POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_0
(TUBULIN BETA-2B
CHAIN)		1wer P120GAP
(Homo
sapiens)		5 / 11SER A 817
ASP A 816
GLU A 854
PRO A 912
LEU A 930
None
1.37A20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_0
(TUBULIN BETA-2B
CHAIN)		2de0 ALPHA-(1,6)-FUCOSYLT
RANSFERASE
(Homo
sapiens)		5 / 11VAL X 262
SER X 263
THR X 265
TYR X 334
LEU X 335
None
1.25A21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_0
(TUBULIN BETA-2B
CHAIN)		2ndh TOLL/INTERLEUKIN-1
RECEPTOR
DOMAIN-CONTAINING
ADAPTER PROTEIN
(Homo
sapiens)		5 / 11VAL A 197
TYR A 195
PRO A 177
TYR A 187
LEU A 191
None
1.36A17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_0
(TUBULIN BETA-2B
CHAIN)		3bin BAND 4.1-LIKE
PROTEIN 3
(Homo
sapiens)		5 / 11VAL A 186
THR A 154
TYR A 150
PRO A 190
LEU A 205
None
1.47A20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_0
(TUBULIN BETA-2B
CHAIN)		4dkd INTERLEUKIN-34
(Homo
sapiens)		5 / 11ASN A 155
VAL A 105
SER A 104
ASP A 107
LEU A 165
None
1.16A19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_0
(TUBULIN BETA-2B
CHAIN)		4jgh CULLIN-5
(Homo
sapiens)		5 / 11GLN D  63
VAL D 135
ASP D 141
THR D 142
LEU D 114
None
1.36A21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_0
(TUBULIN BETA-2B
CHAIN)		4miv N-SULPHOGLUCOSAMINE
SULPHOHYDROLASE
(Homo
sapiens)		5 / 11GLN A 239
SER A 272
ASP A 273
GLU A 292
LEU A  50
None
None
CA  A 601 (-2.3A)
None
None
1.49A23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_0
(TUBULIN BETA-2B
CHAIN)		4n9f CULLIN-5
(Homo
sapiens)		5 / 11GLN U  63
VAL U 135
ASP U 141
THR U 142
LEU U 114
None
1.30A21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_0
(TUBULIN BETA-2B
CHAIN)		5b8c PEMBROLIZUMAB LIGHT
CHAIN VARIABLE
REGION (PEMVL)
PEMBROLIZUMAB HEAVY
CHAIN VARIABLE
REGION (PEMVH)
(Homo
sapiens;
Homo
sapiens)		5 / 11ASN B  59
VAL B  37
TYR B  95
PRO A  48
LEU B  45
None
1.48A13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_0
(TUBULIN BETA-2B
CHAIN)		5jw7 E3 UBIQUITIN-PROTEIN
LIGASE SOPA
E3 UBIQUITIN-PROTEIN
LIGASE TRIM56
(Salmonella
enterica;
Homo
sapiens)		5 / 11VAL A 317
SER A 318
GLU B  58
PRO A 314
LEU A 294
None
1.49A21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_0
(TUBULIN BETA-2B
CHAIN)		5of4 TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPD
SUBUNIT
(Homo
sapiens)		5 / 11VAL B  83
THR B  76
GLU B  79
TYR B  72
LEU B  53
None
1.39A20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_0
(TUBULIN BETA-2B
CHAIN)		5wiv D(4) DOPAMINE
RECEPTOR, SOLUBLE
CYTOCHROME B562
CHIMERA
(Escherichia
coli;
Homo
sapiens)		5 / 11ASN A 125
VAL A 166
SER A 163
THR A 159
PRO A 169
None
OLA  A1209 ( 4.9A)
None
None
None
1.22A21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		1itu RENAL DIPEPTIDASE
(Homo
sapiens)		4 / 7LEU A 196
VAL A 201
ILE A 274
VAL A 232
None
1.11A22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		1xkt FATTY ACID SYNTHASE
(Homo
sapiens)		4 / 7LEU A2416
VAL A2397
GLU A2394
ILE A2250
None
1.12A19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		2i6l MITOGEN-ACTIVATED
PROTEIN KINASE 6
(Homo
sapiens)		4 / 7LEU A  72
VAL A  78
ILE A  83
VAL A  80
None
1.07A20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		2jfe CYTOSOLIC
BETA-GLUCOSIDASE
(Homo
sapiens)		4 / 7GLU X 230
ASN X 374
ILE X 371
VAL X 353
None
1.16A20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		2mbg RALA-BINDING PROTEIN
1
(Homo
sapiens)		4 / 7LEU A 373
GLU A 215
ILE A 230
VAL A 220
None
0.92A20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B
(Eptatretus
burgeri;
Homo
sapiens)		4 / 7LEU B 428
GLU B 472
ASN B 455
ILE B 457
None
1.03A21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		3ky9 PROTO-ONCOGENE VAV
(Homo
sapiens)		4 / 7LEU A 472
VAL A 454
GLU A 500
ILE A 433
None
0.86A20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		4igd MANNAN-BINDING
LECTIN SERINE
PROTEASE 1
(Homo
sapiens)		4 / 7LEU A 479
GLU A 557
ILE A 684
VAL A 486
None
1.20A22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		4um2 TELOMERASE-BINDING
PROTEIN EST1A
(Homo
sapiens)		4 / 7LEU A 920
VAL A 915
ASN A 946
ILE A 945
None
1.07A20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		4ztd PROLIFERATING CELL
NUCLEAR ANTIGEN
(Homo
sapiens)		4 / 7LEU A 227
VAL A 136
GLU A 198
ILE A 128
None
1.11A19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		5gve DNA TOPOISOMERASE
3-BETA-1
(Homo
sapiens)		4 / 7VAL A  61
GLU A  91
ILE A 112
VAL A 129
None
0.74A20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		5wc2 PACHYTENE CHECKPOINT
PROTEIN 2 HOMOLOG
(Homo
sapiens)		4 / 7LEU A 296
VAL A 174
ILE A 240
LYS A 288
None
1.09Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		5wy0 SMALL RNA
2'-O-METHYLTRANSFERA
SE
(Homo
sapiens)		4 / 7LEU A  92
VAL A 119
ILE A  49
VAL A  85
None
None
SAM  A 800 (-4.0A)
SAM  A 800 (-3.5A)
1.15Aundetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_D_6K9D502_0
(TUBULIN BETA-2B
CHAIN)		1wer P120GAP
(Homo
sapiens)		5 / 11SER A 817
ASP A 816
GLU A 854
PRO A 912
LEU A 930
None
1.36A20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_D_6K9D502_0
(TUBULIN BETA-2B
CHAIN)		2de0 ALPHA-(1,6)-FUCOSYLT
RANSFERASE
(Homo
sapiens)		5 / 11VAL X 262
SER X 263
THR X 265
TYR X 334
LEU X 335
None
1.28A21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_D_6K9D502_0
(TUBULIN BETA-2B
CHAIN)		2h2t LOW AFFINITY
IMMUNOGLOBULIN
EPSILON FC RECEPTOR
(LYMPHOCYTE IGE
RECEPTOR)
(FC-EPSILON-RII)
(IMMUNOGLOBULIN
E-BINDING FACTOR)
(CD23 ANTIGEN)
(Homo
sapiens)		5 / 11GLN B 171
VAL B 199
SER B 200
ASP B 236
TYR B 175
None
1.45A16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_D_6K9D502_0
(TUBULIN BETA-2B
CHAIN)		2ndh TOLL/INTERLEUKIN-1
RECEPTOR
DOMAIN-CONTAINING
ADAPTER PROTEIN
(Homo
sapiens)		5 / 11VAL A 197
TYR A 195
PRO A 177
TYR A 187
LEU A 191
None
1.34A17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_D_6K9D502_0
(TUBULIN BETA-2B
CHAIN)		3bin BAND 4.1-LIKE
PROTEIN 3
(Homo
sapiens)		5 / 11VAL A 186
THR A 154
TYR A 150
PRO A 190
LEU A 205
None
1.47A20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_D_6K9D502_0
(TUBULIN BETA-2B
CHAIN)		3fcx S-FORMYLGLUTATHIONE
HYDROLASE
(Homo
sapiens)		5 / 11ASN A 162
VAL A 107
THR A 125
TYR A 191
LEU A 192
None
1.44A19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_D_6K9D502_0
(TUBULIN BETA-2B
CHAIN)		4miv N-SULPHOGLUCOSAMINE
SULPHOHYDROLASE
(Homo
sapiens)		5 / 11GLN A 239
SER A 272
ASP A 273
GLU A 292
LEU A  50
None
None
CA  A 601 (-2.3A)
None
None
1.44A23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_D_6K9D502_0
(TUBULIN BETA-2B
CHAIN)		4n9f CULLIN-5
(Homo
sapiens)		5 / 11GLN U  63
VAL U 135
ASP U 141
THR U 142
LEU U 114
None
1.35A21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_D_6K9D502_0
(TUBULIN BETA-2B
CHAIN)		4ykn PHOSPHATIDYLINOSITOL
3-KINASE REGULATORY
SUBUNIT
ALPHA,PHOSPHATIDYLIN
OSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT ALPHA
ISOFORM FUSION
PROTEIN
(Homo
sapiens)		5 / 11GLN A1637
ASN A1677
THR A1679
PRO A1607
TYR A1641
None
1.45A16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_D_6K9D502_0
(TUBULIN BETA-2B
CHAIN)		5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 2
(Homo
sapiens)		5 / 11ASN I 246
VAL I 498
SER I 360
THR I 242
LEU I 476
None
1.45A16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_D_6K9D502_0
(TUBULIN BETA-2B
CHAIN)		5hph HEAT SHOCK PROTEIN
75 KDA,
MITOCHONDRIAL
(Homo
sapiens)		5 / 11SER A 221
THR A 164
GLU A 167
PRO A 139
LEU A 131
None
1.27A21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_D_6K9D502_0
(TUBULIN BETA-2B
CHAIN)		5of4 TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPD
SUBUNIT
(Homo
sapiens)		5 / 11VAL B  83
THR B  76
GLU B  79
TYR B  72
LEU B  53
None
1.42A20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_D_6K9D502_0
(TUBULIN BETA-2B
CHAIN)		5v8z ENDOPLASMIC
RETICULUM RESIDENT
PROTEIN 29
(Homo
sapiens)		5 / 11GLN A 183
VAL A 191
SER A 190
TYR A 161
LEU A 158
None
1.38A12.77