POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Seq. Identity (%)	View	Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2V0Z_C_C41C1328_1 (RENIN)	1htr	GASTRICSIN (Homo sapiens)	6 / 12	ASP B  32 GLY B  34 SER B  35 ASP B 217 GLY B 219 SER B 221	None	0.62A	36.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2V0Z_C_C41C1328_1 (RENIN)	1htr	GASTRICSIN (Homo sapiens)	6 / 12	ASP B  32 GLY B  34 SER B  35 PHE B 117 ASP B 217 GLY B 219	None	0.58A	36.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2V0Z_C_C41C1328_1 (RENIN)	1htr	GASTRICSIN (Homo sapiens)	5 / 12	ASP B 217 GLY B 219 ASP B  32 GLY B  34 SER B  36	None	0.75A	36.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V0Z_C_C41C1328_1 (RENIN)	1lyb	CATHEPSIN D (Homo sapiens)	6 / 12	GLN A  14 VAL A  31 ASP A  33 GLY A  35 SER A  36 TYR A  78	None	0.28A	20.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2V0Z_C_C41C1328_1 (RENIN)	1qrp	PEPSIN 3A (Homo sapiens)	9 / 12	VAL E  30 ASP E  32 GLY E  34 SER E  35 TYR E  75 PHE E 117 ASP E 215 GLY E 217 SER E 219	HH0  E 327 ( 4.7A) HH0  E 327 (-2.7A) HH0  E 327 (-4.1A) HH0  E 327 (-4.1A) HH0  E 327 (-4.5A) HH0  E 327 ( 4.8A) HH0  E 327 (-2.5A) HH0  E 327 (-3.5A) HH0  E 327 (-3.0A)	0.48A	38.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2V0Z_C_C41C1328_1 (RENIN)	1tzs	CATHEPSIN E (Homo sapiens)	8 / 12	ASP A  43 GLY A  45 SER A  46 TYR A  86 PHE A 128 ASP A 228 GLY A 230 SER A 232	None	0.65A	40.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V0Z_C_C41C1328_1 (RENIN)	2ewy	BETA-SECRETASE 2 (Homo sapiens)	6 / 12	ASP A  48 GLY A  50 SER A  51 TYR A  87 ASP A 241 GLY A 243	DBO  A1001 (-2.7A) DBO  A1001 (-3.7A) DBO  A1001 (-4.1A) DBO  A1001 (-3.8A) DBO  A1001 (-3.2A) DBO  A1001 (-4.2A)	0.39A	27.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V0Z_C_C41C1328_1 (RENIN)	2ewy	BETA-SECRETASE 2 (Homo sapiens)	6 / 12	ASP A 241 GLY A 243 VAL A 344 ASP A  48 GLY A  50 SER A  52	DBO  A1001 (-3.2A) DBO  A1001 (-4.2A) None DBO  A1001 (-2.7A) DBO  A1001 (-3.7A) None	1.19A	27.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2V0Z_C_C41C1328_1 (RENIN)	2g1s	RENIN (Homo sapiens)	5 / 12	ASP A 221 GLY A 223 PRO A 301 ASP A  33 GLY A  35	4IG  A 885 (-2.6A) 4IG  A 885 (-3.9A) None 4IG  A 885 (-2.7A) 4IG  A 885 (-3.5A)	0.91A	100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2V0Z_C_C41C1328_1 (RENIN)	2g1s	RENIN (Homo sapiens)	12 / 12	GLN A  14 VAL A  31 ASP A  33 GLY A  35 SER A  36 TYR A  78 PRO A 113 PHE A 119 VAL A 122 ASP A 221 GLY A 223 SER A 225	4IG  A 885 (-3.2A) 4IG  A 885 (-4.3A) 4IG  A 885 (-2.7A) 4IG  A 885 (-3.5A) 4IG  A 885 ( 4.8A) 4IG  A 885 (-4.0A) 4IG  A 885 (-4.7A) None 4IG  A 885 ( 4.4A) 4IG  A 885 (-2.6A) 4IG  A 885 (-3.9A) 4IG  A 885 (-3.1A)	0.45A	100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2V0Z_C_C41C1328_1 (RENIN)	3oag	RENIN (Homo sapiens)	8 / 12	GLN A  19 VAL A  36 ASP A  38 GLY A  40 SER A  41 PRO A 118 PHE A 124 VAL A 127	LPQ  A 167 ( 4.4A) LPQ  A 167 ( 4.5A) LPQ  A 167 (-2.8A) LPQ  A 167 (-3.8A) LPQ  A 167 ( 3.9A) LPQ  A 167 ( 4.4A) LPQ  A 167 (-4.6A) LPQ  A 167 (-4.6A)	0.50A	100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2V0Z_C_C41C1328_1 (RENIN)	4amt	RENIN (Homo sapiens)	5 / 12	ASP A 269 GLY A 271 PRO A 349 ASP A  81 GLY A  83	None	0.87A	88.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2V0Z_C_C41C1328_1 (RENIN)	4amt	RENIN (Homo sapiens)	6 / 12	GLN A 178 ASP A 269 GLY A 271 ASP A  81 GLY A  83 SER A  85	None	1.00A	88.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2V0Z_C_C41C1328_1 (RENIN)	4amt	RENIN (Homo sapiens)	8 / 12	VAL A  79 ASP A  81 GLY A  83 SER A  84 PHE A 167 VAL A 170 ASP A 269 GLY A 271	None	0.62A	88.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2V0Z_C_C41C1328_1 (RENIN)	4amt	RENIN (Homo sapiens)	8 / 12	VAL A  79 ASP A  81 GLY A  83 SER A  84 VAL A 170 ASP A 269 GLY A 271 SER A 273	None None None None None None None SO4  A1387 (-3.8A)	0.58A	88.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2V0Z_C_C41C1328_1 (RENIN)	4amt	RENIN (Homo sapiens)	6 / 12	VAL A  79 ASP A  81 SER A  84 PRO A 161 PHE A 167 VAL A 170	None	0.66A	88.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V0Z_C_C41C1328_1 (RENIN)	4rcd	BETA-SECRETASE 1 (Homo sapiens)	5 / 12	ASP A  32 GLY A  34 SER A  35 ASP A 228 GLY A 230	3LL  A 501 (-2.8A) 3LL  A 501 ( 3.9A) 3LL  A 501 ( 4.3A) 3LL  A 501 (-2.6A) 3LL  A 501 (-3.0A)	0.32A	26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V0Z_C_C41C1328_1 (RENIN)	4rcd	BETA-SECRETASE 1 (Homo sapiens)	6 / 12	ASP A 228 GLY A 230 VAL A 332 ASP A  32 GLY A  34 SER A  36	3LL  A 501 (-2.6A) 3LL  A 501 (-3.0A) None 3LL  A 501 (-2.8A) 3LL  A 501 ( 3.9A) None	1.04A	26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V0Z_C_C41C1328_1 (RENIN)	6ej2	BETA-SECRETASE 1 (Homo sapiens)	5 / 12	ASP A 441 GLY A 443 SER A 444 ASP A 637 GLY A 639	B7E  A 901 (-2.9A) B7E  A 901 ( 3.8A) B7E  A 901 ( 3.7A) B7E  A 901 (-2.6A) B7E  A 901 (-3.8A)	0.34A	13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V0Z_C_C41C1328_1 (RENIN)	6ej2	BETA-SECRETASE 1 (Homo sapiens)	6 / 12	ASP A 637 GLY A 639 VAL A 741 ASP A 441 GLY A 443 SER A 445	B7E  A 901 (-2.6A) B7E  A 901 (-3.8A) None B7E  A 901 (-2.9A) B7E  A 901 ( 3.8A) None	1.04A	13.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2V0Z_O_C41O1327_1 (RENIN)	1htr	GASTRICSIN (Homo sapiens)	5 / 12	ASP B  32 GLY B  34 ALA B 115 PHE B 117 GLY B 219	None	0.77A	36.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2V0Z_O_C41O1327_1 (RENIN)	1htr	GASTRICSIN (Homo sapiens)	5 / 12	ASP B  32 GLY B  34 ASP B 217 GLY B 219 SER B 221	None	0.65A	36.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2V0Z_O_C41O1327_1 (RENIN)	1htr	GASTRICSIN (Homo sapiens)	5 / 12	ASP B  32 GLY B  34 PHE B 117 ASP B 217 GLY B 219	None	0.56A	36.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2V0Z_O_C41O1327_1 (RENIN)	1htr	GASTRICSIN (Homo sapiens)	5 / 12	ASP B 217 GLY B 219 ASP B  32 GLY B  34 SER B  36	None	0.71A	36.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2V0Z_O_C41O1327_1 (RENIN)	1qrp	PEPSIN 3A (Homo sapiens)	8 / 12	VAL E  30 ASP E  32 GLY E  34 ALA E 115 PHE E 117 ASP E 215 GLY E 217 SER E 219	HH0  E 327 ( 4.7A) HH0  E 327 (-2.7A) HH0  E 327 (-4.1A) None HH0  E 327 ( 4.8A) HH0  E 327 (-2.5A) HH0  E 327 (-3.5A) HH0  E 327 (-3.0A)	0.56A	38.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V0Z_O_C41O1327_1 (RENIN)	1sqw	SACCHAROMYCES CEREVISIAE NIP7P HOMOLOG (Homo sapiens)	5 / 12	VAL A 133 GLY A 130 ALA A 103 VAL A  97 GLY A 144	None	0.91A	20.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2V0Z_O_C41O1327_1 (RENIN)	1tzs	CATHEPSIN E (Homo sapiens)	7 / 12	ASP A  43 GLY A  45 PHE A 128 ASP A 228 GLY A 230 SER A 232 ILE A 307	None	0.92A	40.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2V0Z_O_C41O1327_1 (RENIN)	1tzs	CATHEPSIN E (Homo sapiens)	5 / 12	ASP A 228 GLY A 230 ALA A 311 ASP A  43 GLY A  45	None	0.56A	40.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V0Z_O_C41O1327_1 (RENIN)	2ewy	BETA-SECRETASE 2 (Homo sapiens)	6 / 12	ASP A 241 GLY A 243 VAL A 344 ASP A  48 GLY A  50 SER A  52	DBO  A1001 (-3.2A) DBO  A1001 (-4.2A) None DBO  A1001 (-2.7A) DBO  A1001 (-3.7A) None	1.18A	27.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2V0Z_O_C41O1327_1 (RENIN)	2g1s	RENIN (Homo sapiens)	12 / 12	GLN A  14 VAL A  31 ASP A  33 GLY A  35 ALA A 117 PHE A 119 VAL A 122 GLN A 130 ASP A 221 GLY A 223 SER A 225 ILE A 300	4IG  A 885 (-3.2A) 4IG  A 885 (-4.3A) 4IG  A 885 (-2.7A) 4IG  A 885 (-3.5A) 4IG  A 885 ( 4.6A) None 4IG  A 885 ( 4.4A) None 4IG  A 885 (-2.6A) 4IG  A 885 (-3.9A) 4IG  A 885 (-3.1A) None	0.49A	100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2V0Z_O_C41O1327_1 (RENIN)	3oag	RENIN (Homo sapiens)	8 / 12	GLN A  19 VAL A  36 ASP A  38 GLY A  40 ALA A 122 PHE A 124 VAL A 127 GLN A 135	LPQ  A 167 ( 4.4A) LPQ  A 167 ( 4.5A) LPQ  A 167 (-2.8A) LPQ  A 167 (-3.8A) LPQ  A 167 (-3.6A) LPQ  A 167 (-4.6A) LPQ  A 167 (-4.6A) None	0.38A	100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2V0Z_O_C41O1327_1 (RENIN)	4amt	RENIN (Homo sapiens)	6 / 12	GLN A 178 ASP A 269 GLY A 271 ASP A  81 GLY A  83 SER A  85	None	1.00A	88.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2V0Z_O_C41O1327_1 (RENIN)	4amt	RENIN (Homo sapiens)	6 / 12	VAL A  79 ASP A  81 ALA A 165 PHE A 167 VAL A 170 GLN A 178	None	0.71A	88.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2V0Z_O_C41O1327_1 (RENIN)	4amt	RENIN (Homo sapiens)	8 / 12	VAL A  79 ASP A  81 GLY A  83 PHE A 167 VAL A 170 GLN A 178 ASP A 269 GLY A 271	None	0.66A	88.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2V0Z_O_C41O1327_1 (RENIN)	4amt	RENIN (Homo sapiens)	9 / 12	VAL A  79 ASP A  81 GLY A  83 VAL A 170 GLN A 178 ASP A 269 GLY A 271 SER A 273 ILE A 348	None None None None None None None SO4  A1387 (-3.8A) None	0.70A	88.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V0Z_O_C41O1327_1 (RENIN)	4rcd	BETA-SECRETASE 1 (Homo sapiens)	6 / 12	ASP A 228 GLY A 230 VAL A 332 ASP A  32 GLY A  34 SER A  36	3LL  A 501 (-2.6A) 3LL  A 501 (-3.0A) None 3LL  A 501 (-2.8A) 3LL  A 501 ( 3.9A) None	1.03A	26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V0Z_O_C41O1327_1 (RENIN)	6ej2	BETA-SECRETASE 1 (Homo sapiens)	6 / 12	ASP A 637 GLY A 639 VAL A 741 ASP A 441 GLY A 443 SER A 445	B7E  A 901 (-2.6A) B7E  A 901 (-3.8A) None B7E  A 901 (-2.9A) B7E  A 901 ( 3.8A) None	1.03A	13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V0Z_O_C41O1327_2 (RENIN)	1qmn	ALPHA-1-ANTICHYMOTRY PSIN (Homo sapiens)	4 / 8	SER A 178 SER A 314 THR A 313 LEU A 304	None	1.14A	21.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2V0Z_O_C41O1327_2 (RENIN)	2g1s	RENIN (Homo sapiens)	7 / 8	TYR A  15 SER A  36 TYR A  78 SER A  79 THR A  80 PRO A 113 LEU A 116	None 4IG  A 885 ( 4.8A) 4IG  A 885 (-4.0A) 4IG  A 885 (-3.0A) 4IG  A 885 (-3.5A) 4IG  A 885 (-4.7A) 4IG  A 885 (-3.5A)	0.64A	100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2V0Z_O_C41O1327_2 (RENIN)	2g1s	RENIN (Homo sapiens)	5 / 8	TYR A  15 SER A  36 TYR A  78 SER A  79 THR A 304	None 4IG  A 885 ( 4.8A) 4IG  A 885 (-4.0A) 4IG  A 885 (-3.0A) None	0.65A	100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2V0Z_O_C41O1327_2 (RENIN)	2g1s	RENIN (Homo sapiens)	4 / 8	TYR A  16 SER A  36 SER A  79 THR A  80	None 4IG  A 885 ( 4.8A) 4IG  A 885 (-3.0A) 4IG  A 885 (-3.5A)	0.90A	100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2V0Z_O_C41O1327_2 (RENIN)	3oag	RENIN (Homo sapiens)	4 / 8	TYR A  20 SER A  41 PRO A 118 LEU A 121	None LPQ  A 167 ( 3.9A) LPQ  A 167 ( 4.4A) None	0.61A	100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V0Z_O_C41O1327_2 (RENIN)	3top	MALTASE-GLUCOAMYLASE , INTESTINAL (Homo sapiens)	4 / 8	TYR A1162 TYR A1167 LEU A1450 THR A1552	None	0.99A	17.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2V0Z_O_C41O1327_2 (RENIN)	4amt	RENIN (Homo sapiens)	4 / 8	TYR A 126 SER A 127 THR A 128 PRO A 161	None	0.89A	88.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V0Z_O_C41O1327_2 (RENIN)	4asc	KELCH REPEAT AND BTB DOMAIN-CONTAINING PROTEIN 5 (Homo sapiens)	4 / 8	SER A 413 TYR A 415 LEU A 429 THR A 356	None	1.19A	22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V0Z_O_C41O1327_2 (RENIN)	4cgy	DNA TOPOISOMERASE 3-ALPHA (Homo sapiens)	4 / 8	TYR A 241 SER A 240 THR A 219 LEU A 113	None	0.93A	16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V0Z_O_C41O1327_2 (RENIN)	5kkr	KINASE SUPPRESSOR OF RAS 2 (Homo sapiens)	4 / 8	TYR B 865 THR B 862 LEU B 829 THR B 763	None	1.13A	20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V0Z_O_C41O1327_2 (RENIN)	5m76	LIGHT CHAIN DIMER (Homo sapiens)	4 / 8	SER A 182 TYR A 180 SER A 179 THR A 164	None	1.08A	20.06