POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZI9_A_CL9A401_1
(DEOXYCYTIDINE KINASE)		2a30 DEOXYCYTIDINE KINASE
(Homo
sapiens)		5 / 12ILE A  30
GLU A  53
ARG A 104
ARG A 128
TYR A  86
DCZ  A 302 ( 4.3A)
DCZ  A 302 (-3.0A)
None
DCZ  A 302 (-4.1A)
DCZ  A 302 (-4.6A)
1.47A92.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZI9_A_CL9A401_1
(DEOXYCYTIDINE KINASE)		2a30 DEOXYCYTIDINE KINASE
(Homo
sapiens)		8 / 12ILE A  30
GLU A  53
GLN A  97
ARG A 104
ARG A 128
ARG A 192
GLU A 197
TYR A 204
DCZ  A 302 ( 4.3A)
DCZ  A 302 (-3.0A)
DCZ  A 302 (-3.2A)
None
DCZ  A 302 (-4.1A)
DCZ  A 302 ( 4.9A)
DCZ  A 302 (-3.5A)
None
1.23A92.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZI9_A_CL9A401_1
(DEOXYCYTIDINE KINASE)		2a30 DEOXYCYTIDINE KINASE
(Homo
sapiens)		12 / 12ILE A  30
GLU A  53
TRP A  58
MET A  85
TYR A  86
PHE A  96
GLN A  97
ARG A 104
ARG A 128
ARG A 194
GLU A 197
TYR A 204
DCZ  A 302 ( 4.3A)
DCZ  A 302 (-3.0A)
None
DCZ  A 302 ( 4.3A)
DCZ  A 302 (-4.6A)
DCZ  A 302 (-4.6A)
DCZ  A 302 (-3.2A)
None
DCZ  A 302 (-4.1A)
DCZ  A 302 ( 4.8A)
DCZ  A 302 (-3.5A)
None
0.75A92.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZI9_A_CL9A401_1
(DEOXYCYTIDINE KINASE)		2ocp DEOXYGUANOSINE
KINASE
(Homo
sapiens)		5 / 12GLU A  70
TRP A  75
MET A  99
PHE A 110
GLN A 111
None
None
DTP  A 301 ( 3.9A)
DTP  A 301 (-4.2A)
DTP  A 301 (-2.9A)
1.02A44.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZI9_A_CL9A401_1
(DEOXYCYTIDINE KINASE)		2ocp DEOXYGUANOSINE
KINASE
(Homo
sapiens)		5 / 12ILE A  47
ARG A 142
ARG A 206
GLU A 211
TYR A 218
DTP  A 301 (-3.8A)
DTP  A 301 (-3.2A)
DTP  A 301 (-3.1A)
DTP  A 301 (-3.5A)
None
1.33A44.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZI9_A_CL9A401_1
(DEOXYCYTIDINE KINASE)		2ocp DEOXYGUANOSINE
KINASE
(Homo
sapiens)		10 / 12ILE A  47
TRP A  75
MET A  99
TYR A 100
PHE A 110
GLN A 111
ARG A 142
ARG A 208
GLU A 211
TYR A 218
DTP  A 301 (-3.8A)
None
DTP  A 301 ( 3.9A)
DTP  A 301 (-4.5A)
DTP  A 301 (-4.2A)
DTP  A 301 (-2.9A)
DTP  A 301 (-3.2A)
DTP  A 301 (-3.4A)
DTP  A 301 (-3.5A)
None
0.58A44.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZI9_A_CL9A401_1
(DEOXYCYTIDINE KINASE)		2ocp DEOXYGUANOSINE
KINASE
(Homo
sapiens)		9 / 12ILE A  47
TRP A  75
TYR A 100
PHE A 110
ARG A 118
ARG A 142
ARG A 208
GLU A 211
TYR A 218
DTP  A 301 (-3.8A)
None
DTP  A 301 (-4.5A)
DTP  A 301 (-4.2A)
DTP  A 301 (-3.1A)
DTP  A 301 (-3.2A)
DTP  A 301 (-3.4A)
DTP  A 301 (-3.5A)
None
0.81A44.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_1
(DEOXYCYTIDINE KINASE)		5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL
(Homo
sapiens)		5 / 12ILE w  66
TYR w 118
GLN w 132
ARG w 161
TYR w 233
None
1.19A22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_1
(DEOXYCYTIDINE KINASE)		5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL
(Homo
sapiens)		5 / 12ILE w  66
TYR w 118
GLN w 132
GLU w 226
TYR w 233
None
1.00A22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_1
(DEOXYCYTIDINE KINASE)		5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL
(Homo
sapiens)		5 / 12TYR w 118
GLN w 132
ARG w 139
ARG w 161
TYR w 233
None
1.18A22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_1
(DEOXYCYTIDINE KINASE)		5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL
(Homo
sapiens)		5 / 12TYR w 118
GLN w 132
ARG w 139
GLU w 226
TYR w 233
None
1.08A22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		1b6u P58 KILLER CELL
INHIBITORY RECEPTOR
(Homo
sapiens)		3 / 3ASP A 163
PHE A 164
LEU A 166
None
0.59A21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		1bht HEPATOCYTE GROWTH
FACTOR
(Homo
sapiens)		3 / 3ASP A 117
PHE A  89
LEU A  97
None
0.74A20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		1im9 KILLER CELL
IMMUNOGLOBULIN-LIKE
RECEPTOR 2DL1
(Homo
sapiens)		3 / 3ASP D 163
PHE D 164
LEU D 166
None
0.67A19.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZI9_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		2a30 DEOXYCYTIDINE KINASE
(Homo
sapiens)		3 / 3ASP A 133
PHE A 137
LEU A 141
DCZ  A 302 (-3.2A)
DCZ  A 302 (-3.8A)
None
0.34A92.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		2e30 CALCIUM-BINDING
PROTEIN P22
(Homo
sapiens)		3 / 3ASP A  50
PHE A  51
LEU A  57
None
0.74A23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		2mxp CALCIUM-BINDING AND
COILED-COIL
DOMAIN-CONTAINING
PROTEIN 2
(Homo
sapiens)		3 / 3ASP A  74
PHE A  77
LEU A  81
None
0.66A10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		2nlk PROTEIN TYROSINE
PHOSPHATASE,
RECEPTOR TYPE, G
VARIANT (FRAGMENT)
(Homo
sapiens)		3 / 3ASP A1297
PHE A1298
LEU A1300
None
0.63A19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		2uzx HEPATOCYTE GROWTH
FACTOR RECEPTOR
(Homo
sapiens)		3 / 3ASP B 587
PHE B 588
LEU B 598
None
0.57A17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		3h8n KILLER CELL
IMMUNOGLOBULIN-LIKE
RECEPTOR 2DS4
(Homo
sapiens)		3 / 3ASP A 163
PHE A 164
LEU A 166
None
0.62A20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		3su8 PLEXIN-B1
(Homo
sapiens)		3 / 3ASP X1934
PHE X1937
LEU X1941
None
0.63A18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		3txo PROTEIN KINASE C ETA
TYPE
(Homo
sapiens)		3 / 3ASP A 560
PHE A 563
LEU A 567
None
0.21A21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		3unn MEDIATOR OF DNA
DAMAGE CHECKPOINT
PROTEIN 1
(Homo
sapiens)		3 / 3ASP A  46
PHE A  47
LEU A  49
None
0.71A18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		3wzf ASPARTATE
AMINOTRANSFERASE,
CYTOPLASMIC
(Homo
sapiens)		3 / 3ASP A  27
PHE A  24
LEU A  20
None
0.65A21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		4a6e HYDROXYINDOLE
O-METHYLTRANSFERASE
(Homo
sapiens)		3 / 3ASP A 236
PHE A 237
LEU A 242
SAM  A1349 (-3.5A)
SAM  A1349 (-3.5A)
None
0.45A21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		4gl2 INTERFERON-INDUCED
HELICASE C
DOMAIN-CONTAINING
PROTEIN 1
(Homo
sapiens)		3 / 3ASP A 572
PHE A 573
LEU A 611
None
0.29A17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		4v1d SINGLE CHAIN
ANTIBODY FRAGMENT
RU1, HEAVY CHAIN
SINGLE CHAIN
ANTIBODY FRAGMENT
RU1, LIGHT CHAIN
(Homo
sapiens)		3 / 3ASP D  99
PHE D 111
LEU E 186
None
0.72A18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 5
(Homo
sapiens)		3 / 3ASP O 165
PHE O 162
LEU O 158
None
0.36A18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		5aq0 CARBOXYPEPTIDASE D
(Homo
sapiens)		3 / 3ASP A 456
PHE A 457
LEU A 459
None
0.68A14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		5b39 KILLER CELL
IMMUNOGLOBULIN-LIKE
RECEPTOR 3DL1
(Homo
sapiens)		3 / 3ASP G 258
PHE G 259
LEU G 261
None
0.61A20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		5bug PHOSPHATIDYLINOSITOL
3,4,5-TRISPHOSPHATE
3-PHOSPHATASE AND
DUAL-SPECIFICITY
PROTEIN PHOSPHATASE
PTEN
(Homo
sapiens)		3 / 3ASP A 107
PHE A 104
LEU A 100
None
0.50A22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		5cjb OSTEOCLAST-ASSOCIATE
D
IMMUNOGLOBULIN-LIKE
RECEPTOR
(Homo
sapiens)		3 / 3ASP A 185
PHE A 186
LEU A 188
None
0.69A18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		5i2c GATS-LIKE PROTEIN 3
(Homo
sapiens)		3 / 3ASP A 121
PHE A 122
LEU A 124
None
0.65A21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		5lsp HEPATOCYTE GROWTH
FACTOR RECEPTOR
(Homo
sapiens)		3 / 3ASP A 587
PHE A 588
LEU A 598
None
0.59A20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		5lz6 GOLGI RESIDENT
PROTEIN GCP60
(Homo
sapiens)		3 / 3ASP A 477
PHE A 433
LEU A 505
None
0.63A20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1
(Homo
sapiens)		3 / 3ASP A2372
PHE A2375
LEU A2379
None
0.21A4.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		5v4b F-BOX/WD
REPEAT-CONTAINING
PROTEIN 7
(Homo
sapiens)		3 / 3ASP B2550
PHE B2549
LEU B2547
None
0.60A18.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZI9_B_CL9B401_1
(DEOXYCYTIDINE KINASE)		2a30 DEOXYCYTIDINE KINASE
(Homo
sapiens)		12 / 12ILE A  30
GLU A  53
TRP A  58
MET A  85
TYR A  86
PHE A  96
GLN A  97
ARG A 104
PHE A 137
ARG A 192
GLU A 197
TYR A 204
DCZ  A 302 ( 4.3A)
DCZ  A 302 (-3.0A)
None
DCZ  A 302 ( 4.3A)
DCZ  A 302 (-4.6A)
DCZ  A 302 (-4.6A)
DCZ  A 302 (-3.2A)
None
DCZ  A 302 (-3.8A)
DCZ  A 302 ( 4.9A)
DCZ  A 302 (-3.5A)
None
0.53A92.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZI9_B_CL9B401_1
(DEOXYCYTIDINE KINASE)		2ocp DEOXYGUANOSINE
KINASE
(Homo
sapiens)		5 / 12GLU A  70
TRP A  75
MET A  99
PHE A 110
GLN A 111
None
None
DTP  A 301 ( 3.9A)
DTP  A 301 (-4.2A)
DTP  A 301 (-2.9A)
1.16A44.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZI9_B_CL9B401_1
(DEOXYCYTIDINE KINASE)		2ocp DEOXYGUANOSINE
KINASE
(Homo
sapiens)		5 / 12ILE A  47
TRP A  75
ARG A 118
ARG A 206
GLU A 211
DTP  A 301 (-3.8A)
None
DTP  A 301 (-3.1A)
DTP  A 301 (-3.1A)
DTP  A 301 (-3.5A)
0.95A44.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZI9_B_CL9B401_1
(DEOXYCYTIDINE KINASE)		2ocp DEOXYGUANOSINE
KINASE
(Homo
sapiens)		10 / 12ILE A  47
TRP A  75
MET A  99
TYR A 100
PHE A 110
GLN A 111
PHE A 151
ARG A 206
GLU A 211
TYR A 218
DTP  A 301 (-3.8A)
None
DTP  A 301 ( 3.9A)
DTP  A 301 (-4.5A)
DTP  A 301 (-4.2A)
DTP  A 301 (-2.9A)
DTP  A 301 (-3.3A)
DTP  A 301 (-3.1A)
DTP  A 301 (-3.5A)
None
0.75A44.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_B_CL9B401_1
(DEOXYCYTIDINE KINASE)		4xwh ALPHA-N-ACETYLGLUCOS
AMINIDASE
(Homo
sapiens)		5 / 12ILE A 448
TYR A 132
ARG A 482
ARG A 149
GLU A 153
None
1.24A15.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZIA_A_CL9A401_1
(DEOXYCYTIDINE KINASE)		2a30 DEOXYCYTIDINE KINASE
(Homo
sapiens)		12 / 12ILE A  30
GLU A  53
TRP A  58
LEU A  82
MET A  85
TYR A  86
GLN A  97
ARG A 104
ARG A 128
PHE A 137
GLU A 197
TYR A 204
DCZ  A 302 ( 4.3A)
DCZ  A 302 (-3.0A)
None
DCZ  A 302 ( 4.9A)
DCZ  A 302 ( 4.3A)
DCZ  A 302 (-4.6A)
DCZ  A 302 (-3.2A)
None
DCZ  A 302 (-4.1A)
DCZ  A 302 (-3.8A)
DCZ  A 302 (-3.5A)
None
0.58A92.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZIA_A_CL9A401_1
(DEOXYCYTIDINE KINASE)		2ocp DEOXYGUANOSINE
KINASE
(Homo
sapiens)		10 / 12ILE A  47
TRP A  75
LEU A  96
MET A  99
TYR A 100
GLN A 111
ARG A 142
PHE A 151
GLU A 211
TYR A 218
DTP  A 301 (-3.8A)
None
DTP  A 301 (-4.6A)
DTP  A 301 ( 3.9A)
DTP  A 301 (-4.5A)
DTP  A 301 (-2.9A)
DTP  A 301 (-3.2A)
DTP  A 301 (-3.3A)
DTP  A 301 (-3.5A)
None
0.53A44.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZIA_A_CL9A401_1
(DEOXYCYTIDINE KINASE)		2ocp DEOXYGUANOSINE
KINASE
(Homo
sapiens)		9 / 12ILE A  47
TRP A  75
LEU A  96
TYR A 100
ARG A 118
ARG A 142
PHE A 151
GLU A 211
TYR A 218
DTP  A 301 (-3.8A)
None
DTP  A 301 (-4.6A)
DTP  A 301 (-4.5A)
DTP  A 301 (-3.1A)
DTP  A 301 (-3.2A)
DTP  A 301 (-3.3A)
DTP  A 301 (-3.5A)
None
0.70A44.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_A_CL9A401_1
(DEOXYCYTIDINE KINASE)		5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL
(Homo
sapiens)		6 / 12ILE w  66
GLN w 132
ARG w 139
ARG w 161
GLU w 226
TYR w 233
None
1.09A22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_A_CL9A401_1
(DEOXYCYTIDINE KINASE)		5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL
(Homo
sapiens)		6 / 12ILE w  66
LEU w 114
GLN w 132
ARG w 161
GLU w 226
TYR w 233
None
1.01A22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_A_CL9A401_1
(DEOXYCYTIDINE KINASE)		5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL
(Homo
sapiens)		6 / 12ILE w  66
LEU w 114
TYR w 118
ARG w 161
GLU w 226
TYR w 233
None
1.26A22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_A_CL9A401_1
(DEOXYCYTIDINE KINASE)		5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL
(Homo
sapiens)		6 / 12ILE w  66
TYR w 118
ARG w 139
ARG w 161
GLU w 226
TYR w 233
None
1.19A22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		1jy1 TYROSYL-DNA
PHOSPHODIESTERASE
(Homo
sapiens)		4 / 4VAL A 171
ASP A 187
LEU A 298
ARG A 487
None
1.39A19.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZIA_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		2a30 DEOXYCYTIDINE KINASE
(Homo
sapiens)		4 / 4VAL A  55
ASP A 133
LEU A 141
ARG A 194
None
DCZ  A 302 (-3.2A)
None
DCZ  A 302 ( 4.8A)
0.55A92.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		2a8b RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE R
(Homo
sapiens)		4 / 4VAL A 502
ASP A 474
LEU A 434
ARG A 420
None
1.27A20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		2y6c MATRILYSIN
(Homo
sapiens)		4 / 4VAL A 152
ASP A 194
LEU A 225
ARG A 150
None
CA  A1264 (-3.0A)
None
None
1.17A20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		3g5k PEPTIDE DEFORMYLASE,
MITOCHONDRIAL
(Homo
sapiens)		4 / 4VAL A  24
ASP A 136
LEU A  92
ARG A  62
None
1.29A18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		4c02 ACTIVIN RECEPTOR
TYPE-1
(Homo
sapiens)		4 / 4VAL A 376
ASP A 241
LEU A 281
ARG A 335
None
1.18A19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		4oiv BILE ACID RECEPTOR
(Homo
sapiens)		4 / 4VAL A 301
ASP A 262
LEU A 257
ARG A 335
None
1.14A23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		5bwa ORNITHINE
DECARBOXYLASE
ORNITHINE
DECARBOXYLASE
ANTIZYME 1
(Homo
sapiens)		4 / 4VAL B 158
ASP A 134
LEU A 151
ARG B 100
None
1.40A20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		5h0u MATRIX
METALLOPROTEINASE-14
(Homo
sapiens)		4 / 4VAL A 162
ASP A 212
LEU A 245
ARG A 160
None
CA  A 301 ( 3.0A)
None
None
1.05A18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		5wwt PUTATIVE
METHYLTRANSFERASE
NSUN6
(Homo
sapiens)		4 / 4VAL A 429
ASP A 433
LEU A 439
ARG A 449
None
1.39A19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)
(Homo
sapiens)		4 / 4VAL A 462
ASP A 456
LEU A 391
ARG A 466
None
1.26A11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_B_CL9B401_1
(DEOXYCYTIDINE KINASE)		1osg TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
13B
(Homo
sapiens)		5 / 12VAL A 166
TRP A 168
LEU A 261
PHE A 278
TYR A 246
None
1.27A23.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZIA_B_CL9B401_1
(DEOXYCYTIDINE KINASE)		2a30 DEOXYCYTIDINE KINASE
(Homo
sapiens)		12 / 12ILE A  30
GLU A  53
VAL A  55
TRP A  58
LEU A  82
MET A  85
TYR A  86
GLN A  97
ARG A 104
PHE A 137
GLU A 197
TYR A 204
DCZ  A 302 ( 4.3A)
DCZ  A 302 (-3.0A)
None
None
DCZ  A 302 ( 4.9A)
DCZ  A 302 ( 4.3A)
DCZ  A 302 (-4.6A)
DCZ  A 302 (-3.2A)
None
DCZ  A 302 (-3.8A)
DCZ  A 302 (-3.5A)
None
0.62A92.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZIA_B_CL9B401_1
(DEOXYCYTIDINE KINASE)		2a30 DEOXYCYTIDINE KINASE
(Homo
sapiens)		5 / 12ILE A 200
LEU A  82
MET A  85
GLN A  97
ARG A 128
None
DCZ  A 302 ( 4.9A)
DCZ  A 302 ( 4.3A)
DCZ  A 302 (-3.2A)
DCZ  A 302 (-4.1A)
1.23A92.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZIA_B_CL9B401_1
(DEOXYCYTIDINE KINASE)		2ocp DEOXYGUANOSINE
KINASE
(Homo
sapiens)		5 / 12GLU A  70
VAL A  72
TRP A  75
MET A  99
GLN A 111
None
DTP  A 301 (-4.1A)
None
DTP  A 301 ( 3.9A)
DTP  A 301 (-2.9A)
1.15A44.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZIA_B_CL9B401_1
(DEOXYCYTIDINE KINASE)		2ocp DEOXYGUANOSINE
KINASE
(Homo
sapiens)		10 / 12ILE A  47
VAL A  72
TRP A  75
LEU A  96
MET A  99
TYR A 100
GLN A 111
PHE A 151
GLU A 211
TYR A 218
DTP  A 301 (-3.8A)
DTP  A 301 (-4.1A)
None
DTP  A 301 (-4.6A)
DTP  A 301 ( 3.9A)
DTP  A 301 (-4.5A)
DTP  A 301 (-2.9A)
DTP  A 301 (-3.3A)
DTP  A 301 (-3.5A)
None
0.54A44.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZIA_B_CL9B401_1
(DEOXYCYTIDINE KINASE)		2ocp DEOXYGUANOSINE
KINASE
(Homo
sapiens)		8 / 12ILE A  47
VAL A  72
TRP A  75
LEU A  96
TYR A 100
ARG A 118
GLU A 211
TYR A 218
DTP  A 301 (-3.8A)
DTP  A 301 (-4.1A)
None
DTP  A 301 (-4.6A)
DTP  A 301 (-4.5A)
DTP  A 301 (-3.1A)
DTP  A 301 (-3.5A)
None
0.64A44.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_B_CL9B401_1
(DEOXYCYTIDINE KINASE)		3tac LIPRIN-ALPHA-2
(Homo
sapiens)		5 / 12ILE B 939
TRP B 906
LEU B 907
MET B 913
TYR B 917
None
1.13A23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_B_CL9B401_1
(DEOXYCYTIDINE KINASE)		3tac LIPRIN-ALPHA-2
(Homo
sapiens)		5 / 12ILE B 943
VAL B 903
TRP B 906
LEU B 907
MET B 913
None
1.17A23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_B_CL9B401_1
(DEOXYCYTIDINE KINASE)		3tad LIPRIN-ALPHA-2
(Homo
sapiens)		5 / 12ILE A 939
TRP A 906
LEU A 907
MET A 913
TYR A 917
None
1.13A22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_B_CL9B401_1
(DEOXYCYTIDINE KINASE)		3tad LIPRIN-ALPHA-2
(Homo
sapiens)		5 / 12ILE A 943
VAL A 903
TRP A 906
LEU A 907
MET A 913
None
1.29A22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_B_CL9B401_1
(DEOXYCYTIDINE KINASE)		4zch TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
13,TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
13B,TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
13B
(Homo
sapiens)		5 / 12VAL A 174
TRP A 176
LEU A 269
PHE A 286
TYR A 254
None
1.28A21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_B_CL9B401_1
(DEOXYCYTIDINE KINASE)		4zch TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
13,TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
13B,TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
13B
(Homo
sapiens)		5 / 12VAL A 325
TRP A 327
LEU A 420
PHE A 437
TYR A 405
None
1.29A21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_B_CL9B401_1
(DEOXYCYTIDINE KINASE)		5b4w PLEXIN-B1
(Homo
sapiens)		5 / 12VAL A 208
LEU A 206
TYR A 261
PHE A 218
GLU A 263
None
1.47A20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_B_CL9B401_1
(DEOXYCYTIDINE KINASE)		5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL
(Homo
sapiens)		6 / 12ILE w  66
LEU w 114
TYR w 118
GLN w 132
GLU w 226
TYR w 233
None
1.12A22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_B_CL9B401_1
(DEOXYCYTIDINE KINASE)		5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL
(Homo
sapiens)		6 / 12ILE w  66
TYR w 118
ARG w 139
PHE w 169
GLU w 226
TYR w 233
None
1.50A22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_B_CL9B401_1
(DEOXYCYTIDINE KINASE)		5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL
(Homo
sapiens)		6 / 12ILE w  66
TYR w 118
GLN w 132
ARG w 139
GLU w 226
TYR w 233
None
1.08A22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_B_CL9B401_2
(DEOXYCYTIDINE KINASE)		1now BETA-HEXOSAMINIDASE
BETA CHAIN
(Homo
sapiens)		4 / 4ARG A 528
ASP A 527
LEU A 546
ARG A 512
None
None
GOL  A 559 (-4.5A)
None
1.38A20.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ZIA_B_CL9B401_2
(DEOXYCYTIDINE KINASE)		2a30 DEOXYCYTIDINE KINASE
(Homo
sapiens)		4 / 4ARG A 128
ASP A 133
LEU A 141
ARG A 194
DCZ  A 302 (-4.1A)
DCZ  A 302 (-3.2A)
None
DCZ  A 302 ( 4.8A)
0.68A92.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_B_CL9B401_2
(DEOXYCYTIDINE KINASE)		2dyl DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 7
(Homo
sapiens)		4 / 4ARG A 258
ASP A 259
LEU A 275
ARG A 384
None
1.28A22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_B_CL9B401_2
(DEOXYCYTIDINE KINASE)		4hqp ALPHA7 NICOTINIC
RECEPTOR CHIMERA
(Homo
sapiens;
Lymnaea
stagnalis)		4 / 4ARG A 179
ASP A 193
LEU A  88
ARG A 150
None
1.26A20.14