POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XLX_A_CIOA101_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B)	1pja	PALMITOYL-PROTEIN THIOESTERASE 2 PRECURSOR (Homo sapiens)	5 / 12	LEU A 195 ASN A 177 ILE A 175 SER A 111 GLN A 112	None None None GOL  A1616 (-3.4A) None	1.31A	21.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XLX_A_CIOA101_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B)	1soj	CGMP-INHIBITED 3',5'-CYCLIC PHOSPHODIESTERASE B (Homo sapiens)	7 / 12	TYR A 736 HIS A 737 HIS A 825 THR A 952 ILE A 955 GLN A 988 PHE A 991	IBM  A2111 (-4.5A) IBM  A2111 ( 4.8A) None IBM  A2111 ( 4.8A) IBM  A2111 (-4.2A) IBM  A2111 (-3.3A) IBM  A2111 (-3.6A)	0.59A	30.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XLX_A_CIOA101_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B)	1zkl	HIGH-AFFINITY CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 7A (Homo sapiens)	6 / 12	TYR A 211 HIS A 212 HIS A 256 ASN A 365 GLN A 413 PHE A 416	IBM  A 503 (-4.6A) None None IBM  A 503 ( 4.7A) IBM  A 503 (-3.0A) IBM  A 503 (-3.4A)	0.42A	34.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XLX_A_CIOA101_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B)	2qyk	CYCLIC AMP-SPECIFIC PHOSPHODIESTERASE HSPDE4A10 (Homo sapiens)	5 / 12	HIS A 412 MET A 485 THR A 545 GLN A 581 PHE A 584	ZN  A   1 (-3.3A) None NPV  A   3 ( 4.7A) NPV  A   3 (-3.1A) NPV  A   3 (-3.3A)	1.44A	87.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XLX_A_CIOA101_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B)	2qyk	CYCLIC AMP-SPECIFIC PHOSPHODIESTERASE HSPDE4A10 (Homo sapiens)	12 / 12	TYR A 371 HIS A 372 HIS A 416 MET A 485 LEU A 531 ASN A 533 THR A 545 ILE A 548 MET A 549 SER A 580 GLN A 581 PHE A 584	NPV  A   3 (-4.4A) NPV  A   3 (-4.6A) None None None NPV  A   3 (-4.4A) NPV  A   3 ( 4.7A) NPV  A   3 (-3.8A) NPV  A   3 ( 4.7A) NPV  A   3 (-4.5A) NPV  A   3 (-3.1A) NPV  A   3 (-3.3A)	0.37A	87.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XLX_A_CIOA101_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B)	2qym	PHOSPHODIESTERASE 4C (Homo sapiens)	5 / 12	TYR A 281 ASN A 443 THR A 455 ILE A 458 MET A 459	None	0.81A	75.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XLX_A_CIOA101_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B)	2qym	PHOSPHODIESTERASE 4C (Homo sapiens)	9 / 12	TYR A 281 HIS A 282 HIS A 326 MET A 395 LEU A 441 ASN A 443 THR A 455 ILE A 458 PHE A 494	None	0.50A	75.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XLX_A_CIOA101_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B)	3b2r	CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE (Homo sapiens)	6 / 12	TYR A 612 HIS A 613 HIS A 657 LEU A 765 GLN A 817 PHE A 820	VDN  A   1 (-4.8A) VDN  A   1 (-4.3A) None VDN  A   1 ( 4.7A) VDN  A   1 (-3.0A) VDN  A   1 (-3.6A)	0.96A	28.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XLX_A_CIOA101_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B)	3bjc	CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE (Homo sapiens)	5 / 12	TYR A 612 HIS A 613 HIS A 657 LEU A 765 GLN A 775	None MG  A 877 (-4.4A) MG  A 877 (-4.3A) WAN  A 901 ( 4.7A) WAN  A 901 ( 4.6A)	1.23A	17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XLX_A_CIOA101_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B)	3bjc	CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE (Homo sapiens)	6 / 12	TYR A 612 HIS A 613 HIS A 657 LEU A 765 GLN A 817 PHE A 820	None MG  A 877 (-4.4A) MG  A 877 (-4.3A) WAN  A 901 ( 4.7A) WAN  A 901 (-3.1A) WAN  A 901 (-3.7A)	0.60A	17.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XLX_A_CIOA101_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B)	3ecn	HIGH AFFINITY CAMP-SPECIFIC AND IBMX-INSENSITIVE 3',5'-CYCLIC PHOSPHODIESTERASE 8A (Homo sapiens)	9 / 12	TYR A 555 HIS A 556 HIS A 600 MET A 670 ASN A 729 ILE A 744 SER A 777 GLN A 778 PHE A 781	None None None IBM  A   3 (-4.5A) None IBM  A   3 (-4.3A) None IBM  A   3 (-3.4A) IBM  A   3 (-3.5A)	0.42A	34.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XLX_A_CIOA101_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B)	3g4g	CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D (Homo sapiens)	5 / 12	HIS A 330 MET A 439 LEU A 485 SER A 534 PHE A 538	ZN  A 801 (-3.4A) D71  A 901 ( 4.0A) None D71  A 901 (-3.4A) D71  A 901 (-3.9A)	1.38A	66.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XLX_A_CIOA101_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B)	3g4g	CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D (Homo sapiens)	6 / 12	HIS A 330 MET A 439 LEU A 485 THR A 499 GLN A 535 PHE A 538	ZN  A 801 (-3.4A) D71  A 901 ( 4.0A) None D71  A 901 (-3.6A) D71  A 901 (-3.1A) D71  A 901 (-3.9A)	1.35A	66.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XLX_A_CIOA101_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B)	3g4g	CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D (Homo sapiens)	8 / 12	HIS A 370 MET A 439 LEU A 485 ASN A 487 ILE A 502 MET A 503 SER A 534 PHE A 538	None D71  A 901 ( 4.0A) None D71  A 901 (-4.5A) D71  A 901 (-4.1A) D71  A 901 (-3.6A) D71  A 901 (-3.4A) D71  A 901 (-3.9A)	0.88A	66.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XLX_A_CIOA101_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B)	3g4g	CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D (Homo sapiens)	9 / 12	HIS A 370 MET A 439 LEU A 485 ASN A 487 THR A 499 ILE A 502 MET A 503 GLN A 535 PHE A 538	None D71  A 901 ( 4.0A) None D71  A 901 (-4.5A) D71  A 901 (-3.6A) D71  A 901 (-4.1A) D71  A 901 (-3.6A) D71  A 901 (-3.1A) D71  A 901 (-3.9A)	0.70A	66.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XLX_A_CIOA101_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B)	3g4g	CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D (Homo sapiens)	9 / 12	TYR A 325 HIS A 326 HIS A 370 LEU A 485 ASN A 487 ILE A 502 MET A 503 SER A 534 PHE A 538	None D71  A 901 (-4.5A) None None D71  A 901 (-4.5A) D71  A 901 (-4.1A) D71  A 901 (-3.6A) D71  A 901 (-3.4A) D71  A 901 (-3.9A)	0.66A	66.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XLX_A_CIOA101_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B)	3g4g	CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D (Homo sapiens)	10 / 12	TYR A 325 HIS A 326 HIS A 370 LEU A 485 ASN A 487 THR A 499 ILE A 502 MET A 503 GLN A 535 PHE A 538	None D71  A 901 (-4.5A) None None D71  A 901 (-4.5A) D71  A 901 (-3.6A) D71  A 901 (-4.1A) D71  A 901 (-3.6A) D71  A 901 (-3.1A) D71  A 901 (-3.9A)	0.47A	66.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XLX_A_CIOA101_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B)	3hoc	FILAMIN-A (Homo sapiens)	5 / 12	LEU A 172 THR A 186 ILE A 185 SER A 189 PHE A 188	None	1.34A	22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XLX_A_CIOA101_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B)	3ibj	CGMP-DEPENDENT 3',5'-CYCLIC PHOSPHODIESTERASE (Homo sapiens)	7 / 12	TYR A 655 HIS A 656 HIS A 700 LEU A 809 ILE A 826 GLN A 859 PHE A 862	None	0.99A	19.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XLX_A_CIOA101_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B)	3n3z	HIGH AFFINITY CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 9A (Homo sapiens)	5 / 12	HIS A 252 HIS A 296 MET A 365 ASN A 405 GLN A 453	None None None IBM  A   1 (-3.5A) IBM  A   1 (-3.5A)	0.83A	30.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XLX_A_CIOA101_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B)	3n3z	HIGH AFFINITY CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 9A (Homo sapiens)	5 / 12	HIS A 252 HIS A 296 MET A 365 GLN A 453 PHE A 456	None None None IBM  A   1 (-3.5A) IBM  A   1 (-3.4A)	0.63A	30.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XLX_A_CIOA101_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B)	3o57	CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B (Homo sapiens)	5 / 12	HIS A 274 MET A 347 THR A 407 GLN A 443 PHE A 446	ZN  A   1 (-3.3A) ZG2  A 506 (-3.9A) ZG2  A 506 (-4.3A) ZG2  A 506 (-3.3A) ZG2  A 506 (-3.6A)	1.47A	93.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XLX_A_CIOA101_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B)	3o57	CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B (Homo sapiens)	12 / 12	TYR A 233 HIS A 234 HIS A 278 MET A 347 LEU A 393 ASN A 395 THR A 407 ILE A 410 MET A 411 SER A 442 GLN A 443 PHE A 446	None None None ZG2  A 506 (-3.9A) None ZG2  A 506 (-4.3A) ZG2  A 506 (-4.3A) ZG2  A 506 (-4.4A) None None ZG2  A 506 (-3.3A) ZG2  A 506 (-3.6A)	0.55A	93.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XLX_A_CIOA101_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B)	3qi3	HIGH AFFINITY CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 9A (Homo sapiens)	5 / 12	HIS A 252 HIS A 296 MET A 365 ASN A 405 PHE A 456	PDB  A 600 (-4.6A) None PDB  A 600 ( 4.7A) PDB  A 600 (-4.4A) PDB  A 600 (-3.5A)	0.54A	26.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XLX_A_CIOA101_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B)	3sl5	CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D (Homo sapiens)	5 / 12	HIS A 315 LEU A 399 THR A 333 SER A 368 GLN A 369	HIS  A 315 ( 1.0A) LEU  A 399 ( 0.6A) THR  A 333 ( 0.8A) SER  A 368 (-0.0A) GLN  A 369 (-0.6A)	1.31A	84.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XLX_A_CIOA101_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B)	3sl5	CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D (Homo sapiens)	12 / 12	TYR A 159 HIS A 160 HIS A 204 MET A 273 LEU A 319 ASN A 321 THR A 333 ILE A 336 MET A 337 SER A 368 GLN A 369 PHE A 372	TYR  A 159 (-1.3A) HIS  A 160 ( 1.0A) HIS  A 204 ( 1.0A) MET  A 273 (-0.0A) LEU  A 319 ( 0.6A) ASN  A 321 (-0.6A) THR  A 333 ( 0.8A) ILE  A 336 ( 0.4A) MET  A 337 ( 0.0A) SER  A 368 (-0.0A) GLN  A 369 (-0.6A) PHE  A 372 (-1.3A)	0.54A	84.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XLX_A_CIOA101_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B)	3ui7	CAMP AND CAMP-INHIBITED CGMP 3',5'-CYCLIC PHOSPHODIESTERASE 10A (Homo sapiens)	7 / 12	TYR A 524 HIS A 525 HIS A 567 LEU A 675 ILE A 692 GLN A 726 PHE A 729	C1L  A   1 ( 4.8A) C1L  A   1 (-4.1A) None C1L  A   1 (-4.3A) C1L  A   1 (-4.3A) C1L  A   1 (-2.9A) C1L  A   1 (-3.5A)	0.91A	27.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XLX_A_CIOA101_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B)	4bn5	NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-3, MITOCHONDRIAL (Homo sapiens)	5 / 12	LEU A 347 ASN A 344 THR A 320 ILE A 317 MET A 143	None CNA  A1395 (-3.3A) CNA  A1395 (-4.2A) None None	1.45A	19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XLX_A_CIOA101_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B)	4fzv	PUTATIVE METHYLTRANSFERASE NSUN4 (Homo sapiens)	5 / 12	HIS A 105 LEU A 164 THR A 342 SER A 356 PHE A 354	None	1.41A	21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XLX_A_CIOA101_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B)	4htz	CGMP-DEPENDENT 3',5'-CYCLIC PHOSPHODIESTERASE (Homo sapiens)	7 / 12	TYR A 655 HIS A 656 HIS A 700 LEU A 809 ILE A 826 GLN A 859 PHE A 862	None	0.67A	27.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XLX_A_CIOA101_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B)	4wzi	CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B (Homo sapiens)	12 / 12	TYR A 405 HIS A 406 HIS A 450 MET A 519 LEU A 565 ASN A 567 THR A 579 ILE A 582 MET A 583 SER A 614 GLN A 615 PHE A 618	None MG  A 804 ( 4.9A) None None None None None None None None None None	0.65A	61.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XLX_A_CIOA101_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B)	5b25	CALCIUM/CALMODULIN-D EPENDENT 3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 1B (Homo sapiens)	8 / 12	TYR A 222 HIS A 223 HIS A 267 MET A 336 THR A 385 SER A 420 GLN A 421 PHE A 424	None 4QJ  A 603 ( 4.9A) None 4QJ  A 603 ( 3.9A) None 4QJ  A 603 (-4.7A) 4QJ  A 603 (-3.0A) 4QJ  A 603 (-3.5A)	0.67A	35.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XLX_A_CIOA101_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B)	5mov	CASEIN KINASE II SUBUNIT ALPHA (Homo sapiens)	5 / 12	HIS A 154 LEU A  85 ILE A 174 MET A 163 PHE A 113	None None HC4  A 401 ( 3.7A) HC4  A 401 ( 4.0A) HC4  A 401 (-3.4A)	1.49A	24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XLX_A_CIOA101_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B)	5ohj	CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B (Homo sapiens)	5 / 12	HIS A 446 MET A 519 THR A 579 GLN A 615 PHE A 618	ZN  A 699 (-3.2A) 9VE  A 801 (-3.8A) 9VE  A 801 (-4.1A) 9VE  A 801 (-3.2A) 9VE  A 801 (-3.9A)	1.43A	11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XLX_A_CIOA101_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B)	5ohj	CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B (Homo sapiens)	12 / 12	TYR A 405 HIS A 406 HIS A 450 MET A 519 LEU A 565 ASN A 567 THR A 579 ILE A 582 MET A 583 SER A 614 GLN A 615 PHE A 618	None None None 9VE  A 801 (-3.8A) 9VE  A 801 (-4.7A) 9VE  A 801 (-4.1A) 9VE  A 801 (-4.1A) 9VE  A 801 (-4.1A) 9VE  A 801 ( 4.0A) 9VE  A 801 (-4.7A) 9VE  A 801 (-3.2A) 9VE  A 801 (-3.9A)	0.36A	11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XLX_A_CIOA101_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B)	5wh6	CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D (Homo sapiens)	5 / 12	HIS A 200 MET A 273 THR A 333 GLN A 369 PHE A 372	ZN  A 602 (-3.3A) AKJ  A 601 ( 3.9A) AKJ  A 601 (-4.1A) AKJ  A 601 (-3.0A) AKJ  A 601 (-4.1A)	1.49A	undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XLX_A_CIOA101_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B)	5wh6	CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D (Homo sapiens)	12 / 12	TYR A 159 HIS A 160 HIS A 204 MET A 273 LEU A 319 ASN A 321 THR A 333 ILE A 336 MET A 337 SER A 368 GLN A 369 PHE A 372	AKJ  A 601 ( 4.7A) None None AKJ  A 601 ( 3.9A) AKJ  A 601 ( 4.6A) AKJ  A 601 (-4.3A) AKJ  A 601 (-4.1A) AKJ  A 601 (-3.8A) AKJ  A 601 ( 3.7A) AKJ  A 601 (-2.5A) AKJ  A 601 (-3.0A) AKJ  A 601 (-4.1A)	0.43A	undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XLX_B_CIOB102_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B)	1soj	CGMP-INHIBITED 3',5'-CYCLIC PHOSPHODIESTERASE B (Homo sapiens)	8 / 12	TYR A 736 HIS A 737 HIS A 825 THR A 952 ILE A 955 PHE A 959 GLN A 988 PHE A 991	IBM  A2111 (-4.5A) IBM  A2111 ( 4.8A) None IBM  A2111 ( 4.8A) IBM  A2111 (-4.2A) None IBM  A2111 (-3.3A) IBM  A2111 (-3.6A)	0.53A	30.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XLX_B_CIOB102_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B)	1zkl	HIGH-AFFINITY CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 7A (Homo sapiens)	6 / 12	TYR A 211 HIS A 212 HIS A 256 PHE A 384 GLN A 413 PHE A 416	IBM  A 503 (-4.6A) None None IBM  A 503 (-4.5A) IBM  A 503 (-3.0A) IBM  A 503 (-3.4A)	0.53A	34.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XLX_B_CIOB102_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B)	2qyk	CYCLIC AMP-SPECIFIC PHOSPHODIESTERASE HSPDE4A10 (Homo sapiens)	5 / 12	HIS A 412 MET A 485 THR A 545 GLN A 581 PHE A 584	ZN  A   1 (-3.3A) None NPV  A   3 ( 4.7A) NPV  A   3 (-3.1A) NPV  A   3 (-3.3A)	1.45A	87.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XLX_B_CIOB102_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B)	2qyk	CYCLIC AMP-SPECIFIC PHOSPHODIESTERASE HSPDE4A10 (Homo sapiens)	11 / 12	TYR A 371 HIS A 372 HIS A 416 MET A 485 THR A 545 ILE A 548 MET A 549 PHE A 552 MET A 569 GLN A 581 PHE A 584	NPV  A   3 (-4.4A) NPV  A   3 (-4.6A) None None NPV  A   3 ( 4.7A) NPV  A   3 (-3.8A) NPV  A   3 ( 4.7A) NPV  A   3 (-4.8A) NPV  A   3 (-3.1A) NPV  A   3 (-3.1A) NPV  A   3 (-3.3A)	0.38A	87.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XLX_B_CIOB102_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B)	2qyk	CYCLIC AMP-SPECIFIC PHOSPHODIESTERASE HSPDE4A10 (Homo sapiens)	11 / 12	TYR A 371 HIS A 372 HIS A 416 MET A 485 THR A 545 ILE A 548 MET A 549 PHE A 552 MET A 569 SER A 580 PHE A 584	NPV  A   3 (-4.4A) NPV  A   3 (-4.6A) None None NPV  A   3 ( 4.7A) NPV  A   3 (-3.8A) NPV  A   3 ( 4.7A) NPV  A   3 (-4.8A) NPV  A   3 (-3.1A) NPV  A   3 (-4.5A) NPV  A   3 (-3.3A)	0.54A	87.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XLX_B_CIOB102_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B)	2qym	PHOSPHODIESTERASE 4C (Homo sapiens)	7 / 12	TYR A 281 HIS A 282 HIS A 326 MET A 395 THR A 455 ILE A 458 PHE A 494	None	0.47A	75.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XLX_B_CIOB102_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B)	3b2r	CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE (Homo sapiens)	6 / 12	TYR A 612 HIS A 613 HIS A 657 PHE A 786 GLN A 817 PHE A 820	VDN  A   1 (-4.8A) VDN  A   1 (-4.3A) None None VDN  A   1 (-3.0A) VDN  A   1 (-3.6A)	0.84A	28.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XLX_B_CIOB102_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B)	3bjc	CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE (Homo sapiens)	6 / 12	TYR A 612 HIS A 613 HIS A 657 PHE A 786 GLN A 817 PHE A 820	None MG  A 877 (-4.4A) MG  A 877 (-4.3A) WAN  A 901 (-4.8A) WAN  A 901 (-3.1A) WAN  A 901 (-3.7A)	0.52A	17.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XLX_B_CIOB102_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B)	3ecn	HIGH AFFINITY CAMP-SPECIFIC AND IBMX-INSENSITIVE 3',5'-CYCLIC PHOSPHODIESTERASE 8A (Homo sapiens)	5 / 12	HIS A 556 HIS A 600 ILE A 744 SER A 777 PHE A 781	None None IBM  A   3 (-4.3A) None IBM  A   3 (-3.5A)	0.69A	34.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XLX_B_CIOB102_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B)	3ecn	HIGH AFFINITY CAMP-SPECIFIC AND IBMX-INSENSITIVE 3',5'-CYCLIC PHOSPHODIESTERASE 8A (Homo sapiens)	7 / 12	TYR A 555 HIS A 556 HIS A 600 MET A 670 ILE A 744 GLN A 778 PHE A 781	None None None IBM  A   3 (-4.5A) IBM  A   3 (-4.3A) IBM  A   3 (-3.4A) IBM  A   3 (-3.5A)	0.33A	34.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XLX_B_CIOB102_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B)	3g4g	CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D (Homo sapiens)	10 / 12	TYR A 325 HIS A 326 HIS A 370 THR A 499 ILE A 502 MET A 503 PHE A 506 MET A 523 SER A 534 GLN A 535	None D71  A 901 (-4.5A) None D71  A 901 (-3.6A) D71  A 901 (-4.1A) D71  A 901 (-3.6A) D71  A 901 (-4.8A) D71  A 901 ( 4.0A) D71  A 901 (-3.4A) D71  A 901 (-3.1A)	0.70A	66.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XLX_B_CIOB102_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B)	3g4g	CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D (Homo sapiens)	10 / 12	TYR A 325 HIS A 326 HIS A 370 THR A 499 ILE A 502 MET A 503 PHE A 506 SER A 534 GLN A 535 PHE A 538	None D71  A 901 (-4.5A) None D71  A 901 (-3.6A) D71  A 901 (-4.1A) D71  A 901 (-3.6A) D71  A 901 (-4.8A) D71  A 901 (-3.4A) D71  A 901 (-3.1A) D71  A 901 (-3.9A)	0.44A	66.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XLX_B_CIOB102_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B)	3g4g	CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D (Homo sapiens)	10 / 12	TYR A 325 HIS A 370 MET A 439 THR A 499 ILE A 502 MET A 503 PHE A 506 SER A 534 GLN A 535 PHE A 538	None None D71  A 901 ( 4.0A) D71  A 901 (-3.6A) D71  A 901 (-4.1A) D71  A 901 (-3.6A) D71  A 901 (-4.8A) D71  A 901 (-3.4A) D71  A 901 (-3.1A) D71  A 901 (-3.9A)	0.62A	66.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XLX_B_CIOB102_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B)	3ibj	CGMP-DEPENDENT 3',5'-CYCLIC PHOSPHODIESTERASE (Homo sapiens)	6 / 12	TYR A 655 HIS A 656 HIS A 700 ILE A 826 GLN A 859 PHE A 862	None	0.68A	19.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XLX_B_CIOB102_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B)	3n3z	HIGH AFFINITY CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 9A (Homo sapiens)	5 / 12	HIS A 252 HIS A 296 MET A 365 GLN A 453 PHE A 456	None None None IBM  A   1 (-3.5A) IBM  A   1 (-3.4A)	0.57A	30.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XLX_B_CIOB102_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B)	3n3z	HIGH AFFINITY CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 9A (Homo sapiens)	5 / 12	HIS A 292 MET A 365 PHE A 251 GLN A 453 PHE A 456	ZN  A 507 (-3.5A) None IBM  A   1 ( 4.9A) IBM  A   1 (-3.5A) IBM  A   1 (-3.4A)	1.30A	30.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XLX_B_CIOB102_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B)	3o57	CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B (Homo sapiens)	5 / 12	HIS A 274 MET A 347 THR A 407 GLN A 443 PHE A 446	ZN  A   1 (-3.3A) ZG2  A 506 (-3.9A) ZG2  A 506 (-4.3A) ZG2  A 506 (-3.3A) ZG2  A 506 (-3.6A)	1.47A	93.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XLX_B_CIOB102_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B)	3o57	CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B (Homo sapiens)	11 / 12	TYR A 233 HIS A 234 HIS A 278 MET A 347 THR A 407 ILE A 410 MET A 411 PHE A 414 MET A 431 GLN A 443 PHE A 446	None None None ZG2  A 506 (-3.9A) ZG2  A 506 (-4.3A) ZG2  A 506 (-4.4A) None ZG2  A 506 (-4.4A) ZG2  A 506 (-3.4A) ZG2  A 506 (-3.3A) ZG2  A 506 (-3.6A)	0.59A	93.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XLX_B_CIOB102_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B)	3o57	CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B (Homo sapiens)	11 / 12	TYR A 233 HIS A 234 HIS A 278 MET A 347 THR A 407 ILE A 410 MET A 411 PHE A 414 MET A 431 SER A 442 PHE A 446	None None None ZG2  A 506 (-3.9A) ZG2  A 506 (-4.3A) ZG2  A 506 (-4.4A) None ZG2  A 506 (-4.4A) ZG2  A 506 (-3.4A) None ZG2  A 506 (-3.6A)	0.70A	93.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XLX_B_CIOB102_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B)	3sl5	CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D (Homo sapiens)	10 / 12	TYR A 159 HIS A 160 HIS A 204 MET A 273 ILE A 336 MET A 337 PHE A 340 MET A 357 SER A 368 PHE A 372	TYR  A 159 (-1.3A) HIS  A 160 ( 1.0A) HIS  A 204 ( 1.0A) MET  A 273 (-0.0A) ILE  A 336 ( 0.4A) MET  A 337 ( 0.0A) PHE  A 340 (-1.3A) MET  A 357 (-0.0A) SER  A 368 (-0.0A) PHE  A 372 (-1.3A)	0.74A	84.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XLX_B_CIOB102_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B)	3sl5	CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D (Homo sapiens)	11 / 12	TYR A 159 HIS A 160 HIS A 204 MET A 273 THR A 333 ILE A 336 MET A 337 PHE A 340 MET A 357 GLN A 369 PHE A 372	TYR  A 159 (-1.3A) HIS  A 160 ( 1.0A) HIS  A 204 ( 1.0A) MET  A 273 (-0.0A) THR  A 333 ( 0.8A) ILE  A 336 ( 0.4A) MET  A 337 ( 0.0A) PHE  A 340 (-1.3A) MET  A 357 (-0.0A) GLN  A 369 (-0.6A) PHE  A 372 (-1.3A)	0.54A	84.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XLX_B_CIOB102_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B)	3ui7	CAMP AND CAMP-INHIBITED CGMP 3',5'-CYCLIC PHOSPHODIESTERASE 10A (Homo sapiens)	7 / 12	TYR A 524 HIS A 525 HIS A 567 ILE A 692 PHE A 696 GLN A 726 PHE A 729	C1L  A   1 ( 4.8A) C1L  A   1 (-4.1A) None C1L  A   1 (-4.3A) C1L  A   1 ( 4.7A) C1L  A   1 (-2.9A) C1L  A   1 (-3.5A)	0.68A	27.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XLX_B_CIOB102_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B)	3ui7	CAMP AND CAMP-INHIBITED CGMP 3',5'-CYCLIC PHOSPHODIESTERASE 10A (Homo sapiens)	5 / 12	TYR A 524 ILE A 692 MET A 713 GLN A 726 PHE A 729	C1L  A   1 ( 4.8A) C1L  A   1 (-4.3A) C1L  A   1 (-3.7A) C1L  A   1 (-2.9A) C1L  A   1 (-3.5A)	1.19A	27.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XLX_B_CIOB102_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B)	4htz	CGMP-DEPENDENT 3',5'-CYCLIC PHOSPHODIESTERASE (Homo sapiens)	7 / 12	TYR A 655 HIS A 656 HIS A 700 ILE A 826 PHE A 830 GLN A 859 PHE A 862	None	0.42A	27.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XLX_B_CIOB102_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B)	4htz	CGMP-DEPENDENT 3',5'-CYCLIC PHOSPHODIESTERASE (Homo sapiens)	5 / 12	TYR A 655 ILE A 826 MET A 847 GLN A 859 PHE A 862	None	0.89A	27.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XLX_B_CIOB102_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B)	4wzi	CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B (Homo sapiens)	9 / 12	TYR A 405 HIS A 406 HIS A 450 ILE A 582 MET A 583 PHE A 586 MET A 603 SER A 614 GLN A 615	None MG  A 804 ( 4.9A) None None None None None None None	1.05A	61.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XLX_B_CIOB102_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B)	4wzi	CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B (Homo sapiens)	10 / 12	TYR A 405 HIS A 406 HIS A 450 MET A 519 ILE A 582 MET A 583 PHE A 586 SER A 614 GLN A 615 PHE A 618	None MG  A 804 ( 4.9A) None None None None None None None None	0.88A	61.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XLX_B_CIOB102_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B)	4wzi	CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B (Homo sapiens)	10 / 12	TYR A 405 HIS A 406 HIS A 450 MET A 519 THR A 579 ILE A 582 MET A 583 PHE A 586 GLN A 615 PHE A 618	None MG  A 804 ( 4.9A) None None None None None None None None	0.72A	61.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XLX_B_CIOB102_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B)	4wzi	CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B (Homo sapiens)	9 / 12	TYR A 405 HIS A 406 HIS A 450 THR A 579 ILE A 582 MET A 583 PHE A 586 MET A 603 GLN A 615	None MG  A 804 ( 4.9A) None None None None None None None	0.81A	61.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XLX_B_CIOB102_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B)	5b25	CALCIUM/CALMODULIN-D EPENDENT 3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 1B (Homo sapiens)	8 / 12	TYR A 222 HIS A 223 HIS A 267 MET A 336 THR A 385 PHE A 392 GLN A 421 PHE A 424	None 4QJ  A 603 ( 4.9A) None 4QJ  A 603 ( 3.9A) None GOL  A 607 (-3.9A) 4QJ  A 603 (-3.0A) 4QJ  A 603 (-3.5A)	0.63A	35.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XLX_B_CIOB102_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B)	5ohj	CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B (Homo sapiens)	8 / 12	HIS A 406 HIS A 450 MET A 519 MET A 583 PHE A 586 MET A 603 SER A 614 PHE A 618	None None 9VE  A 801 (-3.8A) 9VE  A 801 ( 4.0A) 9VE  A 801 (-3.6A) 9VE  A 801 (-3.6A) 9VE  A 801 (-4.7A) 9VE  A 801 (-3.9A)	0.94A	11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XLX_B_CIOB102_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B)	5ohj	CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B (Homo sapiens)	5 / 12	HIS A 446 MET A 519 THR A 579 GLN A 615 PHE A 618	ZN  A 699 (-3.2A) 9VE  A 801 (-3.8A) 9VE  A 801 (-4.1A) 9VE  A 801 (-3.2A) 9VE  A 801 (-3.9A)	1.44A	11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XLX_B_CIOB102_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B)	5ohj	CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B (Homo sapiens)	11 / 12	TYR A 405 HIS A 406 HIS A 450 MET A 519 THR A 579 ILE A 582 MET A 583 PHE A 586 MET A 603 GLN A 615 PHE A 618	None None None 9VE  A 801 (-3.8A) 9VE  A 801 (-4.1A) 9VE  A 801 (-4.1A) 9VE  A 801 ( 4.0A) 9VE  A 801 (-3.6A) 9VE  A 801 (-3.6A) 9VE  A 801 (-3.2A) 9VE  A 801 (-3.9A)	0.62A	11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XLX_B_CIOB102_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B)	5wh6	CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D (Homo sapiens)	5 / 12	HIS A 200 MET A 273 THR A 333 GLN A 369 PHE A 372	ZN  A 602 (-3.3A) AKJ  A 601 ( 3.9A) AKJ  A 601 (-4.1A) AKJ  A 601 (-3.0A) AKJ  A 601 (-4.1A)	1.50A	undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XLX_B_CIOB102_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B)	5wh6	CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D (Homo sapiens)	12 / 12	TYR A 159 HIS A 160 HIS A 204 MET A 273 THR A 333 ILE A 336 MET A 337 PHE A 340 MET A 357 SER A 368 GLN A 369 PHE A 372	AKJ  A 601 ( 4.7A) None None AKJ  A 601 ( 3.9A) AKJ  A 601 (-4.1A) AKJ  A 601 (-3.8A) AKJ  A 601 ( 3.7A) AKJ  A 601 (-4.5A) AKJ  A 601 (-3.4A) AKJ  A 601 (-2.5A) AKJ  A 601 (-3.0A) AKJ  A 601 (-4.1A)	0.57A	undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XOM_A_CIOA603_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	1gtu	GLUTATHIONE S-TRANSFERASE (Homo sapiens)	5 / 12	TYR A 126 LEU A 165 ILE A 113 PHE A 119 PHE A 208	None	1.14A	21.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XOM_A_CIOA603_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	1soj	CGMP-INHIBITED 3',5'-CYCLIC PHOSPHODIESTERASE B (Homo sapiens)	7 / 12	TYR A 736 HIS A 737 ASP A 937 ILE A 955 PHE A 959 GLN A 988 PHE A 991	IBM  A2111 (-4.5A) IBM  A2111 ( 4.8A) MG  A2123 (-2.5A) IBM  A2111 (-4.2A) None IBM  A2111 (-3.3A) IBM  A2111 (-3.6A)	0.54A	31.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XOM_A_CIOA603_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	1zkl	HIGH-AFFINITY CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 7A (Homo sapiens)	6 / 12	TYR A 211 HIS A 212 ASP A 362 PHE A 384 GLN A 413 PHE A 416	IBM  A 503 (-4.6A) None ZN  A 501 (-2.5A) IBM  A 503 (-4.5A) IBM  A 503 (-3.0A) IBM  A 503 (-3.4A)	0.58A	33.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XOM_A_CIOA603_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	2qyk	CYCLIC AMP-SPECIFIC PHOSPHODIESTERASE HSPDE4A10 (Homo sapiens)	6 / 12	TYR A 371 ASP A 413 ILE A 548 MET A 549 PHE A 552 MET A 569	NPV  A   3 (-4.4A) MG  A   2 ( 2.6A) NPV  A   3 (-3.8A) NPV  A   3 ( 4.7A) NPV  A   3 (-4.8A) NPV  A   3 (-3.1A)	1.45A	82.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XOM_A_CIOA603_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	2qyk	CYCLIC AMP-SPECIFIC PHOSPHODIESTERASE HSPDE4A10 (Homo sapiens)	12 / 12	TYR A 371 HIS A 372 MET A 485 ASP A 530 LEU A 531 ILE A 548 MET A 549 PHE A 552 MET A 569 SER A 580 GLN A 581 PHE A 584	NPV  A   3 (-4.4A) NPV  A   3 (-4.6A) None ZN  A   1 (-2.5A) None NPV  A   3 (-3.8A) NPV  A   3 ( 4.7A) NPV  A   3 (-4.8A) NPV  A   3 (-3.1A) NPV  A   3 (-4.5A) NPV  A   3 (-3.1A) NPV  A   3 (-3.3A)	0.42A	82.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XOM_A_CIOA603_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	2qym	PHOSPHODIESTERASE 4C (Homo sapiens)	7 / 12	TYR A 281 HIS A 282 MET A 395 ASP A 440 LEU A 441 ILE A 458 PHE A 494	None None None ZN  A   1 (-2.5A) None None None	0.44A	82.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XOM_A_CIOA603_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	3b2r	CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE (Homo sapiens)	5 / 12	TYR A 612 HIS A 613 ASP A 764 LEU A 765 GLN A 775	VDN  A   1 (-4.8A) VDN  A   1 (-4.3A) None VDN  A   1 ( 4.7A) VDN  A   1 ( 4.4A)	1.00A	31.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XOM_A_CIOA603_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	3b2r	CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE (Homo sapiens)	7 / 12	TYR A 612 HIS A 613 ASP A 764 LEU A 765 PHE A 786 GLN A 817 PHE A 820	VDN  A   1 (-4.8A) VDN  A   1 (-4.3A) None VDN  A   1 ( 4.7A) None VDN  A   1 (-3.0A) VDN  A   1 (-3.6A)	0.65A	31.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XOM_A_CIOA603_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	3bjc	CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE (Homo sapiens)	5 / 12	TYR A 612 HIS A 613 ASP A 764 LEU A 765 GLN A 775	None MG  A 877 (-4.4A) ZN  A 876 (-2.5A) WAN  A 901 ( 4.7A) WAN  A 901 ( 4.6A)	0.89A	17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XOM_A_CIOA603_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	3bjc	CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE (Homo sapiens)	7 / 12	TYR A 612 HIS A 613 ASP A 764 LEU A 765 PHE A 786 GLN A 817 PHE A 820	None MG  A 877 (-4.4A) ZN  A 876 (-2.5A) WAN  A 901 ( 4.7A) WAN  A 901 (-4.8A) WAN  A 901 (-3.1A) WAN  A 901 (-3.7A)	0.66A	17.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XOM_A_CIOA603_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	3ecn	HIGH AFFINITY CAMP-SPECIFIC AND IBMX-INSENSITIVE 3',5'-CYCLIC PHOSPHODIESTERASE 8A (Homo sapiens)	8 / 12	TYR A 555 HIS A 556 MET A 670 ASP A 726 ILE A 744 SER A 777 GLN A 778 PHE A 781	None None IBM  A   3 (-4.5A) ZN  A   1 (-2.6A) IBM  A   3 (-4.3A) None IBM  A   3 (-3.4A) IBM  A   3 (-3.5A)	0.37A	33.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XOM_A_CIOA603_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	3g4g	CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D (Homo sapiens)	6 / 12	HIS A 330 MET A 439 LEU A 485 MET A 503 GLN A 535 PHE A 538	ZN  A 801 (-3.4A) D71  A 901 ( 4.0A) None D71  A 901 (-3.6A) D71  A 901 (-3.1A) D71  A 901 (-3.9A)	1.40A	81.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XOM_A_CIOA603_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	3g4g	CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D (Homo sapiens)	10 / 12	TYR A 325 HIS A 326 MET A 439 ASP A 484 LEU A 485 ILE A 502 MET A 503 PHE A 506 GLN A 535 PHE A 538	None D71  A 901 (-4.5A) D71  A 901 ( 4.0A) ZN  A 801 (-2.6A) None D71  A 901 (-4.1A) D71  A 901 (-3.6A) D71  A 901 (-4.8A) D71  A 901 (-3.1A) D71  A 901 (-3.9A)	0.62A	81.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XOM_A_CIOA603_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	3g4g	CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D (Homo sapiens)	10 / 12	TYR A 325 HIS A 326 MET A 439 ASP A 484 LEU A 485 ILE A 502 MET A 503 PHE A 506 SER A 534 PHE A 538	None D71  A 901 (-4.5A) D71  A 901 ( 4.0A) ZN  A 801 (-2.6A) None D71  A 901 (-4.1A) D71  A 901 (-3.6A) D71  A 901 (-4.8A) D71  A 901 (-3.4A) D71  A 901 (-3.9A)	0.80A	81.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XOM_A_CIOA603_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	3g4g	CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D (Homo sapiens)	5 / 12	TYR A 325 ILE A 502 MET A 503 MET A 523 GLN A 535	None D71  A 901 (-4.1A) D71  A 901 (-3.6A) D71  A 901 ( 4.0A) D71  A 901 (-3.1A)	0.74A	81.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XOM_A_CIOA603_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	3g4g	CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D (Homo sapiens)	5 / 12	TYR A 325 ILE A 502 MET A 503 MET A 523 SER A 534	None D71  A 901 (-4.1A) D71  A 901 (-3.6A) D71  A 901 ( 4.0A) D71  A 901 (-3.4A)	1.09A	81.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XOM_A_CIOA603_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	3h5c	PROTEIN Z-DEPENDENT PROTEASE INHIBITOR (Homo sapiens)	5 / 12	LEU A 362 ILE A 203 PHE A 174 MET A 172 PHE A 200	None	1.43A	22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XOM_A_CIOA603_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	3ibj	CGMP-DEPENDENT 3',5'-CYCLIC PHOSPHODIESTERASE (Homo sapiens)	7 / 12	TYR A 655 HIS A 656 ASP A 808 LEU A 809 ILE A 826 GLN A 859 PHE A 862	None None ZN  A   1 (-2.7A) None None None None	1.00A	18.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XOM_A_CIOA603_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	3n3z	HIGH AFFINITY CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 9A (Homo sapiens)	5 / 12	HIS A 252 MET A 365 ASP A 402 GLN A 453 PHE A 456	None None ZN  A 507 (-2.9A) IBM  A   1 (-3.5A) IBM  A   1 (-3.4A)	0.58A	30.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XOM_A_CIOA603_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	3o57	CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B (Homo sapiens)	12 / 12	TYR A 233 HIS A 234 MET A 347 ASP A 392 LEU A 393 ILE A 410 MET A 411 PHE A 414 MET A 431 SER A 442 GLN A 443 PHE A 446	None None ZG2  A 506 (-3.9A) ZN  A   1 (-2.6A) None ZG2  A 506 (-4.4A) None ZG2  A 506 (-4.4A) ZG2  A 506 (-3.4A) None ZG2  A 506 (-3.3A) ZG2  A 506 (-3.6A)	0.66A	82.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XOM_A_CIOA603_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	3sl5	CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D (Homo sapiens)	6 / 12	TYR A 159 ASP A 201 ILE A 336 MET A 337 PHE A 340 MET A 357	TYR  A 159 (-1.3A) ASP  A 201 ( 0.5A) ILE  A 336 ( 0.4A) MET  A 337 ( 0.0A) PHE  A 340 (-1.3A) MET  A 357 (-0.0A)	1.47A	94.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XOM_A_CIOA603_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	3sl5	CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D (Homo sapiens)	12 / 12	TYR A 159 HIS A 160 MET A 273 ASP A 318 LEU A 319 ILE A 336 MET A 337 PHE A 340 MET A 357 SER A 368 GLN A 369 PHE A 372	TYR  A 159 (-1.3A) HIS  A 160 ( 1.0A) MET  A 273 (-0.0A) ASP  A 318 (-0.5A) LEU  A 319 ( 0.6A) ILE  A 336 ( 0.4A) MET  A 337 ( 0.0A) PHE  A 340 (-1.3A) MET  A 357 (-0.0A) SER  A 368 (-0.0A) GLN  A 369 (-0.6A) PHE  A 372 (-1.3A)	0.57A	94.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XOM_A_CIOA603_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	3ui7	CAMP AND CAMP-INHIBITED CGMP 3',5'-CYCLIC PHOSPHODIESTERASE 10A (Homo sapiens)	8 / 12	TYR A 524 HIS A 525 ASP A 674 LEU A 675 ILE A 692 PHE A 696 GLN A 726 PHE A 729	C1L  A   1 ( 4.8A) C1L  A   1 (-4.1A) ZN  A 772 (-2.4A) C1L  A   1 (-4.3A) C1L  A   1 (-4.3A) C1L  A   1 ( 4.7A) C1L  A   1 (-2.9A) C1L  A   1 (-3.5A)	0.89A	28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XOM_A_CIOA603_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	3ui7	CAMP AND CAMP-INHIBITED CGMP 3',5'-CYCLIC PHOSPHODIESTERASE 10A (Homo sapiens)	5 / 12	TYR A 524 HIS A 525 LEU A 635 ILE A 692 PHE A 729	C1L  A   1 ( 4.8A) C1L  A   1 (-4.1A) None C1L  A   1 (-4.3A) C1L  A   1 (-3.5A)	1.45A	28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XOM_A_CIOA603_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	3ui7	CAMP AND CAMP-INHIBITED CGMP 3',5'-CYCLIC PHOSPHODIESTERASE 10A (Homo sapiens)	6 / 12	TYR A 524 LEU A 675 ILE A 692 MET A 713 GLN A 726 PHE A 729	C1L  A   1 ( 4.8A) C1L  A   1 (-4.3A) C1L  A   1 (-4.3A) C1L  A   1 (-3.7A) C1L  A   1 (-2.9A) C1L  A   1 (-3.5A)	1.26A	28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XOM_A_CIOA603_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	4dy0	GLIA-DERIVED NEXIN (Homo sapiens)	5 / 12	ASP A 284 LEU A 321 ILE A 155 PHE A 124 SER A 133	None	1.17A	23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XOM_A_CIOA603_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	4htz	CGMP-DEPENDENT 3',5'-CYCLIC PHOSPHODIESTERASE (Homo sapiens)	5 / 12	TYR A 655 ASP A 697 ILE A 826 PHE A 830 MET A 847	None MG  A1002 ( 2.6A) None None None	1.29A	28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XOM_A_CIOA603_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	4htz	CGMP-DEPENDENT 3',5'-CYCLIC PHOSPHODIESTERASE (Homo sapiens)	8 / 12	TYR A 655 ASP A 808 LEU A 809 ILE A 826 PHE A 830 MET A 847 GLN A 859 PHE A 862	None ZN  A1001 (-2.5A) None None None None None None	0.97A	28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XOM_A_CIOA603_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	4htz	CGMP-DEPENDENT 3',5'-CYCLIC PHOSPHODIESTERASE (Homo sapiens)	8 / 12	TYR A 655 HIS A 656 ASP A 808 LEU A 809 ILE A 826 PHE A 830 GLN A 859 PHE A 862	None None ZN  A1001 (-2.5A) None None None None None	0.67A	28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XOM_A_CIOA603_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	4md8	CASEIN KINASE II SUBUNIT ALPHA (Homo sapiens)	5 / 12	HIS E 154 LEU E  85 ILE E 174 MET E 163 PHE E 113	None	1.34A	21.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XOM_A_CIOA603_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	4wzi	CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B (Homo sapiens)	8 / 12	TYR A 405 HIS A 406 ILE A 582 MET A 583 PHE A 586 MET A 603 SER A 614 GLN A 615	None MG  A 804 ( 4.9A) None None None None None None	0.89A	48.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XOM_A_CIOA603_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	4wzi	CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B (Homo sapiens)	11 / 12	TYR A 405 HIS A 406 MET A 519 ASP A 564 LEU A 565 ILE A 582 MET A 583 PHE A 586 SER A 614 GLN A 615 PHE A 618	None MG  A 804 ( 4.9A) None ZN  A 801 (-2.5A) None None None None None None None	0.61A	48.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XOM_A_CIOA603_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	5b25	CALCIUM/CALMODULIN-D EPENDENT 3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 1B (Homo sapiens)	8 / 12	TYR A 222 HIS A 223 MET A 336 ASP A 370 PHE A 392 SER A 420 GLN A 421 PHE A 424	None 4QJ  A 603 ( 4.9A) 4QJ  A 603 ( 3.9A) ZN  A 601 (-2.5A) GOL  A 607 (-3.9A) 4QJ  A 603 (-4.7A) 4QJ  A 603 (-3.0A) 4QJ  A 603 (-3.5A)	0.56A	38.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XOM_A_CIOA603_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	5in7	NEURONAL MIGRATION PROTEIN DOUBLECORTIN (Homo sapiens)	5 / 12	ASP A 167 LEU A 164 ILE A 149 SER A 205 PHE A 138	None	1.38A	15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XOM_A_CIOA603_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	5mov	CASEIN KINASE II SUBUNIT ALPHA (Homo sapiens)	5 / 12	HIS A 154 LEU A  85 ILE A 174 MET A 163 PHE A 113	None None HC4  A 401 ( 3.7A) HC4  A 401 ( 4.0A) HC4  A 401 (-3.4A)	1.44A	22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XOM_A_CIOA603_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	5ohj	CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B (Homo sapiens)	6 / 12	TYR A 405 ASP A 447 ILE A 582 MET A 583 PHE A 586 MET A 603	None MG  A 700 ( 2.7A) 9VE  A 801 (-4.1A) 9VE  A 801 ( 4.0A) 9VE  A 801 (-3.6A) 9VE  A 801 (-3.6A)	1.41A	11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XOM_A_CIOA603_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	5ohj	CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B (Homo sapiens)	11 / 12	TYR A 405 HIS A 406 MET A 519 ASP A 564 LEU A 565 ILE A 582 MET A 583 PHE A 586 MET A 603 GLN A 615 PHE A 618	None None 9VE  A 801 (-3.8A) ZN  A 699 ( 2.6A) 9VE  A 801 (-4.7A) 9VE  A 801 (-4.1A) 9VE  A 801 ( 4.0A) 9VE  A 801 (-3.6A) 9VE  A 801 (-3.6A) 9VE  A 801 (-3.2A) 9VE  A 801 (-3.9A)	0.59A	11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XOM_A_CIOA603_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	5ohj	CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B (Homo sapiens)	11 / 12	TYR A 405 HIS A 406 MET A 519 ASP A 564 LEU A 565 ILE A 582 MET A 583 PHE A 586 SER A 614 GLN A 615 PHE A 618	None None 9VE  A 801 (-3.8A) ZN  A 699 ( 2.6A) 9VE  A 801 (-4.7A) 9VE  A 801 (-4.1A) 9VE  A 801 ( 4.0A) 9VE  A 801 (-3.6A) 9VE  A 801 (-4.7A) 9VE  A 801 (-3.2A) 9VE  A 801 (-3.9A)	0.27A	11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XOM_A_CIOA603_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	5wh6	CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D (Homo sapiens)	6 / 12	TYR A 159 ASP A 201 ILE A 336 MET A 337 PHE A 340 MET A 357	AKJ  A 601 ( 4.7A) MG  A 603 ( 2.6A) AKJ  A 601 (-3.8A) AKJ  A 601 ( 3.7A) AKJ  A 601 (-4.5A) AKJ  A 601 (-3.4A)	1.46A	undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XOM_A_CIOA603_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	5wh6	CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D (Homo sapiens)	10 / 12	TYR A 159 HIS A 160 ASP A 318 LEU A 319 ILE A 336 MET A 337 PHE A 340 MET A 357 SER A 368 GLN A 369	AKJ  A 601 ( 4.7A) None ZN  A 602 (-2.5A) AKJ  A 601 ( 4.6A) AKJ  A 601 (-3.8A) AKJ  A 601 ( 3.7A) AKJ  A 601 (-4.5A) AKJ  A 601 (-3.4A) AKJ  A 601 (-2.5A) AKJ  A 601 (-3.0A)	0.49A	undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XOM_A_CIOA603_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	5wh6	CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D (Homo sapiens)	11 / 12	TYR A 159 HIS A 160 MET A 273 ASP A 318 LEU A 319 ILE A 336 MET A 337 PHE A 340 MET A 357 GLN A 369 PHE A 372	AKJ  A 601 ( 4.7A) None AKJ  A 601 ( 3.9A) ZN  A 602 (-2.5A) AKJ  A 601 ( 4.6A) AKJ  A 601 (-3.8A) AKJ  A 601 ( 3.7A) AKJ  A 601 (-4.5A) AKJ  A 601 (-3.4A) AKJ  A 601 (-3.0A) AKJ  A 601 (-4.1A)	0.25A	undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XOM_B_CIOB601_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	1gtu	GLUTATHIONE S-TRANSFERASE (Homo sapiens)	5 / 12	TYR A 126 LEU A 165 ILE A 113 PHE A 119 PHE A 208	None	1.14A	21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XOM_B_CIOB601_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	1qbg	NAD(P)H DEHYDROGENASE [QUINONE] 1 (Homo sapiens)	5 / 12	THR A 148 ILE A 192 PHE A  17 MET A  21 SER A 145	FAD  A 501 (-3.9A) FAD  A 501 (-4.5A) FAD  A 501 (-4.9A) None None	1.10A	20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XOM_B_CIOB601_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	1r55	ADAM 33 (Homo sapiens)	5 / 12	MET A 319 LEU A 405 THR A 250 MET A 373 SER A 389	None	1.45A	17.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XOM_B_CIOB601_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	1soj	CGMP-INHIBITED 3',5'-CYCLIC PHOSPHODIESTERASE B (Homo sapiens)	7 / 12	TYR A 736 HIS A 737 THR A 952 ILE A 955 PHE A 959 GLN A 988 PHE A 991	IBM  A2111 (-4.5A) IBM  A2111 ( 4.8A) IBM  A2111 ( 4.8A) IBM  A2111 (-4.2A) None IBM  A2111 (-3.3A) IBM  A2111 (-3.6A)	0.54A	31.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XOM_B_CIOB601_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	1zkl	HIGH-AFFINITY CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 7A (Homo sapiens)	5 / 12	TYR A 211 HIS A 212 PHE A 384 GLN A 413 PHE A 416	IBM  A 503 (-4.6A) None IBM  A 503 (-4.5A) IBM  A 503 (-3.0A) IBM  A 503 (-3.4A)	0.61A	33.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XOM_B_CIOB601_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	2h18	ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 8A (Homo sapiens)	5 / 12	LEU A 128 THR A  24 ILE A  67 MET A  21 SER A  90	None	1.20A	24.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XOM_B_CIOB601_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	2qyk	CYCLIC AMP-SPECIFIC PHOSPHODIESTERASE HSPDE4A10 (Homo sapiens)	12 / 12	TYR A 371 HIS A 372 MET A 485 LEU A 531 THR A 545 ILE A 548 MET A 549 PHE A 552 MET A 569 SER A 580 GLN A 581 PHE A 584	NPV  A   3 (-4.4A) NPV  A   3 (-4.6A) None None NPV  A   3 ( 4.7A) NPV  A   3 (-3.8A) NPV  A   3 ( 4.7A) NPV  A   3 (-4.8A) NPV  A   3 (-3.1A) NPV  A   3 (-4.5A) NPV  A   3 (-3.1A) NPV  A   3 (-3.3A)	0.43A	82.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XOM_B_CIOB601_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	2qyk	CYCLIC AMP-SPECIFIC PHOSPHODIESTERASE HSPDE4A10 (Homo sapiens)	7 / 12	TYR A 371 HIS A 376 MET A 485 THR A 545 SER A 580 GLN A 581 PHE A 584	NPV  A   3 (-4.4A) ZN  A   1 (-3.3A) None NPV  A   3 ( 4.7A) NPV  A   3 (-4.5A) NPV  A   3 (-3.1A) NPV  A   3 (-3.3A)	1.48A	82.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XOM_B_CIOB601_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	2qym	PHOSPHODIESTERASE 4C (Homo sapiens)	7 / 12	TYR A 281 HIS A 282 MET A 395 LEU A 441 THR A 455 ILE A 458 PHE A 494	None	0.46A	82.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XOM_B_CIOB601_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	3b2r	CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE (Homo sapiens)	6 / 12	TYR A 612 HIS A 613 LEU A 765 PHE A 786 GLN A 817 PHE A 820	VDN  A   1 (-4.8A) VDN  A   1 (-4.3A) VDN  A   1 ( 4.7A) None VDN  A   1 (-3.0A) VDN  A   1 (-3.6A)	0.68A	31.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XOM_B_CIOB601_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	3bjc	CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE (Homo sapiens)	6 / 12	TYR A 612 HIS A 613 LEU A 765 PHE A 786 GLN A 817 PHE A 820	None MG  A 877 (-4.4A) WAN  A 901 ( 4.7A) WAN  A 901 (-4.8A) WAN  A 901 (-3.1A) WAN  A 901 (-3.7A)	0.71A	17.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XOM_B_CIOB601_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	3ecn	HIGH AFFINITY CAMP-SPECIFIC AND IBMX-INSENSITIVE 3',5'-CYCLIC PHOSPHODIESTERASE 8A (Homo sapiens)	7 / 12	TYR A 555 HIS A 556 MET A 670 ILE A 744 SER A 777 GLN A 778 PHE A 781	None None IBM  A   3 (-4.5A) IBM  A   3 (-4.3A) None IBM  A   3 (-3.4A) IBM  A   3 (-3.5A)	0.41A	33.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XOM_B_CIOB601_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	3g4g	CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D (Homo sapiens)	9 / 12	TYR A 325 HIS A 326 MET A 439 LEU A 485 ILE A 502 MET A 503 PHE A 506 SER A 534 PHE A 538	None D71  A 901 (-4.5A) D71  A 901 ( 4.0A) None D71  A 901 (-4.1A) D71  A 901 (-3.6A) D71  A 901 (-4.8A) D71  A 901 (-3.4A) D71  A 901 (-3.9A)	0.88A	81.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XOM_B_CIOB601_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	3g4g	CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D (Homo sapiens)	10 / 12	TYR A 325 HIS A 326 MET A 439 LEU A 485 THR A 499 ILE A 502 MET A 503 PHE A 506 GLN A 535 PHE A 538	None D71  A 901 (-4.5A) D71  A 901 ( 4.0A) None D71  A 901 (-3.6A) D71  A 901 (-4.1A) D71  A 901 (-3.6A) D71  A 901 (-4.8A) D71  A 901 (-3.1A) D71  A 901 (-3.9A)	0.66A	81.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XOM_B_CIOB601_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	3g4g	CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D (Homo sapiens)	6 / 12	TYR A 325 ILE A 502 MET A 503 MET A 523 SER A 534 PHE A 538	None D71  A 901 (-4.1A) D71  A 901 (-3.6A) D71  A 901 ( 4.0A) D71  A 901 (-3.4A) D71  A 901 (-3.9A)	1.02A	81.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XOM_B_CIOB601_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	3g4g	CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D (Homo sapiens)	7 / 12	TYR A 325 THR A 499 ILE A 502 MET A 503 MET A 523 GLN A 535 PHE A 538	None D71  A 901 (-3.6A) D71  A 901 (-4.1A) D71  A 901 (-3.6A) D71  A 901 ( 4.0A) D71  A 901 (-3.1A) D71  A 901 (-3.9A)	0.70A	81.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XOM_B_CIOB601_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	3h5c	PROTEIN Z-DEPENDENT PROTEASE INHIBITOR (Homo sapiens)	5 / 12	LEU A 362 ILE A 203 PHE A 174 MET A 172 PHE A 200	None	1.44A	22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XOM_B_CIOB601_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	3hoc	FILAMIN-A (Homo sapiens)	5 / 12	LEU A 172 THR A 186 ILE A 185 SER A 189 PHE A 188	None	1.33A	23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XOM_B_CIOB601_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	3ibj	CGMP-DEPENDENT 3',5'-CYCLIC PHOSPHODIESTERASE (Homo sapiens)	6 / 12	TYR A 655 HIS A 656 LEU A 809 ILE A 826 GLN A 859 PHE A 862	None	1.04A	18.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XOM_B_CIOB601_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	3o57	CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B (Homo sapiens)	11 / 12	TYR A 233 HIS A 234 MET A 347 LEU A 393 THR A 407 ILE A 410 MET A 411 MET A 431 SER A 442 GLN A 443 PHE A 446	None None ZG2  A 506 (-3.9A) None ZG2  A 506 (-4.3A) ZG2  A 506 (-4.4A) None ZG2  A 506 (-3.4A) None ZG2  A 506 (-3.3A) ZG2  A 506 (-3.6A)	0.64A	82.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XOM_B_CIOB601_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	3o57	CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B (Homo sapiens)	11 / 12	TYR A 233 HIS A 234 MET A 347 LEU A 393 THR A 407 ILE A 410 MET A 411 PHE A 414 SER A 442 GLN A 443 PHE A 446	None None ZG2  A 506 (-3.9A) None ZG2  A 506 (-4.3A) ZG2  A 506 (-4.4A) None ZG2  A 506 (-4.4A) None ZG2  A 506 (-3.3A) ZG2  A 506 (-3.6A)	0.59A	82.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XOM_B_CIOB601_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	3sl5	CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D (Homo sapiens)	12 / 12	TYR A 159 HIS A 160 MET A 273 LEU A 319 THR A 333 ILE A 336 MET A 337 PHE A 340 MET A 357 SER A 368 GLN A 369 PHE A 372	TYR  A 159 (-1.3A) HIS  A 160 ( 1.0A) MET  A 273 (-0.0A) LEU  A 319 ( 0.6A) THR  A 333 ( 0.8A) ILE  A 336 ( 0.4A) MET  A 337 ( 0.0A) PHE  A 340 (-1.3A) MET  A 357 (-0.0A) SER  A 368 (-0.0A) GLN  A 369 (-0.6A) PHE  A 372 (-1.3A)	0.59A	94.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XOM_B_CIOB601_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	3ui7	CAMP AND CAMP-INHIBITED CGMP 3',5'-CYCLIC PHOSPHODIESTERASE 10A (Homo sapiens)	5 / 12	TYR A 524 HIS A 525 LEU A 635 ILE A 692 PHE A 729	C1L  A   1 ( 4.8A) C1L  A   1 (-4.1A) None C1L  A   1 (-4.3A) C1L  A   1 (-3.5A)	1.47A	28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XOM_B_CIOB601_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	3ui7	CAMP AND CAMP-INHIBITED CGMP 3',5'-CYCLIC PHOSPHODIESTERASE 10A (Homo sapiens)	7 / 12	TYR A 524 HIS A 525 LEU A 675 ILE A 692 PHE A 696 GLN A 726 PHE A 729	C1L  A   1 ( 4.8A) C1L  A   1 (-4.1A) C1L  A   1 (-4.3A) C1L  A   1 (-4.3A) C1L  A   1 ( 4.7A) C1L  A   1 (-2.9A) C1L  A   1 (-3.5A)	0.93A	28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XOM_B_CIOB601_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	3ui7	CAMP AND CAMP-INHIBITED CGMP 3',5'-CYCLIC PHOSPHODIESTERASE 10A (Homo sapiens)	6 / 12	TYR A 524 LEU A 675 ILE A 692 MET A 713 GLN A 726 PHE A 729	C1L  A   1 ( 4.8A) C1L  A   1 (-4.3A) C1L  A   1 (-4.3A) C1L  A   1 (-3.7A) C1L  A   1 (-2.9A) C1L  A   1 (-3.5A)	1.25A	28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XOM_B_CIOB601_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	4htz	CGMP-DEPENDENT 3',5'-CYCLIC PHOSPHODIESTERASE (Homo sapiens)	7 / 12	TYR A 655 HIS A 656 LEU A 809 ILE A 826 PHE A 830 GLN A 859 PHE A 862	None	0.67A	28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XOM_B_CIOB601_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	4htz	CGMP-DEPENDENT 3',5'-CYCLIC PHOSPHODIESTERASE (Homo sapiens)	7 / 12	TYR A 655 LEU A 809 ILE A 826 PHE A 830 MET A 847 GLN A 859 PHE A 862	None	0.92A	28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XOM_B_CIOB601_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	4md8	CASEIN KINASE II SUBUNIT ALPHA (Homo sapiens)	5 / 12	HIS E 154 LEU E  85 ILE E 174 MET E 163 PHE E 113	None	1.33A	21.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XOM_B_CIOB601_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	4wzi	CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B (Homo sapiens)	11 / 12	TYR A 405 HIS A 406 MET A 519 LEU A 565 THR A 579 ILE A 582 MET A 583 PHE A 586 SER A 614 GLN A 615 PHE A 618	None MG  A 804 ( 4.9A) None None None None None None None None None	0.62A	48.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XOM_B_CIOB601_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	4wzi	CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B (Homo sapiens)	9 / 12	TYR A 405 HIS A 406 THR A 579 ILE A 582 MET A 583 PHE A 586 MET A 603 SER A 614 GLN A 615	None MG  A 804 ( 4.9A) None None None None None None None	0.84A	48.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XOM_B_CIOB601_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	4wzi	CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B (Homo sapiens)	7 / 12	TYR A 405 HIS A 410 MET A 519 LEU A 565 THR A 579 GLN A 615 PHE A 618	None ZN  A 801 (-3.2A) None None None None None	1.45A	48.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1XOM_B_CIOB601_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	5b25	CALCIUM/CALMODULIN-D EPENDENT 3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 1B (Homo sapiens)	8 / 12	TYR A 222 HIS A 223 MET A 336 THR A 385 PHE A 392 SER A 420 GLN A 421 PHE A 424	None 4QJ  A 603 ( 4.9A) 4QJ  A 603 ( 3.9A) None GOL  A 607 (-3.9A) 4QJ  A 603 (-4.7A) 4QJ  A 603 (-3.0A) 4QJ  A 603 (-3.5A)	0.62A	38.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XOM_B_CIOB601_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	5mov	CASEIN KINASE II SUBUNIT ALPHA (Homo sapiens)	5 / 12	HIS A 154 LEU A  85 ILE A 174 MET A 163 PHE A 113	None None HC4  A 401 ( 3.7A) HC4  A 401 ( 4.0A) HC4  A 401 (-3.4A)	1.43A	22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XOM_B_CIOB601_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	5ohj	CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B (Homo sapiens)	11 / 12	TYR A 405 HIS A 406 MET A 519 LEU A 565 THR A 579 ILE A 582 MET A 583 PHE A 586 MET A 603 GLN A 615 PHE A 618	None None 9VE  A 801 (-3.8A) 9VE  A 801 (-4.7A) 9VE  A 801 (-4.1A) 9VE  A 801 (-4.1A) 9VE  A 801 ( 4.0A) 9VE  A 801 (-3.6A) 9VE  A 801 (-3.6A) 9VE  A 801 (-3.2A) 9VE  A 801 (-3.9A)	0.58A	11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XOM_B_CIOB601_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	5ohj	CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B (Homo sapiens)	11 / 12	TYR A 405 HIS A 406 MET A 519 LEU A 565 THR A 579 ILE A 582 MET A 583 PHE A 586 SER A 614 GLN A 615 PHE A 618	None None 9VE  A 801 (-3.8A) 9VE  A 801 (-4.7A) 9VE  A 801 (-4.1A) 9VE  A 801 (-4.1A) 9VE  A 801 ( 4.0A) 9VE  A 801 (-3.6A) 9VE  A 801 (-4.7A) 9VE  A 801 (-3.2A) 9VE  A 801 (-3.9A)	0.29A	11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XOM_B_CIOB601_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	5ohj	CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B (Homo sapiens)	7 / 12	TYR A 405 HIS A 410 MET A 519 LEU A 565 THR A 579 GLN A 615 PHE A 618	None ZN  A 699 (-3.3A) 9VE  A 801 (-3.8A) 9VE  A 801 (-4.7A) 9VE  A 801 (-4.1A) 9VE  A 801 (-3.2A) 9VE  A 801 (-3.9A)	1.47A	11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XOM_B_CIOB601_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	5wh6	CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D (Homo sapiens)	10 / 12	TYR A 159 HIS A 160 LEU A 319 THR A 333 ILE A 336 MET A 337 PHE A 340 MET A 357 SER A 368 GLN A 369	AKJ  A 601 ( 4.7A) None AKJ  A 601 ( 4.6A) AKJ  A 601 (-4.1A) AKJ  A 601 (-3.8A) AKJ  A 601 ( 3.7A) AKJ  A 601 (-4.5A) AKJ  A 601 (-3.4A) AKJ  A 601 (-2.5A) AKJ  A 601 (-3.0A)	0.46A	undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XOM_B_CIOB601_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	5wh6	CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D (Homo sapiens)	11 / 12	TYR A 159 HIS A 160 MET A 273 LEU A 319 THR A 333 ILE A 336 MET A 337 PHE A 340 MET A 357 GLN A 369 PHE A 372	AKJ  A 601 ( 4.7A) None AKJ  A 601 ( 3.9A) AKJ  A 601 ( 4.6A) AKJ  A 601 (-4.1A) AKJ  A 601 (-3.8A) AKJ  A 601 ( 3.7A) AKJ  A 601 (-4.5A) AKJ  A 601 (-3.4A) AKJ  A 601 (-3.0A) AKJ  A 601 (-4.1A)	0.25A	undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XOM_B_CIOB601_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	5wh6	CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D (Homo sapiens)	7 / 12	TYR A 159 HIS A 164 MET A 273 LEU A 319 THR A 333 GLN A 369 PHE A 372	AKJ  A 601 ( 4.7A) ZN  A 602 (-3.3A) AKJ  A 601 ( 3.9A) AKJ  A 601 ( 4.6A) AKJ  A 601 (-4.1A) AKJ  A 601 (-3.0A) AKJ  A 601 (-4.1A)	1.49A	undetectable