POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Seq. Identity (%)
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3PEO_C_CU9C301_1 (SOLUBLE ACETYLCHOLINE RECEPTOR)	4zjs	ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA,SOLUBLE ACETYLCHOLINE RECEPTOR,ACETYLCHOLI NE RECEPTOR SUBUNIT ALPHA,SOLUBLE ACETYLCHOLINE RECEPTOR (Aplysia californica; Homo sapiens)	5 / 12	THR A 36 GLN A 38 TYR A 55 GLN A 57 SER A 167	None	1.16A	82.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3PEO_F_CU9F301_1 (SOLUBLE ACETYLCHOLINE RECEPTOR)	2jk7	BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 4 (Homo sapiens)	4 / 7	TRP A 310 TYR A 329 CYH A 327 CYH A 303	BI6 A1346 (-3.7A) None ZN A1347 (-2.3A) ZN A1347 (-2.2A)	1.14A	18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3PEO_F_CU9F301_1 (SOLUBLE ACETYLCHOLINE RECEPTOR)	2vfk	AKAP18 DELTA (Homo sapiens)	4 / 7	TYR A 280 CYH A 268 CYH A 282 TYR A 279	None	1.27A	18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3PEO_F_CU9F301_1 (SOLUBLE ACETYLCHOLINE RECEPTOR)	3j4r	A-KINASE ANCHOR PROTEIN 18 (Homo sapiens)	4 / 7	TYR A 280 CYH A 268 CYH A 282 TYR A 279	None	1.34A	19.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3PEO_F_CU9F301_1 (SOLUBLE ACETYLCHOLINE RECEPTOR)	4zjs	ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA,SOLUBLE ACETYLCHOLINE RECEPTOR,ACETYLCHOLI NE RECEPTOR SUBUNIT ALPHA,SOLUBLE ACETYLCHOLINE RECEPTOR (Aplysia californica; Homo sapiens)	4 / 7	TYR A 93 TRP A 147 TYR A 188 TYR A 195	None	1.26A	82.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3PEO_F_CU9F301_1 (SOLUBLE ACETYLCHOLINE RECEPTOR)	5jj2	A-KINASE ANCHOR PROTEIN 7 ISOFORM GAMMA (Homo sapiens)	4 / 7	TYR A 275 CYH A 263 CYH A 277 TYR A 274	MLI A 303 ( 4.5A) None None None	1.24A	17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3PEO_F_CU9F301_1 (SOLUBLE ACETYLCHOLINE RECEPTOR)	5m6m	E3 UBIQUITIN-PROTEIN LIGASE XIAP (Homo sapiens)	4 / 7	TRP A 310 TYR A 329 CYH A 327 CYH A 303	7H8 A 403 (-2.8A) None ZN A 401 (-2.2A) ZN A 401 (-2.3A)	1.15A	20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3PEO_F_CU9F301_2 (SOLUBLE ACETYLCHOLINE RECEPTOR)	1dql	IGM MEZ IMMUNOGLOBULIN (Homo sapiens)	4 / 6	GLN L 37 TYR L 86 GLN L 6 ILE L 21	None	1.27A	19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3PEO_F_CU9F301_2 (SOLUBLE ACETYLCHOLINE RECEPTOR)	1htj	KIAA0380 (Homo sapiens)	4 / 6	GLN F 334 TYR F 431 GLN F 453 SER F 333	None	1.29A	22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3PEO_F_CU9F301_2 (SOLUBLE ACETYLCHOLINE RECEPTOR)	1n26	IL-6 RECEPTOR ALPHA CHAIN (Homo sapiens)	4 / 6	GLN A 153 TYR A 148 GLN A 147 SER A 152	None None NDG A 636 (-3.9A) None	1.04A	20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3PEO_F_CU9F301_2 (SOLUBLE ACETYLCHOLINE RECEPTOR)	1zd1	SULFOTRANSFERASE 4A1 (Homo sapiens)	4 / 6	GLN A 70 TYR A 66 GLN A 62 SER A 69	None	1.31A	19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3PEO_F_CU9F301_2 (SOLUBLE ACETYLCHOLINE RECEPTOR)	2dib	FILAMIN-B (Homo sapiens)	4 / 6	THR A 82 TYR A 83 GLN A 84 SER A 48	None	1.30A	20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3PEO_F_CU9F301_2 (SOLUBLE ACETYLCHOLINE RECEPTOR)	2dw4	LYSINE-SPECIFIC HISTONE DEMETHYLASE 1 (Homo sapiens)	4 / 6	GLN A 298 GLN A 348 ILE A 266 SER A 299	None	1.25A	15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3PEO_F_CU9F301_2 (SOLUBLE ACETYLCHOLINE RECEPTOR)	2gy7	ANGIOPOIETIN-2 (Homo sapiens)	4 / 6	THR A 364 GLN A 367 TYR A 369 ILE A 491	None	1.19A	18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3PEO_F_CU9F301_2 (SOLUBLE ACETYLCHOLINE RECEPTOR)	2qho	E3 UBIQUITIN-PROTEIN LIGASE EDD1 (Homo sapiens)	4 / 6	GLN B 194 GLN B 210 ILE B 185 SER B 201	None	1.25A	22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3PEO_F_CU9F301_2 (SOLUBLE ACETYLCHOLINE RECEPTOR)	2v5y	RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE MU (Homo sapiens)	4 / 6	GLN A 515 TYR A 539 GLN A 558 SER A 513	None	0.77A	16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3PEO_F_CU9F301_2 (SOLUBLE ACETYLCHOLINE RECEPTOR)	3qak	ADENOSINE RECEPTOR A2A,LYSOZYME CHIMERA (Escherichia virus T4; Homo sapiens)	4 / 6	THR A1034 TYR A1025 ILE A1017 SER A1036	None	1.27A	17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3PEO_F_CU9F301_2 (SOLUBLE ACETYLCHOLINE RECEPTOR)	3rpi	LIGHT CHAIN FROM HIGHLY POTENT ANTI-HIV NEUTRALIZING ANTIBODY (Homo sapiens)	4 / 6	GLN L 36 TYR L 84 GLN L 6 ILE L 21	None	1.26A	23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3PEO_F_CU9F301_2 (SOLUBLE ACETYLCHOLINE RECEPTOR)	3vw7	PROTEINASE-ACTIVATED RECEPTOR 1, LYSOZYME (Escherichia virus T4; Homo sapiens)	4 / 6	THR A1034 TYR A1025 ILE A1017 SER A1036	None	1.24A	17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3PEO_F_CU9F301_2 (SOLUBLE ACETYLCHOLINE RECEPTOR)	4lg9	F-BOX-LIKE/WD REPEAT-CONTAINING PROTEIN TBL1XR1 (Homo sapiens)	4 / 6	THR A 290 GLN A 302 ILE A 292 SER A 324	None	1.27A	18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3PEO_F_CU9F301_2 (SOLUBLE ACETYLCHOLINE RECEPTOR)	4p6w	GLUCOCORTICOID RECEPTOR (Homo sapiens)	4 / 6	THR A 594 GLN A 760 TYR A 598 ILE A 675	None	1.31A	21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3PEO_F_CU9F301_2 (SOLUBLE ACETYLCHOLINE RECEPTOR)	4rh7	GREEN FLUORESCENT PROTEIN/CYTOPLASMIC DYNEIN 2 HEAVY CHAIN 1 (Homo sapiens; synthetic construct)	4 / 6	THR A3212 GLN A2871 TYR A3213 ILE A2858	None	1.27A	5.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3PEO_F_CU9F301_2 (SOLUBLE ACETYLCHOLINE RECEPTOR)	4x4y	HUMAN VARIABLE LIGHT CHAIN OF HERCEPTIN (Homo sapiens)	4 / 6	GLN B 37 TYR B 86 GLN B 6 ILE B 21	None	1.30A	19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3PEO_F_CU9F301_2 (SOLUBLE ACETYLCHOLINE RECEPTOR)	4zht	BIFUNCTIONAL UDP-N-ACETYLGLUCOSAM INE 2-EPIMERASE/N-ACETYL MANNOSAMINE KINASE (Homo sapiens)	4 / 6	THR A 141 GLN A 322 ILE A 254 SER A 139	None	1.26A	20.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3PEO_F_CU9F301_2 (SOLUBLE ACETYLCHOLINE RECEPTOR)	4zjs	ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA,SOLUBLE ACETYLCHOLINE RECEPTOR,ACETYLCHOLI NE RECEPTOR SUBUNIT ALPHA,SOLUBLE ACETYLCHOLINE RECEPTOR (Aplysia californica; Homo sapiens)	4 / 6	GLN A 38 TYR A 55 ILE A 118 SER A 167	None	1.21A	82.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3PEO_F_CU9F301_2 (SOLUBLE ACETYLCHOLINE RECEPTOR)	4zjs	ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA,SOLUBLE ACETYLCHOLINE RECEPTOR,ACETYLCHOLI NE RECEPTOR SUBUNIT ALPHA,SOLUBLE ACETYLCHOLINE RECEPTOR (Aplysia californica; Homo sapiens)	5 / 6	THR A 36 GLN A 38 GLN A 57 ILE A 118 SER A 167	None	0.77A	82.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3PEO_F_CU9F301_2 (SOLUBLE ACETYLCHOLINE RECEPTOR)	4zwj	CHIMERA PROTEIN OF HUMAN RHODOPSIN, MOUSE S-ARRESTIN, AND T4 ENDOLYSIN (Escherichia virus T4; Homo sapiens; Mus musculus)	4 / 6	THR A1034 TYR A1025 ILE A1017 SER A1036	None	1.24A	14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3PEO_F_CU9F301_2 (SOLUBLE ACETYLCHOLINE RECEPTOR)	5d9q	NIH45-46 SINGLE CHAIN FV (Homo sapiens)	4 / 6	GLN D 235 TYR D 284 GLN D 206 ILE D 221	None	1.27A	19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3PEO_F_CU9F301_2 (SOLUBLE ACETYLCHOLINE RECEPTOR)	5kan	16.G.07 LIGHT CHAIN (Homo sapiens)	4 / 6	GLN I 89 TYR I 36 GLN I 38 SER I 98	None	1.23A	22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3PEO_F_CU9F301_2 (SOLUBLE ACETYLCHOLINE RECEPTOR)	5v88	LYSOZYME,DCN1-LIKE PROTEIN 1 (Escherichia virus T4; Homo sapiens)	4 / 6	THR A 34 TYR A 25 ILE A 17 SER A 36	None	1.24A	18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3PEO_F_CU9F301_2 (SOLUBLE ACETYLCHOLINE RECEPTOR)	5y2z	LEUCINE-RICH GLIOMA-INACTIVATED PROTEIN 1 (Homo sapiens)	4 / 6	THR B 545 GLN B 230 ILE B 547 SER B 236	None	1.28A	15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3PEO_F_CU9F301_2 (SOLUBLE ACETYLCHOLINE RECEPTOR)	6ffh	METABOTROPIC GLUTAMATE RECEPTOR 5,ENDOLYSIN (Escherichia virus T4; Homo sapiens)	4 / 6	THR A1034 TYR A1025 ILE A1017 SER A1036	None	1.26A	16.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3PEO_H_CU9H301_1 (SOLUBLE ACETYLCHOLINE RECEPTOR)	4zjs	ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA,SOLUBLE ACETYLCHOLINE RECEPTOR,ACETYLCHOLI NE RECEPTOR SUBUNIT ALPHA,SOLUBLE ACETYLCHOLINE RECEPTOR (Aplysia californica; Homo sapiens)	5 / 12	THR A 36 GLN A 38 TYR A 55 GLN A 57 SER A 167	None	1.16A	82.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3PEO_J_CU9J301_1 (SOLUBLE ACETYLCHOLINE RECEPTOR)	4zjs	ACETYLCHOLINE RECEPTOR SUBUNIT ALPHA,SOLUBLE ACETYLCHOLINE RECEPTOR,ACETYLCHOLI NE RECEPTOR SUBUNIT ALPHA,SOLUBLE ACETYLCHOLINE RECEPTOR (Aplysia californica; Homo sapiens)	5 / 11	THR A 36 GLN A 38 GLN A 57 ILE A 118 SER A 167	None	0.61A	82.17