POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XKK_E_MFXE1100_1 (TOPOISOMERASE IV DNA)	1hyn	BAND 3 ANION TRANSPORT PROTEIN (Homo sapiens)	3 / 3	ARG P 295 GLU P  85 SER P 224	None	0.82A	19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XKK_E_MFXE1100_1 (TOPOISOMERASE IV DNA)	1kfu	M-CALPAIN LARGE SUBUNIT (Homo sapiens)	3 / 3	ARG L 337 GLU L 470 SER L 241	None	0.94A	22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XKK_E_MFXE1100_1 (TOPOISOMERASE IV DNA)	1l1o	REPLICATION PROTEIN A 70 KDA DNA-BINDING SUBUNIT (Homo sapiens)	3 / 3	ARG C 612 GLU C 601 SER C 613	None	0.94A	13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XKK_E_MFXE1100_1 (TOPOISOMERASE IV DNA)	1qqg	INSULIN RECEPTOR SUBSTRATE 1 (Homo sapiens)	3 / 3	ARG A  20 GLU A  50 SER A  24	None	0.65A	16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XKK_E_MFXE1100_1 (TOPOISOMERASE IV DNA)	1u6g	TIP120 PROTEIN (Homo sapiens)	3 / 3	ARG C1174 GLU C1165 SER C1204	None	0.83A	21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XKK_E_MFXE1100_1 (TOPOISOMERASE IV DNA)	1vyh	PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE IB ALPHA SUBUNIT PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE IB BETA SUBUNIT (Homo sapiens; Mus musculus)	3 / 3	ARG A  60 GLU C 100 SER A  64	None	0.89A	15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XKK_E_MFXE1100_1 (TOPOISOMERASE IV DNA)	1whb	KIAA0055 (Homo sapiens)	3 / 3	ARG A 109 GLU A 132 SER A 110	None	0.91A	11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XKK_E_MFXE1100_1 (TOPOISOMERASE IV DNA)	1y6n	INTERLEUKIN-10 RECEPTOR ALPHA CHAIN (Homo sapiens)	3 / 3	ARG R  78 GLU R   4 SER R  50	None	0.84A	13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XKK_E_MFXE1100_1 (TOPOISOMERASE IV DNA)	1z7z	HUMAN COXSACKIEVIRUS A21 INTERCELLULAR ADHESION MOLECULE-1 (Enterovirus C; Homo sapiens)	3 / 3	ARG 3 180 GLU 1 277 SER I  74	None	0.94A	14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XKK_E_MFXE1100_1 (TOPOISOMERASE IV DNA)	2a9j	BISPHOSPHOGLYCERATE MUTASE (Homo sapiens)	3 / 3	ARG A 117 GLU A 101 SER A 118	3PG  A 408 (-2.8A) None None	0.94A	16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XKK_E_MFXE1100_1 (TOPOISOMERASE IV DNA)	2b5m	DAMAGE-SPECIFIC DNA BINDING PROTEIN 1 (Homo sapiens)	3 / 3	ARG A 327 GLU A 787 SER A 326	None	0.75A	22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XKK_E_MFXE1100_1 (TOPOISOMERASE IV DNA)	2bp1	AFLATOXIN B1 ALDEHYDE REDUCTASE MEMBER 2 (Homo sapiens)	3 / 3	ARG A 206 GLU A 278 SER A 304	None	0.92A	18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XKK_E_MFXE1100_1 (TOPOISOMERASE IV DNA)	2d7i	POLYPEPTIDE N-ACETYLGALACTOSAMIN YLTRANSFERASE 10 (Homo sapiens)	3 / 3	ARG A 221 GLU A 340 SER A 238	NGA  A 702 (-3.6A) None UDP  A 705 (-2.8A)	0.94A	20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XKK_E_MFXE1100_1 (TOPOISOMERASE IV DNA)	2ozo	TYROSINE-PROTEIN KINASE ZAP-70 (Homo sapiens)	3 / 3	ARG A 594 GLU A 453 SER A 144	None	0.91A	21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XKK_E_MFXE1100_1 (TOPOISOMERASE IV DNA)	2qnr	SEPTIN-2 (Homo sapiens)	3 / 3	ARG A 277 GLU A 269 SER A  56	None	0.92A	17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XKK_E_MFXE1100_1 (TOPOISOMERASE IV DNA)	3eh2	PROTEIN TRANSPORT PROTEIN SEC24C (Homo sapiens)	3 / 3	ARG A 268 GLU A 214 SER A 267	None	0.94A	22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XKK_E_MFXE1100_1 (TOPOISOMERASE IV DNA)	3feg	CHOLINE/ETHANOLAMINE KINASE (Homo sapiens)	3 / 3	ARG A 151 GLU A 283 SER A 150	None UNX  A 400 ( 3.2A) AMP  A 398 ( 4.0A)	0.93A	18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XKK_E_MFXE1100_1 (TOPOISOMERASE IV DNA)	3feh	CENTAURIN-ALPHA-1 (Homo sapiens)	3 / 3	ARG A 226 GLU A 178 SER A  91	None	0.95A	17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XKK_E_MFXE1100_1 (TOPOISOMERASE IV DNA)	3fhc	NUCLEAR PORE COMPLEX PROTEIN NUP214 (Homo sapiens)	3 / 3	ARG A  38 GLU A 292 SER A  39	None	0.71A	19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XKK_E_MFXE1100_1 (TOPOISOMERASE IV DNA)	3gcw	PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 (Homo sapiens)	3 / 3	ARG A 495 GLU A 620 SER A 487	None	0.88A	21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XKK_E_MFXE1100_1 (TOPOISOMERASE IV DNA)	3ky9	PROTO-ONCOGENE VAV (Homo sapiens)	3 / 3	ARG A 381 GLU A 372 SER A 289	None	0.73A	21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XKK_E_MFXE1100_1 (TOPOISOMERASE IV DNA)	3pp0	RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 (Homo sapiens)	3 / 3	ARG A 784 GLU A 719 SER A 783	None None 03Q  A   1 (-3.3A)	0.95A	17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XKK_E_MFXE1100_1 (TOPOISOMERASE IV DNA)	3u7u	NEUREGULIN 1 RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4 (Homo sapiens)	3 / 3	ARG A  99 GLU A  18 SER G   3	None	0.84A	21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Z3O_F_MFXF101_1 (DNA TOPOISOMERASE 4 SUBUNIT B,PARE30-PARC55 FUSED TOPO IV FROM S. PNEUMONIAE E-SITE DNA)	1q1q	SULFOTRANSFERASE FAMILY, CYTOSOLIC, 2B, MEMBER 1 ISOFORM A (Homo sapiens)	4 / 5	ARG A 132 GLY A 131 GLU A 196 SER A 108	A3P  A 352 (-3.2A) None None None	1.16A	17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Z3O_F_MFXF101_1 (DNA TOPOISOMERASE 4 SUBUNIT B,PARE30-PARC55 FUSED TOPO IV FROM S. PNEUMONIAE E-SITE DNA)	1q20	SULFOTRANSFERASE FAMILY, CYTOSOLIC, 2B, MEMBER 1 ISOFORM B (Homo sapiens)	4 / 5	ARG A 147 GLY A 146 GLU A 211 SER A 123	A3P  A 314 (-3.0A) None None None	1.21A	17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Z3O_F_MFXF101_1 (DNA TOPOISOMERASE 4 SUBUNIT B,PARE30-PARC55 FUSED TOPO IV FROM S. PNEUMONIAE E-SITE DNA)	1ybw	HEPATOCYTE GROWTH FACTOR ACTIVATOR PRECURSOR (Homo sapiens)	4 / 5	ARG A 624 GLY A 621 GLU A 545 SER A 494	None	0.91A	18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Z3O_F_MFXF101_1 (DNA TOPOISOMERASE 4 SUBUNIT B,PARE30-PARC55 FUSED TOPO IV FROM S. PNEUMONIAE E-SITE DNA)	2dnm	SRP46 SPLICING FACTOR (Homo sapiens)	4 / 5	ARG A  66 ARG A  39 GLY A  38 GLU A  35	None	1.29A	10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Z3O_F_MFXF101_1 (DNA TOPOISOMERASE 4 SUBUNIT B,PARE30-PARC55 FUSED TOPO IV FROM S. PNEUMONIAE E-SITE DNA)	2lgw	DNAJ HOMOLOG SUBFAMILY B MEMBER 2 (Homo sapiens)	4 / 5	ARG A  67 GLY A  69 GLU A  71 SER A   3	None	0.98A	9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Z3O_F_MFXF101_1 (DNA TOPOISOMERASE 4 SUBUNIT B,PARE30-PARC55 FUSED TOPO IV FROM S. PNEUMONIAE E-SITE DNA)	3hx3	RETINALDEHYDE-BINDIN G PROTEIN 1 (Homo sapiens)	4 / 5	ARG A  87 ARG A 115 GLY A 116 GLU A 112	None	1.13A	17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Z3O_F_MFXF101_1 (DNA TOPOISOMERASE 4 SUBUNIT B,PARE30-PARC55 FUSED TOPO IV FROM S. PNEUMONIAE E-SITE DNA)	3nvq	SEMAPHORIN-7A (Homo sapiens)	4 / 5	ARG A 136 GLY A 139 GLU A 138 SER A  84	None	1.00A	20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Z3O_F_MFXF101_1 (DNA TOPOISOMERASE 4 SUBUNIT B,PARE30-PARC55 FUSED TOPO IV FROM S. PNEUMONIAE E-SITE DNA)	3pzd	MYOSIN-X (Homo sapiens)	4 / 5	ARG A1989 GLY A1988 GLU A1987 SER A1976	None	1.26A	21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Z3O_F_MFXF101_1 (DNA TOPOISOMERASE 4 SUBUNIT B,PARE30-PARC55 FUSED TOPO IV FROM S. PNEUMONIAE E-SITE DNA)	3thc	BETA-GALACTOSIDASE (Homo sapiens)	4 / 5	ARG A 148 GLY A 123 GLU A 186 SER A  58	None	1.24A	21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Z3O_F_MFXF101_1 (DNA TOPOISOMERASE 4 SUBUNIT B,PARE30-PARC55 FUSED TOPO IV FROM S. PNEUMONIAE E-SITE DNA)	5c65	SOLUTE CARRIER FAMILY 2, FACILITATED GLUCOSE TRANSPORTER MEMBER 3 (Homo sapiens)	4 / 5	ARG A 248 GLY A 396 GLU A 252 SER A 208	None	1.08A	22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Z3O_F_MFXF101_1 (DNA TOPOISOMERASE 4 SUBUNIT B,PARE30-PARC55 FUSED TOPO IV FROM S. PNEUMONIAE E-SITE DNA)	5e6s	INTEGRIN ALPHA-L (Homo sapiens)	4 / 5	ARG A  18 GLY A  17 GLU A  38 SER A  10	None	1.09A	22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Z3O_F_MFXF101_1 (DNA TOPOISOMERASE 4 SUBUNIT B,PARE30-PARC55 FUSED TOPO IV FROM S. PNEUMONIAE E-SITE DNA)	5hvf	CARBOXYPEPTIDASE B2 (Homo sapiens)	4 / 5	ARG A 235 ARG A 302 GLY A 336 GLU A 338	FLC  A 509 (-2.8A) None None None	1.16A	20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5BS8_G_MFXG101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B DNA SUBSTRATE 24-MER TTACGTGCATAGTCATTCAT GACC)	2atv	RAS-LIKE ESTROGEN-REGULATED GROWTH INHIBITOR (Homo sapiens)	4 / 7	ALA A 149 ARG A  14 GLY A  13 GLU A  94	GDP  A 415 (-3.7A) None None None	0.88A	17.43 24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5BS8_G_MFXG101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B DNA SUBSTRATE 24-MER TTACGTGCATAGTCATTCAT GACC)	2i1y	RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE (Homo sapiens)	4 / 7	ALA A 729 ASP A 911 ARG A 954 GLY A 951	None	0.91A	21.97 24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5BS8_G_MFXG101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B DNA SUBSTRATE 24-MER TTACGTGCATAGTCATTCAT GACC)	2o2k	METHIONINE SYNTHASE (Homo sapiens)	4 / 7	ALA A 935 ASP A1043 THR A1184 GLU A1185	None	0.89A	21.26 22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5BS8_G_MFXG101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B DNA SUBSTRATE 24-MER TTACGTGCATAGTCATTCAT GACC)	3bdl	STAPHYLOCOCCAL NUCLEASE DOMAIN-CONTAINING PROTEIN 1 (Homo sapiens)	4 / 7	ALA A 713 ARG A 707 GLY A 708 GLU A 550	None	0.84A	22.04 21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5BS8_G_MFXG101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B DNA SUBSTRATE 24-MER TTACGTGCATAGTCATTCAT GACC)	3na0	CHOLESTEROL SIDE-CHAIN CLEAVAGE ENZYME, MITOCHONDRIAL (Homo sapiens)	4 / 7	ALA A 173 ASP A 297 ARG A 299 GLY A 300	None	0.60A	22.28 21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5BS8_G_MFXG101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B DNA SUBSTRATE 24-MER TTACGTGCATAGTCATTCAT GACC)	3nzu	PHOSPHATIDYLINOSITOL -4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM (Homo sapiens)	4 / 7	ASP A 653 ARG A 687 GLY A 685 GLU A 187	None	0.86A	19.26 13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5BS8_G_MFXG101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B DNA SUBSTRATE 24-MER TTACGTGCATAGTCATTCAT GACC)	3qxm	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2 (Homo sapiens)	4 / 7	ARG A 450 ASP A 476 ARG A 472 GLY A 469	None	0.82A	22.01 25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5BS8_G_MFXG101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B DNA SUBSTRATE 24-MER TTACGTGCATAGTCATTCAT GACC)	3rc3	ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL (Homo sapiens)	4 / 7	ALA A 217 ARG A 200 THR A 336 GLU A 338	None	0.88A	22.36 16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5BS8_G_MFXG101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B DNA SUBSTRATE 24-MER TTACGTGCATAGTCATTCAT GACC)	4p3w	FILAMIN-A (Homo sapiens)	4 / 7	ALA A2266 ASP A2290 ARG A2288 GLU A2286	None	0.83A	15.51 23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5BS8_H_MFXH101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B DNA SUBSTRATE 24-MER GGTCATGAATGACTATGCAC GTAA)	1he3	BILIVERDIN IX BETA REDUCTASE (Homo sapiens)	4 / 7	ALA A   7 ASP A  54 GLY A  90 THR A  84	None NAP  A1206 (-3.2A) None None	0.95A	19.33 21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5BS8_H_MFXH101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B DNA SUBSTRATE 24-MER GGTCATGAATGACTATGCAC GTAA)	1z0a	RAS-RELATED PROTEIN RAB-2A (Homo sapiens)	4 / 7	ALA A 159 ASP A  61 GLY A  13 GLU A  66	None MG  A1201 (-3.0A) None GDP  A1200 ( 4.8A)	0.99A	14.51 24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5BS8_H_MFXH101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B DNA SUBSTRATE 24-MER GGTCATGAATGACTATGCAC GTAA)	2i1y	RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE (Homo sapiens)	4 / 7	ALA A 729 ASP A 911 ARG A 954 GLY A 951	None	0.94A	21.97 24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5BS8_H_MFXH101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B DNA SUBSTRATE 24-MER GGTCATGAATGACTATGCAC GTAA)	2ome	C-TERMINAL-BINDING PROTEIN 2 (Homo sapiens)	4 / 7	ALA A  79 ASP A 112 GLY A 117 GLU A 360	None	0.95A	22.51 23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5BS8_H_MFXH101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B DNA SUBSTRATE 24-MER GGTCATGAATGACTATGCAC GTAA)	3bdl	STAPHYLOCOCCAL NUCLEASE DOMAIN-CONTAINING PROTEIN 1 (Homo sapiens)	4 / 7	ALA A 713 ARG A 707 GLY A 708 GLU A 550	None	0.85A	22.04 21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5BS8_H_MFXH101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B DNA SUBSTRATE 24-MER GGTCATGAATGACTATGCAC GTAA)	3nzu	PHOSPHATIDYLINOSITOL -4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM (Homo sapiens)	4 / 7	ASP A 653 ARG A 687 GLY A 685 GLU A 187	None	0.88A	19.26 13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5BS8_H_MFXH101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B DNA SUBSTRATE 24-MER GGTCATGAATGACTATGCAC GTAA)	3qxm	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2 (Homo sapiens)	4 / 7	ASP A 476 ARG A 472 GLY A 469 ARG A 450	None	0.85A	22.01 25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5BS8_H_MFXH101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B DNA SUBSTRATE 24-MER GGTCATGAATGACTATGCAC GTAA)	4asi	ACETYL-COA CARBOXYLASE 1 (Homo sapiens)	4 / 7	ALA A2123 ASP A1970 ARG A1972 GLU A1999	None	0.99A	21.83 16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5BS8_H_MFXH101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B DNA SUBSTRATE 24-MER GGTCATGAATGACTATGCAC GTAA)	4px9	ATP-DEPENDENT RNA HELICASE DDX3X (Homo sapiens)	4 / 7	ASP A 329 ARG A 333 GLY A 334 ARG A 363	None	1.03A	21.44 23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5BS8_H_MFXH101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B DNA SUBSTRATE 24-MER GGTCATGAATGACTATGCAC GTAA)	4r7v	ARRESTIN DOMAIN-CONTAINING PROTEIN 3 (Homo sapiens)	4 / 7	ALA A  51 ASP A  14 ARG A  33 GLU A 111	None	0.95A	15.81 20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5BS8_H_MFXH101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B DNA SUBSTRATE 24-MER GGTCATGAATGACTATGCAC GTAA)	4wfs	TRNA-DIHYDROURIDINE( 20) SYNTHASE [NAD(P)+]-LIKE (Homo sapiens)	4 / 7	ALA A 181 ARG A  28 THR A  76 GLU A  80	None	0.93A	21.24 23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5BS8_H_MFXH101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B DNA SUBSTRATE 24-MER GGTCATGAATGACTATGCAC GTAA)	5e7j	ATP-DEPENDENT RNA HELICASE DDX3X (Homo sapiens)	4 / 7	ASP A 329 ARG A 333 GLY A 334 ARG A 363	None	0.83A	22.59 23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5BS8_H_MFXH101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B DNA SUBSTRATE 24-MER GGTCATGAATGACTATGCAC GTAA)	5m6u	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM (Homo sapiens)	4 / 7	ALA A 885 ASP A 807 ARG A 809 GLU A 874	None	0.76A	19.53 13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5BS8_H_MFXH101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B DNA SUBSTRATE 24-MER GGTCATGAATGACTATGCAC GTAA)	5v7i	SERINE HYDROXYMETHYLTRANSFE RASE, MITOCHONDRIAL (Homo sapiens)	4 / 7	ASP A 392 ARG A 395 GLY A 455 THR A 462	None	0.94A	22.87 22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5BTA_G_MFXG101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B DNA SUBSTRATE 24-MER TTACGTGCATAGTCATTCAT GACC)	1ef7	CATHEPSIN X (Homo sapiens)	4 / 7	SER A 183 ARG A 138 GLY A 137 GLU A 139	None	0.94A	20.59 21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5BTA_G_MFXG101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B DNA SUBSTRATE 24-MER TTACGTGCATAGTCATTCAT GACC)	2gkw	TNF RECEPTOR-ASSOCIATED FACTOR 3 (Homo sapiens)	4 / 7	SER A 454 ASP A 419 GLY A 462 GLU A 463	None	0.99A	17.36 22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5BTA_G_MFXG101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B DNA SUBSTRATE 24-MER TTACGTGCATAGTCATTCAT GACC)	2gzh	RAS-RELATED PROTEIN RAB-11A (Homo sapiens)	4 / 7	ARG A 132 SER A 126 ASP A 137 GLU A 144	None	0.98A	17.21 24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5BTA_G_MFXG101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B DNA SUBSTRATE 24-MER TTACGTGCATAGTCATTCAT GACC)	2j6l	ALDEHYDE DEHYDROGENASE FAMILY 7 MEMBER A1 (Homo sapiens)	4 / 7	SER A 431 GLY A 471 THR A 246 GLU A 269	None None NAI  A1501 (-4.2A) NAI  A1501 (-4.0A)	0.98A	22.97 19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5BTA_G_MFXG101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B DNA SUBSTRATE 24-MER TTACGTGCATAGTCATTCAT GACC)	3nzu	PHOSPHATIDYLINOSITOL -4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM (Homo sapiens)	4 / 7	ASP A 653 ARG A 687 GLY A 685 GLU A 187	None	0.81A	19.26 13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5BTA_G_MFXG101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B DNA SUBSTRATE 24-MER TTACGTGCATAGTCATTCAT GACC)	3qxm	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2 (Homo sapiens)	4 / 7	ARG A 450 ASP A 476 ARG A 472 GLY A 469	None	0.80A	22.01 25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5BTA_G_MFXG101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B DNA SUBSTRATE 24-MER TTACGTGCATAGTCATTCAT GACC)	3tg1	DUAL SPECIFICITY PROTEIN PHOSPHATASE 10 (Homo sapiens)	4 / 7	ASP B 176 ARG B 178 GLY B 272 GLU B 238	None	0.97A	12.96 18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5BTA_G_MFXG101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B DNA SUBSTRATE 24-MER TTACGTGCATAGTCATTCAT GACC)	3zyx	AMINE OXIDASE [FLAVIN-CONTAINING] B (Homo sapiens)	5 / 7	SER A  26 ARG A  67 GLY A 443 THR A 430 GLU A 441	None	1.48A	22.90 20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5BTA_G_MFXG101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B DNA SUBSTRATE 24-MER TTACGTGCATAGTCATTCAT GACC)	4cak	INTEGRIN ALPHA-IIB INTEGRIN BETA-3 (Homo sapiens)	4 / 7	SER B 337 ASP A 319 ARG A 317 GLU A 315	None	0.93A	20.68 17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5BTA_G_MFXG101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B DNA SUBSTRATE 24-MER TTACGTGCATAGTCATTCAT GACC)	4px9	ATP-DEPENDENT RNA HELICASE DDX3X (Homo sapiens)	4 / 7	ARG A 363 ASP A 329 ARG A 333 GLY A 334	None	0.96A	21.44 23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5BTA_G_MFXG101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B DNA SUBSTRATE 24-MER TTACGTGCATAGTCATTCAT GACC)	5e7j	ATP-DEPENDENT RNA HELICASE DDX3X (Homo sapiens)	4 / 7	ARG A 363 ASP A 329 ARG A 333 GLY A 334	None	0.79A	22.59 23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5BTA_G_MFXG101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B DNA SUBSTRATE 24-MER TTACGTGCATAGTCATTCAT GACC)	5hvf	CARBOXYPEPTIDASE B2 (Homo sapiens)	4 / 7	ARG A 235 ARG A 302 GLY A 336 GLU A 338	FLC  A 509 (-2.8A) None None None	0.93A	20.35 19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5BTA_G_MFXG101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B DNA SUBSTRATE 24-MER TTACGTGCATAGTCATTCAT GACC)	5nst	HEAVY CHAIN OF ANTIBODY MGD21 (Homo sapiens)	4 / 7	ARG B 134 GLY B 135 THR B 161 GLU B 165	GOL  B 402 (-3.4A) None None None	0.78A	20.98 20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5BTA_G_MFXG101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B DNA SUBSTRATE 24-MER TTACGTGCATAGTCATTCAT GACC)	5v7i	SERINE HYDROXYMETHYLTRANSFE RASE, MITOCHONDRIAL (Homo sapiens)	4 / 7	ASP A 392 ARG A 395 GLY A 455 THR A 462	None	0.97A	22.62 22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5BTA_G_MFXG101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B DNA SUBSTRATE 24-MER TTACGTGCATAGTCATTCAT GACC)	5y3r	DNA-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT (Homo sapiens)	4 / 7	ASP C2429 ARG C  36 GLY C  31 GLU C  84	None	0.94A	8.19 5.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5BTA_H_MFXH101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B DNA SUBSTRATE 24-MER GGTCATGAATGACTATGCAC GTAA)	1ef7	CATHEPSIN X (Homo sapiens)	4 / 6	SER A 183 ARG A 138 GLY A 137 GLU A 139	None	0.94A	20.59 21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5BTA_H_MFXH101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B DNA SUBSTRATE 24-MER GGTCATGAATGACTATGCAC GTAA)	2j6l	ALDEHYDE DEHYDROGENASE FAMILY 7 MEMBER A1 (Homo sapiens)	4 / 6	SER A 431 GLY A 471 THR A 246 GLU A 269	None None NAI  A1501 (-4.2A) NAI  A1501 (-4.0A)	0.99A	22.97 19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5BTA_H_MFXH101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B DNA SUBSTRATE 24-MER GGTCATGAATGACTATGCAC GTAA)	2n82	RNA BINDING PROTEIN FOX-1 HOMOLOG 1 (Homo sapiens)	4 / 6	SER B 122 ARG B 153 GLY B 154 GLU B 152	A  A  31 ( 3.0A) C  A  30 ( 3.6A) U  A  26 ( 3.1A) U  A  27 ( 3.1A)	1.05A	12.13 17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5BTA_H_MFXH101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B DNA SUBSTRATE 24-MER GGTCATGAATGACTATGCAC GTAA)	3bg9	PYRUVATE CARBOXYLASE, MITOCHONDRIAL (Homo sapiens)	4 / 6	SER A 910 ARG A 675 THR A 568 GLU A 605	None	1.09A	22.34 17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5BTA_H_MFXH101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B DNA SUBSTRATE 24-MER GGTCATGAATGACTATGCAC GTAA)	3zyx	AMINE OXIDASE [FLAVIN-CONTAINING] B (Homo sapiens)	5 / 6	SER A  26 ARG A  67 GLY A 443 THR A 430 GLU A 441	None	1.48A	22.90 20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5BTA_H_MFXH101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B DNA SUBSTRATE 24-MER GGTCATGAATGACTATGCAC GTAA)	4zel	DOPAMINE BETA-HYDROXYLASE (Homo sapiens)	4 / 6	GLY A 417 THR A 477 GLU A 486 ARG A 194	None	1.10A	22.04 17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5BTA_H_MFXH101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B DNA SUBSTRATE 24-MER GGTCATGAATGACTATGCAC GTAA)	5hvf	CARBOXYPEPTIDASE B2 (Homo sapiens)	4 / 6	ARG A 302 GLY A 336 GLU A 338 ARG A 235	None None None FLC  A 509 (-2.8A)	0.91A	20.35 19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5BTA_H_MFXH101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B DNA SUBSTRATE 24-MER GGTCATGAATGACTATGCAC GTAA)	5nst	HEAVY CHAIN OF ANTIBODY MGD21 (Homo sapiens)	4 / 6	ARG B 134 GLY B 135 THR B 161 GLU B 165	GOL  B 402 (-3.4A) None None None	0.79A	20.98 20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5BTA_H_MFXH101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B DNA SUBSTRATE 24-MER GGTCATGAATGACTATGCAC GTAA)	5yz0	SERINE/THREONINE-PRO TEIN KINASE ATR (Homo sapiens)	4 / 6	SER A1711 ARG A2533 GLY A2530 GLU A2529	None	1.00A	11.76 16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5CDQ_E_MFXE2101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B,DNA GYRASE SUBUNIT B)	2hi9	PLASMA SERINE PROTEASE INHIBITOR (Homo sapiens)	4 / 5	SER A 252 ARG A 362 GLU A 281 ARG A 367	None	1.07A	21.15 21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5CDQ_E_MFXE2101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B,DNA GYRASE SUBUNIT B)	2zqq	METHYLGLUTACONYL-COA HYDRATASE (Homo sapiens)	4 / 5	SER A 255 ARG A 226 GLU A 298 ARG A 197	None	0.87A	21.89 23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5CDQ_E_MFXE2101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B,DNA GYRASE SUBUNIT B)	3mcf	DIPHOSPHOINOSITOL POLYPHOSPHATE PHOSPHOHYDROLASE 3-ALPHA (Homo sapiens)	4 / 5	SER A  39 GLY A  51 GLU A  53 ARG A 115	FLC  A   0 (-3.0A) None None FLC  A   0 (-3.1A)	1.04A	14.14 22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5CDQ_E_MFXE2101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B,DNA GYRASE SUBUNIT B)	3nvq	SEMAPHORIN-7A (Homo sapiens)	4 / 5	SER A  84 ARG A 136 GLY A 139 GLU A 138	None	0.94A	21.50 15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5CDQ_E_MFXE2101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B,DNA GYRASE SUBUNIT B)	3ol2	PLEXIN-B1 (Homo sapiens)	4 / 5	SER B 241 ARG B 272 GLY B 270 GLU B 269	None	1.18A	20.04 16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5CDQ_E_MFXE2101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B,DNA GYRASE SUBUNIT B)	3u9w	LEUKOTRIENE A-4 HYDROLASE (Homo sapiens)	4 / 5	SER A1290 ARG A1338 GLY A1334 GLU A1335	None	1.06A	22.27 16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5CDQ_E_MFXE2101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B,DNA GYRASE SUBUNIT B)	4qj4	1-PHOSPHATIDYLINOSIT OL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3 (Homo sapiens)	4 / 5	SER B 734 GLY B 301 GLU B 303 ARG B 223	None	1.17A	19.33 13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5CDQ_E_MFXE2101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B,DNA GYRASE SUBUNIT B)	4u0z	ADENOSINE MONOPHOSPHATE-PROTEI N TRANSFERASE FICD (Homo sapiens)	4 / 5	ARG A 165 GLY A 409 GLU A 408 ARG A 180	None	1.14A	21.10 20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5CDQ_E_MFXE2101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B,DNA GYRASE SUBUNIT B)	4wyq	RISC-LOADING COMPLEX SUBUNIT TARBP2 (Homo sapiens)	4 / 5	SER B 302 ARG B 353 GLY B 349 GLU B 350	None	1.12A	10.73 17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5CDQ_E_MFXE2101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B,DNA GYRASE SUBUNIT B)	5c65	SOLUTE CARRIER FAMILY 2, FACILITATED GLUCOSE TRANSPORTER MEMBER 3 (Homo sapiens)	4 / 5	SER A 208 ARG A 248 GLY A 396 GLU A 252	None	0.88A	22.54 16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5CDQ_E_MFXE2101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B,DNA GYRASE SUBUNIT B)	5e6s	INTEGRIN ALPHA-L (Homo sapiens)	4 / 5	SER A  10 ARG A  18 GLY A  17 GLU A  38	None	1.18A	20.76 12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5CDQ_E_MFXE2101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B,DNA GYRASE SUBUNIT B)	5hvf	CARBOXYPEPTIDASE B2 (Homo sapiens)	4 / 5	ARG A 302 GLY A 336 GLU A 338 ARG A 235	None None None FLC  A 509 (-2.8A)	1.12A	22.50 18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5CDQ_E_MFXE2101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B,DNA GYRASE SUBUNIT B)	5k1b	WD REPEAT-CONTAINING PROTEIN 48 (Homo sapiens)	4 / 5	SER B 173 ARG B 272 GLY B 254 GLU B 253	None	1.17A	21.77 16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5CDQ_F_MFXF2101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B,DNA GYRASE SUBUNIT B)	1w6j	LANOSTEROL SYNTHASE (Homo sapiens)	4 / 6	ASP A 367 ARG A  33 GLY A  32 GLU A  30	None	1.06A	20.30 16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5CDQ_F_MFXF2101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B,DNA GYRASE SUBUNIT B)	3cem	GLYCOGEN PHOSPHORYLASE, LIVER FORM (Homo sapiens)	4 / 6	SER A 245 ASP A 181 ARG A 184 GLY A 186	None	1.07A	21.32 13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5CDQ_F_MFXF2101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B,DNA GYRASE SUBUNIT B)	3kyd	SUMO-ACTIVATING ENZYME SUBUNIT 1 SUMO-ACTIVATING ENZYME SUBUNIT 2 (Homo sapiens)	4 / 6	SER A 238 ARG B 414 GLY A 336 GLU B 401	None	1.08A	20.86 22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5CDQ_F_MFXF2101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B,DNA GYRASE SUBUNIT B)	3qxm	GLUTAMATE RECEPTOR IONOTROPIC, KAINATE 2 (Homo sapiens)	4 / 6	ARG A 450 ASP A 476 ARG A 472 GLY A 469	None	1.05A	19.18 22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5CDQ_F_MFXF2101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B,DNA GYRASE SUBUNIT B)	3tht	ALKYLATED DNA REPAIR PROTEIN ALKB HOMOLOG 8 (Homo sapiens)	4 / 6	SER A 330 ASP A 300 ARG A 297 GLY A 232	AKG  A 403 (-3.4A) None None None	1.07A	20.77 18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5CDQ_F_MFXF2101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B,DNA GYRASE SUBUNIT B)	4byf	UNCONVENTIONAL MYOSIN-IC (Homo sapiens)	4 / 6	SER A 242 ARG A 156 GLY A 108 GLU A 106	None None AOV  A1001 (-3.0A) None	1.02A	22.12 14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5CDQ_F_MFXF2101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B,DNA GYRASE SUBUNIT B)	4px9	ATP-DEPENDENT RNA HELICASE DDX3X (Homo sapiens)	4 / 6	ARG A 363 ASP A 329 ARG A 333 GLY A 334	None	0.96A	20.88 21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5CDQ_F_MFXF2101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B,DNA GYRASE SUBUNIT B)	4ri0	SERINE PROTEASE HTRA3 (Homo sapiens)	4 / 6	SER A 375 ASP A 406 ARG A 438 GLY A 439	None	1.06A	22.31 22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5CDQ_F_MFXF2101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B,DNA GYRASE SUBUNIT B)	5b29	FATTY ACID-BINDING PROTEIN, HEART (Homo sapiens)	4 / 6	SER A  34 ASP A  76 ARG A  78 GLY A  24	None PLM  A 200 ( 4.3A) None None	1.03A	17.05 24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5CDQ_F_MFXF2101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B,DNA GYRASE SUBUNIT B)	5e7j	ATP-DEPENDENT RNA HELICASE DDX3X (Homo sapiens)	4 / 6	ARG A 363 ASP A 329 ARG A 333 GLY A 334	None	0.81A	22.08 16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5CDQ_F_MFXF2101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B,DNA GYRASE SUBUNIT B)	5ikp	GLYCOGEN PHOSPHORYLASE, BRAIN FORM (Homo sapiens)	4 / 6	SER A 245 ASP A 181 ARG A 184 GLY A 186	None	0.79A	22.75 12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5CDQ_F_MFXF2101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B,DNA GYRASE SUBUNIT B)	5mvd	DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL (Homo sapiens)	4 / 6	SER A 288 ASP A 311 ARG A 310 GLY A 334	None ACT  A 405 (-3.6A) None FMN  A 401 (-3.5A)	0.92A	24.45 21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5CDQ_V_MFXV2101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B,DNA GYRASE SUBUNIT B)	2pvs	PANCREATIC LIPASE-RELATED PROTEIN 2 (Homo sapiens)	5 / 5	SER A 136 ARG A 164 GLY A 162 GLU A 160 ARG A 168	None	1.44A	21.04 17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5CDQ_V_MFXV2101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B,DNA GYRASE SUBUNIT B)	2zqq	METHYLGLUTACONYL-COA HYDRATASE (Homo sapiens)	4 / 5	SER A 255 ARG A 226 GLU A 298 ARG A 197	None	0.85A	21.89 23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5CDQ_V_MFXV2101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B,DNA GYRASE SUBUNIT B)	3nvq	SEMAPHORIN-7A (Homo sapiens)	4 / 5	SER A  84 ARG A 136 GLY A 139 GLU A 138	None	0.93A	21.50 15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5CDQ_V_MFXV2101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B,DNA GYRASE SUBUNIT B)	3ohm	1-PHOSPHATIDYLINOSIT OL-4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3 (Homo sapiens)	4 / 5	SER B 734 GLY B 301 GLU B 303 ARG B 223	None	1.18A	19.96 12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5CDQ_V_MFXV2101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B,DNA GYRASE SUBUNIT B)	3u9w	LEUKOTRIENE A-4 HYDROLASE (Homo sapiens)	4 / 5	SER A1290 ARG A1338 GLY A1334 GLU A1335	None	1.08A	22.27 16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5CDQ_V_MFXV2101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B,DNA GYRASE SUBUNIT B)	4qj4	1-PHOSPHATIDYLINOSIT OL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-3 (Homo sapiens)	4 / 5	SER B 734 GLY B 301 GLU B 303 ARG B 223	None	1.17A	19.33 13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5CDQ_V_MFXV2101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B,DNA GYRASE SUBUNIT B)	4wyq	RISC-LOADING COMPLEX SUBUNIT TARBP2 (Homo sapiens)	4 / 5	SER B 302 ARG B 353 GLY B 349 GLU B 350	None	1.11A	10.73 17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5CDQ_V_MFXV2101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B,DNA GYRASE SUBUNIT B)	5c65	SOLUTE CARRIER FAMILY 2, FACILITATED GLUCOSE TRANSPORTER MEMBER 3 (Homo sapiens)	4 / 5	SER A 208 ARG A 248 GLY A 396 GLU A 252	None	0.89A	22.54 16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5CDQ_V_MFXV2101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B,DNA GYRASE SUBUNIT B)	5e6s	INTEGRIN ALPHA-L (Homo sapiens)	4 / 5	SER A  10 ARG A  18 GLY A  17 GLU A  38	None	1.17A	20.76 12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5CDQ_V_MFXV2101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B,DNA GYRASE SUBUNIT B)	5hvf	CARBOXYPEPTIDASE B2 (Homo sapiens)	4 / 5	ARG A 302 GLY A 336 GLU A 338 ARG A 235	None None None FLC  A 509 (-2.8A)	1.16A	22.50 18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5CDQ_V_MFXV2101_1 (DNA GYRASE SUBUNIT A DNA GYRASE SUBUNIT B,DNA GYRASE SUBUNIT B)	5k1b	WD REPEAT-CONTAINING PROTEIN 48 (Homo sapiens)	4 / 5	SER B 173 ARG B 272 GLY B 254 GLU B 253	None	1.18A	21.77 16.41