POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ITU_A_CILA451_1
(RENAL DIPEPTIDASE)		1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens)		5 / 12GLU A 425
HIS A 553
HIS A 377
ASN A 519
ASP A 453
 ZN  A1752 (-2.5A)
ZN  A1752 (-3.3A)
ZN  A1751 (-3.3A)
ZN  A1751 (-3.7A)
ZN  A1751 (-2.0A)
1.48A21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ITU_A_CILA451_1
(RENAL DIPEPTIDASE)		2adu METHIONINE
AMINOPEPTIDASE 2
(Homo
sapiens)		5 / 12ASP A 251
HIS A 331
HIS A 339
TYR A 444
PRO A 220
 CO  A 501 ( 1.9A)
CO  A 502 ( 3.2A)
R20  A 906 (-4.0A)
R20  A 906 (-3.5A)
None
1.44A21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ITU_A_CILA451_1
(RENAL DIPEPTIDASE)		2y1h PUTATIVE
DEOXYRIBONUCLEASE
TATDN3
(Homo
sapiens)		5 / 12GLU A 107
HIS A  70
HIS A 147
HIS A 170
ASP A 218
 ZN  A1274 (-2.4A)
PO4  A1275 (-3.8A)
ZN  A1273 ( 3.1A)
ZN  A1273 (-3.2A)
PO4  A1275 ( 2.7A)
1.00A22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ITU_B_CILB452_1
(RENAL DIPEPTIDASE)		2adu METHIONINE
AMINOPEPTIDASE 2
(Homo
sapiens)		5 / 12ASP A 251
HIS A 331
HIS A 339
TYR A 444
PRO A 220
 CO  A 501 ( 1.9A)
CO  A 502 ( 3.2A)
R20  A 906 (-4.0A)
R20  A 906 (-3.5A)
None
1.42A21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ITU_B_CILB452_1
(RENAL DIPEPTIDASE)		2y1h PUTATIVE
DEOXYRIBONUCLEASE
TATDN3
(Homo
sapiens)		5 / 12GLU A 107
HIS A  70
HIS A 147
HIS A 170
ASP A 218
 ZN  A1274 (-2.4A)
PO4  A1275 (-3.8A)
ZN  A1273 ( 3.1A)
ZN  A1273 (-3.2A)
PO4  A1275 ( 2.7A)
1.02A22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ITU_B_CILB452_1
(RENAL DIPEPTIDASE)		3ecn HIGH AFFINITY
CAMP-SPECIFIC AND
IBMX-INSENSITIVE
3',5'-CYCLIC
PHOSPHODIESTERASE 8A
(Homo
sapiens)		5 / 12ASP A 482
GLU A 535
TYR A 516
VAL A 484
PRO A 485
None
1.17A20.46