POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1X8V_A_ESLA471_1 (CYTOCHROME P450 51)	1bc7	PROTEIN (ETS-DOMAIN PROTEIN) (Homo sapiens)	4 / 8	TYR C  82 PHE C  33 ALA C  38 LEU C  59	None	1.11A	13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1X8V_A_ESLA471_1 (CYTOCHROME P450 51)	1hbx	ETS-DOMAIN PROTEIN ELK-4 (Homo sapiens)	4 / 8	TYR G  82 PHE G  33 ALA G  38 LEU G  59	None	1.16A	15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1X8V_A_ESLA471_1 (CYTOCHROME P450 51)	1x9d	ENDOPLASMIC RETICULUM MANNOSYL-OLIGOSACCHA RIDE 1,2-ALPHA-MANNOSIDAS E (Homo sapiens)	4 / 8	TYR A 684 PHE A 605 ARG A 609 LEU A 345	None	1.17A	23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1X8V_A_ESLA471_1 (CYTOCHROME P450 51)	2adc	POLYPYRIMIDINE TRACT-BINDING PROTEIN 1 (Homo sapiens)	4 / 8	TYR A 361 PHE A 438 HIS A 512 LEU A 508	None None U  B 535 ( 4.3A) None	1.16A	20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1X8V_A_ESLA471_1 (CYTOCHROME P450 51)	2q0z	PROTEIN PRO2281 (Homo sapiens)	4 / 8	TYR X 207 PHE X 203 ARG X 236 ALA X 305	None	1.13A	20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1X8V_A_ESLA471_1 (CYTOCHROME P450 51)	4a0k	CULLIN-4A (Homo sapiens)	4 / 8	PHE A 449 HIS A 412 LEU A 366 MET A 361	None	1.15A	20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1X8V_A_ESLA471_1 (CYTOCHROME P450 51)	4elj	RETINOBLASTOMA-ASSOC IATED PROTEIN (Homo sapiens)	4 / 8	TYR A 225 PHE A 226 ALA A 201 LEU A 303	None	1.08A	20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1X8V_A_ESLA471_1 (CYTOCHROME P450 51)	5apa	ASPARTYL/ASPARAGINYL BETA-HYDROXYLASE (Homo sapiens)	4 / 8	TYR A 667 PHE A 612 ALA A 640 MET A 605	None	1.04A	18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1X8V_A_ESLA471_1 (CYTOCHROME P450 51)	5jz8	ASPARTYL/ASPARAGINYL BETA-HYDROXYLASE (Homo sapiens)	4 / 8	TYR A 667 PHE A 612 ALA A 640 MET A 605	None ACT  A 803 (-4.8A) None None	1.00A	21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1X8V_A_ESLA472_1 (CYTOCHROME P450 51)	1zs6	NUCLEOSIDE DIPHOSPHATE KINASE 3 (Homo sapiens)	4 / 6	MET A  85 VAL A  82 LEU A  81 PHE A  77	None None ADP  A 201 (-4.1A) ADP  A 201 (-3.5A)	1.00A	18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1X8V_A_ESLA472_1 (CYTOCHROME P450 51)	2jeo	URIDINE-CYTIDINE KINASE 1 (Homo sapiens)	4 / 6	MET A  97 VAL A 135 LEU A  25 PHE A 152	None	0.98A	17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1X8V_A_ESLA472_1 (CYTOCHROME P450 51)	2okj	GLUTAMATE DECARBOXYLASE 1 (Homo sapiens)	4 / 6	VAL A 337 LEU A 282 PHE A 303 MET A 276	None	1.12A	23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1X8V_A_ESLA472_1 (CYTOCHROME P450 51)	2v9k	UNCHARACTERIZED PROTEIN FLJ32312 (Homo sapiens)	4 / 6	MET A 250 VAL A 249 LEU A 253 PHE A 261	None	1.22A	22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1X8V_A_ESLA472_1 (CYTOCHROME P450 51)	2wq9	RETINOL-BINDING PROTEIN 4 (Homo sapiens)	4 / 6	MET A  73 VAL A  93 LEU A  97 PHE A  96	OLA  A1179 ( 4.9A) None None None	1.20A	15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1X8V_A_ESLA472_1 (CYTOCHROME P450 51)	3ibj	CGMP-DEPENDENT 3',5'-CYCLIC PHOSPHODIESTERASE (Homo sapiens)	4 / 6	MET A 694 LEU A 738 PHE A 746 MET A 761	None	1.08A	20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1X8V_A_ESLA472_1 (CYTOCHROME P450 51)	3kg5	B-CELL ANTIGEN RECEPTOR COMPLEX-ASSOCIATED PROTEIN BETA CHAIN (Homo sapiens)	4 / 6	MET A  96 VAL A 142 LEU A 140 MET A  63	None	1.08A	13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1X8V_A_ESLA472_1 (CYTOCHROME P450 51)	3mop	INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE-LIKE 2 (Homo sapiens)	4 / 6	VAL K  75 LEU K  78 PHE K  31 MET K  20	None	1.08A	14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1X8V_A_ESLA472_1 (CYTOCHROME P450 51)	3odo	RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 1 (Homo sapiens)	4 / 6	MET A 434 VAL A 437 LEU A 438 PHE A 461	None	0.91A	22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1X8V_A_ESLA472_1 (CYTOCHROME P450 51)	3zkm	FAB HEAVY CHAIN (Homo sapiens)	4 / 6	VAL C  37 LEU C  48 PHE C  63 MET C  82	None None GOL  C1217 (-4.0A) None	1.10A	17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1X8V_A_ESLA472_1 (CYTOCHROME P450 51)	4htz	CGMP-DEPENDENT 3',5'-CYCLIC PHOSPHODIESTERASE (Homo sapiens)	4 / 6	MET A 694 LEU A 738 PHE A 746 MET A 761	None	1.13A	19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1X8V_A_ESLA472_1 (CYTOCHROME P450 51)	4kro	CETUXIMAB HEAVY CHAIN (Homo sapiens; Mus musculus)	4 / 6	VAL D  37 LEU D  48 PHE D  63 MET D  82	None	1.10A	17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1X8V_A_ESLA472_1 (CYTOCHROME P450 51)	4zud	CHIMERA PROTEIN OF SOLUBLE CYTOCHROME B562 AND TYPE-1 ANGIOTENSIN II RECEPTOR (Escherichia coli; Homo sapiens)	4 / 6	MET A 243 VAL A 246 LEU A 247 PHE A 251	None	1.04A	23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1X8V_A_ESLA472_1 (CYTOCHROME P450 51)	5e9j	MRNA CAP GUANINE-N7 METHYLTRANSFERASE,MR NA CAP GUANINE-N7 METHYLTRANSFERASE (Homo sapiens)	4 / 6	MET A 179 VAL A 182 LEU A 183 PHE A 187	None	0.91A	19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1X8V_A_ESLA472_1 (CYTOCHROME P450 51)	5fwj	HISTONE DEMETHYLASE JARID1C (Homo sapiens)	4 / 6	VAL A 486 LEU A 487 PHE A 642 MET A 497	None	1.10A	20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1X8V_A_ESLA472_1 (CYTOCHROME P450 51)	6b9h	PROTEIN HOOK HOMOLOG 3 (Homo sapiens)	4 / 6	MET A  41 VAL A  44 LEU A  45 PHE A  53	None	1.19A	12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3Q95_A_ESLA700_1 (ESTROGEN RECEPTOR)	1ef1	MOESIN (Homo sapiens)	6 / 12	LEU A 125 ALA A 129 LEU A 192 ILE A 115 GLY A 109 LEU A 111	None	1.28A	22.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3Q95_A_ESLA700_1 (ESTROGEN RECEPTOR)	1pcg	ESTROGEN RECEPTOR (Homo sapiens)	12 / 12	MET A 343 LEU A 346 ALA A 350 GLU A 353 LEU A 387 MET A 388 LEU A 391 ARG A 394 ILE A 424 GLY A 521 HIS A 524 LEU A 525	EST  A   1 ( 4.0A) EST  A   1 (-4.4A) EST  A   1 ( 3.7A) EST  A   1 (-2.8A) EST  A   1 (-4.0A) None EST  A   1 ( 3.9A) EST  A   1 (-3.7A) EST  A   1 ( 4.5A) EST  A   1 ( 4.1A) EST  A   1 (-3.8A) EST  A   1 (-3.6A)	0.33A	98.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3Q95_A_ESLA700_1 (ESTROGEN RECEPTOR)	1pcg	ESTROGEN RECEPTOR (Homo sapiens)	6 / 12	MET A 343 LEU A 346 LEU A 402 ILE A 424 GLY A 521 HIS A 524	EST  A   1 ( 4.0A) EST  A   1 (-4.4A) None EST  A   1 ( 4.5A) EST  A   1 ( 4.1A) EST  A   1 (-3.8A)	1.34A	98.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3Q95_A_ESLA700_1 (ESTROGEN RECEPTOR)	1uhl	RETINOIC ACID RECEPTOR RXR-BETA (Homo sapiens)	5 / 12	ALA A 343 LEU A 380 ARG A 387 ILE A 499 GLY A 500	MEI  A1001 (-3.3A) MEI  A1001 (-3.8A) MEI  A1001 (-3.6A) None None	1.03A	31.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3Q95_A_ESLA700_1 (ESTROGEN RECEPTOR)	1xb7	STEROID HORMONE RECEPTOR ERR1 (Homo sapiens)	5 / 12	LEU A 324 GLU A 331 LEU A 365 ARG A 372 HIS A 494	None	0.56A	32.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3Q95_A_ESLA700_1 (ESTROGEN RECEPTOR)	1xls	RETINOIC ACID RECEPTOR RXR-ALPHA (Homo sapiens)	5 / 12	ALA A 272 LEU A 309 ARG A 316 ILE A 428 GLY A 429	9CR  A 801 (-3.5A) 9CR  A 801 (-4.2A) 9CR  A 801 (-2.6A) None None	1.00A	30.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3Q95_A_ESLA700_1 (ESTROGEN RECEPTOR)	2gpv	ESTROGEN-RELATED RECEPTOR GAMMA (Homo sapiens)	6 / 12	LEU A 268 ALA A 272 GLU A 275 LEU A 309 ARG A 316 HIS A 434	OHT  A 500 (-4.1A) OHT  A 500 (-3.5A) OHT  A 500 (-2.6A) OHT  A 500 ( 4.0A) OHT  A 500 (-3.8A) OHT  A 500 ( 4.7A)	0.59A	36.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3Q95_A_ESLA700_1 (ESTROGEN RECEPTOR)	2ocf	ESTROGEN RECEPTOR (Homo sapiens)	12 / 12	MET A 343 LEU A 346 ALA A 350 GLU A 353 LEU A 387 MET A 388 LEU A 391 ARG A 394 ILE A 424 GLY A 521 HIS A 524 LEU A 525	EST  A 596 (-4.8A) EST  A 596 (-4.4A) EST  A 596 ( 3.9A) EST  A 596 (-2.7A) EST  A 596 ( 4.2A) None EST  A 596 ( 4.6A) EST  A 596 (-4.0A) EST  A 596 ( 4.7A) EST  A 596 ( 4.0A) EST  A 596 (-4.2A) EST  A 596 (-3.6A)	0.44A	100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3Q95_A_ESLA700_1 (ESTROGEN RECEPTOR)	2ocf	ESTROGEN RECEPTOR (Homo sapiens)	6 / 12	MET A 343 LEU A 346 LEU A 402 ILE A 424 GLY A 521 HIS A 524	EST  A 596 (-4.8A) EST  A 596 (-4.4A) None EST  A 596 ( 4.7A) EST  A 596 ( 4.0A) EST  A 596 (-4.2A)	1.30A	100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3Q95_A_ESLA700_1 (ESTROGEN RECEPTOR)	3dzu	RETINOIC ACID RECEPTOR RXR-ALPHA (Homo sapiens)	5 / 12	ALA A 272 LEU A 309 ARG A 316 ILE A 428 GLY A 429	9CR  A7223 (-4.2A) 9CR  A7223 ( 4.4A) 9CR  A7223 (-3.7A) None None	0.99A	20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3Q95_A_ESLA700_1 (ESTROGEN RECEPTOR)	3kn1	GOLGI PHOSPHOPROTEIN 3 (Homo sapiens)	5 / 12	LEU A 133 ALA A 136 LEU A 156 ILE A  95 LEU A 103	None	1.01A	23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3Q95_A_ESLA700_1 (ESTROGEN RECEPTOR)	3p8c	NCK-ASSOCIATED PROTEIN 1 (Homo sapiens)	5 / 12	LEU B 375 ALA B 378 LEU B 408 HIS B 575 LEU B 539	None	1.11A	13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3Q95_A_ESLA700_1 (ESTROGEN RECEPTOR)	3sm9	METABOTROPIC GLUTAMATE RECEPTOR 3 (Homo sapiens)	5 / 12	ALA A  80 LEU A 135 ILE A 117 GLY A  17 HIS A  69	None	1.03A	19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3Q95_A_ESLA700_1 (ESTROGEN RECEPTOR)	4j5x	RETINOIC ACID RECEPTOR RXR-ALPHA, NUCLEAR RECEPTOR COACTIVATOR 1 (Homo sapiens)	5 / 12	ALA D 272 LEU D 309 ARG D 316 ILE D 345 LEU D 436	None	0.97A	28.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3Q95_A_ESLA700_1 (ESTROGEN RECEPTOR)	4j5x	RETINOIC ACID RECEPTOR RXR-ALPHA, NUCLEAR RECEPTOR COACTIVATOR 1 (Homo sapiens)	5 / 12	ALA D 272 LEU D 309 ARG D 316 ILE D 428 GLY D 429	None	0.96A	28.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3Q95_A_ESLA700_1 (ESTROGEN RECEPTOR)	4rm9	EZRIN (Homo sapiens)	6 / 12	LEU A 125 ALA A 129 LEU A 192 ILE A 115 GLY A 109 LEU A 111	None	1.21A	16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3Q95_A_ESLA700_1 (ESTROGEN RECEPTOR)	4udb	MINERALOCORTICOID RECEPTOR (Homo sapiens)	5 / 12	LEU A 769 ALA A 773 LEU A 810 LEU A 814 ARG A 817	CV7  A1987 (-4.1A) CV7  A1987 (-3.5A) CV7  A1987 (-4.0A) CV7  A1987 ( 4.0A) CV7  A1987 (-3.7A)	0.36A	27.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3Q95_A_ESLA700_1 (ESTROGEN RECEPTOR)	4uhi	STEROL 14-ALPHA DEMETHYLASE (Homo sapiens)	5 / 12	LEU A 305 LEU A 286 ARG A 272 GLY A 162 LEU A 159	None None None None VFV  A 580 (-4.5A)	1.03A	21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3Q95_A_ESLA700_1 (ESTROGEN RECEPTOR)	5cni	METABOTROPIC GLUTAMATE RECEPTOR 2 (Homo sapiens)	5 / 12	ALA A  98 LEU A 154 ILE A 136 GLY A  35 HIS A  87	None	0.90A	18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3Q95_A_ESLA700_1 (ESTROGEN RECEPTOR)	5kzn	METABOTROPIC GLUTAMATE RECEPTOR 2 (Homo sapiens)	5 / 12	ALA A  98 LEU A 154 ILE A 136 GLY A  35 HIS A  87	None	0.97A	16.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3Q95_A_ESLA700_1 (ESTROGEN RECEPTOR)	5toa	ESTROGEN RECEPTOR BETA (Homo sapiens)	5 / 12	ALA A 302 GLU A 305 ARG A 346 ILE A 373 LEU A 476	EST  A 601 ( 3.9A) EST  A 601 (-2.4A) EST  A 601 (-4.1A) None EST  A 601 (-3.5A)	1.11A	56.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3Q95_A_ESLA700_1 (ESTROGEN RECEPTOR)	5toa	ESTROGEN RECEPTOR BETA (Homo sapiens)	7 / 12	MET A 294 LEU A 298 GLU A 305 MET A 340 LEU A 343 ARG A 346 ILE A 376	None EST  A 601 (-4.1A) EST  A 601 (-2.4A) EST  A 601 ( 4.8A) EST  A 601 ( 4.4A) EST  A 601 (-4.1A) EST  A 601 ( 4.4A)	1.44A	56.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3Q95_A_ESLA700_1 (ESTROGEN RECEPTOR)	5toa	ESTROGEN RECEPTOR BETA (Homo sapiens)	12 / 12	MET A 295 LEU A 298 ALA A 302 GLU A 305 LEU A 339 MET A 340 LEU A 343 ARG A 346 ILE A 376 GLY A 472 HIS A 475 LEU A 476	EST  A 601 ( 4.4A) EST  A 601 (-4.1A) EST  A 601 ( 3.9A) EST  A 601 (-2.4A) EST  A 601 (-3.9A) EST  A 601 ( 4.8A) EST  A 601 ( 4.4A) EST  A 601 (-4.1A) EST  A 601 ( 4.4A) EST  A 601 (-4.0A) EST  A 601 (-4.4A) EST  A 601 (-3.5A)	0.37A	56.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3Q95_A_ESLA700_1 (ESTROGEN RECEPTOR)	5toa	ESTROGEN RECEPTOR BETA (Homo sapiens)	7 / 12	MET A 295 LEU A 298 LEU A 354 ILE A 376 GLY A 472 HIS A 475 LEU A 476	EST  A 601 ( 4.4A) EST  A 601 (-4.1A) None EST  A 601 ( 4.4A) EST  A 601 (-4.0A) EST  A 601 (-4.4A) EST  A 601 (-3.5A)	1.38A	56.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3Q95_A_ESLA700_1 (ESTROGEN RECEPTOR)	5uan	RETINOIC ACID RECEPTOR RXR-ALPHA (Homo sapiens)	5 / 12	ALA A 272 LEU A 309 ARG A 316 ILE A 428 GLY A 429	9CR  A 503 (-3.5A) 9CR  A 503 (-3.7A) 9CR  A 503 (-3.0A) None None	1.07A	24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3Q95_A_ESLA700_1 (ESTROGEN RECEPTOR)	5xdr	PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE DHX15 (Homo sapiens)	5 / 12	ALA A 563 LEU A 242 ILE A 519 GLY A 518 LEU A 555	None	1.12A	17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3Q95_A_ESLA700_1 (ESTROGEN RECEPTOR)	6brr	DNA (CYTOSINE-5)-METHYLT RANSFERASE 3A (Homo sapiens)	5 / 12	LEU A 901 LEU A 653 LEU A 905 ILE A 705 GLY A 646	None	1.14A	16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3Q95_B_ESLB700_1 (ESTROGEN RECEPTOR)	1dtd	CARBOXYPEPTIDASE A2 (Homo sapiens)	5 / 12	LEU A 435 ALA A 434 LEU A 462 ILE A 451 LEU A 653	None	1.07A	21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3Q95_B_ESLB700_1 (ESTROGEN RECEPTOR)	1ef1	MOESIN (Homo sapiens)	5 / 12	LEU A 125 ALA A 129 ILE A 115 GLY A 109 LEU A 111	None	0.93A	22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3Q95_B_ESLB700_1 (ESTROGEN RECEPTOR)	1ih5	AQUAPORIN-1 (Homo sapiens)	5 / 12	LEU A  19 ALA A  20 LEU A  63 ILE A  70 GLY A  72	None	0.98A	22.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3Q95_B_ESLB700_1 (ESTROGEN RECEPTOR)	1pcg	ESTROGEN RECEPTOR (Homo sapiens)	12 / 12	MET A 343 LEU A 346 LEU A 349 ALA A 350 GLU A 353 LEU A 387 MET A 388 ARG A 394 ILE A 424 GLY A 521 HIS A 524 LEU A 525	EST  A   1 ( 4.0A) EST  A   1 (-4.4A) EST  A   1 ( 4.8A) EST  A   1 ( 3.7A) EST  A   1 (-2.8A) EST  A   1 (-4.0A) None EST  A   1 (-3.7A) EST  A   1 ( 4.5A) EST  A   1 ( 4.1A) EST  A   1 (-3.8A) EST  A   1 (-3.6A)	0.31A	98.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3Q95_B_ESLB700_1 (ESTROGEN RECEPTOR)	1uhl	RETINOIC ACID RECEPTOR RXR-BETA (Homo sapiens)	5 / 12	ALA A 343 LEU A 380 ARG A 387 ILE A 499 GLY A 500	MEI  A1001 (-3.3A) MEI  A1001 (-3.8A) MEI  A1001 (-3.6A) None None	1.05A	31.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3Q95_B_ESLB700_1 (ESTROGEN RECEPTOR)	1xb7	STEROID HORMONE RECEPTOR ERR1 (Homo sapiens)	6 / 12	LEU A 324 LEU A 327 GLU A 331 LEU A 365 ARG A 372 HIS A 494	None	0.55A	32.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3Q95_B_ESLB700_1 (ESTROGEN RECEPTOR)	1xls	RETINOIC ACID RECEPTOR RXR-ALPHA (Homo sapiens)	5 / 12	ALA A 272 LEU A 309 ARG A 316 ILE A 428 GLY A 429	9CR  A 801 (-3.5A) 9CR  A 801 (-4.2A) 9CR  A 801 (-2.6A) None None	1.04A	30.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3Q95_B_ESLB700_1 (ESTROGEN RECEPTOR)	2gpv	ESTROGEN-RELATED RECEPTOR GAMMA (Homo sapiens)	7 / 12	LEU A 268 LEU A 271 ALA A 272 GLU A 275 LEU A 309 ARG A 316 HIS A 434	OHT  A 500 (-4.1A) OHT  A 500 ( 4.4A) OHT  A 500 (-3.5A) OHT  A 500 (-2.6A) OHT  A 500 ( 4.0A) OHT  A 500 (-3.8A) OHT  A 500 ( 4.7A)	0.57A	36.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3Q95_B_ESLB700_1 (ESTROGEN RECEPTOR)	2ocf	ESTROGEN RECEPTOR (Homo sapiens)	12 / 12	MET A 343 LEU A 346 LEU A 349 ALA A 350 GLU A 353 LEU A 387 MET A 388 ARG A 394 ILE A 424 GLY A 521 HIS A 524 LEU A 525	EST  A 596 (-4.8A) EST  A 596 (-4.4A) EST  A 596 ( 4.1A) EST  A 596 ( 3.9A) EST  A 596 (-2.7A) EST  A 596 ( 4.2A) None EST  A 596 (-4.0A) EST  A 596 ( 4.7A) EST  A 596 ( 4.0A) EST  A 596 (-4.2A) EST  A 596 (-3.6A)	0.40A	100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3Q95_B_ESLB700_1 (ESTROGEN RECEPTOR)	2zkj	[PYRUVATE DEHYDROGENASE [LIPOAMIDE]] KINASE ISOZYME 4 (Homo sapiens)	5 / 12	GLU A 373 ARG A  64 ILE A 179 GLY A  44 LEU A  41	None	1.09A	19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3Q95_B_ESLB700_1 (ESTROGEN RECEPTOR)	3dzu	RETINOIC ACID RECEPTOR RXR-ALPHA (Homo sapiens)	5 / 12	ALA A 272 LEU A 309 ARG A 316 ILE A 428 GLY A 429	9CR  A7223 (-4.2A) 9CR  A7223 ( 4.4A) 9CR  A7223 (-3.7A) None None	1.01A	20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3Q95_B_ESLB700_1 (ESTROGEN RECEPTOR)	3eo3	BIFUNCTIONAL UDP-N-ACETYLGLUCOSAM INE 2-EPIMERASE/N-ACETYL MANNOSAMINE KINASE (Homo sapiens)	5 / 12	LEU A 625 ALA A 624 LEU A 671 ILE A 678 GLY A 646	None	1.06A	23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3Q95_B_ESLB700_1 (ESTROGEN RECEPTOR)	3kn1	GOLGI PHOSPHOPROTEIN 3 (Homo sapiens)	5 / 12	LEU A 133 ALA A 136 LEU A 156 ILE A  95 LEU A 103	None	1.05A	23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3Q95_B_ESLB700_1 (ESTROGEN RECEPTOR)	3sm9	METABOTROPIC GLUTAMATE RECEPTOR 3 (Homo sapiens)	5 / 12	LEU A  81 ALA A  80 ILE A 117 GLY A  17 HIS A  69	None	0.99A	19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3Q95_B_ESLB700_1 (ESTROGEN RECEPTOR)	4j5x	RETINOIC ACID RECEPTOR RXR-ALPHA, NUCLEAR RECEPTOR COACTIVATOR 1 (Homo sapiens)	5 / 12	ALA D 272 LEU D 309 ARG D 316 ILE D 345 LEU D 436	None	0.95A	28.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3Q95_B_ESLB700_1 (ESTROGEN RECEPTOR)	4j5x	RETINOIC ACID RECEPTOR RXR-ALPHA, NUCLEAR RECEPTOR COACTIVATOR 1 (Homo sapiens)	5 / 12	ALA D 272 LEU D 309 ARG D 316 ILE D 428 GLY D 429	None	0.98A	28.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3Q95_B_ESLB700_1 (ESTROGEN RECEPTOR)	4rm9	EZRIN (Homo sapiens)	5 / 12	LEU A 125 ALA A 129 ILE A 115 GLY A 109 LEU A 111	None	0.87A	16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3Q95_B_ESLB700_1 (ESTROGEN RECEPTOR)	4s15	NUCLEAR RECEPTOR ROR-ALPHA (Homo sapiens)	5 / 12	MET A 270 LEU A 273 LEU A 276 ALA A 277 LEU A 422	None	0.60A	24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3Q95_B_ESLB700_1 (ESTROGEN RECEPTOR)	4udb	MINERALOCORTICOID RECEPTOR (Homo sapiens)	5 / 12	LEU A 769 LEU A 772 ALA A 773 LEU A 810 ARG A 817	CV7  A1987 (-4.1A) CV7  A1987 ( 4.5A) CV7  A1987 (-3.5A) CV7  A1987 (-4.0A) CV7  A1987 (-3.7A)	0.33A	27.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3Q95_B_ESLB700_1 (ESTROGEN RECEPTOR)	4yub	NICOTINATE PHOSPHORIBOSYLTRANSF ERASE (Homo sapiens)	5 / 12	LEU A  56 LEU A 114 ALA A 115 LEU A 109 GLY A  59	None	1.02A	19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3Q95_B_ESLB700_1 (ESTROGEN RECEPTOR)	5cni	METABOTROPIC GLUTAMATE RECEPTOR 2 (Homo sapiens)	5 / 12	LEU A  99 ALA A  98 ILE A 136 GLY A  35 HIS A  87	None	1.00A	18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3Q95_B_ESLB700_1 (ESTROGEN RECEPTOR)	5gk9	BRD1 PROTEIN HISTONE ACETYLTRANSFERASE KAT7 (Homo sapiens)	5 / 12	MET A 564 LEU A 575 LEU A 573 GLU B  58 LEU A 531	None	1.06A	20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3Q95_B_ESLB700_1 (ESTROGEN RECEPTOR)	5j6s	ENDOPLASMIC RETICULUM AMINOPEPTIDASE 2 (Homo sapiens)	5 / 12	LEU A 757 LEU A 754 ALA A 753 LEU A 697 HIS A 708	None	1.01A	16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3Q95_B_ESLB700_1 (ESTROGEN RECEPTOR)	5kzn	METABOTROPIC GLUTAMATE RECEPTOR 2 (Homo sapiens)	5 / 12	LEU A  99 ALA A  98 ILE A 136 GLY A  35 HIS A  87	None	0.89A	16.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3Q95_B_ESLB700_1 (ESTROGEN RECEPTOR)	5toa	ESTROGEN RECEPTOR BETA (Homo sapiens)	12 / 12	MET A 295 LEU A 298 LEU A 301 ALA A 302 GLU A 305 LEU A 339 MET A 340 ARG A 346 ILE A 376 GLY A 472 HIS A 475 LEU A 476	EST  A 601 ( 4.4A) EST  A 601 (-4.1A) EST  A 601 ( 4.3A) EST  A 601 ( 3.9A) EST  A 601 (-2.4A) EST  A 601 (-3.9A) EST  A 601 ( 4.8A) EST  A 601 (-4.1A) EST  A 601 ( 4.4A) EST  A 601 (-4.0A) EST  A 601 (-4.4A) EST  A 601 (-3.5A)	0.38A	56.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3Q95_B_ESLB700_1 (ESTROGEN RECEPTOR)	5uan	RETINOIC ACID RECEPTOR RXR-ALPHA (Homo sapiens)	5 / 12	ALA A 272 LEU A 309 ARG A 316 ILE A 428 GLY A 429	9CR  A 503 (-3.5A) 9CR  A 503 (-3.7A) 9CR  A 503 (-3.0A) None None	1.09A	24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3Q95_B_ESLB700_1 (ESTROGEN RECEPTOR)	6ez8	FACTOR VIII INTRON 22 PROTEIN HUNTINGTIN (Homo sapiens)	5 / 12	LEU B  98 ALA B  94 LEU B 125 HIS A2771 LEU B  71	None	1.09A	15.06