POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTF_A_2TNA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		1d1t ALCOHOL
DEHYDROGENASE CLASS
IV SIGMA CHAIN
(Homo
sapiens)		4 / 5LEU A 345
ILE A 172
SER A 177
GLY A 179
None
0.96A14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTF_A_2TNA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		1h4w TRYPSIN IVA
(Homo
sapiens)		4 / 5LEU A 155
ILE A  73
SER A  32
GLY A  43
None
0.97A16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTF_A_2TNA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		1u3t ALCOHOL
DEHYDROGENASE ALPHA
CHAIN
(Homo
sapiens)		4 / 5LEU A 345
ILE A 172
SER A 177
GLY A 179
None
0.95A16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTF_A_2TNA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		2a1a INTERFERON-INDUCED,
DOUBLE-STRANDED
RNA-ACTIVATED
PROTEIN KINASE
(Homo
sapiens)		4 / 5LEU B 474
ILE B 420
GLY B 401
HIS B 406
None
0.95A21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTF_A_2TNA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		2buj SERINE/THREONINE-PRO
TEIN KINASE 16
(Homo
sapiens)		4 / 5LEU A 221
ILE A 154
GLY A 135
HIS A 140
None
0.71A14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTF_A_2TNA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		2oq5 TRANSMEMBRANE
PROTEASE, SERINE 11E
(Homo
sapiens)		4 / 5LEU A 155
ILE A  75
SER A  32
GLY A  43
None
0.97A20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTF_A_2TNA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		2vc2 INTEGRIN ALPHA-IIB
(Homo
sapiens)		4 / 5LEU A 306
ILE A 360
SER A 292
GLY A 290
None
0.89A14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTF_A_2TNA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		2z2w WEE1-LIKE PROTEIN
KINASE
(Homo
sapiens)		4 / 5LEU A 503
ILE A 432
GLY A 413
HIS A 418
None
0.84A17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTF_A_2TNA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6
(Homo
sapiens)		4 / 5LEU A 371
ILE A 317
GLY A 298
HIS A 303
None
0.94A12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTF_A_2TNA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		3v4p INTEGRIN ALPHA-4
(Homo
sapiens)		4 / 5LEU A 290
ILE A 339
SER A 276
GLY A 274
None
0.67A11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTF_A_2TNA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		4bkw ZINC FINGER FYVE
DOMAIN-CONTAINING
PROTEIN 9
(Homo
sapiens)		4 / 5LEU A1120
ILE A1072
SER A1201
GLY A1225
None
0.99A12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTF_A_2TNA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		4cak INTEGRIN ALPHA-IIB
(Homo
sapiens)		4 / 5LEU A 306
ILE A 360
SER A 292
GLY A 290
None
0.72A7.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTF_A_2TNA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3
(Homo
sapiens)		4 / 5LEU A 207
ILE A 152
GLY A 133
HIS A 138
None
0.82A17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTF_A_2TNA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens)		4 / 5LEU A 377
ILE A 323
GLY A 304
HIS A 309
None
0.95A12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTF_A_2TNA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		4mng TRA@ PROTEIN,TRA@
PROTEIN, TI ANTIGEN
CD3-ASSOCIATED
PROTEIN GAMMA CHAIN
V-J-C REGION
(Homo
sapiens)		4 / 5LEU E 221
ILE E 254
SER E 229
GLY E 230
None
0.83A15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTF_A_2TNA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5
(Homo
sapiens)		4 / 5LEU A 371
ILE A 317
GLY A 298
HIS A 303
None
0.92A12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTF_A_2TNA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		4y85 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 8
(Homo
sapiens)		4 / 5LEU A 313
ILE A 259
GLY A 240
HIS A 245
None
0.91A14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTF_A_2TNA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		4zgz ANTIZYME INHIBITOR 1
(Homo
sapiens)		4 / 5LEU A 232
ILE A  62
SER A 270
GLY A 235
None
0.96A14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTF_A_2TNA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		5uuu BETA-ADRENERGIC
RECEPTOR KINASE 1
(Homo
sapiens)		4 / 5LEU A 377
ILE A 323
GLY A 304
HIS A 309
None
0.89A11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTF_A_2TNA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		5vdk WEE1-LIKE PROTEIN
KINASE 2
(Homo
sapiens)		4 / 5LEU A 420
ILE A 345
GLY A 326
HIS A 331
None
0.84A18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTF_A_2TNA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		6ao5 SERINE/THREONINE-PRO
TEIN KINASE 3
(Homo
sapiens)		4 / 5LEU A 207
ILE A 152
GLY A 133
HIS A 138
None
0.97A16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUB_A_2TNA134_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2
(Homo
sapiens)		4 / 4LEU A 761
ILE A 767
HIS A 708
LYS A 723
None
1.46A8.81