POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4IAQ_A_2GMA2001_1 (CHIMERA PROTEIN OF HUMAN 5-HYDROXYTRYPTAMINE RECEPTOR 1B AND E. COLI SOLUBLE CYTOCHROME B562)	1wuu	GALACTOKINASE (Homo sapiens)	5 / 12	LEU A 333 VAL A 338 PHE A 378 LEU A 40 THR A 352	None	1.42A	19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4IAQ_A_2GMA2001_1 (CHIMERA PROTEIN OF HUMAN 5-HYDROXYTRYPTAMINE RECEPTOR 1B AND E. COLI SOLUBLE CYTOCHROME B562)	1yvl	SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA (Homo sapiens)	5 / 12	LEU A 464 CYH A 543 VAL A 334 PHE A 487 THR A 427	None	1.31A	20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4IAQ_A_2GMA2001_1 (CHIMERA PROTEIN OF HUMAN 5-HYDROXYTRYPTAMINE RECEPTOR 1B AND E. COLI SOLUBLE CYTOCHROME B562)	2q8h	[PYRUVATE DEHYDROGENASE [LIPOAMIDE]] KINASE ISOZYME 1 (Homo sapiens)	5 / 12	LEU A 83 ALA A 129 LEU A 200 PHE A 202 THR A 139	None	1.42A	19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4IAQ_A_2GMA2001_1 (CHIMERA PROTEIN OF HUMAN 5-HYDROXYTRYPTAMINE RECEPTOR 1B AND E. COLI SOLUBLE CYTOCHROME B562)	2wtk	STE20-RELATED KINASE ADAPTER PROTEIN ALPHA (Homo sapiens)	5 / 12	LEU B 390 ALA B 273 PHE B 378 PHE B 352 PHE B 379	None	1.41A	23.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4IAQ_A_2GMA2001_1 (CHIMERA PROTEIN OF HUMAN 5-HYDROXYTRYPTAMINE RECEPTOR 1B AND E. COLI SOLUBLE CYTOCHROME B562)	3pbl	D(3) DOPAMINE RECEPTOR, LYSOZYME CHIMERA (Escherichia virus T4; Homo sapiens)	5 / 12	ASP A 110 TRP A 342 PHE A 345 PHE A 346 THR A 369	ETQ A1200 (-3.5A) None ETQ A1200 (-4.4A) ETQ A1200 ( 4.5A) ETQ A1200 (-4.5A)	0.67A	30.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4IAQ_A_2GMA2001_1 (CHIMERA PROTEIN OF HUMAN 5-HYDROXYTRYPTAMINE RECEPTOR 1B AND E. COLI SOLUBLE CYTOCHROME B562)	3sm9	METABOTROPIC GLUTAMATE RECEPTOR 3 (Homo sapiens)	5 / 12	LEU A 136 VAL A 120 MET A 47 PHE A 20 THR A 73	None None None None CL A 486 (-3.1A)	1.30A	20.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4IAQ_A_2GMA2001_1 (CHIMERA PROTEIN OF HUMAN 5-HYDROXYTRYPTAMINE RECEPTOR 1B AND E. COLI SOLUBLE CYTOCHROME B562)	4ib4	CHIMERA PROTEIN OF HUMAN 5-HYDROXYTRYPTAMINE RECEPTOR 2B AND E. COLI SOLUBLE CYTOCHROME B562 (Escherichia coli; Homo sapiens)	6 / 12	LEU A 132 ASP A 135 ALA A 225 TRP A 337 PHE A 340 PHE A 341	None ERM A2001 (-3.2A) ERM A2001 (-3.4A) None ERM A2001 (-4.3A) None	0.31A	49.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4IAQ_A_2GMA2001_1 (CHIMERA PROTEIN OF HUMAN 5-HYDROXYTRYPTAMINE RECEPTOR 1B AND E. COLI SOLUBLE CYTOCHROME B562)	4ib4	CHIMERA PROTEIN OF HUMAN 5-HYDROXYTRYPTAMINE RECEPTOR 2B AND E. COLI SOLUBLE CYTOCHROME B562 (Escherichia coli; Homo sapiens)	5 / 12	LEU A 209 ALA A 225 TRP A 337 PHE A 340 PHE A 341	ERM A2001 (-3.7A) ERM A2001 (-3.4A) None ERM A2001 (-4.3A) None	1.38A	49.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4IAQ_A_2GMA2001_1 (CHIMERA PROTEIN OF HUMAN 5-HYDROXYTRYPTAMINE RECEPTOR 1B AND E. COLI SOLUBLE CYTOCHROME B562)	4nge	PRESEQUENCE PROTEASE, MITOCHONDRIAL (Homo sapiens)	5 / 12	LEU D 160 PHE D 168 PHE D 288 LEU D 145 THR D 167	None None MLY D 287 ( 4.0A) None None	1.43A	17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4IAQ_A_2GMA2001_1 (CHIMERA PROTEIN OF HUMAN 5-HYDROXYTRYPTAMINE RECEPTOR 1B AND E. COLI SOLUBLE CYTOCHROME B562)	4ns5	ZINC FINGER MYND DOMAIN-CONTAINING PROTEIN 11 (Homo sapiens)	5 / 12	ASP A 307 ALA A 286 PHE A 310 LEU A 264 PHE A 273	None	1.32A	17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4IAQ_A_2GMA2001_1 (CHIMERA PROTEIN OF HUMAN 5-HYDROXYTRYPTAMINE RECEPTOR 1B AND E. COLI SOLUBLE CYTOCHROME B562)	5fbh	EXTRACELLULAR CALCIUM-SENSING RECEPTOR (Homo sapiens)	5 / 12	LEU B 157 VAL B 141 MET B 74 PHE B 38 THR B 100	None None None None CL B 605 (-2.8A)	1.34A	20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4IAQ_A_2GMA2001_1 (CHIMERA PROTEIN OF HUMAN 5-HYDROXYTRYPTAMINE RECEPTOR 1B AND E. COLI SOLUBLE CYTOCHROME B562)	5k5t	EXTRACELLULAR CALCIUM-SENSING RECEPTOR (Homo sapiens)	5 / 12	LEU A 157 VAL A 141 MET A 74 PHE A 38 THR A 100	None None None None CA A 701 (-3.2A)	1.27A	21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4IAQ_A_2GMA2001_1 (CHIMERA PROTEIN OF HUMAN 5-HYDROXYTRYPTAMINE RECEPTOR 1B AND E. COLI SOLUBLE CYTOCHROME B562)	5of4	TFIIH BASAL TRANSCRIPTION FACTOR COMPLEX HELICASE XPD SUBUNIT (Homo sapiens)	5 / 12	ASP B 131 CYH B 134 ALA B 139 PHE B 193 LEU B 107	None SF4 B1000 (-2.3A) None SF4 B1000 (-4.9A) None	1.45A	20.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4IAQ_A_2GMA2001_1 (CHIMERA PROTEIN OF HUMAN 5-HYDROXYTRYPTAMINE RECEPTOR 1B AND E. COLI SOLUBLE CYTOCHROME B562)	5v54	5-HYDROXYTRYPTAMINE RECEPTOR 1B,OB-1 FUSED 5-HT1B RECEPTOR,5-HYDROXYTR YPTAMINE RECEPTOR 1B (Homo sapiens; Spodoptera frugiperda)	7 / 12	ASP A 129 CYH A 133 ALA A 216 TRP A 327 PHE A 330 PHE A 351 THR A 355	89F A1201 (-3.3A) 89F A1201 (-4.5A) 89F A1201 ( 3.9A) 89F A1201 (-3.6A) 89F A1201 (-4.1A) None 89F A1201 (-4.0A)	0.91A	100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4IAQ_A_2GMA2001_1 (CHIMERA PROTEIN OF HUMAN 5-HYDROXYTRYPTAMINE RECEPTOR 1B AND E. COLI SOLUBLE CYTOCHROME B562)	5v54	5-HYDROXYTRYPTAMINE RECEPTOR 1B,OB-1 FUSED 5-HT1B RECEPTOR,5-HYDROXYTR YPTAMINE RECEPTOR 1B (Homo sapiens; Spodoptera frugiperda)	8 / 12	ASP A 129 CYH A 133 TRP A 327 PHE A 330 PHE A 331 MET A 337 PHE A 351 THR A 355	89F A1201 (-3.3A) 89F A1201 (-4.5A) 89F A1201 (-3.6A) 89F A1201 (-4.1A) 89F A1201 (-4.6A) None None 89F A1201 (-4.0A)	1.24A	100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4IAQ_A_2GMA2001_1 (CHIMERA PROTEIN OF HUMAN 5-HYDROXYTRYPTAMINE RECEPTOR 1B AND E. COLI SOLUBLE CYTOCHROME B562)	5v54	5-HYDROXYTRYPTAMINE RECEPTOR 1B,OB-1 FUSED 5-HT1B RECEPTOR,5-HYDROXYTR YPTAMINE RECEPTOR 1B (Homo sapiens; Spodoptera frugiperda)	7 / 12	ASP A 129 CYH A 133 VAL A 201 ALA A 216 TRP A 327 PHE A 330 THR A 355	89F A1201 (-3.3A) 89F A1201 (-4.5A) None 89F A1201 ( 3.9A) 89F A1201 (-3.6A) 89F A1201 (-4.1A) 89F A1201 (-4.0A)	1.02A	100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4IAQ_A_2GMA2001_1 (CHIMERA PROTEIN OF HUMAN 5-HYDROXYTRYPTAMINE RECEPTOR 1B AND E. COLI SOLUBLE CYTOCHROME B562)	5v54	5-HYDROXYTRYPTAMINE RECEPTOR 1B,OB-1 FUSED 5-HT1B RECEPTOR,5-HYDROXYTR YPTAMINE RECEPTOR 1B (Homo sapiens; Spodoptera frugiperda)	8 / 12	ASP A 129 CYH A 133 VAL A 201 TRP A 327 PHE A 330 PHE A 331 MET A 337 THR A 355	89F A1201 (-3.3A) 89F A1201 (-4.5A) None 89F A1201 (-3.6A) 89F A1201 (-4.1A) 89F A1201 (-4.6A) None 89F A1201 (-4.0A)	1.24A	100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4IAQ_A_2GMA2001_1 (CHIMERA PROTEIN OF HUMAN 5-HYDROXYTRYPTAMINE RECEPTOR 1B AND E. COLI SOLUBLE CYTOCHROME B562)	5v54	5-HYDROXYTRYPTAMINE RECEPTOR 1B,OB-1 FUSED 5-HT1B RECEPTOR,5-HYDROXYTR YPTAMINE RECEPTOR 1B (Homo sapiens; Spodoptera frugiperda)	8 / 12	LEU A 126 ASP A 129 CYH A 133 ALA A 216 PHE A 330 LEU A 348 PHE A 351 THR A 355	89F A1201 (-4.9A) 89F A1201 (-3.3A) 89F A1201 (-4.5A) 89F A1201 ( 3.9A) 89F A1201 (-4.1A) None None 89F A1201 (-4.0A)	0.94A	100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4IAQ_A_2GMA2001_1 (CHIMERA PROTEIN OF HUMAN 5-HYDROXYTRYPTAMINE RECEPTOR 1B AND E. COLI SOLUBLE CYTOCHROME B562)	5v54	5-HYDROXYTRYPTAMINE RECEPTOR 1B,OB-1 FUSED 5-HT1B RECEPTOR,5-HYDROXYTR YPTAMINE RECEPTOR 1B (Homo sapiens; Spodoptera frugiperda)	8 / 12	LEU A 126 ASP A 129 CYH A 133 PHE A 330 PHE A 331 LEU A 348 PHE A 351 THR A 355	89F A1201 (-4.9A) 89F A1201 (-3.3A) 89F A1201 (-4.5A) 89F A1201 (-4.1A) 89F A1201 (-4.6A) None None 89F A1201 (-4.0A)	0.88A	100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4IAQ_A_2GMA2001_1 (CHIMERA PROTEIN OF HUMAN 5-HYDROXYTRYPTAMINE RECEPTOR 1B AND E. COLI SOLUBLE CYTOCHROME B562)	5v54	5-HYDROXYTRYPTAMINE RECEPTOR 1B,OB-1 FUSED 5-HT1B RECEPTOR,5-HYDROXYTR YPTAMINE RECEPTOR 1B (Homo sapiens; Spodoptera frugiperda)	8 / 12	LEU A 126 ASP A 129 CYH A 133 PHE A 330 PHE A 331 MET A 337 PHE A 351 THR A 355	89F A1201 (-4.9A) 89F A1201 (-3.3A) 89F A1201 (-4.5A) 89F A1201 (-4.1A) 89F A1201 (-4.6A) None None 89F A1201 (-4.0A)	1.20A	100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4IAQ_A_2GMA2001_1 (CHIMERA PROTEIN OF HUMAN 5-HYDROXYTRYPTAMINE RECEPTOR 1B AND E. COLI SOLUBLE CYTOCHROME B562)	5v54	5-HYDROXYTRYPTAMINE RECEPTOR 1B,OB-1 FUSED 5-HT1B RECEPTOR,5-HYDROXYTR YPTAMINE RECEPTOR 1B (Homo sapiens; Spodoptera frugiperda)	7 / 12	LEU A 126 ASP A 129 CYH A 133 VAL A 201 ALA A 216 PHE A 330 THR A 355	89F A1201 (-4.9A) 89F A1201 (-3.3A) 89F A1201 (-4.5A) None 89F A1201 ( 3.9A) 89F A1201 (-4.1A) 89F A1201 (-4.0A)	0.92A	100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4IAQ_A_2GMA2001_1 (CHIMERA PROTEIN OF HUMAN 5-HYDROXYTRYPTAMINE RECEPTOR 1B AND E. COLI SOLUBLE CYTOCHROME B562)	5v54	5-HYDROXYTRYPTAMINE RECEPTOR 1B,OB-1 FUSED 5-HT1B RECEPTOR,5-HYDROXYTR YPTAMINE RECEPTOR 1B (Homo sapiens; Spodoptera frugiperda)	8 / 12	LEU A 126 ASP A 129 CYH A 133 VAL A 201 PHE A 330 PHE A 331 MET A 337 THR A 355	89F A1201 (-4.9A) 89F A1201 (-3.3A) 89F A1201 (-4.5A) None 89F A1201 (-4.1A) 89F A1201 (-4.6A) None 89F A1201 (-4.0A)	1.17A	100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4IAQ_A_2GMA2001_1 (CHIMERA PROTEIN OF HUMAN 5-HYDROXYTRYPTAMINE RECEPTOR 1B AND E. COLI SOLUBLE CYTOCHROME B562)	5wiv	D(4) DOPAMINE RECEPTOR, SOLUBLE CYTOCHROME B562 CHIMERA (Escherichia coli; Homo sapiens)	5 / 12	ASP A 115 TRP A 407 PHE A 410 PHE A 411 THR A 434	AQD A1201 (-3.3A) None AQD A1201 (-4.7A) AQD A1201 (-4.6A) AQD A1201 (-3.5A)	0.61A	49.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4IAQ_A_2GMA2001_1 (CHIMERA PROTEIN OF HUMAN 5-HYDROXYTRYPTAMINE RECEPTOR 1B AND E. COLI SOLUBLE CYTOCHROME B562)	6b3x	CLEAVAGE STIMULATION FACTOR SUBUNIT 1 (Homo sapiens)	5 / 12	ASP A 372 CYH A 379 VAL A 354 ALA A 359 TRP A 381	None	1.25A	22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4IAQ_A_2GMA2001_1 (CHIMERA PROTEIN OF HUMAN 5-HYDROXYTRYPTAMINE RECEPTOR 1B AND E. COLI SOLUBLE CYTOCHROME B562)	6cm4	D(2) DOPAMINE RECEPTOR, ENDOLYSIN CHIMERA (Escherichia virus T4; Homo sapiens)	6 / 12	ASP A 114 CYH A 118 TRP A 386 PHE A 389 PHE A 390 THR A 412	8NU A2001 ( 3.0A) 8NU A2001 ( 4.0A) 8NU A2001 ( 3.8A) 8NU A2001 ( 4.5A) 8NU A2001 ( 4.8A) 8NU A2001 ( 3.8A)	0.79A	13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4IAQ_A_2GMA2001_1 (CHIMERA PROTEIN OF HUMAN 5-HYDROXYTRYPTAMINE RECEPTOR 1B AND E. COLI SOLUBLE CYTOCHROME B562)	6fx4	E3 UBIQUITIN-PROTEIN LIGASE SMURF2 (Homo sapiens)	5 / 12	ASP A 91 ALA A 108 PHE A 44 LEU A 67 PHE A 68	None	1.25A	15.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4IAQ_A_2GMA2001_1 (CHIMERA PROTEIN OF HUMAN 5-HYDROXYTRYPTAMINE RECEPTOR 1B AND E. COLI SOLUBLE CYTOCHROME B562)	6g79	5-HYDROXYTRYPTAMINE RECEPTOR 1B (Homo sapiens)	5 / 12	ALA S 216 TRP S 327 PHE S 330 PHE S 331 PHE S 351	EP5 S 401 ( 4.0A) None EP5 S 401 (-4.0A) EP5 S 401 (-4.7A) EP5 S 401 (-4.5A)	1.07A	95.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4IAQ_A_2GMA2001_1 (CHIMERA PROTEIN OF HUMAN 5-HYDROXYTRYPTAMINE RECEPTOR 1B AND E. COLI SOLUBLE CYTOCHROME B562)	6g79	5-HYDROXYTRYPTAMINE RECEPTOR 1B (Homo sapiens)	9 / 12	LEU S 126 ASP S 129 CYH S 133 VAL S 201 ALA S 216 TRP S 327 PHE S 330 PHE S 331 THR S 355	None EP5 S 401 (-3.3A) EP5 S 401 (-4.2A) EP5 S 401 (-4.1A) EP5 S 401 ( 4.0A) None EP5 S 401 (-4.0A) EP5 S 401 (-4.7A) None	0.63A	95.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4IAQ_A_2GMA2001_2 (CHIMERA PROTEIN OF HUMAN 5-HYDROXYTRYPTAMINE RECEPTOR 1B AND E. COLI SOLUBLE CYTOCHROME B562)	1fnf	FIBRONECTIN (Homo sapiens)	4 / 6	ILE A1172 THR A1169 VAL A1194 SER A1225	None	1.05A	21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4IAQ_A_2GMA2001_2 (CHIMERA PROTEIN OF HUMAN 5-HYDROXYTRYPTAMINE RECEPTOR 1B AND E. COLI SOLUBLE CYTOCHROME B562)	1hlg	LIPASE, GASTRIC (Homo sapiens)	4 / 6	TRP A 275 ILE A 161 SER A 164 ASP A 331	None	1.10A	20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4IAQ_A_2GMA2001_2 (CHIMERA PROTEIN OF HUMAN 5-HYDROXYTRYPTAMINE RECEPTOR 1B AND E. COLI SOLUBLE CYTOCHROME B562)	2nqa	CALPAIN 8 (Homo sapiens)	4 / 6	TRP A 106 ILE A 111 THR A 115 ASP A 206	None	1.10A	22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4IAQ_A_2GMA2001_2 (CHIMERA PROTEIN OF HUMAN 5-HYDROXYTRYPTAMINE RECEPTOR 1B AND E. COLI SOLUBLE CYTOCHROME B562)	2xzo	REGULATOR OF NONSENSE TRANSCRIPTS 1 (Homo sapiens)	4 / 6	ILE A 329 THR A 325 VAL A 405 ASP A 369	None	1.17A	21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4IAQ_A_2GMA2001_2 (CHIMERA PROTEIN OF HUMAN 5-HYDROXYTRYPTAMINE RECEPTOR 1B AND E. COLI SOLUBLE CYTOCHROME B562)	2y7j	PHOSPHORYLASE B KINASE GAMMA CATALYTIC CHAIN, TESTIS/LIVER ISOFORM (Homo sapiens)	4 / 6	ILE A 94 THR A 92 VAL A 42 ASP A 28	None	1.17A	21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4IAQ_A_2GMA2001_2 (CHIMERA PROTEIN OF HUMAN 5-HYDROXYTRYPTAMINE RECEPTOR 1B AND E. COLI SOLUBLE CYTOCHROME B562)	3g4g	CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D (Homo sapiens)	4 / 6	ILE A 502 THR A 499 VAL A 373 ASP A 322	D71 A 901 (-4.1A) D71 A 901 (-3.6A) None None	1.06A	20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4IAQ_A_2GMA2001_2 (CHIMERA PROTEIN OF HUMAN 5-HYDROXYTRYPTAMINE RECEPTOR 1B AND E. COLI SOLUBLE CYTOCHROME B562)	3o57	CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B (Homo sapiens)	4 / 6	ILE A 410 THR A 407 VAL A 281 ASP A 230	ZG2 A 506 (-4.4A) ZG2 A 506 (-4.3A) None None	1.09A	22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4IAQ_A_2GMA2001_2 (CHIMERA PROTEIN OF HUMAN 5-HYDROXYTRYPTAMINE RECEPTOR 1B AND E. COLI SOLUBLE CYTOCHROME B562)	3rn2	INTERFERON-INDUCIBLE PROTEIN AIM2 (Homo sapiens)	4 / 6	ILE A 334 THR A 301 VAL A 264 ASP A 286	None	1.13A	19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4IAQ_A_2GMA2001_2 (CHIMERA PROTEIN OF HUMAN 5-HYDROXYTRYPTAMINE RECEPTOR 1B AND E. COLI SOLUBLE CYTOCHROME B562)	3s5n	4-HYDROXY-2-OXOGLUTA RATE ALDOLASE, MITOCHONDRIAL (Homo sapiens)	4 / 6	ILE A 151 THR A 155 VAL A 180 ASP A 197	None	0.89A	21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4IAQ_A_2GMA2001_2 (CHIMERA PROTEIN OF HUMAN 5-HYDROXYTRYPTAMINE RECEPTOR 1B AND E. COLI SOLUBLE CYTOCHROME B562)	3t1w	FOUR-DOMAIN FIBRONECTIN FRAGMENT (Homo sapiens)	4 / 6	ILE A1203 THR A1200 VAL A1225 SER A1256	None	1.12A	20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4IAQ_A_2GMA2001_2 (CHIMERA PROTEIN OF HUMAN 5-HYDROXYTRYPTAMINE RECEPTOR 1B AND E. COLI SOLUBLE CYTOCHROME B562)	4wlh	KYNURENINE--OXOGLUTA RATE TRANSAMINASE 1 (Homo sapiens)	4 / 6	ILE A 229 THR A 239 VAL A 190 SER A 231	None	1.04A	21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4IAQ_A_2GMA2001_2 (CHIMERA PROTEIN OF HUMAN 5-HYDROXYTRYPTAMINE RECEPTOR 1B AND E. COLI SOLUBLE CYTOCHROME B562)	4wp0	KYNURENINE--OXOGLUTA RATE TRANSAMINASE 1 (Homo sapiens)	4 / 6	ILE A 229 THR A 239 VAL A 190 SER A 231	None	0.90A	21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4IAQ_A_2GMA2001_2 (CHIMERA PROTEIN OF HUMAN 5-HYDROXYTRYPTAMINE RECEPTOR 1B AND E. COLI SOLUBLE CYTOCHROME B562)	4ypg	INTERFERON ALPHA-2 (Homo sapiens)	4 / 6	TRP C 76 THR C 14 VAL C 142 SER C 152	None	1.09A	16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4IAQ_A_2GMA2001_2 (CHIMERA PROTEIN OF HUMAN 5-HYDROXYTRYPTAMINE RECEPTOR 1B AND E. COLI SOLUBLE CYTOCHROME B562)	5igq	E3 UBIQUITIN-PROTEIN LIGASE RFWD2 (Homo sapiens)	4 / 6	ILE A 473 VAL A 495 SER A 426 ASP A 535	None	1.06A	20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4IAQ_A_2GMA2001_2 (CHIMERA PROTEIN OF HUMAN 5-HYDROXYTRYPTAMINE RECEPTOR 1B AND E. COLI SOLUBLE CYTOCHROME B562)	5ohj	CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B (Homo sapiens)	4 / 6	ILE A 582 THR A 579 VAL A 453 ASP A 402	9VE A 801 (-4.1A) 9VE A 801 (-4.1A) None None	1.05A	11.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4IAQ_A_2GMA2001_2 (CHIMERA PROTEIN OF HUMAN 5-HYDROXYTRYPTAMINE RECEPTOR 1B AND E. COLI SOLUBLE CYTOCHROME B562)	5v54	5-HYDROXYTRYPTAMINE RECEPTOR 1B,OB-1 FUSED 5-HT1B RECEPTOR,5-HYDROXYTR YPTAMINE RECEPTOR 1B (Homo sapiens; Spodoptera frugiperda)	6 / 6	TRP A 125 ILE A 130 THR A 134 VAL A 200 SER A 212 ASP A 352	None 89F A1201 (-4.3A) 89F A1201 (-4.2A) None 89F A1201 ( 3.8A) None	0.85A	100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4IAQ_A_2GMA2001_2 (CHIMERA PROTEIN OF HUMAN 5-HYDROXYTRYPTAMINE RECEPTOR 1B AND E. COLI SOLUBLE CYTOCHROME B562)	5xbf	HARMONIN UNCONVENTIONAL MYOSIN-VIIB (Homo sapiens)	4 / 6	ILE A2038 THR A2006 VAL A2025 ASP B 547	None	1.03A	22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4IAQ_A_2GMA2001_2 (CHIMERA PROTEIN OF HUMAN 5-HYDROXYTRYPTAMINE RECEPTOR 1B AND E. COLI SOLUBLE CYTOCHROME B562)	6bqh	5-HYDROXYTRYPTAMINE RECEPTOR 2C,SOLUBLE CYTOCHROME B562 (Escherichia coli; Homo sapiens)	4 / 6	TRP A 130 THR A 139 VAL A 208 SER A 219	None E2J A1201 (-4.3A) None E2J A1201 (-3.2A)	0.90A	11.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4IAQ_A_2GMA2001_2 (CHIMERA PROTEIN OF HUMAN 5-HYDROXYTRYPTAMINE RECEPTOR 1B AND E. COLI SOLUBLE CYTOCHROME B562)	6g79	5-HYDROXYTRYPTAMINE RECEPTOR 1B (Homo sapiens)	4 / 6	TRP S 125 ILE S 130 THR S 134 SER S 212	None EP5 S 401 (-4.2A) EP5 S 401 (-3.8A) EP5 S 401 (-3.3A)	0.72A	95.18