  A1015 (-4.0A)
1.20A8.49