POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2P16_A_GG2A298_1 (COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR))	1elv	COMPLEMENT C1S COMPONENT (Homo sapiens)	7 / 12	ASP A 611 SER A 617 VAL A 638 TRP A 640 GLY A 641 GLY A 648 TYR A 650	None SO4  A2001 ( 2.7A) None None None None None	0.35A	28.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2P16_A_GG2A298_1 (COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR))	1fxy	COAGULATION FACTOR XA-TRYPSIN CHIMERA (Homo sapiens)	8 / 12	TYR A  99 ASP A 189 SER A 195 VAL A 213 TRP A 215 GLY A 216 GLY A 226 TYR A 228	0G6  A   1 (-4.0A) 0G6  A   1 (-2.8A) 0G6  A   1 (-1.4A) None None 0G6  A   1 (-3.9A) 0G6  A   1 (-3.3A) None	0.55A	65.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2P16_A_GG2A298_1 (COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR))	1gvl	KALLIKREIN 6 (Homo sapiens)	5 / 12	SER A 195 VAL A 213 GLY A 216 GLY A 226 TYR A 228	None	0.80A	34.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2P16_A_GG2A298_1 (COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR))	1gvl	KALLIKREIN 6 (Homo sapiens)	5 / 12	VAL A 213 TRP A 215 GLY A 216 GLY A 226 TYR A 228	None	0.39A	34.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2P16_A_GG2A298_1 (COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR))	1h4w	TRYPSIN IVA (Homo sapiens)	7 / 12	ASP A 189 SER A 195 VAL A 213 TRP A 215 GLY A 216 GLY A 226 TYR A 228	BEN  A 250 (-2.9A) BEN  A 250 (-3.6A) None None BEN  A 250 (-3.9A) BEN  A 250 (-3.3A) None	0.30A	36.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2P16_A_GG2A298_1 (COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR))	1o5f	SERINE PROTEASE HEPSIN (Homo sapiens)	8 / 12	ASP H 189 ALA H 190 SER H 195 VAL H 213 TRP H 215 GLY H 216 GLY H 226 TYR H 228	CR9  H 256 (-2.4A) CR9  H 256 (-2.9A) CR9  H 256 (-1.5A) CR9  H 256 (-4.3A) None CR9  H 256 ( 3.8A) CR9  H 256 (-3.0A) None	0.25A	36.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2P16_A_GG2A298_1 (COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR))	1orf	GRANZYME A (Homo sapiens)	5 / 12	ASP A 189 SER A 195 GLY A 216 GLY A 226 TYR A 228	0G6  A   1 (-2.9A) 0G6  A   1 (-1.3A) 0G6  A   1 (-3.3A) 0G6  A   1 (-3.5A) None	0.31A	29.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2P16_A_GG2A298_1 (COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR))	1q3x	MANNAN-BINDING LECTIN SERINE PROTEASE 2 (Homo sapiens)	7 / 12	ASP A 627 SER A 633 VAL A 653 TRP A 655 GLY A 656 GLY A 667 TYR A 669	NA  A 800 ( 4.6A) GOL  A 701 (-3.0A) GOL  A 701 (-4.9A) None GOL  A 701 ( 4.1A) GOL  A 701 ( 4.0A) None	0.49A	26.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2P16_A_GG2A298_1 (COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR))	1ybw	HEPATOCYTE GROWTH FACTOR ACTIVATOR PRECURSOR (Homo sapiens)	6 / 12	ASP A 592 ALA A 593 CYH A 594 SER A 598 GLY A 629 TYR A 631	None	0.99A	33.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2P16_A_GG2A298_1 (COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR))	1zjk	MANNAN-BINDING LECTIN SERINE PROTEASE 2 (Homo sapiens)	5 / 12	VAL A 653 TRP A 655 GLY A 656 GLY A 667 TYR A 669	None	0.27A	26.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2P16_A_GG2A298_1 (COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR))	1zlr	COAGULATION FACTOR XI (Homo sapiens)	7 / 12	ASP A 189 ALA A 190 SER A 195 TRP A 215 GLY A 216 GLY A 226 TYR A 228	368  A 901 (-2.8A) 368  A 901 (-3.7A) 368  A 901 (-1.4A) None 368  A 901 (-3.6A) 368  A 901 (-3.5A) None	0.37A	34.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2P16_A_GG2A298_1 (COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR))	2ei8	COAGULATION FACTOR X, HEAVY CHAIN (Homo sapiens)	10 / 12	TYR A  99 PHE A 174 ASP A 189 ALA A 190 SER A 195 VAL A 213 TRP A 215 GLY A 216 GLY A 226 TYR A 228	DT8  A 700 (-3.4A) DT8  A 700 (-3.4A) DT8  A 700 (-3.5A) DT8  A 700 (-3.6A) DT8  A 700 ( 3.9A) DT8  A 700 ( 4.1A) DT8  A 700 (-3.9A) DT8  A 700 (-3.5A) DT8  A 700 (-3.5A) DT8  A 700 (-3.5A)	0.28A	100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2P16_A_GG2A298_1 (COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR))	2odp	COMPLEMENT C2 (Homo sapiens)	5 / 12	TYR A 538 SER A 659 VAL A 677 TRP A 679 GLY A 680	None	0.58A	18.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2P16_A_GG2A298_1 (COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR))	2oq5	TRANSMEMBRANE PROTEASE, SERINE 11E (Homo sapiens)	8 / 12	ASP A 189 ALA A 190 SER A 195 VAL A 213 TRP A 215 GLY A 216 GLY A 226 TYR A 228	BEN  A 245 (-3.0A) BEN  A 245 (-3.9A) BEN  A 245 (-3.3A) None None BEN  A 245 ( 3.8A) BEN  A 245 (-3.4A) None	0.29A	34.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2P16_A_GG2A298_1 (COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR))	2pks	THROMBIN HEAVY CHAIN FRAGMENT (Homo sapiens)	8 / 12	ASP C 229 ALA C 230 SER C 235 VAL C 255 TRP C 257 GLY C 258 GLY C 268 TYR C 270	G44  C 101 (-2.6A) G44  C 101 (-3.8A) G44  C 101 (-3.5A) None G44  C 101 (-4.1A) G44  C 101 (-3.3A) G44  C 101 (-3.0A) None	0.35A	23.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2P16_A_GG2A298_1 (COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR))	2psy	KALLIKREIN-5 (Homo sapiens)	7 / 12	ASP A 189 SER A 195 VAL A 213 TRP A 215 GLY A 216 GLY A 226 TYR A 228	None	0.38A	31.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2P16_A_GG2A298_1 (COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR))	2qy0	COMPLEMENT C1R SUBCOMPONENT (Homo sapiens)	8 / 12	ASP B 631 ALA B 632 SER B 637 VAL B 657 TRP B 659 GLY B 660 GLY B 668 TYR B 670	None	0.43A	40.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2P16_A_GG2A298_1 (COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR))	2r0l	HEPATOCYTE GROWTH FACTOR ACTIVATOR (Homo sapiens)	7 / 12	ASP A 189 ALA A 190 SER A 195 TRP A 215 GLY A 216 GLY A 226 TYR A 228	None	0.45A	33.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2P16_A_GG2A298_1 (COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR))	2r2w	PLASMINOGEN ACTIVATOR, UROKINASE (Homo sapiens)	6 / 12	ASP U 189 VAL U 213 TRP U 215 GLY U 216 GLY U 226 TYR U 228	4PG  U 300 (-2.8A) None None 4PG  U 300 (-3.3A) 4PG  U 300 (-3.2A) None	0.35A	32.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2P16_A_GG2A298_1 (COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR))	2wpm	COAGULATION FACTOR IXA HEAVY CHAIN (Homo sapiens)	8 / 12	TYR S  99 PHE S 174 ASP S 189 SER S 195 TRP S 215 GLY S 216 GLY S 226 TYR S 228	None	0.45A	46.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2P16_A_GG2A298_1 (COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR))	2xrc	HUMAN COMPLEMENT FACTOR I (Homo sapiens)	5 / 12	TYR A 408 VAL A 526 TRP A 528 GLY A 539 TYR A 541	None	0.50A	16.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2P16_A_GG2A298_1 (COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR))	2zec	TRYPTASE BETA 2 (Homo sapiens)	7 / 12	ASP A 203 SER A 209 VAL A 227 TRP A 229 GLY A 230 GLY A 240 TYR A 242	11N  A   1 (-2.6A) 11N  A   1 (-3.3A) None None 11N  A   1 (-3.9A) 11N  A   1 (-3.6A) None	0.38A	34.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2P16_A_GG2A298_1 (COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR))	3f6u	VITAMIN K-DEPENDENT PROTEIN C HEAVY CHAIN (Homo sapiens)	8 / 12	ASP H 189 ALA H 190 SER H 195 VAL H 213 TRP H 215 GLY H 216 GLY H 226 TYR H 228	0G6  H   1 (-2.8A) 0G6  H   1 (-3.4A) 0G6  H   1 (-1.8A) None 0G6  H   1 (-4.1A) 0G6  H   1 (-3.8A) 0G6  H   1 ( 3.9A) None	0.34A	37.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2P16_A_GG2A298_1 (COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR))	3gov	MASP-1 (Homo sapiens)	8 / 12	ASP B 640 ALA B 641 SER B 646 VAL B 666 TRP B 668 GLY B 669 GLY B 679 TYR B 681	None	0.45A	32.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2P16_A_GG2A298_1 (COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR))	3gym	PROSTASIN (Homo sapiens)	8 / 12	ASP A 189 ALA A 190 SER A 195 VAL A 213 TRP A 215 GLY A 216 GLY A 226 TYR A 228	None	0.36A	33.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2P16_A_GG2A298_1 (COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR))	3r3g	THROMBIN HEAVY CHAIN (Homo sapiens)	8 / 12	ASP B 189 ALA B 190 SER B 195 VAL B 213 TRP B 215 GLY B 216 GLY B 226 TYR B 228	None	0.32A	40.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2P16_A_GG2A298_1 (COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR))	4d9r	COMPLEMENT FACTOR D (Homo sapiens)	5 / 12	ASP A 189 SER A 195 VAL A 213 GLY A 226 TYR A 228	None	0.32A	32.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2P16_A_GG2A298_1 (COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR))	4fxg	MANNAN-BINDING LECTIN SERINE PROTEASE 2 B CHAIN (Homo sapiens)	6 / 12	ASP H 627 VAL H 653 TRP H 655 GLY H 656 GLY H 667 TYR H 669	None	0.32A	34.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2P16_A_GG2A298_1 (COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR))	4h4f	CHYMOTRYPSIN-C (Homo sapiens)	5 / 12	ALA A 190 SER A 195 VAL A 213 GLY A 216 TYR A 228	None	0.36A	34.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2P16_A_GG2A298_1 (COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR))	4igd	MANNAN-BINDING LECTIN SERINE PROTEASE 1 (Homo sapiens)	5 / 12	SER A 646 VAL A 666 TRP A 668 GLY A 679 TYR A 681	None None GOL  A 702 (-3.9A) None None	0.52A	21.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2P16_A_GG2A298_1 (COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR))	4iw4	MANNAN-BINDING LECTIN SERINE PROTEASE 3 (Homo sapiens)	7 / 12	ASP E 639 SER E 645 VAL E 665 TRP E 667 GLY E 668 GLY E 680 TYR E 682	None	0.51A	35.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2P16_A_GG2A298_1 (COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR))	4iw4	MANNAN-BINDING LECTIN SERINE PROTEASE 3 (Homo sapiens)	7 / 12	TYR E 531 ASP E 639 VAL E 665 TRP E 667 GLY E 668 GLY E 680 TYR E 682	None	0.76A	35.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2P16_A_GG2A298_1 (COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR))	4j1y	COMPLEMENT C1S SUBCOMPONENT (Homo sapiens)	5 / 12	TYR A 648 PHE A 647 ALA A 619 GLY A 565 TYR A 665	None	1.13A	25.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2P16_A_GG2A298_1 (COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR))	4k8y	KALLIKREIN-4 (Homo sapiens)	6 / 12	ASP A 189 SER A 195 VAL A 213 GLY A 216 GLY A 226 TYR A 228	None	0.42A	29.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2P16_A_GG2A298_1 (COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR))	4kkd	MANNAN-BINDING LECTIN SERINE PROTEASE 1 (Homo sapiens)	6 / 12	TYR A 550 VAL A 684 TRP A 686 GLY A 687 GLY A 699 TYR A 701	None	0.66A	23.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2P16_A_GG2A298_1 (COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR))	4nff	KALLIKREIN-2 (Homo sapiens)	5 / 12	ASP A 189 SER A 195 TRP A 215 GLY A 216 TYR A 228	0G6  A 301 (-3.0A) 0G6  A 301 (-1.4A) 0G6  A 301 (-3.7A) 0G6  A 301 (-3.4A) None	0.47A	34.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2P16_A_GG2A298_1 (COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR))	4r0i	SUPPRESSOR OF TUMORIGENICITY 14 PROTEIN (Homo sapiens)	7 / 12	ASP A 189 SER A 195 VAL A 213 TRP A 215 GLY A 216 GLY A 226 TYR A 228	3KM  A 900 (-2.9A) 3KM  A 900 (-3.6A) None None 3KM  A 900 (-3.4A) 3KM  A 900 (-3.2A) None	0.28A	33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2P16_A_GG2A298_1 (COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR))	4wwy	TRYPSIN-1 (Homo sapiens)	7 / 12	ASP A 189 SER A 195 VAL A 213 TRP A 215 GLY A 216 GLY A 226 TYR A 228	None	0.34A	35.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2P16_A_GG2A298_1 (COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR))	4ylq	COAGULATION FACTOR VII (Homo sapiens)	7 / 12	ASP H 189 SER H 195 VAL H 213 TRP H 215 GLY H 216 GLY H 226 TYR H 228	0Z7  H 501 (-2.3A) 0Z7  H 501 (-1.4A) 0Z7  H 501 ( 4.7A) TMA  H 508 ( 3.9A) 0Z7  H 501 (-3.4A) 0Z7  H 501 (-3.0A) None	0.30A	40.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2P16_A_GG2A298_1 (COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR))	5brr	TISSUE-TYPE PLASMINOGEN ACTIVATOR (Homo sapiens)	7 / 12	TYR E  99 ASP E 189 ALA E 190 TRP E 215 GLY E 216 GLY E 226 TYR E 228	None	0.43A	38.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2P16_A_GG2A298_1 (COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR))	5eod	COAGULATION FACTOR XI (Homo sapiens)	5 / 12	SER A 557 TRP A 577 GLY A 578 GLY A 588 TYR A 590	None	0.84A	15.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2P16_A_GG2A298_1 (COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR))	5f8z	PLASMA KALLIKREIN LIGHT CHAIN (Homo sapiens)	6 / 12	ASP A 189 ALA A 190 SER A 195 GLY A 216 GLY A 226 TYR A 228	None	0.56A	35.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2P16_A_GG2A298_1 (COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR))	5f8z	PLASMA KALLIKREIN LIGHT CHAIN (Homo sapiens)	6 / 12	ASP A 189 ALA A 190 TRP A 215 GLY A 216 GLY A 226 TYR A 228	None	0.27A	35.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2P16_A_GG2A298_1 (COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR))	5fah	KALLIKREIN-7 (Homo sapiens)	6 / 12	ALA A 190 SER A 195 VAL A 213 TRP A 215 GLY A 226 TYR A 228	5VT  A 302 (-3.8A) 5VT  A 302 (-4.0A) None None 5VT  A 302 ( 4.3A) None	0.85A	33.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2P16_A_GG2A298_1 (COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR))	5fah	KALLIKREIN-7 (Homo sapiens)	6 / 12	ALA A 190 VAL A 213 TRP A 215 GLY A 216 GLY A 226 TYR A 228	5VT  A 302 (-3.8A) None None 5VT  A 302 (-3.4A) 5VT  A 302 ( 4.3A) None	0.41A	33.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2P16_A_GG2A298_1 (COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR))	5ms3	KALLIKREIN-8 (Homo sapiens)	6 / 12	ASP A 189 SER A 195 TRP A 215 GLY A 216 GLY A 226 TYR A 228	None	0.29A	21.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2P16_A_GG2A298_1 (COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR))	5o32	COMPLEMENT FACTOR I (Homo sapiens)	7 / 12	ASP I 519 ALA I 520 VAL I 544 TRP I 546 GLY I 547 GLY I 557 TYR I 559	None	0.82A	33.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2P16_A_GG2A298_1 (COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR))	5o32	COMPLEMENT FACTOR I (Homo sapiens)	7 / 12	TYR I 426 ASP I 519 VAL I 544 TRP I 546 GLY I 547 GLY I 557 TYR I 559	None	0.81A	33.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2P16_A_GG2A298_1 (COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR))	5to3	PROTHROMBIN,THROMBOM ODULIN (Homo sapiens)	7 / 12	ASP B 214 ALA B 215 SER B 220 VAL B 240 GLY B 243 GLY B 253 TYR B 255	0G6  B 501 (-2.9A) 0G6  B 501 (-3.4A) 0G6  B 501 (-1.3A) None 0G6  B 501 (-3.7A) 0G6  B 501 (-3.6A) None	0.31A	26.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2P16_A_GG2A298_1 (COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR))	5ubm	COMPLEMENT C1S SUBCOMPONENT (Homo sapiens)	7 / 12	ASP A 626 SER A 632 VAL A 653 TRP A 655 GLY A 656 GLY A 663 TYR A 665	None	0.50A	33.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2P16_A_GG2A298_1 (COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR))	6b74	COAGULATION FACTOR XII (Homo sapiens)	8 / 12	TYR B  99 ASP B 189 ALA B 190 SER B 195 TRP B 215 GLY B 216 GLY B 226 TYR B 228	None BEN  B 301 (-2.7A) BEN  B 301 (-4.1A) SO4  B 304 ( 2.5A) None BEN  B 301 (-3.3A) BEN  B 301 (-3.1A) None	0.38A	17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2P16_A_GG2A298_2 (COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR))	1b72	PROTEIN (HOMEOBOX PROTEIN HOX-B1) (Homo sapiens)	3 / 3	ARG A 213 GLU A 217 GLN A 214	None	0.99A	16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2P16_A_GG2A298_2 (COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR))	1bf5	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA (Homo sapiens)	3 / 3	ARG A 321 GLU A 320 GLN A 322	None	1.06A	17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2P16_A_GG2A298_2 (COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR))	1dmw	PHENYLALANINE HYDROXYLASE (Homo sapiens)	3 / 3	ARG A 176 GLU A 228 GLN A 226	None	0.96A	22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2P16_A_GG2A298_2 (COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR))	1hnf	CD2 (Homo sapiens)	3 / 3	ARG A 105 GLU A 104 GLN A  15	None NAG  A 502 (-3.9A) None	0.96A	21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2P16_A_GG2A298_2 (COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR))	1snx	TYROSINE-PROTEIN KINASE ITK/TSK (Homo sapiens)	3 / 3	ARG A 394 GLU A 395 GLN A 373	None	1.09A	22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2P16_A_GG2A298_2 (COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR))	1ssl	HEPATOCYTE GROWTH FACTOR RECEPTOR (Homo sapiens)	3 / 3	ARG A  33 GLU A  35 GLN A  23	None	0.86A	11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2P16_A_GG2A298_2 (COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR))	1uj3	IGG FAB HEAVY CHAIN (Homo sapiens)	3 / 3	ARG B 340 GLU B 389 GLN B 343	None	0.76A	22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2P16_A_GG2A298_2 (COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR))	1wi5	RRP5 PROTEIN HOMOLOG (Homo sapiens)	3 / 3	ARG A 238 GLU A 235 GLN A 234	None	0.94A	17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2P16_A_GG2A298_2 (COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR))	2d8x	PROTEIN PINCH (Homo sapiens)	3 / 3	ARG A  33 GLU A  39 GLN A  38	None	1.04A	17.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2P16_A_GG2A298_2 (COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR))	2ei8	COAGULATION FACTOR X, HEAVY CHAIN (Homo sapiens)	3 / 3	ARG A 143 GLU A 147 GLN A 192	None None DT8  A 700 (-3.9A)	1.03A	100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2P16_A_GG2A298_2 (COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR))	2kvr	UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 7 (Homo sapiens)	3 / 3	ARG A  85 GLU A 127 GLN A  83	None	0.99A	19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2P16_A_GG2A298_2 (COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR))	2ozu	HISTONE ACETYLTRANSFERASE MYST3 (Homo sapiens)	3 / 3	ARG A 533 GLU A 530 GLN A 529	None	1.10A	20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2P16_A_GG2A298_2 (COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR))	2vkw	NEURAL CELL ADHESION MOLECULE 1,140 KDA ISOFORM (Homo sapiens)	3 / 3	ARG A 632 GLU A 676 GLN A 678	None	1.10A	19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2P16_A_GG2A298_2 (COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR))	3edv	SPECTRIN BETA CHAIN, BRAIN 1 (Homo sapiens)	3 / 3	ARG A1741 GLU A1738 GLN A1737	MG  A1006 ( 3.9A) None MG  A1006 ( 4.5A)	1.09A	23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2P16_A_GG2A298_2 (COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR))	3hhr	HUMAN GROWTH HORMONE RECEPTOR (HGHBP) (Homo sapiens)	3 / 3	ARG B  43 GLU B  44 GLN B 216	None	1.01A	23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2P16_A_GG2A298_2 (COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR))	3x1o	ROQUIN-1 (Homo sapiens)	3 / 3	ARG A 280 GLU A 201 GLN A 200	None	1.09A	19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2P16_A_GG2A298_2 (COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR))	4pxj	C-JUN-AMINO-TERMINAL KINASE-INTERACTING PROTEIN 3 (Homo sapiens)	3 / 3	ARG A 459 GLU A 456 GLN A 455	EDO  A 504 ( 2.9A) None EDO  A 504 (-3.2A)	1.08A	13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2P16_A_GG2A298_2 (COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR))	4qik	ROQUIN-1 (Homo sapiens)	3 / 3	ARG A 280 GLU A 201 GLN A 200	None	1.09A	22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2P16_A_GG2A298_2 (COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR))	4v06	TRYPTOPHAN 5-HYDROXYLASE 2 (Homo sapiens)	3 / 3	ARG A 209 GLU A 261 GLN A 259	None	1.02A	22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2P16_A_GG2A298_2 (COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR))	4wlp	UBIQUITIN CARBOXYL-TERMINAL HYDROLASE ISOZYME L5 (Homo sapiens)	3 / 3	ARG A 137 GLU A   7 GLN A 138	None	0.93A	21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2P16_A_GG2A298_2 (COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR))	5ko1	MIXED LINEAGE KINASE DOMAIN-LIKE PROTEIN (Homo sapiens)	3 / 3	ARG A 449 GLU A 431 GLN A 430	None	0.92A	21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2P16_A_GG2A298_2 (COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR))	5m32	26S PROTEASE REGULATORY SUBUNIT 4 (Homo sapiens)	3 / 3	ARG d 307 GLU d 304 GLN d 306	None	0.85A	21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2P16_A_GG2A298_2 (COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR))	5myb	ANGIOPOIETIN-1 RECEPTOR (Homo sapiens)	3 / 3	ARG A 580 GLU A 579 GLN A 589	None	0.85A	17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2P16_A_GG2A298_2 (COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR))	5tc4	BIFUNCTIONAL METHYLENETETRAHYDROF OLATE DEHYDROGENASE/CYCLOH YDROLASE, MITOCHONDRIAL (Homo sapiens)	3 / 3	ARG A 299 GLU A  36 GLN A 300	None	0.97A	22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2P16_A_GG2A298_2 (COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR))	5van	BETA-KLOTHO (Homo sapiens)	3 / 3	ARG A 397 GLU A 398 GLN A 445	None	1.10A	17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2P16_A_GG2A298_2 (COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR))	5wy5	MELANOMA-ASSOCIATED ANTIGEN G1 NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 1 HOMOLOG (Homo sapiens)	3 / 3	ARG A  17 GLU B 159 GLN A  20	None	1.02A	20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2P16_A_GG2A298_2 (COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR))	5xgj	PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM (Homo sapiens)	3 / 3	ARG A  93 GLU A 710 GLN A  75	None	0.98A	19.67