POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens)		7 / 11TYR A 211
VAL A 380
PHE A 384
LEU A 401
ILE A 409
GLN A 413
PHE A 416
IBM  A 503 (-4.6A)
IBM  A 503 (-4.7A)
IBM  A 503 (-4.5A)
None
None
IBM  A 503 (-3.0A)
IBM  A 503 (-3.4A)
0.88A28.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		2i3b HUMAN CANCER-RELATED
NTPASE
(Homo
sapiens)		5 / 11ILE A 138
VAL A   4
PHE A 166
LEU A 176
ILE A  18
None
1.17A19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		2xio PUTATIVE
DEOXYRIBONUCLEASE
TATDN1
(Homo
sapiens)		5 / 11SER A 214
VAL A 273
ALA A 272
LEU A 281
PHE A 195
None
1.12A21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		2y25 MYOMESIN
(Homo
sapiens)		5 / 11SER A1657
ILE A1584
VAL A1582
LEU A1578
PHE A1631
None
1.24A21.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens)		9 / 11TYR A 612
ILE A 778
VAL A 782
ALA A 783
PHE A 786
ILE A 813
MET A 816
GLN A 817
PHE A 820
VDN  A   1 (-4.8A)
None
VDN  A   1 ( 4.7A)
VDN  A   1 ( 4.0A)
None
VDN  A   1 ( 4.2A)
VDN  A   1 (-4.0A)
VDN  A   1 (-3.0A)
VDN  A   1 (-3.6A)
0.74A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens)		9 / 11TYR A 612
ILE A 778
VAL A 782
ALA A 783
PHE A 786
ILE A 813
MET A 816
GLN A 817
PHE A 820
None
None
WAN  A 901 ( 4.9A)
WAN  A 901 (-3.6A)
WAN  A 901 (-4.8A)
WAN  A 901 ( 4.3A)
WAN  A 901 (-4.3A)
WAN  A 901 (-3.1A)
WAN  A 901 (-3.7A)
0.65A100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		3ezq PROTEIN FADD
TUMOR NECROSIS
FACTOR RECEPTOR
SUPERFAMILY MEMBER 6
(Homo
sapiens)		5 / 11TYR A 232
ILE A 236
VAL B 103
ALA B 100
LEU B 165
None
1.23A19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		4dpg LYSINE--TRNA LIGASE
(Homo
sapiens)		5 / 11ILE A 564
ALA A 555
PHE A 557
ILE A 551
MET A 549
None
1.26A19.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens)		6 / 11TYR A 655
ILE A 822
PHE A 830
ILE A 855
GLN A 859
PHE A 862
None
0.68A35.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		4q9z HUMAN PROTEIN KINASE
C THETA
(Homo
sapiens)		5 / 11SER A 433
ILE A 518
ALA A 521
LEU A 432
MET A 458
None
None
PZW  A 801 ( 4.6A)
None
PZW  A 801 (-4.4A)
1.13A21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		5b25 CALCIUM/CALMODULIN-D
EPENDENT
3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 1B
(Homo
sapiens)		5 / 11TYR A 222
PHE A 392
LEU A 409
GLN A 421
PHE A 424
None
GOL  A 607 (-3.9A)
GOL  A 607 (-4.6A)
4QJ  A 603 (-3.0A)
4QJ  A 603 (-3.5A)
1.05A28.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		5dpt PLECKSTRIN HOMOLOGY
DOMAIN-CONTAINING
FAMILY M MEMBER 1,
GAMMA-AMINOBUTYRIC
ACID
RECEPTOR-ASSOCIATED
PROTEIN-LIKE
1,GAMMA-AMINOBUTYRIC
ACID
RECEPTOR-ASSOCIATED
PROTEIN-LIKE 1
(Homo
sapiens)		5 / 11ILE A  39
VAL A 114
ALA A 115
PHE A  85
LEU A  83
None
1.18A16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		5ivw GENERAL
TRANSCRIPTION FACTOR
IIH SUBUNIT 3
(Homo
sapiens)		5 / 11SER 3  35
ILE 3  60
VAL 3  15
LEU 3  34
MET 3 119
None
1.28A21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		5u7z ACID CERAMIDASE
(Homo
sapiens)		5 / 11TYR B 233
ILE B 236
ALA B 277
ILE B 249
PHE A 136
None
1.21A12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_A_CIAA1003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		5x68 KYNURENINE
3-MONOOXYGENASE
(Homo
sapiens)		5 / 11ILE A 215
ALA A 225
LEU A 197
ILE A 199
PHE A 261
None
1.27A14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens)		6 / 12TYR A 211
VAL A 380
PHE A 384
LEU A 401
GLN A 413
PHE A 416
IBM  A 503 (-4.6A)
IBM  A 503 (-4.7A)
IBM  A 503 (-4.5A)
None
IBM  A 503 (-3.0A)
IBM  A 503 (-3.4A)
0.73A28.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		2bzn GMP REDUCTASE 2
(Homo
sapiens)		5 / 12ILE A 305
VAL A 228
ALA A 229
PHE A 232
LEU A 324
None
0.96A21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		2cpe RNA-BINDING PROTEIN
EWS
(Homo
sapiens)		5 / 12ALA A 426
ILE A 363
VAL A 365
ALA A 413
PHE A 380
None
0.92A17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		2l29 INSULIN-LIKE GROWTH
FACTOR 2 RECEPTOR
VARIANT
(Homo
sapiens)		5 / 12TYR A1606
GLN A1569
ILE A1572
VAL A1574
ALA A1565
None
1.02A16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		2r15 MYOMESIN-1
(Homo
sapiens)		5 / 12ILE A1633
ILE A1584
VAL A1582
LEU A1578
PHE A1631
None
1.07A21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		2y25 MYOMESIN
(Homo
sapiens)		5 / 12ILE A1633
ILE A1584
VAL A1582
LEU A1578
PHE A1631
None
1.02A21.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens)		11 / 12TYR A 612
ALA A 767
ILE A 768
GLN A 775
ILE A 778
VAL A 782
ALA A 783
PHE A 786
MET A 816
GLN A 817
PHE A 820
VDN  A   1 (-4.8A)
VDN  A   1 ( 3.8A)
VDN  A   1 (-4.5A)
VDN  A   1 ( 4.4A)
None
VDN  A   1 ( 4.7A)
VDN  A   1 ( 4.0A)
None
VDN  A   1 (-4.0A)
VDN  A   1 (-3.0A)
VDN  A   1 (-3.6A)
0.60A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens)		11 / 12TYR A 612
ALA A 767
ILE A 768
GLN A 775
ILE A 778
VAL A 782
ALA A 783
PHE A 786
MET A 816
GLN A 817
PHE A 820
None
WAN  A 901 ( 3.9A)
WAN  A 901 ( 4.9A)
WAN  A 901 ( 4.6A)
None
WAN  A 901 ( 4.9A)
WAN  A 901 (-3.6A)
WAN  A 901 (-4.8A)
WAN  A 901 (-4.3A)
WAN  A 901 (-3.1A)
WAN  A 901 (-3.7A)
0.63A100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens)		5 / 12TYR A 655
ILE A 822
PHE A 830
GLN A 859
PHE A 862
None
0.68A35.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens)		5 / 12ALA A 190
ILE A 194
GLN A 309
ILE A 174
LEU A 239
None
1.01A18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		4uz1 NOTUM
(Homo
sapiens)		5 / 12ALA A 290
ILE A 291
ILE A 283
ALA A 342
PHE A 320
None
0.99A18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		5b25 CALCIUM/CALMODULIN-D
EPENDENT
3',5'-CYCLIC
NUCLEOTIDE
PHOSPHODIESTERASE 1B
(Homo
sapiens)		5 / 12TYR A 222
PHE A 392
LEU A 409
GLN A 421
PHE A 424
None
GOL  A 607 (-3.9A)
GOL  A 607 (-4.6A)
4QJ  A 603 (-3.0A)
4QJ  A 603 (-3.5A)
1.01A28.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2
(Homo
sapiens)		5 / 12ALA A 257
ILE A 262
ALA A 242
LEU A 208
PHE A 120
None
1.05A21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		5w4b ADENOSYLHOMOCYSTEINA
SE
(Homo
sapiens)		5 / 12ALA A 177
ILE A 178
ILE A 153
LEU A  63
GLN A 369
None
0.92A21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		1mox EPIDERMAL GROWTH
FACTOR RECEPTOR
(Homo
sapiens)		5 / 12ALA A 448
ILE A 451
ILE A 439
VAL A 437
ILE A 402
None
1.11A20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		1r6u TRYPTOPHANYL-TRNA
SYNTHETASE
(Homo
sapiens)		5 / 12ALA A 285
ILE A 254
VAL A 258
ILE A 278
PHE A 267
None
0.99A22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens)		6 / 12TYR A 211
VAL A 380
PHE A 384
ILE A 409
GLN A 413
PHE A 416
IBM  A 503 (-4.6A)
IBM  A 503 (-4.7A)
IBM  A 503 (-4.5A)
None
IBM  A 503 (-3.0A)
IBM  A 503 (-3.4A)
0.82A29.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A
(Homo
sapiens)		6 / 12TYR A 211
VAL A 380
PHE A 384
LEU A 401
GLN A 413
PHE A 416
IBM  A 503 (-4.6A)
IBM  A 503 (-4.7A)
IBM  A 503 (-4.5A)
None
IBM  A 503 (-3.0A)
IBM  A 503 (-3.4A)
0.87A29.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		2i3b HUMAN CANCER-RELATED
NTPASE
(Homo
sapiens)		5 / 12ILE A 138
VAL A   4
PHE A 166
LEU A 176
ILE A  18
None
1.05A17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		2j6l ALDEHYDE
DEHYDROGENASE FAMILY
7 MEMBER A1
(Homo
sapiens)		5 / 12ALA A 130
ILE A 126
ILE A 183
LEU A 267
ILE A 163
None
1.08A20.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens)		11 / 12TYR A 612
ALA A 767
ILE A 768
GLN A 775
ILE A 778
VAL A 782
PHE A 786
ILE A 813
MET A 816
GLN A 817
PHE A 820
VDN  A   1 (-4.8A)
VDN  A   1 ( 3.8A)
VDN  A   1 (-4.5A)
VDN  A   1 ( 4.4A)
None
VDN  A   1 ( 4.7A)
None
VDN  A   1 ( 4.2A)
VDN  A   1 (-4.0A)
VDN  A   1 (-3.0A)
VDN  A   1 (-3.6A)
0.53A94.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens)		11 / 12TYR A 612
ALA A 767
ILE A 768
GLN A 775
ILE A 778
VAL A 782
PHE A 786
ILE A 813
MET A 816
GLN A 817
PHE A 820
None
WAN  A 901 ( 3.9A)
WAN  A 901 ( 4.9A)
WAN  A 901 ( 4.6A)
None
WAN  A 901 ( 4.9A)
WAN  A 901 (-4.8A)
WAN  A 901 ( 4.3A)
WAN  A 901 (-4.3A)
WAN  A 901 (-3.1A)
WAN  A 901 (-3.7A)
0.68A46.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens)		5 / 12TYR A 655
ILE A 822
ILE A 855
GLN A 859
PHE A 862
None
0.86A22.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens)		5 / 12TYR A 655
ILE A 822
PHE A 830
ILE A 855
GLN A 859
None
0.73A34.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		4htz CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE
(Homo
sapiens)		5 / 12TYR A 655
PHE A 830
ILE A 855
GLN A 859
PHE A 862
None
0.40A34.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		4hwi HEAT SHOCK COGNATE
71 KDA PROTEIN
(Homo
sapiens)		5 / 12ILE A 334
ILE A 209
VAL A 207
PHE A 205
LEU A 200
None
1.11A22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		4i6f SERINE/THREONINE-PRO
TEIN KINASE PLK2
(Homo
sapiens)		5 / 12ALA A 307
ILE A 311
VAL A 182
LEU A 208
ILE A 189
None
0.93A23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		4jmk DUAL SPECIFICITY
PROTEIN PHOSPHATASE
8
(Homo
sapiens)		5 / 12ALA A 248
ILE A 250
PHE A 289
LEU A 221
ILE A 258
SO4  A 501 (-3.8A)
SO4  A 501 (-4.6A)
None
None
None
1.06A18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens)		5 / 12ALA A 190
ILE A 194
GLN A 309
ILE A 174
LEU A 239
None
0.96A19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		5bqm SOMATOLIBERIN,BOTULI
NUM NEUROTOXIN TYPE
D
(Clostridium
botulinum;
Homo
sapiens)		5 / 12ALA B 799
ILE B 800
ILE B 640
PHE B 643
PHE B 671
None
0.89A20.66