POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_D8ZA831_0
(GEPHYRIN)		3vgo E3 UBIQUITIN-PROTEIN
LIGASE CBL-B
(Homo
sapiens)		5 / 11MET A  53
ILE A 122
LEU A 114
ILE A 149
MET A 153
None
1.49A9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_D8ZA831_0
(GEPHYRIN)		3zyx AMINE OXIDASE
[FLAVIN-CONTAINING]
B
(Homo
sapiens)		5 / 11PHE A 423
ILE A 261
LEU A 414
ILE A 286
MET A 285
None
1.40A10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_D8ZA831_0
(GEPHYRIN)		4zxb INSULIN RECEPTOR
(Homo
sapiens)		5 / 11ILE E 478
LEU E 473
ARG E 488
PRO E 549
ILE E 534
None
1.28A7.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_D8ZA831_0
(GEPHYRIN)		5kqv INSULIN
RECEPTOR,INSULIN
RECEPTOR
(Homo
sapiens)		5 / 11ILE E 478
LEU E 473
ARG E 488
PRO E 549
ILE E 534
None
1.27A8.70