POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1R_A_LZUA801_1
(MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1)		1a27 17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE
(Homo
sapiens)		5 / 12LEU A 138
VAL A  86
ALA A 243
PHE A 240
LEU A  18
None
1.08A21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1R_A_LZUA801_1
(MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1)		2h5g DELTA
1-PYRROLINE-5-CARBOX
YLATE SYNTHETASE
(Homo
sapiens)		5 / 12LEU A 501
VAL A 478
ALA A 491
LEU A 754
LEU A 757
None
0.91A23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1R_A_LZUA801_1
(MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1)		2ojq PROGRAMMED CELL
DEATH 6-INTERACTING
PROTEIN
(Homo
sapiens)		5 / 12VAL A 503
VAL A 498
LEU A 443
LEU A 444
LEU A 684
None
1.14A23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1R_A_LZUA801_1
(MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1)		2pl3 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX10
(Homo
sapiens)		5 / 12VAL A 195
VAL A 220
ALA A 224
GLU A 223
LEU A 153
None
None
None
MG  A 301 ( 3.0A)
EOH  A 400 (-4.7A)
1.06A21.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4I1R_A_LZUA801_1
(MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1)		3v4o MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1
(Homo
sapiens)		7 / 12VAL A 344
LEU A 346
LYS A 379
VAL A 381
ALA A 394
GLU A 397
PHE A 398
None
0.80A94.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4I1R_A_LZUA801_1
(MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1)		3v4o MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1
(Homo
sapiens)		8 / 12VAL A 344
LEU A 346
VAL A 381
ALA A 394
GLU A 397
PHE A 398
LEU A 400
LEU A 401
None
0.80A94.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1R_A_LZUA801_1
(MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1)		4bhi GAMMA-BUTYROBETAINE
DIOXYGENASE
(Homo
sapiens)		5 / 12VAL A 237
ALA A 313
GLU A 316
PHE A 317
LEU A 320
None
0.98A21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1R_A_LZUA801_1
(MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1)		4cak INTEGRIN ALPHA-IIB
(Homo
sapiens)		5 / 12VAL A 618
PHE A 719
LEU A 737
LEU A 738
LEU A 614
None
1.11A18.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4I1R_A_LZUA801_1
(MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1)		4i1p MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1
(Homo
sapiens)		7 / 12VAL A 344
LEU A 346
LYS A 379
VAL A 381
ALA A 394
GLU A 397
PHE A 398
None
0.64A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4I1R_A_LZUA801_1
(MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1)		4i1p MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1
(Homo
sapiens)		8 / 12VAL A 344
LEU A 346
VAL A 381
ALA A 394
GLU A 397
PHE A 398
LEU A 400
LEU A 401
None
0.78A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1R_A_LZUA801_1
(MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1)		4kq8 CYTOCHROME P450 19A1
(Homo
sapiens)		5 / 12VAL A 185
PHE A 316
LEU A 315
LEU A 319
LEU A 172
None
1.13A22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1R_A_LZUA801_1
(MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1)		4run ODORANT-BINDING
PROTEIN 2A
(Homo
sapiens)		5 / 12LEU A 113
ALA A 124
GLU A 127
PHE A 128
LEU A 131
None
0.87A19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1R_A_LZUA801_1
(MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1)		5c50 AUTOPHAGY-RELATED
PROTEIN 101
(Homo
sapiens)		5 / 12LEU A 148
VAL A 144
ALA A  20
GLU A  19
PHE A  62
None
1.00A17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1R_A_LZUA801_1
(MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1)		5ijh XENOTROPIC AND
POLYTROPIC
RETROVIRUS RECEPTOR
1
(Homo
sapiens)		5 / 12LEU A  87
ALA A 134
GLU A 137
PHE A 138
LEU A 140
None
1.09A21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1R_A_LZUA801_1
(MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1)		5tzy FREE FATTY ACID
RECEPTOR
1,ENDOLYSIN,FREE
FATTY ACID RECEPTOR
1
(Escherichia
virus
T4;
Homo
sapiens)		5 / 12VAL A 134
ALA A  85
PHE A  88
LEU A  90
LEU A 171
7OS  A2403 (-4.6A)
None
None
None
MK6  A2402 (-4.7A)
1.09A23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1R_A_LZUA801_1
(MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1)		6bbo APOBEC3H
(Homo
sapiens)		5 / 12LEU A 126
VAL A 133
ALA A  89
LEU A 104
LEU A  80
None
1.04A11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1R_A_LZUA801_1
(MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1)		6ckv BCL-2-RELATED
OVARIAN KILLER
PROTEIN
(Homo
sapiens)		5 / 12LEU A  63
VAL A  59
ALA A  33
GLU A  37
LEU A  71
None
1.07A12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_LZUA3008_1
(ALDEHYDE OXIDASE)		2kn6 APOPTOSIS-ASSOCIATED
SPECK-LIKE PROTEIN
CONTAINING A CARD
(Homo
sapiens)		4 / 8GLU A 193
ASP A 191
ARG A 125
TRP A 169
None
1.15A10.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_LZUA3008_1
(ALDEHYDE OXIDASE)		3ksy SON OF SEVENLESS
HOMOLOG 1
(Homo
sapiens)		4 / 8GLU A 272
ASP A 271
ARG A 694
PRO A 621
None
1.15A21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_LZUA3008_1
(ALDEHYDE OXIDASE)		4nhy 2-OXOGLUTARATE AND
IRON-DEPENDENT
OXYGENASE
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens)		4 / 8GLU A 158
ASP A 157
SER A 216
PRO A 214
None
MN  A 601 ( 2.5A)
None
None
0.86A17.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UHX_A_LZUA3008_1
(ALDEHYDE OXIDASE)		5epg ALDEHYDE OXIDASE
(Homo
sapiens)		6 / 8GLU A 577
ASP A 578
SER A1060
ARG A1061
PRO A1066
TRP A1122
None
1.39A99.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UHX_A_LZUA3008_1
(ALDEHYDE OXIDASE)		5epg ALDEHYDE OXIDASE
(Homo
sapiens)		7 / 8HIS A 575
ASP A 578
SER A1060
ARG A1061
PRO A1066
TRP A1122
TRP A1125
None
0.92A99.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_LZUA3008_1
(ALDEHYDE OXIDASE)		5fuz 645 FAB, HEAVY CHAIN
(Homo
sapiens)		4 / 8ASP H 109
ARG H  97
PRO H 106
TRP H  47
None
1.17A10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_LZUA3008_1
(ALDEHYDE OXIDASE)		5vqm PA41 FAB HEAVY CHAIN
(Homo
sapiens)		4 / 8ASP H 107
SER H  99
ARG H  98
PRO H 104
None
0.92A5.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_LZUA3008_1
(ALDEHYDE OXIDASE)		6bq1 PHOSPHATIDYLINOSITOL
4-KINASE III ALPHA
(PI4KA)
(Homo
sapiens)		4 / 8HIS A1702
GLU A1699
ASP A1698
PRO A1891
None
1.12A0.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UHX_A_LZUA3008_1
(ALDEHYDE OXIDASE)		6en4 SPLICING FACTOR 3B
SUBUNIT 3
(Homo
sapiens)		4 / 8HIS A 730
ASP A1203
ARG A 676
PRO A 733
None
1.18A5.01