POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		2a8b RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE R
(Homo
sapiens)		5 / 12LEU A 434
ILE A 463
THR A 465
ASP A 475
LEU A 535
None
1.14A17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		2bv5 TYROSINE-PROTEIN
PHOSPHATASE,
NON-RECEPTOR TYPE 5
(Homo
sapiens)		6 / 12LEU A 317
ILE A 346
THR A 348
ASP A 358
ILE A 400
LEU A 418
None
1.10A17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		2c7s RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE KAPPA
(Homo
sapiens)		5 / 12LEU A 930
ILE A 957
THR A 959
ASP A 969
LEU A1030
None
1.18A18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		2m5v NACHT, LRR AND PYD
DOMAINS-CONTAINING
PROTEIN 10
(Homo
sapiens)		5 / 12LEU A  15
LEU A  63
ALA A  72
THR A  38
LEU A  92
None
1.18A18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		2qep RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE N2
(Homo
sapiens)		5 / 12LEU A 789
ILE A 817
THR A 819
ASP A 829
LEU A 892
None
1.17A15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		2uzp PROTEIN KINASE C
GAMMA TYPE
(Homo
sapiens)		5 / 12LEU A 240
LEU A 163
THR A 212
ILE A 201
LEU A 200
None
1.07A18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		2ypr PROTEIN FEV
(Homo
sapiens)		5 / 12LEU A 101
ALA A 104
GLN A  48
ILE A  66
LEU A  77
None
1.07A20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens)		5 / 12LEU A 406
ALA A 510
ILE A 388
HIS A 424
ILE A 461
None
CSO  A 509 (-3.8A)
GOL  A 902 (-3.5A)
None
None
1.02A20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		4bpc RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S
(Homo
sapiens)		5 / 12LEU A1435
ILE A1462
THR A1464
ASP A1474
LEU A1536
None
1.13A12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		4fww MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR
(Homo
sapiens)		5 / 12LEU A 235
LEU A 398
ILE A 247
THR A 263
ILE A 218
None
SO4  A 605 (-4.6A)
None
None
None
1.10A15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		4oqa POLY [ADP-RIBOSE]
POLYMERASE 1
(Homo
sapiens)		5 / 12LEU C 698
ILE C 643
THR C 556
HIS C 742
LEU C 768
None
1.07A15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		4p5x CALCIUM-BINDING
MITOCHONDRIAL
CARRIER PROTEIN
ARALAR1
(Homo
sapiens)		5 / 12TYR A 218
LEU A 277
ALA A 205
ASP A 276
LEU A 266
None
1.13A19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		4qt8 MACROPHAGE-STIMULATI
NG PROTEIN RECEPTOR
(Homo
sapiens)		5 / 12LEU B 235
LEU B 398
ILE B 247
THR B 263
ILE B 218
None
1.14A12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		4r7p UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE
(Homo
sapiens)		5 / 12LEU A 108
ILE A 146
THR A 142
ILE A 263
LEU A 264
None
1.13A16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		5i2c GATS-LIKE PROTEIN 3
(Homo
sapiens)		5 / 12LEU A 113
ALA A  72
GLN A  70
HIS A 175
ILE A 280
ARG  A 401 ( 4.9A)
None
None
None
ARG  A 401 (-3.9A)
1.01A18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		5k8r PROTOCADHERIN
GAMMA-B3
(Homo
sapiens)		5 / 12LEU A 264
LEU A 232
THR A 213
GLN A 214
ILE A 252
None
1.16A14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		5ool 39S RIBOSOMAL
PROTEIN L37,
MITOCHONDRIAL
(Homo
sapiens)		5 / 12LEU 5 113
ILE 5 314
THR 5 126
ILE 5 262
LEU 5 265
None
1.14A16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		5uiw C-C CHEMOKINE
RECEPTOR TYPE
5,RUBREDOXIN CHIMERA
(Clostridium
pasteurianum;
Homo
sapiens)		5 / 12TYR A 297
LEU A  69
ALA A  73
ILE A 237
LEU A 236
None
1.16A14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		1evs ONCOSTATIN M
(Homo
sapiens)		4 / 7PHE A  70
LEU A  14
GLU A  59
ARG A  63
None
0.94A21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		1fgg GLUCURONYLTRANSFERAS
E I
(Homo
sapiens)		4 / 7PHE A 204
LEU A 100
LEU A 130
ARG A 201
None
0.99A17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		1fw1 GLUTATHIONE
TRANSFERASE ZETA
(Homo
sapiens)		4 / 7PHE A 139
LEU A 142
LEU A 146
GLU A 174
None
1.04A18.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		1o1u GASTROTROPIN
(Homo
sapiens)		4 / 7PHE A  17
LEU A  21
GLU A 110
ARG A 121
None
1.04A41.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		1y97 THREE PRIME REPAIR
EXONUCLEASE 2
(Homo
sapiens)		4 / 7LEU A 197
LEU A 172
GLU A 207
ARG A 204
None
1.01A18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		2id5 LEUCINE RICH REPEAT
NEURONAL 6A
(Homo
sapiens)		4 / 7PHE A 292
LEU A 301
LEU A 325
GLU A 288
None
0.89A13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		2l9r HOMEOBOX PROTEIN
NKX-3.1
(Homo
sapiens)		4 / 7PHE A  52
LEU A  37
LEU A  41
ARG A  55
None
1.01A17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		2o36 THIMET
OLIGOPEPTIDASE
(Homo
sapiens)		5 / 7LEU A 376
LEU A 377
ARG A 647
GLU A 630
ARG A 626
None
1.43A11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		2ooq RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE T
(Homo
sapiens)		4 / 7LEU A1043
ARG A1089
GLU A1063
ARG A1065
None
None
None
B3P  A 301 (-4.3A)
1.07A19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		2pla GLYCEROL-3-PHOSPHATE
DEHYDROGENASE 1-LIKE
PROTEIN
(Homo
sapiens)		4 / 7PHE A 188
LEU A 183
LEU A 182
PRO A  72
None
0.97A17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		2w2j CARBONIC
ANHYDRASE-RELATED
PROTEIN
(Homo
sapiens)		4 / 7PHE A 117
LEU A 253
GLU A 114
ARG A 116
None
0.96A21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		2ykq LINE-1 ORF1P
(Homo
sapiens)		4 / 7LEU A 249
PRO A 214
GLU A 169
ARG A 202
None
1.03A21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		2z65 TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens)		4 / 7PHE A 171
LEU A 180
LEU A 208
GLU A 142
None
0.95A18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		3hhd FATTY ACID SYNTHASE
(Homo
sapiens)		4 / 7LEU A 374
LEU A 369
GLU A 270
ARG A 310
None
1.05A9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		3hhd FATTY ACID SYNTHASE
(Homo
sapiens)		4 / 7PHE A 450
LEU A 454
LEU A 424
ARG A 443
None
1.03A9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		3hk0 GROWTH FACTOR
RECEPTOR-BOUND
PROTEIN 10
(Homo
sapiens)		4 / 7LEU A 227
LEU A 223
GLU A 167
ARG A 337
None
None
None
SCN  A  15 (-3.8A)
0.98A18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		1bjx PROTEIN DISULFIDE
ISOMERASE
(Homo
sapiens)		5 / 12PHE A 144
ILE A 169
THR A 121
LEU A 123
VAL A 186
None
1.25A21.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		1jjx BRAIN-TYPE FATTY
ACID BINDING PROTEIN
(Homo
sapiens)		5 / 12PHE A  64
ILE A  62
THR A  60
VAL A  84
LEU A  91
None
0.99A35.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		2ji4 PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE-ASSOCIATE
D PROTEIN 2
(Homo
sapiens)		5 / 12VAL A  78
ILE A 108
THR A 144
LEU A 142
PHE A 156
None
1.20A14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		2p26 INTEGRIN BETA-2
(Homo
sapiens)		5 / 12VAL A 358
PHE A 404
ILE A 406
LEU A  76
LEU A  83
None
1.23A18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		2p26 INTEGRIN BETA-2
(Homo
sapiens)		5 / 12VAL A 358
PHE A 404
LEU A  76
VAL A 417
LEU A  83
None
1.16A18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		2qos COMPLEMENT COMPONENT
8, GAMMA POLYPEPTIDE
(Homo
sapiens)		5 / 12VAL C  57
PHE C  27
THR C  62
VAL C 107
LEU C 118
None
1.15A20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		2z7x TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens)		5 / 12PHE A 256
ILE A 261
LEU A 289
LEU A 273
PHE A 295
None
1.01A14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		3dqv CULLIN-5
(Homo
sapiens)		5 / 12VAL C1595
ILE C1686
LEU C1674
VAL C1647
LEU C1603
None
1.19A15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		3eh2 PROTEIN TRANSPORT
PROTEIN SEC24C
(Homo
sapiens)		5 / 12VAL A 464
PHE A 466
THR A 448
LEU A 480
THR A 430
None
1.15A10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		3odo RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1
(Homo
sapiens)		5 / 12PHE A 725
ILE A 755
THR A 758
LEU A 710
LEU A 654
None
1.14A15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		3ose SERINE/THREONINE-PRO
TEIN KINASE MARK1
(Homo
sapiens)		5 / 12VAL A 724
LYS A 783
VAL A 770
LEU A 795
THR A 708
None
1.09A20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		3qxl RAS-SPECIFIC GUANINE
NUCLEOTIDE-RELEASING
FACTOR RALGPS1
(Homo
sapiens)		5 / 12VAL A  46
PHE A 125
ILE A 128
LEU A 132
VAL A 105
None
1.24A17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		3vzb SPHINGOSINE KINASE 1
(Homo
sapiens)		5 / 12VAL A  19
PHE A  34
VAL A  38
LEU A  42
THR A 139
None
1.19A14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B
(Homo
sapiens)		5 / 12VAL A 189
PHE A 185
THR A 121
LEU A 155
VAL A 169
None
1.22A13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		4lr2 BIS(5'-ADENOSYL)-TRI
PHOSPHATASE ENPP4
(Homo
sapiens)		5 / 12VAL A  57
ILE A 233
THR A 235
LEU A  30
LEU A 396
None
1.21A14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		4n2c PROTEIN-ARGININE
DEIMINASE TYPE-2
(Homo
sapiens)		5 / 12PHE A 478
ILE A 303
LEU A 304
LEU A 559
PHE A 656
None
1.15A11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		4rma EZRIN
(Homo
sapiens)		5 / 12VAL A  42
THR A  36
LEU A  16
LEU A  61
PHE A  18
None
1.24A18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		5c4t NUCLEAR RECEPTOR
ROR-GAMMA
(Homo
sapiens)		5 / 12ILE A 397
LEU A 391
CYH A 393
LEU A 475
HIS A 479
GOL  A 607 (-4.5A)
None
None
None
None
1.28A16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		5f9w HEAVY CHAIN OF
CH235-LINEAGE
ANTIBODY CH235
(Homo
sapiens)		5 / 12LEU B   4
CYH B  92
VAL B  37
LEU B  47
HIS B  35
None
1.13A18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens)		5 / 12ILE A 335
LEU A 337
CYH A 372
LEU A 353
THR A 368
None
1.27A8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		5udy ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 7
(Homo
sapiens)		5 / 12VAL A  62
ILE A 242
THR A 244
LEU A  35
LEU A 413
None
None
None
None
IOD  A 521 ( 4.6A)
1.20A15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		5vem ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 5
(Homo
sapiens)		5 / 12VAL A  59
ILE A 234
THR A 236
LEU A  32
LEU A 399
None
1.02A13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		6fuy VINCULIN
(Homo
sapiens)		5 / 12VAL A 131
THR A 125
LEU A 182
THR A   6
HIS A   5
None
1.29A23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		1au1 INTERFERON-BETA
(Homo
sapiens)		4 / 6LEU A  87
ASN A 158
ILE A  66
PHE A  70
None
1.16A20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		2crf RAN BINDING PROTEIN
3
(Homo
sapiens)		4 / 6LEU A  36
ASN A  57
ILE A 103
PHE A 116
None
1.21A23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		2jgn ATP-DEPENDENT RNA
HELICASE DDX3X
(Homo
sapiens)		4 / 6LEU A 456
ASN A 435
ILE A 513
PHE A 515
None
0.89A21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL
(Homo
sapiens)		4 / 6LEU A 305
GLN A 338
ILE A 298
PHE A 301
None
1.07A10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		2y8f RAN-BINDING PROTEIN
3
(Homo
sapiens)		4 / 6LEU A 340
ASN A 361
ILE A 407
PHE A 420
None
1.08A23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		3ddu PROLYL ENDOPEPTIDASE
(Homo
sapiens)		4 / 6LEU A 584
ASN A 565
GLN A 524
PHE A 608
None
1.21A10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		3rc0 N-LYSINE
METHYLTRANSFERASE
SETD6
(Homo
sapiens)		4 / 6ASN A 404
GLN A 467
ILE A 356
PHE A 354
EDO  A 477 ( 4.7A)
None
None
None
1.10A15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		3tni CYCLIN-T1
(Homo
sapiens)		4 / 6LEU B 241
ASN B  43
GLN B  56
PHE B 187
None
1.24A17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		3vi3 INTEGRIN ALPHA-5
(Homo
sapiens)		4 / 6LEU A 113
ASN A 211
GLN A 218
PHE A 172
None
1.24A11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		4hsu LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1B
(Homo
sapiens)		4 / 6LEU A 376
GLN A 621
ILE A 406
PHE A 404
None
1.03A10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		4ole NEXT TO BRCA1 GENE 1
PROTEIN
(Homo
sapiens)		4 / 6LEU A 419
LYS A 394
GLN A 387
PHE A 446
None
1.04A20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		4x5t PROTON-GATED ION
CHANNEL,GLRA1
PROTEIN,GLRA1
PROTEIN
(Gloeobacter
violaceus;
Homo
sapiens)		4 / 6LEU A  24
GLN A 219
ILE A 162
PHE A 165
None
1.06A17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		5e7j ATP-DEPENDENT RNA
HELICASE DDX3X
(Homo
sapiens)		4 / 6LEU A 457
ASN A 436
ILE A 514
PHE A 516
None
0.89A17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		5fu7 CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT 1
(Homo
sapiens)		4 / 6LEU A2258
ASN A2204
GLN A2213
ILE A2215
None
1.22A11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 2
(Homo
sapiens)		4 / 6LEU I  60
ASN I  66
GLN I  31
ILE I  53
None
1.16A7.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		1hkk CHITOTRIOSIDASE-1
(Homo
sapiens)		5 / 10ILE A  96
ASN A 115
LEU A 137
LEU A 158
VAL A 110
None
ZN  A1393 (-4.0A)
None
None
None
1.23A22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		1wl4 ACETYL-COENZYME A
ACETYLTRANSFERASE 2
(Homo
sapiens)		5 / 10ARG A 279
ILE A 280
ALA A 278
LEU A 363
LEU A 367
None
1.16A22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		1y8q UBIQUITIN-LIKE 2
ACTIVATING ENZYME
E1B
(Homo
sapiens)		5 / 10ILE B 326
ASN B 360
ALA B 358
LEU B 196
LEU B 192
None
1.12A19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		2nsm CARBOXYPEPTIDASE N
CATALYTIC CHAIN
(Homo
sapiens)		5 / 10PHE A 357
ALA A 337
ASN A 333
LEU A 334
VAL A 326
None
1.24A19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		2oj4 REGULATOR OF
G-PROTEIN SIGNALING
3
(Homo
sapiens)		5 / 10ILE A  68
ALA A  60
ASN A  89
LEU A  90
VAL A  93
None
1.16A21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		2px9 SUMO-ACTIVATING
ENZYME SUBUNIT 2
(Homo
sapiens)		5 / 10ILE A 326
ASN A 360
ALA A 358
LEU A 196
LEU A 192
None
1.16A21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		3dxb THIOREDOXIN
N-TERMINALLY FUSED
TO PUF60(UHM)
(Escherichia
coli;
Homo
sapiens)		5 / 10ASN A 427
ALA A 366
LEU A 447
ASN A 450
LEU A 451
None
1.17A21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		3ihy PHOSPHATIDYLINOSITOL
3-KINASE CATALYTIC
SUBUNIT TYPE 3
(Homo
sapiens)		5 / 10ARG A 320
ALA A 348
LEU A 330
LEU A 334
VAL A 337
None
1.18A21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		4o9r SMOOTHENED
HOMOLOG/SOLUBLE
CYTOCHROME B562
CHIMERIC PROTEIN
(Escherichia
coli;
Homo
sapiens)		5 / 10ILE A1072
ALA A1091
LEU A1010
ASN A1013
LEU A1014
None
0.77A22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		4rwa SOLUBLE CYTOCHROME
B562,DELTA-TYPE
OPIOID RECEPTOR
(Escherichia
coli;
Homo
sapiens)		5 / 10ILE A1072
ALA A1091
LEU A1010
ASN A1013
LEU A1014
None
0.87A22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		5aga DNA POLYMERASE THETA
(Homo
sapiens)		5 / 10ILE A 428
PHE A 422
LEU A 440
LEU A 452
VAL A 450
None
1.23A17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		5xoc THIOREDOXIN
1,FORKHEAD BOX
PROTEIN H1
(Escherichia
coli;
Homo
sapiens)		5 / 10ASN B 294
ALA B 233
LEU B 314
ASN B 317
LEU B 318
None
1.18A11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		6dip NOCTURNIN
(Homo
sapiens)		5 / 10PHE A 216
ASN A 252
ALA A 266
LEU A 287
LEU A 255
None
1.08A12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		6ez8 HUNTINGTIN
(Homo
sapiens)		5 / 10ILE A2446
ASN A2495
ALA A2498
LEU A2467
VAL A2470
None
1.21A13.53