POTENTIAL TARGETS FROM HUMAN (RESULTS FROM SUB-STRUCTURAL SIMILARITY SEARCHES)
1) User may click on the DrReposER ID (the second column) to get information on the binding sites and drug molecule.
2) Click View (the second last column) to view matched residues and superposition in the NGL viewer (upper right part).
3) User may also click on the Dock (the last column) to get script for molecular docking in UCSF Chimera through AutoDock Vina.

DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TZF_B_08DB280_1
(7,8-DIHYDROPTEROATE
SYNTHASE)		1jmy BILE-SALT-ACTIVATED
LIPASE
(Homo
sapiens)		4 / 8PHE A 235
PRO A 233
GLY A 286
PHE A 287
None
1.02A19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TZF_B_08DB280_1
(7,8-DIHYDROPTEROATE
SYNTHASE)		1q4x THYROID HORMONE
RECEPTOR BETA-1
(Homo
sapiens)		4 / 8PHE A 455
THR A 273
GLY A 345
PHE A 269
G24  A 462 (-3.8A)
G24  A 462 (-4.5A)
G24  A 462 ( 4.1A)
G24  A 462 (-4.2A)
1.05A21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TZF_B_08DB280_1
(7,8-DIHYDROPTEROATE
SYNTHASE)		1z8l GLUTAMATE
CARBOXYPEPTIDASE II
(Homo
sapiens)		4 / 8PHE A 144
PRO A 160
GLY A 251
SER A 142
None
1.10A17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TZF_B_08DB280_1
(7,8-DIHYDROPTEROATE
SYNTHASE)		2h8l PROTEIN
DISULFIDE-ISOMERASE
A3
(Homo
sapiens)		4 / 8PHE A 148
GLY A 158
PHE A 159
SER A 136
None
0.96A19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TZF_B_08DB280_1
(7,8-DIHYDROPTEROATE
SYNTHASE)		2j3s FILAMIN-A
(Homo
sapiens)		4 / 8THR A2263
ARG A2264
GLY A2236
PHE A2311
DIO  A3331 ( 4.0A)
None
None
None
0.98A21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TZF_B_08DB280_1
(7,8-DIHYDROPTEROATE
SYNTHASE)		2wg3 DESERT HEDGEHOG
PROTEIN N-PRODUCT
(Homo
sapiens)		4 / 8THR A  56
ARG A  55
PRO A  62
LYS A 187
None
1.09A20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TZF_B_08DB280_1
(7,8-DIHYDROPTEROATE
SYNTHASE)		3h0t FAB FRAGMENT, HEAVY
CHAIN
(Homo
sapiens)		4 / 8THR B  94
PRO B  91
GLY B 183
SER B 122
None
1.04A20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TZF_B_08DB280_1
(7,8-DIHYDROPTEROATE
SYNTHASE)		4f58 HEAVY CHAIN OF FAB
OF A NEUTRALIZING
ANTIBODY L3
(Homo
sapiens)		4 / 8THR H  87
PRO H  84
GLY H 174
SER H 113
None
1.05A22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TZF_B_08DB280_1
(7,8-DIHYDROPTEROATE
SYNTHASE)		4nkq CYTOKINE RECEPTOR
COMMON SUBUNIT BETA
(Homo
sapiens)		4 / 8ARG A 327
GLY A 275
PHE A 277
SER A 273
None
1.10A20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TZF_B_08DB280_1
(7,8-DIHYDROPTEROATE
SYNTHASE)		4ono BETA-2-MICROGLOBULIN
/T-CELL SURFACE
GLYCOPROTEIN
CD1C/T-CELL SURFACE
GLYCOPROTEIN CD1B
CHIMERIC PROTEIN
(Homo
sapiens)		4 / 8PHE A 125
THR A 281
GLY A 171
PHE A 173
PMK  A 401 ( 4.2A)
CL  A 402 (-3.6A)
None
None
0.95A22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TZF_B_08DB280_1
(7,8-DIHYDROPTEROATE
SYNTHASE)		4s3n 2'-5'-OLIGOADENYLATE
SYNTHASE 3
(Homo
sapiens)		4 / 8PHE A 131
THR A 119
PRO A 121
SER A 145
None
0.98A22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TZF_B_08DB280_1
(7,8-DIHYDROPTEROATE
SYNTHASE)		5fws KREMEN PROTEIN 1
(Homo
sapiens)		4 / 8PHE A 168
THR A 133
PRO A 131
GLY A 127
None
1.04A20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TZF_B_08DB280_1
(7,8-DIHYDROPTEROATE
SYNTHASE)		5fww KREMEN PROTEIN 1
(Homo
sapiens)		4 / 8PHE B 168
THR B 133
PRO B 131
GLY B 127
None
1.02A19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TZF_B_08DB280_1
(7,8-DIHYDROPTEROATE
SYNTHASE)		5n7f MEMBRANE-ASSOCIATED
GUANYLATE KINASE, WW
AND PDZ
DOMAIN-CONTAINING
PROTEIN 1,ANNEXIN A2
(Homo
sapiens)		4 / 8ARG A 476
GLY A 481
PHE A 482
SER A 479
None
1.07A21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TZF_B_08DB280_1
(7,8-DIHYDROPTEROATE
SYNTHASE)		5udy ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 7
(Homo
sapiens)		4 / 8THR A  84
GLY A 144
PHE A  80
SER A 139
None
1.10A22.20